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The map label for this gene is fhuA [H]

Identifier: 120612371

GI number: 120612371

Start: 4115994

End: 4118195

Strand: Direct

Name: fhuA [H]

Synonym: Aave_3728

Alternate gene names: 120612371

Gene position: 4115994-4118195 (Clockwise)

Preceding gene: 120612370

Following gene: 120612381

Centisome position: 76.89

GC content: 70.48

Gene sequence:

>2202_bases
ATGCGCCATGTTTCCGCCGCGAGGCCTGCGCGGCAGCGCCTGCTGCACGCTTCCATCACCGCGGCCTTCGGCACCGCGGC
CGTGCTGTCCACCCCGCTGGCGGGGGCACAGGACGCCTCCGCCGGCTCCACCACGCTGCCCACGGTCACGGTGACCGGCG
GCGCCGAGGAGAGCGCCACGGGCCGGGTGAACGGCTACACGGCACGCCGCAGCGCGACCGCCACCAAGACGGACACCCCC
CTGATCGAGACGCCGCAGTCCATTTCGGTGATCCCGGCGGACCTGATGGAGGCGCAGGGCGCGCGCACGGTGAAGGACGC
GCTCAGCTACTCGCCGGGCGTGATCCCGACGCGCTTCGGCGCGGACTCGCGCTACGACTGGATCTCGCTGCGCGGCTTCG
ATGCCTATTCGCCGGGCTTCTACCTGGACGGCATGCCGCTGCGCAACAACGGCAACTGGGGCATCTGGCCCGTGGAGAGC
TATGGGGCCGAGCGGATCGAACTGCTGCGCGGGCCGGCGTCGGTGCTGTACGGCATGAGCGGCCCGGGCGGGCTGGTGAA
CGCCGTGAGCAAGCGCCCGACGGCCGAGCCGCTGCGCGAGGTGCAGGTGCAGATCGGCGACCACGGGCGCCGCCAGATCG
CGGCCGACGTGTCCGGCCCGCTGCGCGAGGATGGCAAGCTGCTCTACCGCCTGACCGCGCTCACGCGCGATGCCGAGCTG
CCGGCGGGCGACATGAAGGACGACCGCACCTTCATCGCCCCGGCCTTCACCTGGAAGCCCTCCGGCGACACCAGCCTGAC
CGTGCTGTCGCAGTTCGGCCGCACCCGCGCCGGGGTGTACTCGCGCACGCGGCCGGCCGTGGGCTCGCTGGTGCCGACGG
CCATCGGCACCACCATCCCGAGCGACCTGTTCGCCGGGGAGCCGGGCTACAACCGCTTCGACATGGACACCGCGATGATC
GGCTACCTGTTCGAGCACCGCATCGATGATGCCTTCACCGTGCGGCAGAACGCGCGCTACGGCCGCCTCGAGGTGGACTA
CACCGCGGTGCAGGGACGCAACTTCATCACCGTGAACCCGGCGAACCCGCGCGATCCGGCGAATTTCTCCACGCTGCGGC
GCACGGTGTCGGGCAGCAACGAGCGCATCCACGCGCTGAACCTCGACAACCAGCTGGAAGCGCGCCTGCGCTCGGGCGAC
GTGCAGCACACCGTGCTGGCCGGGCTGGAATACCAGCGCACCCGCATCGACCAGGTCAGCTACAGCGGCGGCTCCGCGAG
CCCGCTCGACATCTACAACCCCGTGTATGGCGGCGCGGTGCAGCTGCCCGCGCCGTGGTACGACGGCGTCGCCACGCTCG
CGCAGACCGGCTTCTATCTGCAGGACCAGATCAAGTGGCGCGACCGCTGGGTGCTCACGCTGGGCGCGCGCTACGACCGC
GCCACCAGCGATGCGGACAGCCGGCTGGACGGCAGCCGGACCAGGGTGTCGGAACACAAGGCGACGAAGCGCGCGGGCCT
GACCTACCTGGCCGAGAGCGGCTGGGCGCCGTACGTGAGCTATACCGAATCGTTCGTGCCCACGGCCATGCGCAACCCGG
CCACGGGCCAGCCGTTCAAGCCCGAGACCGGCCGCCAGTACGAAGCCGGCGTGCGCTACCAGCCCGAGGGCGGCAGGCAG
CGCTACAGCGCCGCCATCTTCGACCTGCGCCGCAAGAACTACCTGACCGCGGACGACAATTTCGTGCCGCGCCAGACCGG
CGAGATCCAGGTGCGCGGCCTGGAGCTGGAAGCCTCGGCCGAGCTGATGCCGCGCCTGAACGTGGTGGGCTCCTACACCT
ACACGCCCACGGCGAAGATCACGGCCAGCAGCACGGCGCGCGAGATCGGCAAGCCGCTCACGGCGGTGTCGCGCAACGCC
GCGGCGCTGTGGGTGGACTACCGGTTCGCGAACCGCATCAAGGTGGGCCTGGGCGCGCGCTACACCGGATCCAACCATGG
CGACCTGGACGCGGCGCCGGCGAAGGTGCCGTCCTTCACCGTGTTCGACGCGATGATCGGCTACGACATCGACCGCTGGA
GCTTCGCGCTGAACGTGCGCAACCTGGGCGACAAGACGTATATCGGCAACTGCGACCAGTACGGCAACTGCTACTACGGC
GATCCGCGCCGGGTGGTGGCGACGGCCACGTACCGCTGGTAA

Upstream 100 bases:

>100_bases
AAAAACGTAACTGCGGACTGTTTAATAAGAAACATTCTCATTACAATTCGTATGCATTCCGCACTTCTGCACTTATTCCA
TATCTGAAGGGGGTTTTCCG

Downstream 100 bases:

>100_bases
GGCCGGCAGGCGCTTTCGGGCGCCTGCTTTTGTTTCATGCGCGCGGGGCGCGGTCGGCCGCGCGCAGTGCCTCGCGCAGG
GCCCCGATGAAGGCGGGCTG

Product: TonB-dependent siderophore receptor

Products: NA

Alternate protein names: Ferric hydroxamate receptor; Ferric hydroxamate uptake [H]

Number of amino acids: Translated: 733; Mature: 733

Protein sequence:

>733_residues
MRHVSAARPARQRLLHASITAAFGTAAVLSTPLAGAQDASAGSTTLPTVTVTGGAEESATGRVNGYTARRSATATKTDTP
LIETPQSISVIPADLMEAQGARTVKDALSYSPGVIPTRFGADSRYDWISLRGFDAYSPGFYLDGMPLRNNGNWGIWPVES
YGAERIELLRGPASVLYGMSGPGGLVNAVSKRPTAEPLREVQVQIGDHGRRQIAADVSGPLREDGKLLYRLTALTRDAEL
PAGDMKDDRTFIAPAFTWKPSGDTSLTVLSQFGRTRAGVYSRTRPAVGSLVPTAIGTTIPSDLFAGEPGYNRFDMDTAMI
GYLFEHRIDDAFTVRQNARYGRLEVDYTAVQGRNFITVNPANPRDPANFSTLRRTVSGSNERIHALNLDNQLEARLRSGD
VQHTVLAGLEYQRTRIDQVSYSGGSASPLDIYNPVYGGAVQLPAPWYDGVATLAQTGFYLQDQIKWRDRWVLTLGARYDR
ATSDADSRLDGSRTRVSEHKATKRAGLTYLAESGWAPYVSYTESFVPTAMRNPATGQPFKPETGRQYEAGVRYQPEGGRQ
RYSAAIFDLRRKNYLTADDNFVPRQTGEIQVRGLELEASAELMPRLNVVGSYTYTPTAKITASSTAREIGKPLTAVSRNA
AALWVDYRFANRIKVGLGARYTGSNHGDLDAAPAKVPSFTVFDAMIGYDIDRWSFALNVRNLGDKTYIGNCDQYGNCYYG
DPRRVVATATYRW

Sequences:

>Translated_733_residues
MRHVSAARPARQRLLHASITAAFGTAAVLSTPLAGAQDASAGSTTLPTVTVTGGAEESATGRVNGYTARRSATATKTDTP
LIETPQSISVIPADLMEAQGARTVKDALSYSPGVIPTRFGADSRYDWISLRGFDAYSPGFYLDGMPLRNNGNWGIWPVES
YGAERIELLRGPASVLYGMSGPGGLVNAVSKRPTAEPLREVQVQIGDHGRRQIAADVSGPLREDGKLLYRLTALTRDAEL
PAGDMKDDRTFIAPAFTWKPSGDTSLTVLSQFGRTRAGVYSRTRPAVGSLVPTAIGTTIPSDLFAGEPGYNRFDMDTAMI
GYLFEHRIDDAFTVRQNARYGRLEVDYTAVQGRNFITVNPANPRDPANFSTLRRTVSGSNERIHALNLDNQLEARLRSGD
VQHTVLAGLEYQRTRIDQVSYSGGSASPLDIYNPVYGGAVQLPAPWYDGVATLAQTGFYLQDQIKWRDRWVLTLGARYDR
ATSDADSRLDGSRTRVSEHKATKRAGLTYLAESGWAPYVSYTESFVPTAMRNPATGQPFKPETGRQYEAGVRYQPEGGRQ
RYSAAIFDLRRKNYLTADDNFVPRQTGEIQVRGLELEASAELMPRLNVVGSYTYTPTAKITASSTAREIGKPLTAVSRNA
AALWVDYRFANRIKVGLGARYTGSNHGDLDAAPAKVPSFTVFDAMIGYDIDRWSFALNVRNLGDKTYIGNCDQYGNCYYG
DPRRVVATATYRW
>Mature_733_residues
MRHVSAARPARQRLLHASITAAFGTAAVLSTPLAGAQDASAGSTTLPTVTVTGGAEESATGRVNGYTARRSATATKTDTP
LIETPQSISVIPADLMEAQGARTVKDALSYSPGVIPTRFGADSRYDWISLRGFDAYSPGFYLDGMPLRNNGNWGIWPVES
YGAERIELLRGPASVLYGMSGPGGLVNAVSKRPTAEPLREVQVQIGDHGRRQIAADVSGPLREDGKLLYRLTALTRDAEL
PAGDMKDDRTFIAPAFTWKPSGDTSLTVLSQFGRTRAGVYSRTRPAVGSLVPTAIGTTIPSDLFAGEPGYNRFDMDTAMI
GYLFEHRIDDAFTVRQNARYGRLEVDYTAVQGRNFITVNPANPRDPANFSTLRRTVSGSNERIHALNLDNQLEARLRSGD
VQHTVLAGLEYQRTRIDQVSYSGGSASPLDIYNPVYGGAVQLPAPWYDGVATLAQTGFYLQDQIKWRDRWVLTLGARYDR
ATSDADSRLDGSRTRVSEHKATKRAGLTYLAESGWAPYVSYTESFVPTAMRNPATGQPFKPETGRQYEAGVRYQPEGGRQ
RYSAAIFDLRRKNYLTADDNFVPRQTGEIQVRGLELEASAELMPRLNVVGSYTYTPTAKITASSTAREIGKPLTAVSRNA
AALWVDYRFANRIKVGLGARYTGSNHGDLDAAPAKVPSFTVFDAMIGYDIDRWSFALNVRNLGDKTYIGNCDQYGNCYYG
DPRRVVATATYRW

Specific function: This receptor binds the ferrichrome-iron ligand. It interacts with the tonB protein, which is responsible for energy coupling of the ferrichrome-promoted iron transport system. Acts as a receptor for bacteriophage T5 as well as T1, phi80 and colicin M. Bi

COG id: COG1629

COG function: function code P; Outer membrane receptor proteins, mostly Fe transport

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1786344, Length=742, Percent_Identity=38.544474393531, Blast_Score=434, Evalue=1e-122,
Organism=Escherichia coli, GI1787024, Length=781, Percent_Identity=26.2483994878361, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI1787344, Length=729, Percent_Identity=24.0054869684499, Blast_Score=120, Evalue=4e-28,
Organism=Escherichia coli, GI1788478, Length=725, Percent_Identity=23.448275862069, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917
- InterPro:   IPR010105 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 80206; Mature: 80206

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHVSAARPARQRLLHASITAAFGTAAVLSTPLAGAQDASAGSTTLPTVTVTGGAEESAT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCC
GRVNGYTARRSATATKTDTPLIETPQSISVIPADLMEAQGARTVKDALSYSPGVIPTRFG
CCCCCEEECCCCCCCCCCCCCCCCCCCCEECCHHHHHCCCCHHHHHHHCCCCCCCEEECC
ADSRYDWISLRGFDAYSPGFYLDGMPLRNNGNWGIWPVESYGAERIELLRGPASVLYGMS
CCCCCCEEEEECCCCCCCCEEECCEEECCCCCCCEEECHHCCHHHHHHHCCCHHHEECCC
GPGGLVNAVSKRPTAEPLREVQVQIGDHGRRQIAADVSGPLREDGKLLYRLTALTRDAEL
CCCHHHHHHHCCCCHHHHHHHHEEECCCCCEEEEECCCCCCCCCCEEEEEEEHHHCCCCC
PAGDMKDDRTFIAPAFTWKPSGDTSLTVLSQFGRTRAGVYSRTRPAVGSLVPTAIGTTIP
CCCCCCCCCEEEEEEEEECCCCCCHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHCCCC
SDLFAGEPGYNRFDMDTAMIGYLFEHRIDDAFTVRQNARYGRLEVDYTAVQGRNFITVNP
HHHHCCCCCCCEECHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEEEECCCEEEEECC
ANPRDPANFSTLRRTVSGSNERIHALNLDNQLEARLRSGDVQHTVLAGLEYQRTRIDQVS
CCCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCCHHHHCCCHHHHHHCEEE
YSGGSASPLDIYNPVYGGAVQLPAPWYDGVATLAQTGFYLQDQIKWRDRWVLTLGARYDR
CCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCEEEEEEEECEEEEEEECCCCCC
ATSDADSRLDGSRTRVSEHKATKRAGLTYLAESGWAPYVSYTESFVPTAMRNPATGQPFK
CCCCCHHCCCCCHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHCCHHHCCCCCCCCCC
PETGRQYEAGVRYQPEGGRQRYSAAIFDLRRKNYLTADDNFVPRQTGEIQVRGLELEASA
CCCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCH
ELMPRLNVVGSYTYTPTAKITASSTAREIGKPLTAVSRNAAALWVDYRFANRIKVGLGAR
HHCCCEEEEEEEEECCCEEEECCHHHHHHCCCHHHHCCCCEEEEEEEEECCEEEECCCEE
YTGSNHGDLDAAPAKVPSFTVFDAMIGYDIDRWSFALNVRNLGDKTYIGNCDQYGNCYYG
ECCCCCCCCCCCCCCCCCEEHHHHHHCCCCCCEEEEEEEECCCCCCEECCCCCCCCEEEC
DPRRVVATATYRW
CCCEEEEEEEECC
>Mature Secondary Structure
MRHVSAARPARQRLLHASITAAFGTAAVLSTPLAGAQDASAGSTTLPTVTVTGGAEESAT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCC
GRVNGYTARRSATATKTDTPLIETPQSISVIPADLMEAQGARTVKDALSYSPGVIPTRFG
CCCCCEEECCCCCCCCCCCCCCCCCCCCEECCHHHHHCCCCHHHHHHHCCCCCCCEEECC
ADSRYDWISLRGFDAYSPGFYLDGMPLRNNGNWGIWPVESYGAERIELLRGPASVLYGMS
CCCCCCEEEEECCCCCCCCEEECCEEECCCCCCCEEECHHCCHHHHHHHCCCHHHEECCC
GPGGLVNAVSKRPTAEPLREVQVQIGDHGRRQIAADVSGPLREDGKLLYRLTALTRDAEL
CCCHHHHHHHCCCCHHHHHHHHEEECCCCCEEEEECCCCCCCCCCEEEEEEEHHHCCCCC
PAGDMKDDRTFIAPAFTWKPSGDTSLTVLSQFGRTRAGVYSRTRPAVGSLVPTAIGTTIP
CCCCCCCCCEEEEEEEEECCCCCCHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHCCCC
SDLFAGEPGYNRFDMDTAMIGYLFEHRIDDAFTVRQNARYGRLEVDYTAVQGRNFITVNP
HHHHCCCCCCCEECHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEEEECCCEEEEECC
ANPRDPANFSTLRRTVSGSNERIHALNLDNQLEARLRSGDVQHTVLAGLEYQRTRIDQVS
CCCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCCHHHHCCCHHHHHHCEEE
YSGGSASPLDIYNPVYGGAVQLPAPWYDGVATLAQTGFYLQDQIKWRDRWVLTLGARYDR
CCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCEEEEEEEECEEEEEEECCCCCC
ATSDADSRLDGSRTRVSEHKATKRAGLTYLAESGWAPYVSYTESFVPTAMRNPATGQPFK
CCCCCHHCCCCCHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHCCHHHCCCCCCCCCC
PETGRQYEAGVRYQPEGGRQRYSAAIFDLRRKNYLTADDNFVPRQTGEIQVRGLELEASA
CCCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCH
ELMPRLNVVGSYTYTPTAKITASSTAREIGKPLTAVSRNAAALWVDYRFANRIKVGLGAR
HHCCCEEEEEEEEECCCEEEECCHHHHHHCCCHHHHCCCCEEEEEEEEECCEEEECCCEE
YTGSNHGDLDAAPAKVPSFTVFDAMIGYDIDRWSFALNVRNLGDKTYIGNCDQYGNCYYG
ECCCCCCCCCCCCCCCCCEEHHHHHHCCCCCCEEEEEEEECCCCCCEECCCCCCCCEEEC
DPRRVVATATYRW
CCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3079747; 8202364; 9278503; 2823072; 7515827; 8617231; 9856937; 9865695; 10850805 [H]