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The map label for this gene is obgE

Identifier: 120612317

GI number: 120612317

Start: 4050507

End: 4051580

Strand: Reverse

Name: obgE

Synonym: Aave_3673

Alternate gene names: 120612317

Gene position: 4051580-4050507 (Counterclockwise)

Preceding gene: 120612318

Following gene: 120612316

Centisome position: 75.69

GC content: 67.04

Gene sequence:

>1074_bases
ATGAAGTTCGTCGACGAAGCCTTTATTGACGTGGCCGCAGGGGATGGCGGCAACGGCTGTGTATCGTTCCGGCACGAGAA
GTACAAGGAATTCGGTGGACCCAACGGAGGGGATGGCGGGCGCGGCGGGCACGTGTTCGCCGTGGCCGACCCGAGCCTGA
ACACGCTCGTGGATTACCGCTATTCCCGCCGGCACGAGGCCAAGCGCGGCGAACACGGCATGGGTTCCGACATGTTCGGC
GCGGCGGGGGACGACATCACCCTCAAGATGCCGGTGGGCACCATCATCTCCGACGCGGACACCGGCGAGGTGCTGTTCGA
GCTGCTCAAGCCCGGCGAGACCATCACCATCGCCAAGGGCGGCGACGGCGGTTTCGGCAACATGCGCTTCAAGAGCGCGA
TCAACCGGGCCCCGCGCCAGAAGACGCCCGGCTGGCCGGGCGAGCGCCGCAACCTCAAGCTCGAGCTCAAGGTGCTGGCC
GACGTGGGACTGTTGGGCATGCCCAACGCCGGCAAGTCCACCTTCATCGCCGCCGTTTCCAACGCGCGGCCCAAGATCGC
CGACTATCCCTTCACCACGCTGCACCCCAACCTGGGCGTGGTGCGGGTTGGCCCTGAGCAGAGCTTCGTGGTCGCGGACA
TTCCGGGGCTGATCGAAGGCGCCTCGGAAGGCGCCGGGCTGGGACACCAGTTCCTGCGCCACCTGCAGCGCACCCGGTTG
CTGCTGCACGTGGTGGATCTGGCGCCGTTCGACGAGAGCGTGGACCCGGTCGCGCAGGCCACCGCGATCGTCGGCGAACT
GCGCAAGTACGACGCCGAGCTCTACGAGAAGCCGCGGTGGCTGGTGCTCAACAAGCTCGACATGGTGCCGGGCGACGAGC
GGGCTGCGCGCGTCAAGGATTTCGTGAAGCGCTTCCGCTGGAAGGGTCCGGTGTTCGAGATTTCGGCGCTCACCCGCGAG
GGCTGCGAGCCCTTGATCCAGGCGATCTATCAGCACGTGCGCGCCCAGCAGCAGGCCGAGCAGGTGCAGGAAGTGGTCGA
TCCGCGCTTCGCGGACGACGCGGCTTCGGATTGA

Upstream 100 bases:

>100_bases
CTGAGCGGTTCCGTCCTGACCAAGCAGTGAAGCCCCGACCTGTCGGGGCTTCGTCGTTTTTAGCGCCGGGGCGCAATCCC
CGTTTTTGTAAACTCTCTTC

Downstream 100 bases:

>100_bases
CGGGCAGGGCCGCCATCCCCGGTGGGTGGCGGCGTGGGGCCGCTGCGGCGGCCGGCGCTATGAAAGAAGACGGGGATACA
TGGTTTCGAGCATATTGCGA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKFVDEAFIDVAAGDGGNGCVSFRHEKYKEFGGPNGGDGGRGGHVFAVADPSLNTLVDYRYSRRHEAKRGEHGMGSDMFG
AAGDDITLKMPVGTIISDADTGEVLFELLKPGETITIAKGGDGGFGNMRFKSAINRAPRQKTPGWPGERRNLKLELKVLA
DVGLLGMPNAGKSTFIAAVSNARPKIADYPFTTLHPNLGVVRVGPEQSFVVADIPGLIEGASEGAGLGHQFLRHLQRTRL
LLHVVDLAPFDESVDPVAQATAIVGELRKYDAELYEKPRWLVLNKLDMVPGDERAARVKDFVKRFRWKGPVFEISALTRE
GCEPLIQAIYQHVRAQQQAEQVQEVVDPRFADDAASD

Sequences:

>Translated_357_residues
MKFVDEAFIDVAAGDGGNGCVSFRHEKYKEFGGPNGGDGGRGGHVFAVADPSLNTLVDYRYSRRHEAKRGEHGMGSDMFG
AAGDDITLKMPVGTIISDADTGEVLFELLKPGETITIAKGGDGGFGNMRFKSAINRAPRQKTPGWPGERRNLKLELKVLA
DVGLLGMPNAGKSTFIAAVSNARPKIADYPFTTLHPNLGVVRVGPEQSFVVADIPGLIEGASEGAGLGHQFLRHLQRTRL
LLHVVDLAPFDESVDPVAQATAIVGELRKYDAELYEKPRWLVLNKLDMVPGDERAARVKDFVKRFRWKGPVFEISALTRE
GCEPLIQAIYQHVRAQQQAEQVQEVVDPRFADDAASD
>Mature_357_residues
MKFVDEAFIDVAAGDGGNGCVSFRHEKYKEFGGPNGGDGGRGGHVFAVADPSLNTLVDYRYSRRHEAKRGEHGMGSDMFG
AAGDDITLKMPVGTIISDADTGEVLFELLKPGETITIAKGGDGGFGNMRFKSAINRAPRQKTPGWPGERRNLKLELKVLA
DVGLLGMPNAGKSTFIAAVSNARPKIADYPFTTLHPNLGVVRVGPEQSFVVADIPGLIEGASEGAGLGHQFLRHLQRTRL
LLHVVDLAPFDESVDPVAQATAIVGELRKYDAELYEKPRWLVLNKLDMVPGDERAARVKDFVKRFRWKGPVFEISALTRE
GCEPLIQAIYQHVRAQQQAEQVQEVVDPRFADDAASD

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=324, Percent_Identity=41.358024691358, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI111955139, Length=362, Percent_Identity=35.9116022099448, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI111955063, Length=194, Percent_Identity=39.1752577319588, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI58761500, Length=136, Percent_Identity=32.3529411764706, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789574, Length=350, Percent_Identity=54.5714285714286, Blast_Score=335, Evalue=2e-93,
Organism=Escherichia coli, GI1787454, Length=138, Percent_Identity=34.0579710144928, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790615, Length=165, Percent_Identity=35.1515151515151, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=336, Percent_Identity=38.3928571428571, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17552324, Length=311, Percent_Identity=29.903536977492, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17509631, Length=139, Percent_Identity=33.8129496402878, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321962, Length=196, Percent_Identity=39.2857142857143, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321773, Length=155, Percent_Identity=29.6774193548387, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24585318, Length=307, Percent_Identity=38.1107491856677, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI20129375, Length=328, Percent_Identity=36.5853658536585, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24640873, Length=135, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640877, Length=135, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640875, Length=135, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_ACIAC (A1TTD3)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_971995.1
- ProteinModelPortal:   A1TTD3
- SMR:   A1TTD3
- STRING:   A1TTD3
- GeneID:   4665152
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3673
- NMPDR:   fig|397945.5.peg.3137
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   YIQADEN
- PhylomeDB:   A1TTD3
- ProtClustDB:   PRK12299
- BioCyc:   AAVE397945:AAVE_3673-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 38877; Mature: 38877

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVDEAFIDVAAGDGGNGCVSFRHEKYKEFGGPNGGDGGRGGHVFAVADPSLNTLVDYR
CCCHHHHHHEEECCCCCCCEEECHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHH
YSRRHEAKRGEHGMGSDMFGAAGDDITLKMPVGTIISDADTGEVLFELLKPGETITIAKG
HHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCEECCCCHHHHHHHHHCCCCEEEEEEC
GDGGFGNMRFKSAINRAPRQKTPGWPGERRNLKLELKVLADVGLLGMPNAGKSTFIAAVS
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEEEC
NARPKIADYPFTTLHPNLGVVRVGPEQSFVVADIPGLIEGASEGAGLGHQFLRHLQRTRL
CCCCCCCCCCCEEECCCCCEEEECCCCCEEEECCCHHHCCCCCCCCHHHHHHHHHHHHHH
LLHVVDLAPFDESVDPVAQATAIVGELRKYDAELYEKPRWLVLNKLDMVPGDERAARVKD
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCHHHHHHHH
FVKRFRWKGPVFEISALTREGCEPLIQAIYQHVRAQQQAEQVQEVVDPRFADDAASD
HHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKFVDEAFIDVAAGDGGNGCVSFRHEKYKEFGGPNGGDGGRGGHVFAVADPSLNTLVDYR
CCCHHHHHHEEECCCCCCCEEECHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHH
YSRRHEAKRGEHGMGSDMFGAAGDDITLKMPVGTIISDADTGEVLFELLKPGETITIAKG
HHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCEECCCCHHHHHHHHHCCCCEEEEEEC
GDGGFGNMRFKSAINRAPRQKTPGWPGERRNLKLELKVLADVGLLGMPNAGKSTFIAAVS
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEEEC
NARPKIADYPFTTLHPNLGVVRVGPEQSFVVADIPGLIEGASEGAGLGHQFLRHLQRTRL
CCCCCCCCCCCEEECCCCCEEEECCCCCEEEECCCHHHCCCCCCCCHHHHHHHHHHHHHH
LLHVVDLAPFDESVDPVAQATAIVGELRKYDAELYEKPRWLVLNKLDMVPGDERAARVKD
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCHHHHHHHH
FVKRFRWKGPVFEISALTREGCEPLIQAIYQHVRAQQQAEQVQEVVDPRFADDAASD
HHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA