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The map label for this gene is gcvA [H]

Identifier: 120612532

GI number: 120612532

Start: 4316821

End: 4317684

Strand: Direct

Name: gcvA [H]

Synonym: Aave_3892

Alternate gene names: 120612532

Gene position: 4316821-4317684 (Clockwise)

Preceding gene: 120612523

Following gene: 120612533

Centisome position: 80.65

GC content: 70.6

Gene sequence:

>864_bases
ATGCCGCTGAAGGCACTGCGGGCGTTCGTGGCCGTCGGCCGGCACGGCAAGTTCACGCGGGCGGCCAGTGCGCTCGGCAT
CACGCAGGGCGCGGTCAGCCGCCACATCGCCGTGCTGGAAGCGTTCGCGGGCACGGCGCTGTTCATACGCCGGGGCGCCA
CCATCGAGATGACGCCGGCCGGGCTCCAGCTCTTCGAGGCGGTGAAGGACGCGATGTCCACCATCGAGCTGACGATGCAG
TTGCTGGCGCAGAAGGGCAAACGGCACGACCGCCTGCGGGTGCGCACGTCCATGCCCAGCTTCGCGATGACGGTGGTGGT
GCCGGCGCTCGGCGCCTTCTCGGCGGCCAGCGGGGCCCAGGTCGACCTCATCACGTCCCTGTCGCCCCCCCTGCCCTCCG
ACGACTTCGACGTACTCGTCACCCGCGACCTGAGCCTGGGCGGGACGGAGTCCTGGGAGCTGGTCCGCGAAGAGCTGGTC
TGCGTCGGCTCGCCATCCCAGGTGGCCGCGCACCGGTCGGACGCCGTGGCGCACTGGCCCATGGTGGCGTCCAGGTCGCG
CCCGGAGCTGCTCGCGTCGTGGGCCCTCGCCGCGAACCTGCCGCCGGACAGCCTGCACGTCGTGGCCACGTACGACCATC
TGTTCCTGGCGCTGACCGCCGCCATCGGCGGCTCGGGATTCCTCGTCGTGCCCCGGCTGTTCGTGCTCGACCAGCTCCGC
GACGGCACGCTCCAGCTGGCGGACGAGCGGGTCGTCAACTCGGGCGCGAGCTATGTCGCGTACCTGAACGAGATGAGCTC
GCACACGCAGCTCGCGCAGGACTTCTGCCGGTGGCTGAAGGCGCTGCTGAGAGATCGAAAGTGA

Upstream 100 bases:

>100_bases
TCATTGTTTCCAGTCAAGACGCCGGGATCAATGCACGCTGTGTGACAGTATTCTTGTTCGCTGGACTTTTATGAAGAAAA
TTAATACTGACTCCGCCGAG

Downstream 100 bases:

>100_bases
ACCGCCCCTGAGCAGCCCTGGCAAGGCGGTGTTCGTGGGCTACCCGGTGGCCTATGGGCTTCCCCGGTTTCCCGGACGCT
TTGCCTAACCCTTCAAGCGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MPLKALRAFVAVGRHGKFTRAASALGITQGAVSRHIAVLEAFAGTALFIRRGATIEMTPAGLQLFEAVKDAMSTIELTMQ
LLAQKGKRHDRLRVRTSMPSFAMTVVVPALGAFSAASGAQVDLITSLSPPLPSDDFDVLVTRDLSLGGTESWELVREELV
CVGSPSQVAAHRSDAVAHWPMVASRSRPELLASWALAANLPPDSLHVVATYDHLFLALTAAIGGSGFLVVPRLFVLDQLR
DGTLQLADERVVNSGASYVAYLNEMSSHTQLAQDFCRWLKALLRDRK

Sequences:

>Translated_287_residues
MPLKALRAFVAVGRHGKFTRAASALGITQGAVSRHIAVLEAFAGTALFIRRGATIEMTPAGLQLFEAVKDAMSTIELTMQ
LLAQKGKRHDRLRVRTSMPSFAMTVVVPALGAFSAASGAQVDLITSLSPPLPSDDFDVLVTRDLSLGGTESWELVREELV
CVGSPSQVAAHRSDAVAHWPMVASRSRPELLASWALAANLPPDSLHVVATYDHLFLALTAAIGGSGFLVVPRLFVLDQLR
DGTLQLADERVVNSGASYVAYLNEMSSHTQLAQDFCRWLKALLRDRK
>Mature_286_residues
PLKALRAFVAVGRHGKFTRAASALGITQGAVSRHIAVLEAFAGTALFIRRGATIEMTPAGLQLFEAVKDAMSTIELTMQL
LAQKGKRHDRLRVRTSMPSFAMTVVVPALGAFSAASGAQVDLITSLSPPLPSDDFDVLVTRDLSLGGTESWELVREELVC
VGSPSQVAAHRSDAVAHWPMVASRSRPELLASWALAANLPPDSLHVVATYDHLFLALTAAIGGSGFLVVPRLFVLDQLRD
GTLQLADERVVNSGASYVAYLNEMSSHTQLAQDFCRWLKALLRDRK

Specific function: Not known, the gcv operon regulated by the E.coli homolog does not exist in H.influenzae, so it probably acts as a transcriptional regulator on some other operon [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789173, Length=296, Percent_Identity=28.7162162162162, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786448, Length=250, Percent_Identity=29.2, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 30942; Mature: 30811

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLKALRAFVAVGRHGKFTRAASALGITQGAVSRHIAVLEAFAGTALFIRRGATIEMTPA
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEECHH
GLQLFEAVKDAMSTIELTMQLLAQKGKRHDRLRVRTSMPSFAMTVVVPALGAFSAASGAQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCC
VDLITSLSPPLPSDDFDVLVTRDLSLGGTESWELVREELVCVGSPSQVAAHRSDAVAHWP
EEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCHHHCC
MVASRSRPELLASWALAANLPPDSLHVVATYDHLFLALTAAIGGSGFLVVPRLFVLDQLR
HHHCCCCHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
DGTLQLADERVVNSGASYVAYLNEMSSHTQLAQDFCRWLKALLRDRK
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PLKALRAFVAVGRHGKFTRAASALGITQGAVSRHIAVLEAFAGTALFIRRGATIEMTPA
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEECHH
GLQLFEAVKDAMSTIELTMQLLAQKGKRHDRLRVRTSMPSFAMTVVVPALGAFSAASGAQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCC
VDLITSLSPPLPSDDFDVLVTRDLSLGGTESWELVREELVCVGSPSQVAAHRSDAVAHWP
EEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCHHHCC
MVASRSRPELLASWALAANLPPDSLHVVATYDHLFLALTAAIGGSGFLVVPRLFVLDQLR
HHHCCCCHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
DGTLQLADERVVNSGASYVAYLNEMSSHTQLAQDFCRWLKALLRDRK
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]