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The map label for this gene is ureC

Identifier: 120612180

GI number: 120612180

Start: 3902637

End: 3904355

Strand: Direct

Name: ureC

Synonym: Aave_3529

Alternate gene names: 120612180

Gene position: 3902637-3904355 (Clockwise)

Preceding gene: 120612179

Following gene: 120612181

Centisome position: 72.91

GC content: 69.4

Gene sequence:

>1719_bases
ATGGCCACCGTCTCCCGCCGCGCCTATGCGGAAATGTTCGGCCCCACCGTGGGCGACCGCGTGCGGCTGGCCGACACCGG
CCTCGTCGCCGAAGTCGAGCAGGACTTCACCCTGCGCGCCGGCGGCTACGGCGAGGAAGTCAAGTTCGGCGGCGGCAAGA
CCATCCGCGACGGCATGGCCCAGAGCCAGCGCACCCGTGCAGAAGGGGCGATGGACACCGTGCTCACCAACGCCCTCGTC
ATCGACCACTGGGGCATCGTCAAGGCCGACATCGGCCTGAAGGACGGCCGTGTCGCCGCCATCGGCAAGGCCGGCAACCC
CGACACCCAGCCCGGCGTGGACATCGTCATCGGCCCCGGCACCGAGATCATCAGTTGCGAAGGCAACATCGTCACGGCCG
GCGGCATCGACAGCCACATCCACTTCATCTGCCCGCAGCAGATCGAAGAGGCGCTGGCCTCGGGCATCACCACCATGCTC
GGCGGCGGCACCGGCCCGGCCACCGGCACGCTGGCCACCACCTGCACGCCCGGCCCCTGGCACATCGAGCGCATGCTGCA
GGCGGCCGACGCCTTCCCCATGAACATCGGCTTCCTGGGCAAGGGCAACGCCAGCCTGCCCGCCGCATTGCACGAACAGA
TCGAGGCCGGCGTGATCGGCCTCAAACTCCACGAAGACTGGGGCACCACCCCCTCGGCCATCAGCAACTGCATGGACGTG
GCCGACGCCACCGACACCCAGGTGGCGATCCACTCCGACACGCTCAACGAGAGCGGCTTCGTCGAGAACACCATCGCCGC
CGTGGGCGGACGCGGCATCTGCGCCTTCCACACCGAGGGCGCGGGCGGCGGCCACGCGCCGGACATCCTGCGCGTGGTGG
GCGAGGACAACTTCCTGCCCTCCTCCACCAACCCCACCATGCCCTACACGCGCAACACGCTGGACGAGCACGTGGACATG
CTCATGGTGTGCCACCACCTGGACGCGGCCATCGCCGAAGACCTGGCCTTCGCCGAGAGCCGCATCCGCAAGGAAACCAT
CGCCGCCGAGGACATCCTGCACGACCTGGGCGCCATCAGCATGATGAGCAGCGACAGCCAGGCCATGGGCCGCGTGGGCG
AGGTCATCCTGCGCACCTGGCAGACCGCCGACAAGATGAAGCAGCAGCGCGGCGCCCTGCCCGAGGACGGCGCCCGCAAC
GACAACCACCGCATCAAGCGCTACGTCGCCAAATACACCATCAACCCCGCGATCGCCCACGGCATCTCCCACGACGTGGG
CAGCCTGGAGGTCGGCAAGTGGGCCGACATCGTGGTCTGGAAGCCAGCCTTCTTCGGCGTGAAGCCCGCGATGGTCCTCA
AGGGCGGCAGCATCGCGGTGGCCGCCATGGGCGACCCGAACGCGTCCATCCCCACGCCGCAGCCCGTGCACTACCGCCCC
ATGTTCGGCGCCTTCGGCGGCTCCCTGGCCCGGTCGTCGCTCACCTTCGTCTCGCAGGCGGCCATGGCGGCCGGCGTGCG
CGAGCGCTTCGGCCTGGCCAAGCAGCTGAGCGCCGTGCGCGGCATCCGCGGCGTGCGCAAGCAGCACATGGTGCACAACG
GCTACACCCCGCGCATGGAGATCGACGCGCAGACCTACACCGTGCGCGCCGACGGCCAGTTGCTCACCTGCGAGTCCGCC
ACCCGCCTGCCGCTGGCGCAGCGCTACTTCCTTTTCTGA

Upstream 100 bases:

>100_bases
GCAGGCACTGCGGAGACCGCCCCCGGCCTGCCGCAGCAGCCCTGACCCGCCCCGCCTCTTCACGCCCCAAGCCACGCCCC
CGGAAAGGCAAGACCACACC

Downstream 100 bases:

>100_bases
GCCCGCCGATGAACGCGCCCACCCCAGCCTCCACGACCGCCCCGCTCCTGCGCATCCGCCTGGACGACCTGAGCGATCCG
CGCATCGCCGTGTTCCTGCA

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha

Number of amino acids: Translated: 572; Mature: 571

Protein sequence:

>572_residues
MATVSRRAYAEMFGPTVGDRVRLADTGLVAEVEQDFTLRAGGYGEEVKFGGGKTIRDGMAQSQRTRAEGAMDTVLTNALV
IDHWGIVKADIGLKDGRVAAIGKAGNPDTQPGVDIVIGPGTEIISCEGNIVTAGGIDSHIHFICPQQIEEALASGITTML
GGGTGPATGTLATTCTPGPWHIERMLQAADAFPMNIGFLGKGNASLPAALHEQIEAGVIGLKLHEDWGTTPSAISNCMDV
ADATDTQVAIHSDTLNESGFVENTIAAVGGRGICAFHTEGAGGGHAPDILRVVGEDNFLPSSTNPTMPYTRNTLDEHVDM
LMVCHHLDAAIAEDLAFAESRIRKETIAAEDILHDLGAISMMSSDSQAMGRVGEVILRTWQTADKMKQQRGALPEDGARN
DNHRIKRYVAKYTINPAIAHGISHDVGSLEVGKWADIVVWKPAFFGVKPAMVLKGGSIAVAAMGDPNASIPTPQPVHYRP
MFGAFGGSLARSSLTFVSQAAMAAGVRERFGLAKQLSAVRGIRGVRKQHMVHNGYTPRMEIDAQTYTVRADGQLLTCESA
TRLPLAQRYFLF

Sequences:

>Translated_572_residues
MATVSRRAYAEMFGPTVGDRVRLADTGLVAEVEQDFTLRAGGYGEEVKFGGGKTIRDGMAQSQRTRAEGAMDTVLTNALV
IDHWGIVKADIGLKDGRVAAIGKAGNPDTQPGVDIVIGPGTEIISCEGNIVTAGGIDSHIHFICPQQIEEALASGITTML
GGGTGPATGTLATTCTPGPWHIERMLQAADAFPMNIGFLGKGNASLPAALHEQIEAGVIGLKLHEDWGTTPSAISNCMDV
ADATDTQVAIHSDTLNESGFVENTIAAVGGRGICAFHTEGAGGGHAPDILRVVGEDNFLPSSTNPTMPYTRNTLDEHVDM
LMVCHHLDAAIAEDLAFAESRIRKETIAAEDILHDLGAISMMSSDSQAMGRVGEVILRTWQTADKMKQQRGALPEDGARN
DNHRIKRYVAKYTINPAIAHGISHDVGSLEVGKWADIVVWKPAFFGVKPAMVLKGGSIAVAAMGDPNASIPTPQPVHYRP
MFGAFGGSLARSSLTFVSQAAMAAGVRERFGLAKQLSAVRGIRGVRKQHMVHNGYTPRMEIDAQTYTVRADGQLLTCESA
TRLPLAQRYFLF
>Mature_571_residues
ATVSRRAYAEMFGPTVGDRVRLADTGLVAEVEQDFTLRAGGYGEEVKFGGGKTIRDGMAQSQRTRAEGAMDTVLTNALVI
DHWGIVKADIGLKDGRVAAIGKAGNPDTQPGVDIVIGPGTEIISCEGNIVTAGGIDSHIHFICPQQIEEALASGITTMLG
GGTGPATGTLATTCTPGPWHIERMLQAADAFPMNIGFLGKGNASLPAALHEQIEAGVIGLKLHEDWGTTPSAISNCMDVA
DATDTQVAIHSDTLNESGFVENTIAAVGGRGICAFHTEGAGGGHAPDILRVVGEDNFLPSSTNPTMPYTRNTLDEHVDML
MVCHHLDAAIAEDLAFAESRIRKETIAAEDILHDLGAISMMSSDSQAMGRVGEVILRTWQTADKMKQQRGALPEDGARND
NHRIKRYVAKYTINPAIAHGISHDVGSLEVGKWADIVVWKPAFFGVKPAMVLKGGSIAVAAMGDPNASIPTPQPVHYRPM
FGAFGGSLARSSLTFVSQAAMAAGVRERFGLAKQLSAVRGIRGVRKQHMVHNGYTPRMEIDAQTYTVRADGQLLTCESAT
RLPLAQRYFLF

Specific function: Unknown

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE1_ACIAC (A1TSZ6)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_971858.1
- ProteinModelPortal:   A1TSZ6
- SMR:   A1TSZ6
- STRING:   A1TSZ6
- MEROPS:   M38.982
- GeneID:   4667450
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3529
- NMPDR:   fig|397945.5.peg.3016
- eggNOG:   COG0804
- HOGENOM:   HBG357507
- OMA:   TIHAFHT
- ProtClustDB:   PRK13207
- BioCyc:   AAVE397945:AAVE_3529-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01953
- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950
- PRINTS:   PR01752
- TIGRFAMs:   TIGR01792

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha; SSF51338 Metalo_hydrolase

EC number: =3.5.1.5

Molecular weight: Translated: 60788; Mature: 60657

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS01120 UREASE_1; PS00145 UREASE_2; PS51368 UREASE_3

Important sites: ACT_SITE 325-325 BINDING 224-224

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVSRRAYAEMFGPTVGDRVRLADTGLVAEVEQDFTLRAGGYGEEVKFGGGKTIRDGMA
CCCCCHHHHHHHHCCCCCCEEEEECCCCEEECCCCEEEECCCCCCEEEECCCCHHHHHHH
QSQRTRAEGAMDTVLTNALVIDHWGIVKADIGLKDGRVAAIGKAGNPDTQPGVDIVIGPG
HHHHHHHHHHHHHHHHHEEEEECCCEEEECCCCCCCCEEEEECCCCCCCCCCCEEEECCC
TEIISCEGNIVTAGGIDSHIHFICPQQIEEALASGITTMLGGGTGPATGTLATTCTPGPW
CEEEEECCCEEEECCCCCCEEEECHHHHHHHHHHCHHHHHCCCCCCCCCCEEEECCCCHH
HIERMLQAADAFPMNIGFLGKGNASLPAALHEQIEAGVIGLKLHEDWGTTPSAISNCMDV
HHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHH
ADATDTQVAIHSDTLNESGFVENTIAAVGGRGICAFHTEGAGGGHAPDILRVVGEDNFLP
CCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCC
SSTNPTMPYTRNTLDEHVDMLMVCHHLDAAIAEDLAFAESRIRKETIAAEDILHDLGAIS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MMSSDSQAMGRVGEVILRTWQTADKMKQQRGALPEDGARNDNHRIKRYVAKYTINPAIAH
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHH
GISHDVGSLEVGKWADIVVWKPAFFGVKPAMVLKGGSIAVAAMGDPNASIPTPQPVHYRP
CCCCCCCCEECCCCEEEEEECCHHHCCCCEEEEECCCEEEEEECCCCCCCCCCCCCEECC
MFGAFGGSLARSSLTFVSQAAMAAGVRERFGLAKQLSAVRGIRGVRKQHMVHNGYTPRME
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
IDAQTYTVRADGQLLTCESATRLPLAQRYFLF
ECCEEEEEEECCCEEEECCCCCCCHHHHHHCC
>Mature Secondary Structure 
ATVSRRAYAEMFGPTVGDRVRLADTGLVAEVEQDFTLRAGGYGEEVKFGGGKTIRDGMA
CCCCHHHHHHHHCCCCCCEEEEECCCCEEECCCCEEEECCCCCCEEEECCCCHHHHHHH
QSQRTRAEGAMDTVLTNALVIDHWGIVKADIGLKDGRVAAIGKAGNPDTQPGVDIVIGPG
HHHHHHHHHHHHHHHHHEEEEECCCEEEECCCCCCCCEEEEECCCCCCCCCCCEEEECCC
TEIISCEGNIVTAGGIDSHIHFICPQQIEEALASGITTMLGGGTGPATGTLATTCTPGPW
CEEEEECCCEEEECCCCCCEEEECHHHHHHHHHHCHHHHHCCCCCCCCCCEEEECCCCHH
HIERMLQAADAFPMNIGFLGKGNASLPAALHEQIEAGVIGLKLHEDWGTTPSAISNCMDV
HHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHH
ADATDTQVAIHSDTLNESGFVENTIAAVGGRGICAFHTEGAGGGHAPDILRVVGEDNFLP
CCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCC
SSTNPTMPYTRNTLDEHVDMLMVCHHLDAAIAEDLAFAESRIRKETIAAEDILHDLGAIS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MMSSDSQAMGRVGEVILRTWQTADKMKQQRGALPEDGARNDNHRIKRYVAKYTINPAIAH
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHH
GISHDVGSLEVGKWADIVVWKPAFFGVKPAMVLKGGSIAVAAMGDPNASIPTPQPVHYRP
CCCCCCCCEECCCCEEEEEECCHHHCCCCEEEEECCCEEEEEECCCCCCCCCCCCCEECC
MFGAFGGSLARSSLTFVSQAAMAAGVRERFGLAKQLSAVRGIRGVRKQHMVHNGYTPRME
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
IDAQTYTVRADGQLLTCESATRLPLAQRYFLF
ECCEEEEEEECCCEEEECCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA