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The map label for this gene is dppA [H]

Identifier: 120612266

GI number: 120612266

Start: 3990774

End: 3992261

Strand: Direct

Name: dppA [H]

Synonym: Aave_3619

Alternate gene names: 120612266

Gene position: 3990774-3992261 (Clockwise)

Preceding gene: 120612265

Following gene: 120612267

Centisome position: 74.56

GC content: 69.02

Gene sequence:

>1488_bases
ATGCCCATCGACCGCCGCACCCTCCTCGCCGCAGCTGCCGCCTCGCCGCTGGCACTGCCGCTGCCCGCCCTGGCCCAGCC
CCGGAAGGACACCGTCGTGCTGGCGATGACGCTGGAGCCGCCGGGCCTGGATCCGACGTCTGGTGCGGCATCGGCCATCG
GCGAGATCACGCTCTACAACGTGTTCGAGACGCTGACCCGGATCAACCCCGACGGCAGTACCTCCCCGCTGCTGGCGGAA
CGATGGGACATCTCCCCGGACCTGAAGACCCTCACTTTCCACCTGCGCCGGGGCGTGAAATTCCACAATGGCGCAGCGTT
CAATGCCGAGGCGGTGAAGTATTCCTTCGACCGTGCGGCCGTGGAGAAAAGCACCAACAAGGACAAGCGCACCTTCGCGA
ACCTCACGGCGCAGGTGGTGGACGAGCACACGGTGACCGTCGCCAGCAAGGAAGCCGATCCGGACCTGCTGTTCCTGCTC
GGCCAGGCCACGGCCGCGATCGTGGAGCCCACGAGTGCGGAGGGCAACGGCGTGCGGCCGGTGGGCACGGGGCCCTACCA
GTTCACGGCCTGGAGCCAGGGGGCGTCCGTCACGCTGACCGCGTGGGACGGCTACCGCACGCCGGGCACGGCGAAGATCC
GCCGCGCGGTGTTCCGCTTCATCTCCGATCCTGCCGCCCAGGTGGCGGCCCTGATGGCGGGCGACGTGGACGCGTTCCCG
CGCGTGGCGCCGCGCAGCGTGCCCCAGTTCAAGGCCAATCCGCGCTTCCAGGTGATCGTGAGCGGCTCCCGCGCCAAGAC
CATCCTCGCGATCAACAACCAGCGCAAGCCCCTGGACGATGTGCGCGTGCGCCGGGCCATCGCGGCAGCGATCGACCGCA
AGGCGGTGATCCAGGGCGGCGCGGACGGGTTGGGCGTTCCCATCGGCAGCCATTACGTCCCGGGCGCGTTCGGCTACGTG
GACACCACGGGAGTCAACCCCTACGACCCCGACAAGGCCCGGCGGCTGCTGGCGGAGGCTGGCGTGAAGACGCCGCTCGA
GCTCACGATGACGCTCCCCCCCACGCCCTATGCGCGCCAGGGCGGCGAGGTGATCGCGGCGCAGCTGGCCAAGGTGGGCA
TCGTGGCGAAGCCGAGGAACGTGGAATGGGCGCAGTGGTTGAGCGGCACCTATGCCAACAGGAACTACGACCTCACGCTG
ATTTCCCACGTGGAGCCCTTCGATCTGGGCAATTTCGCCAAGCCCGACTACTACTGGGGATACCGTTCGCCGCGGTTCGA
CGCGCTTTACGAGCAGATCAGGAACGCGGCCCAGCCCGCCGACCGGGCCCGGCTGCTGGGCGATGCGCAGCGGCTGCTGG
CGGAGGACTGCGTGCACGCGTTCCTCTACCAGGCGCAATGGGCCACGGTGGCCAACCGGAACCTGCGGGGCCTGTGGAAG
GACATGCCCATCTTCGCCAACGACCTGTCGGCGCTGTCGTGGGCGTGA

Upstream 100 bases:

>100_bases
GGGGTGACGGTGTCGGACCGGCCTGGCGACGCCGGGCAGCATGGTGGAATGCGCCACGTGGTGTAAAAACGCACCCGGAC
CCACCGGAGACACACCGCCC

Downstream 100 bases:

>100_bases
GGGGAACCTCCGGCATGCCGCGCAGGCCGGCACCACGCCGGGCATGAACCCGCGGCACATCTTTTTTTTCGCCCCTACTT
CCCTGGACACCCCACCGAAT

Product: extracellular solute-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Dipeptide-binding protein; DBP [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MPIDRRTLLAAAAASPLALPLPALAQPRKDTVVLAMTLEPPGLDPTSGAASAIGEITLYNVFETLTRINPDGSTSPLLAE
RWDISPDLKTLTFHLRRGVKFHNGAAFNAEAVKYSFDRAAVEKSTNKDKRTFANLTAQVVDEHTVTVASKEADPDLLFLL
GQATAAIVEPTSAEGNGVRPVGTGPYQFTAWSQGASVTLTAWDGYRTPGTAKIRRAVFRFISDPAAQVAALMAGDVDAFP
RVAPRSVPQFKANPRFQVIVSGSRAKTILAINNQRKPLDDVRVRRAIAAAIDRKAVIQGGADGLGVPIGSHYVPGAFGYV
DTTGVNPYDPDKARRLLAEAGVKTPLELTMTLPPTPYARQGGEVIAAQLAKVGIVAKPRNVEWAQWLSGTYANRNYDLTL
ISHVEPFDLGNFAKPDYYWGYRSPRFDALYEQIRNAAQPADRARLLGDAQRLLAEDCVHAFLYQAQWATVANRNLRGLWK
DMPIFANDLSALSWA

Sequences:

>Translated_495_residues
MPIDRRTLLAAAAASPLALPLPALAQPRKDTVVLAMTLEPPGLDPTSGAASAIGEITLYNVFETLTRINPDGSTSPLLAE
RWDISPDLKTLTFHLRRGVKFHNGAAFNAEAVKYSFDRAAVEKSTNKDKRTFANLTAQVVDEHTVTVASKEADPDLLFLL
GQATAAIVEPTSAEGNGVRPVGTGPYQFTAWSQGASVTLTAWDGYRTPGTAKIRRAVFRFISDPAAQVAALMAGDVDAFP
RVAPRSVPQFKANPRFQVIVSGSRAKTILAINNQRKPLDDVRVRRAIAAAIDRKAVIQGGADGLGVPIGSHYVPGAFGYV
DTTGVNPYDPDKARRLLAEAGVKTPLELTMTLPPTPYARQGGEVIAAQLAKVGIVAKPRNVEWAQWLSGTYANRNYDLTL
ISHVEPFDLGNFAKPDYYWGYRSPRFDALYEQIRNAAQPADRARLLGDAQRLLAEDCVHAFLYQAQWATVANRNLRGLWK
DMPIFANDLSALSWA
>Mature_494_residues
PIDRRTLLAAAAASPLALPLPALAQPRKDTVVLAMTLEPPGLDPTSGAASAIGEITLYNVFETLTRINPDGSTSPLLAER
WDISPDLKTLTFHLRRGVKFHNGAAFNAEAVKYSFDRAAVEKSTNKDKRTFANLTAQVVDEHTVTVASKEADPDLLFLLG
QATAAIVEPTSAEGNGVRPVGTGPYQFTAWSQGASVTLTAWDGYRTPGTAKIRRAVFRFISDPAAQVAALMAGDVDAFPR
VAPRSVPQFKANPRFQVIVSGSRAKTILAINNQRKPLDDVRVRRAIAAAIDRKAVIQGGADGLGVPIGSHYVPGAFGYVD
TTGVNPYDPDKARRLLAEAGVKTPLELTMTLPPTPYARQGGEVIAAQLAKVGIVAKPRNVEWAQWLSGTYANRNYDLTLI
SHVEPFDLGNFAKPDYYWGYRSPRFDALYEQIRNAAQPADRARLLGDAQRLLAEDCVHAFLYQAQWATVANRNLRGLWKD
MPIFANDLSALSWA

Specific function: Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=423, Percent_Identity=30.0236406619385, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI1787052, Length=515, Percent_Identity=26.2135922330097, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI1787762, Length=507, Percent_Identity=25.4437869822485, Blast_Score=112, Evalue=8e-26,
Organism=Escherichia coli, GI1789887, Length=303, Percent_Identity=29.7029702970297, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1787551, Length=481, Percent_Identity=23.7006237006237, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1787495, Length=516, Percent_Identity=24.6124031007752, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87081878, Length=497, Percent_Identity=23.943661971831, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789397, Length=381, Percent_Identity=21.7847769028871, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 53744; Mature: 53612

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS01040 SBP_BACTERIAL_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIDRRTLLAAAAASPLALPLPALAQPRKDTVVLAMTLEPPGLDPTSGAASAIGEITLYN
CCCCHHHHHHHHCCCCCCCCCHHHCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHH
VFETLTRINPDGSTSPLLAERWDISPDLKTLTFHLRRGVKFHNGAAFNAEAVKYSFDRAA
HHHHHHHCCCCCCCCCCCHHCCCCCCCHHHHHHHHHCCCEECCCCCCCCHHHEEEHHHHH
VEKSTNKDKRTFANLTAQVVDEHTVTVASKEADPDLLFLLGQATAAIVEPTSAEGNGVRP
HHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCEEEECCCCCCCCCCCC
VGTGPYQFTAWSQGASVTLTAWDGYRTPGTAKIRRAVFRFISDPAAQVAALMAGDVDAFP
CCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
RVAPRSVPQFKANPRFQVIVSGSRAKTILAINNQRKPLDDVRVRRAIAAAIDRKAVIQGG
CCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCC
ADGLGVPIGSHYVPGAFGYVDTTGVNPYDPDKARRLLAEAGVKTPLELTMTLPPTPYARQ
CCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCC
GGEVIAAQLAKVGIVAKPRNVEWAQWLSGTYANRNYDLTLISHVEPFDLGNFAKPDYYWG
CCHHHHHHHHHHCEEECCCCCCHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCC
YRSPRFDALYEQIRNAAQPADRARLLGDAQRLLAEDCVHAFLYQAQWATVANRNLRGLWK
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
DMPIFANDLSALSWA
CCCCHHCCHHHHCCC
>Mature Secondary Structure 
PIDRRTLLAAAAASPLALPLPALAQPRKDTVVLAMTLEPPGLDPTSGAASAIGEITLYN
CCCHHHHHHHHCCCCCCCCCHHHCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHH
VFETLTRINPDGSTSPLLAERWDISPDLKTLTFHLRRGVKFHNGAAFNAEAVKYSFDRAA
HHHHHHHCCCCCCCCCCCHHCCCCCCCHHHHHHHHHCCCEECCCCCCCCHHHEEEHHHHH
VEKSTNKDKRTFANLTAQVVDEHTVTVASKEADPDLLFLLGQATAAIVEPTSAEGNGVRP
HHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCEEEECCCCCCCCCCCC
VGTGPYQFTAWSQGASVTLTAWDGYRTPGTAKIRRAVFRFISDPAAQVAALMAGDVDAFP
CCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
RVAPRSVPQFKANPRFQVIVSGSRAKTILAINNQRKPLDDVRVRRAIAAAIDRKAVIQGG
CCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCC
ADGLGVPIGSHYVPGAFGYVDTTGVNPYDPDKARRLLAEAGVKTPLELTMTLPPTPYARQ
CCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCC
GGEVIAAQLAKVGIVAKPRNVEWAQWLSGTYANRNYDLTLISHVEPFDLGNFAKPDYYWG
CCHHHHHHHHHHCEEECCCCCCHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCC
YRSPRFDALYEQIRNAAQPADRARLLGDAQRLLAEDCVHAFLYQAQWATVANRNLRGLWK
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
DMPIFANDLSALSWA
CCCCHHCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1702779; 1956284; 7536291; 8041620; 9278503; 9298646; 9600841; 8563629; 8527431 [H]