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The map label for this gene is trpS [H]

Identifier: 120612354

GI number: 120612354

Start: 4088410

End: 4089717

Strand: Direct

Name: trpS [H]

Synonym: Aave_3711

Alternate gene names: 120612354

Gene position: 4088410-4089717 (Clockwise)

Preceding gene: 120612353

Following gene: 120612355

Centisome position: 76.38

GC content: 70.87

Gene sequence:

>1308_bases
ATGAGCACCACGCGCTTTCTCACCGGCATCACGACCACGGGCACGCCCCACCTGGGCAACTTCGTCGGCTCGATCCGCCC
CTCGGTGGCGGCCAGCCAGCGGCCCGGCGTGCAGAGCTTCTACTTCCTGGCGAACTACCACGCGCTCATCAAGTGCGAGG
ACCCGGCGCGCATCCAGCGCTCCACGGTGGAGATCGCCGCGAGTTGGCTGGCCGCGGGCCTGGACCCGGAGCACGTCACG
TTCTACCGGCAGTCCGACATCCCCGAGATCCCGGAGCTGAACTGGCTGCTGTCGTGCGTGACCGGCAAGGGCCTGCTCAA
CCGCGCCCATGCCTACAAGGCATCGCAGGACAAGAACGAGGCCGCGGGCCGGGAGCTGGACGACGGCGTGACGGCCGGCC
TCTTCATGTACCCGGTGCTGATGGCCGCGGACATCCTGGCCTTCAAGGCACACAAGGTGCCGGTGGGGCGCGACCAGGTA
CAGCACATCGAGATGGCGCGCGACATCGCGTCGAGCTTCAACCACCTCTACGGCGAGCATTTCGTGCTGCCCGAAGCGGC
GATCGACGAACACGTGGCCACGCTGCCCGGGCTGGACGGCCGCAAGATGAGCAAGAGCTACGACAACACGATCCCGCTCT
TCTCGCCGCGCGAGCAGCTGCGCCGGCTGATCAACAGCATCCAGACCGATTCGCGTGCGCCCGGCGAACCCAAGGACACG
GAGGGCTCCGCCCTGTTCCAGATCTACCGCGCATTCGCCACCGACGCGGAAACCGAGGCGCTGCGCCGGCAGTTCGCCGA
GGGCATCGCCTGGGGCGAGGCCAAGCAGATCCTGTTCGAGCGCGTGGACGGCGTGGTCGGGCCGATGCGCGAGCGCTACG
ACGCGCTGATCGCCGATCCGGGCCGCATCGAGGACATCCTGCTCGCGGGCGCCGAGAAGGCCCGTGCGGAGGCCGGCCCC
CTGCTGCGCGACCTGCGCCATGCCGTGGGCCTGCGCAGCCTGCGCGGCGGTGCGGTGGCGGCCGGTGCGCCGCGCGCGGC
CGCGAAGGCCGCCGCCCTGCCTTCGTTCAAGCAGTACCGCGAGGCGGATGGCCGCTTCTACTTCAAGCTCGTCGCCGCGG
ACGGCCGCCTGCTGCTGCAGAGCACGGGCTTCACCGCGCCGCGCGACGCGGGCCAGGCGATCGCCCGGCTGCAGAAGGAG
CCTGGCGCCCTGGCGGCGCTGGCGGACCACCTGGCGCCCGTGGACGGCGTGGAGGCCGGCGACGTGGAAGCCGCGTTGCA
GGCCCTGGTCCAGGCTGCCGAAGCCTGA

Upstream 100 bases:

>100_bases
CTGCTGGGCTGAGCCGGCGCGGCGCCCGCGGGCCGTGCGGCGGCCCGCCCTTCTTTCCGTTTCCGTTTTCCGTTTCCTCC
GGCCCCGAGCCGCTTCGACC

Downstream 100 bases:

>100_bases
GCGGGGGCCGCGGCGCACCGGCCGGCGGTGCGGCGCGGAAGGCACGGGAGGTGACGCCCGAGGGCCTTCCGAACTCCGAC
CATAACGCTTAGTTTGCCCC

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSTTRFLTGITTTGTPHLGNFVGSIRPSVAASQRPGVQSFYFLANYHALIKCEDPARIQRSTVEIAASWLAAGLDPEHVT
FYRQSDIPEIPELNWLLSCVTGKGLLNRAHAYKASQDKNEAAGRELDDGVTAGLFMYPVLMAADILAFKAHKVPVGRDQV
QHIEMARDIASSFNHLYGEHFVLPEAAIDEHVATLPGLDGRKMSKSYDNTIPLFSPREQLRRLINSIQTDSRAPGEPKDT
EGSALFQIYRAFATDAETEALRRQFAEGIAWGEAKQILFERVDGVVGPMRERYDALIADPGRIEDILLAGAEKARAEAGP
LLRDLRHAVGLRSLRGGAVAAGAPRAAAKAAALPSFKQYREADGRFYFKLVAADGRLLLQSTGFTAPRDAGQAIARLQKE
PGALAALADHLAPVDGVEAGDVEAALQALVQAAEA

Sequences:

>Translated_435_residues
MSTTRFLTGITTTGTPHLGNFVGSIRPSVAASQRPGVQSFYFLANYHALIKCEDPARIQRSTVEIAASWLAAGLDPEHVT
FYRQSDIPEIPELNWLLSCVTGKGLLNRAHAYKASQDKNEAAGRELDDGVTAGLFMYPVLMAADILAFKAHKVPVGRDQV
QHIEMARDIASSFNHLYGEHFVLPEAAIDEHVATLPGLDGRKMSKSYDNTIPLFSPREQLRRLINSIQTDSRAPGEPKDT
EGSALFQIYRAFATDAETEALRRQFAEGIAWGEAKQILFERVDGVVGPMRERYDALIADPGRIEDILLAGAEKARAEAGP
LLRDLRHAVGLRSLRGGAVAAGAPRAAAKAAALPSFKQYREADGRFYFKLVAADGRLLLQSTGFTAPRDAGQAIARLQKE
PGALAALADHLAPVDGVEAGDVEAALQALVQAAEA
>Mature_434_residues
STTRFLTGITTTGTPHLGNFVGSIRPSVAASQRPGVQSFYFLANYHALIKCEDPARIQRSTVEIAASWLAAGLDPEHVTF
YRQSDIPEIPELNWLLSCVTGKGLLNRAHAYKASQDKNEAAGRELDDGVTAGLFMYPVLMAADILAFKAHKVPVGRDQVQ
HIEMARDIASSFNHLYGEHFVLPEAAIDEHVATLPGLDGRKMSKSYDNTIPLFSPREQLRRLINSIQTDSRAPGEPKDTE
GSALFQIYRAFATDAETEALRRQFAEGIAWGEAKQILFERVDGVVGPMRERYDALIADPGRIEDILLAGAEKARAEAGPL
LRDLRHAVGLRSLRGGAVAAGAPRAAAKAAALPSFKQYREADGRFYFKLVAADGRLLLQSTGFTAPRDAGQAIARLQKEP
GALAALADHLAPVDGVEAGDVEAALQALVQAAEA

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=338, Percent_Identity=31.3609467455621, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI41352700, Length=187, Percent_Identity=39.0374331550802, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1789786, Length=341, Percent_Identity=34.3108504398827, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71982800, Length=341, Percent_Identity=31.0850439882698, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71982793, Length=341, Percent_Identity=31.0850439882698, Blast_Score=141, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6320474, Length=356, Percent_Identity=30.6179775280899, Blast_Score=137, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24666151, Length=362, Percent_Identity=31.2154696132597, Blast_Score=130, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR010879
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 47018; Mature: 46887

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTRFLTGITTTGTPHLGNFVGSIRPSVAASQRPGVQSFYFLANYHALIKCEDPARIQR
CCCCEEEEEECCCCCCHHHHHHHHCCCCHHCCCCCCCHHHHHHCCCEEEEEECCHHHHHH
STVEIAASWLAAGLDPEHVTFYRQSDIPEIPELNWLLSCVTGKGLLNRAHAYKASQDKNE
HHHHHHHHHHHCCCCHHHEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCHH
AAGRELDDGVTAGLFMYPVLMAADILAFKAHKVPVGRDQVQHIEMARDIASSFNHLYGEH
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
FVLPEAAIDEHVATLPGLDGRKMSKSYDNTIPLFSPREQLRRLINSIQTDSRAPGEPKDT
EECCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
EGSALFQIYRAFATDAETEALRRQFAEGIAWGEAKQILFERVDGVVGPMRERYDALIADP
CHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GRIEDILLAGAEKARAEAGPLLRDLRHAVGLRSLRGGAVAAGAPRAAAKAAALPSFKQYR
CHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHH
EADGRFYFKLVAADGRLLLQSTGFTAPRDAGQAIARLQKEPGALAALADHLAPVDGVEAG
HCCCCEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCC
DVEAALQALVQAAEA
CHHHHHHHHHHHHCC
>Mature Secondary Structure 
STTRFLTGITTTGTPHLGNFVGSIRPSVAASQRPGVQSFYFLANYHALIKCEDPARIQR
CCCEEEEEECCCCCCHHHHHHHHCCCCHHCCCCCCCHHHHHHCCCEEEEEECCHHHHHH
STVEIAASWLAAGLDPEHVTFYRQSDIPEIPELNWLLSCVTGKGLLNRAHAYKASQDKNE
HHHHHHHHHHHCCCCHHHEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCHH
AAGRELDDGVTAGLFMYPVLMAADILAFKAHKVPVGRDQVQHIEMARDIASSFNHLYGEH
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
FVLPEAAIDEHVATLPGLDGRKMSKSYDNTIPLFSPREQLRRLINSIQTDSRAPGEPKDT
EECCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
EGSALFQIYRAFATDAETEALRRQFAEGIAWGEAKQILFERVDGVVGPMRERYDALIADP
CHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GRIEDILLAGAEKARAEAGPLLRDLRHAVGLRSLRGGAVAAGAPRAAAKAAALPSFKQYR
CHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHH
EADGRFYFKLVAADGRLLLQSTGFTAPRDAGQAIARLQKEPGALAALADHLAPVDGVEAG
HCCCCEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCC
DVEAALQALVQAAEA
CHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]