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The map label for this gene is ctaC [H]

Identifier: 120612546

GI number: 120612546

Start: 4330321

End: 4331493

Strand: Reverse

Name: ctaC [H]

Synonym: Aave_3907

Alternate gene names: 120612546

Gene position: 4331493-4330321 (Counterclockwise)

Preceding gene: 120612547

Following gene: 120612545

Centisome position: 80.92

GC content: 65.98

Gene sequence:

>1173_bases
ATGAAGAAAAGCATTTCCAACCCGCTGCCTTCGTTGCTGCTGCTGTGCGGAGCATGGGTGGGGGGCGCCGCGCAGGCGGT
GCAGGACCTTCCCGGCGGCCCGGCCGTGCGCCAGCTCAATCTCGCGCCCCCGGTCACGCGCATCGCCGAGGAGCAGCATT
TCCTGCACTGGATGATGCTCGTCATCTGCACGCTGATCTTCGTGGGCGTGTTCTCGGTGATGTTCTATTCCATCTGGAAG
CACCGCAAGTCGCAGGGCGCCAAGCCCGCCAACTTCCACGAGTCCGTCACGGTCGAGGTGATCTGGACCATCGTTCCCTT
CATCATCGTGATCCTCATGGCCCTGCCGGCCACCAAGGTGCTCGTCGCCCAGAAGGACACCACCAACGCCGACCTCACGG
TGAAGGTCACCGGCTACCAGTGGAAGTGGGGCTACGACTACATCAACGGCGAGGGCCAGGGCCTGGCCTACATCTCCACG
CTCGACAACAGCCACCGCCGGCTCTCCGACAGCGGCAGGGTCGCCGACGCGCCGCCGGACTACCTGCTCAAGGTGGACAA
CCCCCTGGTCGTGCCCGTTGGCAAGAAGGTGCGCGTGATCACCACCGCCAACGACGTCATCCATTCGTTCATGGTGCCGG
CCTTCGGCATCAAGCAGGACGCGATCCCCGGCTTCGTGCGCGACACCTGGTTCCGCGCCGACAAGGTCGGCGACTACTAC
GGGCAGTGCGCCGAGCTCTGCGGCAAGGAGCACGCCTACATGCCCATCCACGTGAAGGTGCTCTCCGCGGCCGACTACAC
CCAGTGGGTCGCCGCCGAGAAGAAGAAGGCCGCCGCCAAGGCCGACGATCCCAACAAGGTCTGGACGCTGACCGACATCG
TGGCCCGCGGCGAGAAGGTCTATGCCGCCAACTGCGCCGCCTGCCACCAGCCCAACGGCAAGGGCGCCGGCCCCATCAAG
CCCCTCGACGGCTCGGCCATCGTGAAGGACGAGGACCACACCAGGCAGATCCAGATCGTGCTCAAGGGCGCGGCAGGCGG
CGCCATGCCCTCCTGGGCGCAACTGAGCGACACCGACCTCGCGGCCGTGGTCAGCTACACGAAGAACGCCTGGTCCAACA
AGACCGGCCAGATCGTCCAGCCCGCGGAAATCGTGGCCCAGCGCGGCAAGTGA

Upstream 100 bases:

>100_bases
TGCGCCCCGGCTGTCGGAATCCGCATGCCCCCGGGCGCCGCCCGACCCCACGCGGGCGCGCCCTGGGGAAAGGGTTAATT
GAGGCTGAGAAGTGAGAACT

Downstream 100 bases:

>100_bases
GACAGCTAAAGCATTGAGGAACCCGACATGAGCGCAGTTCTCGACCCCACCGGGCATGCCGCCGGCCATGACCACGGCGG
CCACGACCACGACCATGCAC

Product: cytochrome c oxidase subunit II

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II; Oxidase aa(3) subunit 2 [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKKSISNPLPSLLLLCGAWVGGAAQAVQDLPGGPAVRQLNLAPPVTRIAEEQHFLHWMMLVICTLIFVGVFSVMFYSIWK
HRKSQGAKPANFHESVTVEVIWTIVPFIIVILMALPATKVLVAQKDTTNADLTVKVTGYQWKWGYDYINGEGQGLAYIST
LDNSHRRLSDSGRVADAPPDYLLKVDNPLVVPVGKKVRVITTANDVIHSFMVPAFGIKQDAIPGFVRDTWFRADKVGDYY
GQCAELCGKEHAYMPIHVKVLSAADYTQWVAAEKKKAAAKADDPNKVWTLTDIVARGEKVYAANCAACHQPNGKGAGPIK
PLDGSAIVKDEDHTRQIQIVLKGAAGGAMPSWAQLSDTDLAAVVSYTKNAWSNKTGQIVQPAEIVAQRGK

Sequences:

>Translated_390_residues
MKKSISNPLPSLLLLCGAWVGGAAQAVQDLPGGPAVRQLNLAPPVTRIAEEQHFLHWMMLVICTLIFVGVFSVMFYSIWK
HRKSQGAKPANFHESVTVEVIWTIVPFIIVILMALPATKVLVAQKDTTNADLTVKVTGYQWKWGYDYINGEGQGLAYIST
LDNSHRRLSDSGRVADAPPDYLLKVDNPLVVPVGKKVRVITTANDVIHSFMVPAFGIKQDAIPGFVRDTWFRADKVGDYY
GQCAELCGKEHAYMPIHVKVLSAADYTQWVAAEKKKAAAKADDPNKVWTLTDIVARGEKVYAANCAACHQPNGKGAGPIK
PLDGSAIVKDEDHTRQIQIVLKGAAGGAMPSWAQLSDTDLAAVVSYTKNAWSNKTGQIVQPAEIVAQRGK
>Mature_390_residues
MKKSISNPLPSLLLLCGAWVGGAAQAVQDLPGGPAVRQLNLAPPVTRIAEEQHFLHWMMLVICTLIFVGVFSVMFYSIWK
HRKSQGAKPANFHESVTVEVIWTIVPFIIVILMALPATKVLVAQKDTTNADLTVKVTGYQWKWGYDYINGEGQGLAYIST
LDNSHRRLSDSGRVADAPPDYLLKVDNPLVVPVGKKVRVITTANDVIHSFMVPAFGIKQDAIPGFVRDTWFRADKVGDYY
GQCAELCGKEHAYMPIHVKVLSAADYTQWVAAEKKKAAAKADDPNKVWTLTDIVARGEKVYAANCAACHQPNGKGAGPIK
PLDGSAIVKDEDHTRQIQIVLKGAAGGAMPSWAQLSDTDLAAVVSYTKNAWSNKTGQIVQPAEIVAQRGK

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) [H]

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=171, Percent_Identity=37.4269005847953, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6226540, Length=209, Percent_Identity=33.9712918660287, Blast_Score=130, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759 [H]

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 42484; Mature: 42484

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS00078 COX2 ; PS50999 COX2_TM ; PS50857 COX2_CUA ; PS51007 CYTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSISNPLPSLLLLCGAWVGGAAQAVQDLPGGPAVRQLNLAPPVTRIAEEQHFLHWMML
CCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
VICTLIFVGVFSVMFYSIWKHRKSQGAKPANFHESVTVEVIWTIVPFIIVILMALPATKV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
LVAQKDTTNADLTVKVTGYQWKWGYDYINGEGQGLAYISTLDNSHRRLSDSGRVADAPPD
EEEECCCCCCEEEEEEECEEEEECCCEECCCCCCEEEEEECCCCHHHCCCCCCCCCCCCC
YLLKVDNPLVVPVGKKVRVITTANDVIHSFMVPAFGIKQDAIPGFVRDTWFRADKVGDYY
CEEEECCCEEEECCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GQCAELCGKEHAYMPIHVKVLSAADYTQWVAAEKKKAAAKADDPNKVWTLTDIVARGEKV
HHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHCCCEE
YAANCAACHQPNGKGAGPIKPLDGSAIVKDEDHTRQIQIVLKGAAGGAMPSWAQLSDTDL
EEECCHHHCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCHH
AAVVSYTKNAWSNKTGQIVQPAEIVAQRGK
HHHHHHHHHHCCCCCCCEECHHHHHHCCCC
>Mature Secondary Structure
MKKSISNPLPSLLLLCGAWVGGAAQAVQDLPGGPAVRQLNLAPPVTRIAEEQHFLHWMML
CCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
VICTLIFVGVFSVMFYSIWKHRKSQGAKPANFHESVTVEVIWTIVPFIIVILMALPATKV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
LVAQKDTTNADLTVKVTGYQWKWGYDYINGEGQGLAYISTLDNSHRRLSDSGRVADAPPD
EEEECCCCCCEEEEEEECEEEEECCCEECCCCCCEEEEEECCCCHHHCCCCCCCCCCCCC
YLLKVDNPLVVPVGKKVRVITTANDVIHSFMVPAFGIKQDAIPGFVRDTWFRADKVGDYY
CEEEECCCEEEECCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GQCAELCGKEHAYMPIHVKVLSAADYTQWVAAEKKKAAAKADDPNKVWTLTDIVARGEKV
HHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHCCCEE
YAANCAACHQPNGKGAGPIKPLDGSAIVKDEDHTRQIQIVLKGAAGGAMPSWAQLSDTDL
EEECCHHHCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCHH
AAVVSYTKNAWSNKTGQIVQPAEIVAQRGK
HHHHHHHHHHCCCCCCCEECHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1648008 [H]