Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 120612294

GI number: 120612294

Start: 4024916

End: 4026145

Strand: Reverse

Name: serA [H]

Synonym: Aave_3649

Alternate gene names: 120612294

Gene position: 4026145-4024916 (Counterclockwise)

Preceding gene: 120612302

Following gene: 120612293

Centisome position: 75.22

GC content: 67.4

Gene sequence:

>1230_bases
ATGACCAAGACATCGCTGGACAAGAGCAAGATCAAGTTCCTTCTGCTGGAGGGTGTGCACCCTTCCGCGCTCGACGTGCT
GCGCGGCGCGGGCTATACGCAGATCGAGGCATTGCCGGGGGCGCTGGAAGGCGAGGAACTGCACCGCAAGATCGCCGACG
CGCATTTCCTGGGCATCCGTTCGCGCACCCAGCTCACGGCCGAGGTGTTCGCGCACGCACACAAGCTCGTGGCCGTGGGG
GCCTTCTGCATCGGCACGAACCAGATCGACCTGGAGGCGGCGCGCGAGCGCGGCATCGCGGTGTTCAACGCGCCGTATTC
CAACACCCGCTCGGTGGCCGAGCTGGTGCTGGCCGAGGCCATCCTGCTGCTGCGCGGCGTGCCCGAGAAGAACGCCGTGG
CGCACCGCGGCGGCTGGCTCAAGAGCGCCGAGAACGCCTACGAGATCCGCGGCAAGACGCTGGGCATCGTCGGCTACGGC
TCCATCGGCACGCAGCTGTCGGTGCTGGCCGAGGCGCTGGGCATGCATGTCGTCTTCCACGACGTGGTCAGCAAGCTGCC
GCTGGGCAACGCCCGCCAGGCGCCGTCGCTGCAGGCCCTGCTCGCGCAGAGCGATATCGTGACCCTGCACGTGCCCGAGC
TGCCCTCCACGCAGTGGATGATCGGGCCCGAAGAGATCGCGGCCATGAAGCCGGGCGCGATCCTGATCAATGCGGCGCGC
GGCACGGTGGTGCGCATCGAGGCGCTGGCCGAGTCGATCCGCGCCAGGAAGCTGCTCGGCGCGGCCATCGACGTGTTTCC
GGTCGAGCCGCGCAGCAACAAGGACGAGTTCACCTCGCCCCTGCGCGGCATGGACAACGTCATCCTCACGCCCCACATCG
GCGGCTCCACCATGGAGGCGCAGGCCAACATCGGGCTGGAGGTGGCGGAAAAGCTGGTGAAGTACAGCGACAACGGCACG
TCCACCTCGTCGGTGAACTTTCCCGAGGTGGCGCTGCCCGCGCACCCGGGCAAGCACCGCATCCTGCACATCCACCGGAA
CGTGCCGGGTGTGCTGTCGGCCATCAACCAGGTGTTCGCCGACAACCAGATCAACATCGCCGCCCAGTACCTGCAGACCA
ACGAGAAGGTGGGCTACGTGGTGATCGACATCGACGCGCAGTCGTCCGAGCTGGCGCAGGACAAGCTCGCGAGCGTCCCG
GGTACCATCCGCAGCCGCGTGCTGTTCTGA

Upstream 100 bases:

>100_bases
CCCGCAGGTACAGGGTTTCTTCCCATTGCACAATGGTCGGCCGCCTGCAAGGCGTTGGCCTGCTCCCTTCCCTTCCTTAC
TTCTCCTTCCCCGTAGTTCC

Downstream 100 bases:

>100_bases
GCGCGGGGCGGCGGCGGCCGTGCGCGCGGCTGCGTGCCCGGCAGCGCCGCCGCCGCCCGAGCACGGCAGGCGCGGCTGGC
TTAAAATCGCGGCCCCTCCC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MTKTSLDKSKIKFLLLEGVHPSALDVLRGAGYTQIEALPGALEGEELHRKIADAHFLGIRSRTQLTAEVFAHAHKLVAVG
AFCIGTNQIDLEAARERGIAVFNAPYSNTRSVAELVLAEAILLLRGVPEKNAVAHRGGWLKSAENAYEIRGKTLGIVGYG
SIGTQLSVLAEALGMHVVFHDVVSKLPLGNARQAPSLQALLAQSDIVTLHVPELPSTQWMIGPEEIAAMKPGAILINAAR
GTVVRIEALAESIRARKLLGAAIDVFPVEPRSNKDEFTSPLRGMDNVILTPHIGGSTMEAQANIGLEVAEKLVKYSDNGT
STSSVNFPEVALPAHPGKHRILHIHRNVPGVLSAINQVFADNQINIAAQYLQTNEKVGYVVIDIDAQSSELAQDKLASVP
GTIRSRVLF

Sequences:

>Translated_409_residues
MTKTSLDKSKIKFLLLEGVHPSALDVLRGAGYTQIEALPGALEGEELHRKIADAHFLGIRSRTQLTAEVFAHAHKLVAVG
AFCIGTNQIDLEAARERGIAVFNAPYSNTRSVAELVLAEAILLLRGVPEKNAVAHRGGWLKSAENAYEIRGKTLGIVGYG
SIGTQLSVLAEALGMHVVFHDVVSKLPLGNARQAPSLQALLAQSDIVTLHVPELPSTQWMIGPEEIAAMKPGAILINAAR
GTVVRIEALAESIRARKLLGAAIDVFPVEPRSNKDEFTSPLRGMDNVILTPHIGGSTMEAQANIGLEVAEKLVKYSDNGT
STSSVNFPEVALPAHPGKHRILHIHRNVPGVLSAINQVFADNQINIAAQYLQTNEKVGYVVIDIDAQSSELAQDKLASVP
GTIRSRVLF
>Mature_408_residues
TKTSLDKSKIKFLLLEGVHPSALDVLRGAGYTQIEALPGALEGEELHRKIADAHFLGIRSRTQLTAEVFAHAHKLVAVGA
FCIGTNQIDLEAARERGIAVFNAPYSNTRSVAELVLAEAILLLRGVPEKNAVAHRGGWLKSAENAYEIRGKTLGIVGYGS
IGTQLSVLAEALGMHVVFHDVVSKLPLGNARQAPSLQALLAQSDIVTLHVPELPSTQWMIGPEEIAAMKPGAILINAARG
TVVRIEALAESIRARKLLGAAIDVFPVEPRSNKDEFTSPLRGMDNVILTPHIGGSTMEAQANIGLEVAEKLVKYSDNGTS
TSSVNFPEVALPAHPGKHRILHIHRNVPGVLSAINQVFADNQINIAAQYLQTNEKVGYVVIDIDAQSSELAQDKLASVPG
TIRSRVLF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=33.4384858044164, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI145580578, Length=278, Percent_Identity=30.9352517985612, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4557499, Length=278, Percent_Identity=30.9352517985612, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI61743967, Length=292, Percent_Identity=29.7945205479452, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4557497, Length=292, Percent_Identity=29.7945205479452, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI145580575, Length=271, Percent_Identity=32.1033210332103, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI6912396, Length=280, Percent_Identity=26.0714285714286, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1789279, Length=411, Percent_Identity=63.2603406326034, Blast_Score=524, Evalue=1e-150,
Organism=Escherichia coli, GI87082289, Length=279, Percent_Identity=31.5412186379928, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1787645, Length=249, Percent_Identity=26.5060240963855, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788660, Length=270, Percent_Identity=31.1111111111111, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=328, Percent_Identity=34.4512195121951, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI25147481, Length=293, Percent_Identity=25.2559726962457, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=48.792270531401, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=47.5845410628019, Blast_Score=381, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6324964, Length=256, Percent_Identity=31.640625, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=249, Percent_Identity=28.9156626506024, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6324980, Length=199, Percent_Identity=30.1507537688442, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19921140, Length=319, Percent_Identity=31.0344827586207, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646446, Length=242, Percent_Identity=34.297520661157, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646448, Length=242, Percent_Identity=34.297520661157, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646452, Length=242, Percent_Identity=34.297520661157, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646450, Length=242, Percent_Identity=34.297520661157, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI62472511, Length=242, Percent_Identity=34.297520661157, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28571528, Length=294, Percent_Identity=29.2517006802721, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574286, Length=272, Percent_Identity=27.5735294117647, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24585514, Length=309, Percent_Identity=25.2427184466019, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28574282, Length=309, Percent_Identity=25.2427184466019, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28574284, Length=309, Percent_Identity=25.2427184466019, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45551003, Length=309, Percent_Identity=25.2427184466019, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45552429, Length=309, Percent_Identity=25.2427184466019, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24585516, Length=305, Percent_Identity=23.2786885245902, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 43875; Mature: 43744

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTSLDKSKIKFLLLEGVHPSALDVLRGAGYTQIEALPGALEGEELHRKIADAHFLGIR
CCCCCCCHHHEEEEEEECCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHEECC
SRTQLTAEVFAHAHKLVAVGAFCIGTNQIDLEAARERGIAVFNAPYSNTRSVAELVLAEA
CHHHHHHHHHHHHHHHHHHHEEEECCCCEEHHHHHHCCCEEEECCCCCHHHHHHHHHHHH
ILLLRGVPEKNAVAHRGGWLKSAENAYEIRGKTLGIVGYGSIGTQLSVLAEALGMHVVFH
HHHHCCCCCCCCHHHCCCCCCCCCCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHH
DVVSKLPLGNARQAPSLQALLAQSDIVTLHVPELPSTQWMIGPEEIAAMKPGAILINAAR
HHHHHCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCEEECHHHHHHCCCCEEEEEECC
GTVVRIEALAESIRARKLLGAAIDVFPVEPRSNKDEFTSPLRGMDNVILTPHIGGSTMEA
CCEEEHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHCCCCCEEEECCCCCCCEEH
QANIGLEVAEKLVKYSDNGTSTSSVNFPEVALPAHPGKHRILHIHRNVPGVLSAINQVFA
HCCCCHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCEEEEEECCCCHHHHHHHHHHC
DNQINIAAQYLQTNEKVGYVVIDIDAQSSELAQDKLASVPGTIRSRVLF
CCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCHHHHHHCCC
>Mature Secondary Structure 
TKTSLDKSKIKFLLLEGVHPSALDVLRGAGYTQIEALPGALEGEELHRKIADAHFLGIR
CCCCCCHHHEEEEEEECCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHEECC
SRTQLTAEVFAHAHKLVAVGAFCIGTNQIDLEAARERGIAVFNAPYSNTRSVAELVLAEA
CHHHHHHHHHHHHHHHHHHHEEEECCCCEEHHHHHHCCCEEEECCCCCHHHHHHHHHHHH
ILLLRGVPEKNAVAHRGGWLKSAENAYEIRGKTLGIVGYGSIGTQLSVLAEALGMHVVFH
HHHHCCCCCCCCHHHCCCCCCCCCCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHH
DVVSKLPLGNARQAPSLQALLAQSDIVTLHVPELPSTQWMIGPEEIAAMKPGAILINAAR
HHHHHCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCEEECHHHHHHCCCCEEEEEECC
GTVVRIEALAESIRARKLLGAAIDVFPVEPRSNKDEFTSPLRGMDNVILTPHIGGSTMEA
CCEEEHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHCCCCCEEEECCCCCCCEEH
QANIGLEVAEKLVKYSDNGTSTSSVNFPEVALPAHPGKHRILHIHRNVPGVLSAINQVFA
HCCCCHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCEEEEEECCCCHHHHHHHHHHC
DNQINIAAQYLQTNEKVGYVVIDIDAQSSELAQDKLASVPGTIRSRVLF
CCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]