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The map label for this gene is 120612052

Identifier: 120612052

GI number: 120612052

Start: 3755352

End: 3756098

Strand: Direct

Name: 120612052

Synonym: Aave_3398

Alternate gene names: NA

Gene position: 3755352-3756098 (Clockwise)

Preceding gene: 120612047

Following gene: 120612053

Centisome position: 70.16

GC content: 73.09

Gene sequence:

>747_bases
GTGGGCCTGCAGGTCACGAGCTGCGGCGTCCACCCCACGCAGGGCCCCTGGTCCGGCACTGCCGCCCAGCCCACGCGCGC
CGGCCAGTTCACGGAGTGCCGCCAGCACTTCGCCGGCGGCGTGCCGCCCCTCACCCCCGATGCGCCCCGGCTGCGCGAGC
TGTGCTTCGACGCCTTCGCGGTGCTCCACAGCGGCAACACACGCACCCCCGTGTATGTGGCCGAGCGGCTCAACCGCCAG
ATCCTGCAGCAGGCCCGGCAGCAGCACCGCACCGACCATTTCTACGCGGACGCGCGGCTGCCGCGCGGCGAGCGCGCCGA
ACTCGAGGATTACCGCGGCTCGGGCTATGCCCGCGGCCACATGGCGCCTGCGGGCGACATGGGCACCCCCGAAGCCATGG
CGCAGTCGTTCAGCCTCGCCAACATGGTGCCGCAGGATCCGAAGCAGAACAGCGGCCCCTGGGCACGCATCGAGGAGGAC
ACGCGCCGCTACGCGATGCGCGCGCGCGGCGACGTCTATGTCATCACCGGCCCCGTCTTCGAGCCCGGGGCCAGGACCAT
CGGCGCCGGACAGGTGGCCGTGCCTTCGCACCTGTTCAAGCTGGTGTACGACGCCGGGACCGGGCATTCCTGGGCGCACT
GGCAGCAGAACGCGCCGGGCGCCACCGCCGGCCCGCCGATCACGCTGCAGGAAGTGGAGCGCCGCACCGGCATGCGGCTG
CTGCCCTCCCCGGTGCCCGCGCATTGA

Upstream 100 bases:

>100_bases
GCGCAGAAAGAAATCCTCCCGCTCCCCCTCCATCGCCCTCCTGCACCGGTCCTCAGGCCGCGTGCGCCGGTTGCTGGTTT
CCCTGTTCACCTCCGCGGTC

Downstream 100 bases:

>100_bases
CGCATCTTCGAGACGACCCCTTCCCACCTGCACGGCAATAGCTGTATATTCATACAGTCATTGCTACTTCAGGAGAAAAG
GCATGTCCGAAACCGCCACC

Product: DNA/RNA non-specific endonuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MGLQVTSCGVHPTQGPWSGTAAQPTRAGQFTECRQHFAGGVPPLTPDAPRLRELCFDAFAVLHSGNTRTPVYVAERLNRQ
ILQQARQQHRTDHFYADARLPRGERAELEDYRGSGYARGHMAPAGDMGTPEAMAQSFSLANMVPQDPKQNSGPWARIEED
TRRYAMRARGDVYVITGPVFEPGARTIGAGQVAVPSHLFKLVYDAGTGHSWAHWQQNAPGATAGPPITLQEVERRTGMRL
LPSPVPAH

Sequences:

>Translated_248_residues
MGLQVTSCGVHPTQGPWSGTAAQPTRAGQFTECRQHFAGGVPPLTPDAPRLRELCFDAFAVLHSGNTRTPVYVAERLNRQ
ILQQARQQHRTDHFYADARLPRGERAELEDYRGSGYARGHMAPAGDMGTPEAMAQSFSLANMVPQDPKQNSGPWARIEED
TRRYAMRARGDVYVITGPVFEPGARTIGAGQVAVPSHLFKLVYDAGTGHSWAHWQQNAPGATAGPPITLQEVERRTGMRL
LPSPVPAH
>Mature_247_residues
GLQVTSCGVHPTQGPWSGTAAQPTRAGQFTECRQHFAGGVPPLTPDAPRLRELCFDAFAVLHSGNTRTPVYVAERLNRQI
LQQARQQHRTDHFYADARLPRGERAELEDYRGSGYARGHMAPAGDMGTPEAMAQSFSLANMVPQDPKQNSGPWARIEEDT
RRYAMRARGDVYVITGPVFEPGARTIGAGQVAVPSHLFKLVYDAGTGHSWAHWQQNAPGATAGPPITLQEVERRTGMRLL
PSPVPAH

Specific function: Unknown

COG id: COG1864

COG function: function code F; DNA/RNA endonuclease G, NUC1

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA/RNA non-specific endonuclease family [H]

Homologues:

Organism=Homo sapiens, GI224451073, Length=225, Percent_Identity=34.2222222222222, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI224451075, Length=174, Percent_Identity=36.7816091954023, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI53759134, Length=205, Percent_Identity=31.219512195122, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17505967, Length=206, Percent_Identity=29.126213592233, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322253, Length=211, Percent_Identity=28.436018957346, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24581065, Length=229, Percent_Identity=28.3842794759825, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI20129899, Length=257, Percent_Identity=27.2373540856031, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018524
- InterPro:   IPR001604
- InterPro:   IPR020821 [H]

Pfam domain/function: PF01223 Endonuclease_NS [H]

EC number: 3.1.30.-

Molecular weight: Translated: 27112; Mature: 26981

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLQVTSCGVHPTQGPWSGTAAQPTRAGQFTECRQHFAGGVPPLTPDAPRLRELCFDAFA
CCCEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
VLHSGNTRTPVYVAERLNRQILQQARQQHRTDHFYADARLPRGERAELEDYRGSGYARGH
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHCCCCCCCCC
MAPAGDMGTPEAMAQSFSLANMVPQDPKQNSGPWARIEEDTRRYAMRARGDVYVITGPVF
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCEEEEECCCC
EPGARTIGAGQVAVPSHLFKLVYDAGTGHSWAHWQQNAPGATAGPPITLQEVERRTGMRL
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHCCCEE
LPSPVPAH
CCCCCCCC
>Mature Secondary Structure 
GLQVTSCGVHPTQGPWSGTAAQPTRAGQFTECRQHFAGGVPPLTPDAPRLRELCFDAFA
CCEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
VLHSGNTRTPVYVAERLNRQILQQARQQHRTDHFYADARLPRGERAELEDYRGSGYARGH
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHCCCCCCCCC
MAPAGDMGTPEAMAQSFSLANMVPQDPKQNSGPWARIEEDTRRYAMRARGDVYVITGPVF
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCEEEEECCCC
EPGARTIGAGQVAVPSHLFKLVYDAGTGHSWAHWQQNAPGATAGPPITLQEVERRTGMRL
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHCCCEE
LPSPVPAH
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]