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The map label for this gene is bccA [H]

Identifier: 120612161

GI number: 120612161

Start: 3880148

End: 3881899

Strand: Reverse

Name: bccA [H]

Synonym: Aave_3510

Alternate gene names: 120612161

Gene position: 3881899-3880148 (Counterclockwise)

Preceding gene: 120612162

Following gene: 120612158

Centisome position: 72.52

GC content: 73.69

Gene sequence:

>1752_bases
ATGAAGAAAGTCCTGATCGCCAACCGCGGCGAGATCGCCGTCCGCATCGCCCGCGCCTGTGCCGACCACGGTCTCGCGTC
CGTCGCCGTCTATGCCGATGCCGACATCGACGCCCTGCATGTGCGCATGGCCGACGAGGCCTGGGGCCTGGGCGGCGACC
GCCCGGCCGACACCTACCTGCACATCGACAAGCTGCTGGACGCCGCCCGCAGGAGCGGTGCCGACGCCGTGCACCCCGGC
TACGGTTTTTTGTCCGAGAACGCGGGCTTCGCGCGCGCGGTGATCGGCGCGGGCCTGACCTGGATCGGCCCGCCGCCCGA
GGCCATCGAGCGCCTGGGCGACAAGGTCGAGGCGCGCAGGCTCGCGCTGCAGGTGGGCGCGCCGCTCGTGCAGGGCACGG
CCGGCCCGGTGCGGGACGTCTCCGAGGTGCTCGCCTTCGCCGGGCAGCATGGGCTGCCGATCATCATCAAGGCGGCGTTC
GGCGGCGGCGGCCGCGGCATGAAGATCGCGTGGCGCATGGACGAGGTGGAAGACCTCTACGCCTCCGCCGTGCGCGAGGC
CACGGCCGCCTTCGGGCGCGGCGAATGCTTCGTGGAGCAGTTCCTGGACCGCCCGCGCCATATCGAGGCCCAGGTGCTGG
CCGACACGCACGGCAACGTGGTGGTGCTGGGCACGCGCGATTGTTCCCTGCAGCGCCGCAACCAGAAACTGGTGGAGGAG
GCGCCCGCGCCCTTTCTCACGCCCCAGCAGCGCGAGCGCATCCACGCGGCCGCGCGCGATATCTGCGCCGCCGCCGGCTA
CACCAGCGCGGGCACGGTGGAATTTTTGCTTTCGGGCACGGGGGCGATCTCGTTCCTCGAAGTGAACACGCGCCTGCAGG
TGGAGCACCCCGTCACCGAGCAGACGACCGGCATCGATCTGGTGGTGGAGCAGTTCCGCATCGCCGAGGGCCTGCCGCTG
CGCACCACGCGGACGCCCGAACCCCTGGGCCACGCGTTCGAGTTCCGCATCAATGCGGAGGACGTGGGCCGCGGCTTCCT
GCCCACGCCGGGCGGCGTGACCGCGTTCGAGCCGCCCTCGGGCCCGGGCGTGCGGCTGGACACCGGCGTGCAGGCCGGCT
CCATCGTGCCGGGCACTTTCGATTCGCTCATGGCCAAGCTCATCGTCTCCGGCGCCACGCGCGAGCAGGCCATCGCCCGG
GCGCGCCGCGCGCTGCGCGAGTTCCGCATCGGCGGCGTGGCCTCGGTCCTGCCGTTCCACCGCGCGGTGATGGAGCACCC
GGATTTCACGAACGGCGAGGCGTTGCGCGTGCACACCCGCTGGATCGAGACCGACTTCGCCGGGCCGCTGGCCGCCGCGG
CGCGCGCCGAGCCGCCGGCCGATACCGCGCTCGTGCGCACCGCCATCGAGATCGACGGCCGCCGCGTGGCCCTGGGCCTG
CCCGCGCTGCTGCTGCAGGGCCTGCAGGCTGGACCGGGCGCGCAGCCTGCCGGCGCCCTGGCGCAGGCCGCGACCCCGGG
GGGCACGGGAGAGGAGGGCGCCGTGCCCGCGCCCGTGGCCGGCACCGTGCAGGCATGGAAGGTGACGGAGGGCGACACCG
TGGCCGAGGGCGACGTGGTGGCCGTGATGGAGGCGATGAAGATGGAGATGCAGGTCACCGCGCCGCGCGCGGGGCGCATC
GCCGGGCTGGTGGCCGTGGGGAGCTACCAGGCGGCCGGGGCGCCGCTGGCCCGGGTGCGGCTGGATGGCTGA

Upstream 100 bases:

>100_bases
CGCATGGGTGCGCTTCCGTCCCATCCGGGCGTTCGAGCCGGTCACGCGCCCGTGAACACCATGAAAAAAGTCTTGATGGC
TTGCAGCGAAAGTTGATCCG

Downstream 100 bases:

>100_bases
GGCCGCGGCGCATGGGCCCGCCGTCCGCCCGCTTCACTGCCGGGGCTGCGATGGCCTCACCATGTGCCCGCGCGGGTGCA
GGTGGTTCGCTGCGGCAGGC

Product: carbamoyl-phosphate synthase L chain, ATP-binding

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 583; Mature: 583

Protein sequence:

>583_residues
MKKVLIANRGEIAVRIARACADHGLASVAVYADADIDALHVRMADEAWGLGGDRPADTYLHIDKLLDAARRSGADAVHPG
YGFLSENAGFARAVIGAGLTWIGPPPEAIERLGDKVEARRLALQVGAPLVQGTAGPVRDVSEVLAFAGQHGLPIIIKAAF
GGGGRGMKIAWRMDEVEDLYASAVREATAAFGRGECFVEQFLDRPRHIEAQVLADTHGNVVVLGTRDCSLQRRNQKLVEE
APAPFLTPQQRERIHAAARDICAAAGYTSAGTVEFLLSGTGAISFLEVNTRLQVEHPVTEQTTGIDLVVEQFRIAEGLPL
RTTRTPEPLGHAFEFRINAEDVGRGFLPTPGGVTAFEPPSGPGVRLDTGVQAGSIVPGTFDSLMAKLIVSGATREQAIAR
ARRALREFRIGGVASVLPFHRAVMEHPDFTNGEALRVHTRWIETDFAGPLAAAARAEPPADTALVRTAIEIDGRRVALGL
PALLLQGLQAGPGAQPAGALAQAATPGGTGEEGAVPAPVAGTVQAWKVTEGDTVAEGDVVAVMEAMKMEMQVTAPRAGRI
AGLVAVGSYQAAGAPLARVRLDG

Sequences:

>Translated_583_residues
MKKVLIANRGEIAVRIARACADHGLASVAVYADADIDALHVRMADEAWGLGGDRPADTYLHIDKLLDAARRSGADAVHPG
YGFLSENAGFARAVIGAGLTWIGPPPEAIERLGDKVEARRLALQVGAPLVQGTAGPVRDVSEVLAFAGQHGLPIIIKAAF
GGGGRGMKIAWRMDEVEDLYASAVREATAAFGRGECFVEQFLDRPRHIEAQVLADTHGNVVVLGTRDCSLQRRNQKLVEE
APAPFLTPQQRERIHAAARDICAAAGYTSAGTVEFLLSGTGAISFLEVNTRLQVEHPVTEQTTGIDLVVEQFRIAEGLPL
RTTRTPEPLGHAFEFRINAEDVGRGFLPTPGGVTAFEPPSGPGVRLDTGVQAGSIVPGTFDSLMAKLIVSGATREQAIAR
ARRALREFRIGGVASVLPFHRAVMEHPDFTNGEALRVHTRWIETDFAGPLAAAARAEPPADTALVRTAIEIDGRRVALGL
PALLLQGLQAGPGAQPAGALAQAATPGGTGEEGAVPAPVAGTVQAWKVTEGDTVAEGDVVAVMEAMKMEMQVTAPRAGRI
AGLVAVGSYQAAGAPLARVRLDG
>Mature_583_residues
MKKVLIANRGEIAVRIARACADHGLASVAVYADADIDALHVRMADEAWGLGGDRPADTYLHIDKLLDAARRSGADAVHPG
YGFLSENAGFARAVIGAGLTWIGPPPEAIERLGDKVEARRLALQVGAPLVQGTAGPVRDVSEVLAFAGQHGLPIIIKAAF
GGGGRGMKIAWRMDEVEDLYASAVREATAAFGRGECFVEQFLDRPRHIEAQVLADTHGNVVVLGTRDCSLQRRNQKLVEE
APAPFLTPQQRERIHAAARDICAAAGYTSAGTVEFLLSGTGAISFLEVNTRLQVEHPVTEQTTGIDLVVEQFRIAEGLPL
RTTRTPEPLGHAFEFRINAEDVGRGFLPTPGGVTAFEPPSGPGVRLDTGVQAGSIVPGTFDSLMAKLIVSGATREQAIAR
ARRALREFRIGGVASVLPFHRAVMEHPDFTNGEALRVHTRWIETDFAGPLAAAARAEPPADTALVRTAIEIDGRRVALGL
PALLLQGLQAGPGAQPAGALAQAATPGGTGEEGAVPAPVAGTVQAWKVTEGDTVAEGDVVAVMEAMKMEMQVTAPRAGRI
AGLVAVGSYQAAGAPLARVRLDG

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=452, Percent_Identity=44.6902654867257, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI106049295, Length=452, Percent_Identity=44.6902654867257, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI106049292, Length=452, Percent_Identity=44.6902654867257, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI189095269, Length=434, Percent_Identity=44.2396313364055, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI65506442, Length=434, Percent_Identity=44.2396313364055, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI295821183, Length=434, Percent_Identity=44.2396313364055, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI116805327, Length=444, Percent_Identity=43.018018018018, Blast_Score=359, Evalue=4e-99,
Organism=Homo sapiens, GI38679971, Length=525, Percent_Identity=30.8571428571429, Blast_Score=225, Evalue=8e-59,
Organism=Homo sapiens, GI38679974, Length=525, Percent_Identity=30.8571428571429, Blast_Score=225, Evalue=8e-59,
Organism=Homo sapiens, GI38679960, Length=525, Percent_Identity=30.8571428571429, Blast_Score=225, Evalue=9e-59,
Organism=Homo sapiens, GI38679977, Length=525, Percent_Identity=30.8571428571429, Blast_Score=225, Evalue=9e-59,
Organism=Homo sapiens, GI38679967, Length=525, Percent_Identity=30.8571428571429, Blast_Score=225, Evalue=9e-59,
Organism=Homo sapiens, GI134142062, Length=521, Percent_Identity=31.0940499040307, Blast_Score=207, Evalue=3e-53,
Organism=Escherichia coli, GI1789654, Length=434, Percent_Identity=46.5437788018433, Blast_Score=355, Evalue=3e-99,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=46.7706013363029, Blast_Score=380, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71987519, Length=445, Percent_Identity=44.9438202247191, Blast_Score=368, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=43.5665914221219, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI133931226, Length=456, Percent_Identity=29.6052631578947, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71997168, Length=638, Percent_Identity=25.8620689655172, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=444, Percent_Identity=29.5045045045045, Blast_Score=179, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6319695, Length=444, Percent_Identity=45.045045045045, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6321376, Length=444, Percent_Identity=45.945945945946, Blast_Score=354, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6319685, Length=432, Percent_Identity=39.5833333333333, Blast_Score=303, Evalue=6e-83,
Organism=Saccharomyces cerevisiae, GI6323863, Length=476, Percent_Identity=29.4117647058824, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6324343, Length=512, Percent_Identity=29.1015625, Blast_Score=194, Evalue=4e-50,
Organism=Drosophila melanogaster, GI281363050, Length=438, Percent_Identity=48.1735159817352, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652224, Length=438, Percent_Identity=48.1735159817352, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652222, Length=438, Percent_Identity=48.1735159817352, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652220, Length=438, Percent_Identity=48.1735159817352, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652218, Length=438, Percent_Identity=48.1735159817352, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652212, Length=438, Percent_Identity=48.1735159817352, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652210, Length=438, Percent_Identity=48.1735159817352, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652214, Length=438, Percent_Identity=48.1735159817352, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI19921944, Length=438, Percent_Identity=48.1735159817352, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652216, Length=438, Percent_Identity=48.1735159817352, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24651757, Length=450, Percent_Identity=41.3333333333333, Blast_Score=332, Evalue=4e-91,
Organism=Drosophila melanogaster, GI24651759, Length=412, Percent_Identity=41.0194174757282, Blast_Score=298, Evalue=6e-81,
Organism=Drosophila melanogaster, GI161076407, Length=499, Percent_Identity=30.2605210420842, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24586460, Length=499, Percent_Identity=30.2605210420842, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI161076409, Length=499, Percent_Identity=30.2605210420842, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24586458, Length=499, Percent_Identity=30.2605210420842, Blast_Score=199, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 61236; Mature: 61236

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLIANRGEIAVRIARACADHGLASVAVYADADIDALHVRMADEAWGLGGDRPADTYL
CCCEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECHHHCCCCCCCCCHHHH
HIDKLLDAARRSGADAVHPGYGFLSENAGFARAVIGAGLTWIGPPPEAIERLGDKVEARR
HHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LALQVGAPLVQGTAGPVRDVSEVLAFAGQHGLPIIIKAAFGGGGRGMKIAWRMDEVEDLY
HHHHHCCCHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEEECHHHHHHH
ASAVREATAAFGRGECFVEQFLDRPRHIEAQVLADTHGNVVVLGTRDCSLQRRNQKLVEE
HHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHH
APAPFLTPQQRERIHAAARDICAAAGYTSAGTVEFLLSGTGAISFLEVNTRLQVEHPVTE
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEECCEEEECCCCCC
QTTGIDLVVEQFRIAEGLPLRTTRTPEPLGHAFEFRINAEDVGRGFLPTPGGVTAFEPPS
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECHHHHCCCCCCCCCCCEECCCCC
GPGVRLDTGVQAGSIVPGTFDSLMAKLIVSGATREQAIARARRALREFRIGGVASVLPFH
CCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
RAVMEHPDFTNGEALRVHTRWIETDFAGPLAAAARAEPPADTALVRTAIEIDGRRVALGL
HHHHCCCCCCCCCEEEEEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHEEECCCEEEECC
PALLLQGLQAGPGAQPAGALAQAATPGGTGEEGAVPAPVAGTVQAWKVTEGDTVAEGDVV
HHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHH
AVMEAMKMEMQVTAPRAGRIAGLVAVGSYQAAGAPLARVRLDG
HHHHHHHHHEEEECCCCCCEEEEEEECCCCCCCCCEEEEEECC
>Mature Secondary Structure
MKKVLIANRGEIAVRIARACADHGLASVAVYADADIDALHVRMADEAWGLGGDRPADTYL
CCCEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECHHHCCCCCCCCCHHHH
HIDKLLDAARRSGADAVHPGYGFLSENAGFARAVIGAGLTWIGPPPEAIERLGDKVEARR
HHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LALQVGAPLVQGTAGPVRDVSEVLAFAGQHGLPIIIKAAFGGGGRGMKIAWRMDEVEDLY
HHHHHCCCHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEEECHHHHHHH
ASAVREATAAFGRGECFVEQFLDRPRHIEAQVLADTHGNVVVLGTRDCSLQRRNQKLVEE
HHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHH
APAPFLTPQQRERIHAAARDICAAAGYTSAGTVEFLLSGTGAISFLEVNTRLQVEHPVTE
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEECCEEEECCCCCC
QTTGIDLVVEQFRIAEGLPLRTTRTPEPLGHAFEFRINAEDVGRGFLPTPGGVTAFEPPS
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECHHHHCCCCCCCCCCCEECCCCC
GPGVRLDTGVQAGSIVPGTFDSLMAKLIVSGATREQAIARARRALREFRIGGVASVLPFH
CCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
RAVMEHPDFTNGEALRVHTRWIETDFAGPLAAAARAEPPADTALVRTAIEIDGRRVALGL
HHHHCCCCCCCCCEEEEEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHEEECCCEEEECC
PALLLQGLQAGPGAQPAGALAQAATPGGTGEEGAVPAPVAGTVQAWKVTEGDTVAEGDVV
HHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHH
AVMEAMKMEMQVTAPRAGRIAGLVAVGSYQAAGAPLARVRLDG
HHHHHHHHHEEEECCCCCCEEEEEEECCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7909542; 11234002 [H]