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The map label for this gene is trxA [H]

Identifier: 120611307

GI number: 120611307

Start: 2896650

End: 2896982

Strand: Reverse

Name: trxA [H]

Synonym: Aave_2639

Alternate gene names: 120611307

Gene position: 2896982-2896650 (Counterclockwise)

Preceding gene: 120611311

Following gene: 120611306

Centisome position: 54.12

GC content: 63.96

Gene sequence:

>333_bases
ATGGCCAGCGAACTGATCAAACACATCTCCGACGCCAGCTTCGAAGCCGACGTGCTGCAACCCGGCACCACGGTACTGGT
GGACTACTGGGCCGAATGGTGCGGCCCGTGCAAGATGATCGCCCCCATCCTCGACGAGGTGGCGGGCTCCTACCAGGGCA
AGCTCACCGTGGCCAAGATGAACGTGGACGAAAACCGCGAAGTGCCCGCCAAGTTCGGCATCCGCGGCATCCCCACGCTC
ATGCTGTTCAAGGACGGCCAGCTCGCCGCCACGAAGGTCGGCGCGATGAGCAAGGCCCAGCTGACGTCCTTCATCGACCA
GCAGCTCGCCTGA

Upstream 100 bases:

>100_bases
TCCACCACATCGAGCAGGGAATGTCTTTCTGTCACAATCCCAGGACTGTATCCGCACCTTTCCCCACAATCCATTTCTTC
GCCTCCACAAGGAACGCGCC

Downstream 100 bases:

>100_bases
GCCGCCCTCGTCCCCTCCGGTGCGGCAGGCCTGCATGCCGCCTGCGCACCGGCCTCTCCTGCCTTGCGGCACGCACTTGC
CGGTACCCGTGCAGAGACAG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 110; Mature: 109

Protein sequence:

>110_residues
MASELIKHISDASFEADVLQPGTTVLVDYWAEWCGPCKMIAPILDEVAGSYQGKLTVAKMNVDENREVPAKFGIRGIPTL
MLFKDGQLAATKVGAMSKAQLTSFIDQQLA

Sequences:

>Translated_110_residues
MASELIKHISDASFEADVLQPGTTVLVDYWAEWCGPCKMIAPILDEVAGSYQGKLTVAKMNVDENREVPAKFGIRGIPTL
MLFKDGQLAATKVGAMSKAQLTSFIDQQLA
>Mature_109_residues
ASELIKHISDASFEADVLQPGTTVLVDYWAEWCGPCKMIAPILDEVAGSYQGKLTVAKMNVDENREVPAKFGIRGIPTLM
LFKDGQLAATKVGAMSKAQLTSFIDQQLA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=31.5217391304348, Blast_Score=73, Evalue=4e-14,
Organism=Homo sapiens, GI21361657, Length=102, Percent_Identity=31.3725490196078, Blast_Score=67, Evalue=3e-12,
Organism=Homo sapiens, GI5031973, Length=100, Percent_Identity=29, Blast_Score=62, Evalue=8e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=64.8148148148148, Blast_Score=156, Evalue=4e-40,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=42.3913043478261, Blast_Score=94, Evalue=2e-21,
Organism=Escherichia coli, GI87081747, Length=88, Percent_Identity=36.3636363636364, Blast_Score=69, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=39.1752577319588, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71998175, Length=74, Percent_Identity=44.5945945945946, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71980565, Length=88, Percent_Identity=35.2272727272727, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=75, Percent_Identity=34.6666666666667, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=71, Percent_Identity=45.0704225352113, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=71, Percent_Identity=42.2535211267606, Blast_Score=65, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=40, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24664269, Length=87, Percent_Identity=35.632183908046, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573567, Length=94, Percent_Identity=28.7234042553192, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17648013, Length=77, Percent_Identity=36.3636363636364, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583090, Length=77, Percent_Identity=36.3636363636364, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11932; Mature: 11801

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASELIKHISDASFEADVLQPGTTVLVDYWAEWCGPCKMIAPILDEVAGSYQGKLTVAKM
CHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEE
NVDENREVPAKFGIRGIPTLMLFKDGQLAATKVGAMSKAQLTSFIDQQLA
CCCCCCCCCHHCCCCCCCEEEEEECCCCHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
ASELIKHISDASFEADVLQPGTTVLVDYWAEWCGPCKMIAPILDEVAGSYQGKLTVAKM
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEE
NVDENREVPAKFGIRGIPTLMLFKDGQLAATKVGAMSKAQLTSFIDQQLA
CCCCCCCCCHHCCCCCCCEEEEEECCCCHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]