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The map label for this gene is moaA [H]

Identifier: 120611327

GI number: 120611327

Start: 2919461

End: 2920621

Strand: Reverse

Name: moaA [H]

Synonym: Aave_2659

Alternate gene names: 120611327

Gene position: 2920621-2919461 (Counterclockwise)

Preceding gene: 120611328

Following gene: 120611326

Centisome position: 54.56

GC content: 70.89

Gene sequence:

>1161_bases
ATGCGGCAGAATCCAGCCATGGCCGAACGTGTGATTCCGCTCGTGGACCAGCGCATCGCCGCGCTGCGGCCCCGCATGCC
CGAAGGCCCTTTCGCAGGGCCTGCAGGATGGCTCGCCGATGCGCTGGGCCGGCCCTTGCGCGACCTGCGCATCAGCGTCA
CCGACCGCTGCAACTTCCGCTGCAGCTACTGCATGCCCAAGGAAGTCTTCGGCAAGGACTATCCCTACCTCTCCCACGGC
GACCTGCTCAGCTTCGAGGAGATCACGCGCCTGGCGCGGGTCTTCCTGGCCCATGGCGTGCGCAAGATCCGGCTCACGGG
CGGGGAACCGCTGCTGCGGCGGCACCTGGAGAACCTGGTGGAGCAGCTCGCCGGGCTGCGCACCGCCGAGGGCCGCGTGC
CCGACCTGACGCTGACCACCAACGGCTCGCTGCTCGCCCGCAAGGCCCGGGCCCTGCGCGACGCGGGGCTGGCGCGGCTC
ACCGTCAGCCTGGACAGCCTGCAGGACAGCGTCTTCCGCCGCATGAACGACGTGGACTTTCCCGTGGCGGAGGTGCTCTC
TGGCATCGAGGCCGCCCAGGCGGCCGGGTTCGAGCGCATCAAGGTCAACATGGTGGTCAAGCGCGGCACCAACGACCACG
AGATCGTGCCCATGGCCCGCCATTTCCGGGGCACCGGCATCACGCTGCGCTTCATCGAATACATGGACGTGGGCGCCACG
AACGGGTGGCGCATGGACGAGGTGCTACCGTCGGCGCAGGTGATCGACCGGCTCCGGCAGGAACTGCCCCTGGTGCAGCT
GCCTCCCGCGGCCCCCGGAGAAACCGCCGAGCGCTGGGGTTATGCCGACGCACAGGGCCGGCACGACCCCGCCCTGGGAG
AAGTGGGAACGATCAGCAGCGTCACCCGCGCGTTCTGCGGCGATTGCAACCGCGCCCGGCTGTCGATGGAAGGCCGGCTC
TACCTGTGCCTCTTCGCCACGCAGGGCTGGGACCTGCGCGCGCTGCTGCGCGGCGGGGCCGCCGACCCCGATCTGGCCGC
GGCCATCGCCGGCATCTGGCAGGGCCGCACCGACCGCTATTCCGAACTGCGGGGCAGCCTGCCGCCGGCCACCGGCGCGC
CGGCCGCGCGGCGCGTCGAGATGAGCTACATCGGCGGATGA

Upstream 100 bases:

>100_bases
CTTTCGCACCGAAGGTTCGGGCCGGCAGGAGGCTCCACGGAAGCCGGGGAAATTGACGGGCATCAATATTCCGCCGTCCG
CCCATACCCCTACTGCGGCC

Downstream 100 bases:

>100_bases
GGCGCGGGGGGCCATGGTGATCGGCCGCGCGGACATCGCCGGCATGGTCCTGGCCGGCGGCCAGGGCTCGCGCATGGGCG
GGCTGGACAAGGGGCTGCAG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MRQNPAMAERVIPLVDQRIAALRPRMPEGPFAGPAGWLADALGRPLRDLRISVTDRCNFRCSYCMPKEVFGKDYPYLSHG
DLLSFEEITRLARVFLAHGVRKIRLTGGEPLLRRHLENLVEQLAGLRTAEGRVPDLTLTTNGSLLARKARALRDAGLARL
TVSLDSLQDSVFRRMNDVDFPVAEVLSGIEAAQAAGFERIKVNMVVKRGTNDHEIVPMARHFRGTGITLRFIEYMDVGAT
NGWRMDEVLPSAQVIDRLRQELPLVQLPPAAPGETAERWGYADAQGRHDPALGEVGTISSVTRAFCGDCNRARLSMEGRL
YLCLFATQGWDLRALLRGGAADPDLAAAIAGIWQGRTDRYSELRGSLPPATGAPAARRVEMSYIGG

Sequences:

>Translated_386_residues
MRQNPAMAERVIPLVDQRIAALRPRMPEGPFAGPAGWLADALGRPLRDLRISVTDRCNFRCSYCMPKEVFGKDYPYLSHG
DLLSFEEITRLARVFLAHGVRKIRLTGGEPLLRRHLENLVEQLAGLRTAEGRVPDLTLTTNGSLLARKARALRDAGLARL
TVSLDSLQDSVFRRMNDVDFPVAEVLSGIEAAQAAGFERIKVNMVVKRGTNDHEIVPMARHFRGTGITLRFIEYMDVGAT
NGWRMDEVLPSAQVIDRLRQELPLVQLPPAAPGETAERWGYADAQGRHDPALGEVGTISSVTRAFCGDCNRARLSMEGRL
YLCLFATQGWDLRALLRGGAADPDLAAAIAGIWQGRTDRYSELRGSLPPATGAPAARRVEMSYIGG
>Mature_386_residues
MRQNPAMAERVIPLVDQRIAALRPRMPEGPFAGPAGWLADALGRPLRDLRISVTDRCNFRCSYCMPKEVFGKDYPYLSHG
DLLSFEEITRLARVFLAHGVRKIRLTGGEPLLRRHLENLVEQLAGLRTAEGRVPDLTLTTNGSLLARKARALRDAGLARL
TVSLDSLQDSVFRRMNDVDFPVAEVLSGIEAAQAAGFERIKVNMVVKRGTNDHEIVPMARHFRGTGITLRFIEYMDVGAT
NGWRMDEVLPSAQVIDRLRQELPLVQLPPAAPGETAERWGYADAQGRHDPALGEVGTISSVTRAFCGDCNRARLSMEGRL
YLCLFATQGWDLRALLRGGAADPDLAAAIAGIWQGRTDRYSELRGSLPPATGAPAARRVEMSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=339, Percent_Identity=37.1681415929204, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI22027536, Length=338, Percent_Identity=37.2781065088757, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1786999, Length=354, Percent_Identity=35.0282485875706, Blast_Score=174, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI32566331, Length=376, Percent_Identity=31.1170212765957, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17561210, Length=357, Percent_Identity=32.2128851540616, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI32566329, Length=357, Percent_Identity=31.3725490196078, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI28574490, Length=344, Percent_Identity=35.1744186046512, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI28574488, Length=332, Percent_Identity=35.8433734939759, Blast_Score=190, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 42495; Mature: 42495

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQNPAMAERVIPLVDQRIAALRPRMPEGPFAGPAGWLADALGRPLRDLRISVTDRCNFR
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHEEEEECCCCCE
CSYCMPKEVFGKDYPYLSHGDLLSFEEITRLARVFLAHGVRKIRLTGGEPLLRRHLENLV
ECCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
EQLAGLRTAEGRVPDLTLTTNGSLLARKARALRDAGLARLTVSLDSLQDSVFRRMNDVDF
HHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCC
PVAEVLSGIEAAQAAGFERIKVNMVVKRGTNDHEIVPMARHFRGTGITLRFIEYMDVGAT
CHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCEECHHHHHCCCCCEEEEEEEHHHCCCC
NGWRMDEVLPSAQVIDRLRQELPLVQLPPAAPGETAERWGYADAQGRHDPALGEVGTISS
CCCCHHHHCCHHHHHHHHHHHCCEEECCCCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHH
VTRAFCGDCNRARLSMEGRLYLCLFATQGWDLRALLRGGAADPDLAAAIAGIWQGRTDRY
HHHHHHCCCCCEEEEECCCEEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCHHH
SELRGSLPPATGAPAARRVEMSYIGG
HHHHCCCCCCCCCCHHHEEEEHCCCC
>Mature Secondary Structure
MRQNPAMAERVIPLVDQRIAALRPRMPEGPFAGPAGWLADALGRPLRDLRISVTDRCNFR
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHEEEEECCCCCE
CSYCMPKEVFGKDYPYLSHGDLLSFEEITRLARVFLAHGVRKIRLTGGEPLLRRHLENLV
ECCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
EQLAGLRTAEGRVPDLTLTTNGSLLARKARALRDAGLARLTVSLDSLQDSVFRRMNDVDF
HHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCC
PVAEVLSGIEAAQAAGFERIKVNMVVKRGTNDHEIVPMARHFRGTGITLRFIEYMDVGAT
CHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCEECHHHHHCCCCCEEEEEEEHHHCCCC
NGWRMDEVLPSAQVIDRLRQELPLVQLPPAAPGETAERWGYADAQGRHDPALGEVGTISS
CCCCHHHHCCHHHHHHHHHHHCCEEECCCCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHH
VTRAFCGDCNRARLSMEGRLYLCLFATQGWDLRALLRGGAADPDLAAAIAGIWQGRTDRY
HHHHHHCCCCCEEEEECCCEEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCHHH
SELRGSLPPATGAPAARRVEMSYIGG
HHHHCCCCCCCCCCHHHEEEEHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]