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The map label for this gene is pth

Identifier: 120612259

GI number: 120612259

Start: 3985504

End: 3986145

Strand: Direct

Name: pth

Synonym: Aave_3612

Alternate gene names: 120612259

Gene position: 3985504-3986145 (Clockwise)

Preceding gene: 120612258

Following gene: 120612261

Centisome position: 74.46

GC content: 69.16

Gene sequence:

>642_bases
ATGATCAAACTGTTTGTGGGCCTGGGCAACCCCGGGCCGGATTACGACGCCACGCGGCACAACGCGGGCTTCTGGTGGAT
CGACGGGCTGGCCCGCGACCTGAAGGTGCACCTCGTGCCGGAGCGGGCCTATCACGGGCTGGTCGCCCGGGCGAACGTGA
ACGGGCAGAGCGTGTGGCTGCTGCAGCCGCAGACCTTCATGAACCTCTCGGGCAAGTCGGTGGCCGCACTGGCCCGCTTC
TTCAAGATCCAGCCGCAGGAAATCCTGGTGGCACACGATGAGCTGGACATCCTGCCGGGACAGGCCAAGCTCAAGCGTGG
CGGCAGCCACGCCGGGCACAACGGCCTGCGCGACATCCACGCCCAGCTGGGCTCGCCGGATTACTGGCGCCTGCGCATCG
GGATCGGGCACCCGGGCGTGAAGGCCGAGGTGGCGAACTGGGTGCTCAAGAAGCCGTCGCCCGACCACCGCACGCTGATC
GAGGACAGCATTGCCCACTCCCTGAAGGCCGCGCCCGCCATGCTGGCCGGAGACATGGACAAGGCCACGCTGCTGGTGCA
CACGACCAAGCCGCCGCGGCCCAAGCCCCCACGGCCGGCTGCGGCACCGGTGGACGCGCCTGCGGCTCCTGGCGACCAGT
AG

Upstream 100 bases:

>100_bases
CCGCGGGCCGCCCTCGCCGGCCACGGCCCACCGCTTCCGAGCGCGTGGGCCGTTGCTTTTTGGGGCGCCTGCCGGCGCTC
CCCGGATAATCGCGCGCACC

Downstream 100 bases:

>100_bases
GCGGGTTCGCGCCGCGGTGCACGGCCCCGCGCGCTATCCGGAGGTTTCGGAGGGACGTTCCGGAGCCCCTGGACCTGCTG
CCGCCCCGGCCAGGCGCACG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MIKLFVGLGNPGPDYDATRHNAGFWWIDGLARDLKVHLVPERAYHGLVARANVNGQSVWLLQPQTFMNLSGKSVAALARF
FKIQPQEILVAHDELDILPGQAKLKRGGSHAGHNGLRDIHAQLGSPDYWRLRIGIGHPGVKAEVANWVLKKPSPDHRTLI
EDSIAHSLKAAPAMLAGDMDKATLLVHTTKPPRPKPPRPAAAPVDAPAAPGDQ

Sequences:

>Translated_213_residues
MIKLFVGLGNPGPDYDATRHNAGFWWIDGLARDLKVHLVPERAYHGLVARANVNGQSVWLLQPQTFMNLSGKSVAALARF
FKIQPQEILVAHDELDILPGQAKLKRGGSHAGHNGLRDIHAQLGSPDYWRLRIGIGHPGVKAEVANWVLKKPSPDHRTLI
EDSIAHSLKAAPAMLAGDMDKATLLVHTTKPPRPKPPRPAAAPVDAPAAPGDQ
>Mature_213_residues
MIKLFVGLGNPGPDYDATRHNAGFWWIDGLARDLKVHLVPERAYHGLVARANVNGQSVWLLQPQTFMNLSGKSVAALARF
FKIQPQEILVAHDELDILPGQAKLKRGGSHAGHNGLRDIHAQLGSPDYWRLRIGIGHPGVKAEVANWVLKKPSPDHRTLI
EDSIAHSLKAAPAMLAGDMDKATLLVHTTKPPRPKPPRPAAAPVDAPAAPGDQ

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=159, Percent_Identity=38.9937106918239, Blast_Score=91, Evalue=8e-19,
Organism=Escherichia coli, GI1787455, Length=190, Percent_Identity=52.1052631578947, Blast_Score=172, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_ACIAC (A1TT75)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_971937.1
- ProteinModelPortal:   A1TT75
- SMR:   A1TT75
- STRING:   A1TT75
- GeneID:   4666879
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3612
- NMPDR:   fig|397945.5.peg.3080
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   SHAGHNG
- PhylomeDB:   A1TT75
- ProtClustDB:   PRK05426
- BioCyc:   AAVE397945:AAVE_3612-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 23101; Mature: 23101

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLFVGLGNPGPDYDATRHNAGFWWIDGLARDLKVHLVPERAYHGLVARANVNGQSVWL
CEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCEEEEEECCHHHCCEEEEECCCCCEEEE
LQPQTFMNLSGKSVAALARFFKIQPQEILVAHDELDILPGQAKLKRGGSHAGHNGLRDIH
ECCHHHCCCCCCHHHHHHHHHHCCCHHEEEECCCCEECCCHHHHHCCCCCCCCCCHHHHH
AQLGSPDYWRLRIGIGHPGVKAEVANWVLKKPSPDHRTLIEDSIAHSLKAAPAMLAGDMD
HHCCCCCEEEEEEECCCCCCHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCHHHHHCCCC
KATLLVHTTKPPRPKPPRPAAAPVDAPAAPGDQ
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIKLFVGLGNPGPDYDATRHNAGFWWIDGLARDLKVHLVPERAYHGLVARANVNGQSVWL
CEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCEEEEEECCHHHCCEEEEECCCCCEEEE
LQPQTFMNLSGKSVAALARFFKIQPQEILVAHDELDILPGQAKLKRGGSHAGHNGLRDIH
ECCHHHCCCCCCHHHHHHHHHHCCCHHEEEECCCCEECCCHHHHHCCCCCCCCCCHHHHH
AQLGSPDYWRLRIGIGHPGVKAEVANWVLKKPSPDHRTLIEDSIAHSLKAAPAMLAGDMD
HHCCCCCEEEEEEECCCCCCHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCHHHHHCCCC
KATLLVHTTKPPRPKPPRPAAAPVDAPAAPGDQ
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA