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The map label for this gene is carA [H]

Identifier: 120611278

GI number: 120611278

Start: 2859176

End: 2860354

Strand: Direct

Name: carA [H]

Synonym: Aave_2610

Alternate gene names: 120611278

Gene position: 2859176-2860354 (Clockwise)

Preceding gene: 120611277

Following gene: 120611279

Centisome position: 53.41

GC content: 66.33

Gene sequence:

>1179_bases
TTGTCTCTCAAGGGAACCTTCCCTCCCGCCATCCTGGCGCTCGCAGACGGCACGGTCTTTATTGGTCGCTCGATCGGTGC
CACCGGCACCACGGTCGGTGAAGTGGTGTTCAACACCGCCATCACCGGCTACCAGGAAATCCTCACCGACCCCAGCTATT
GCCAGCAGATCGTCACGCTGACGTATCCGCACATCGGCAACTACGGTGTCAATACGGAGGATGTCGAGGCCGACAAGATC
CATGCCGCAGGTCTCATCATCAAGGACCTGCCCCTGCTGGCCAGCAATTTCCGCAGCACCGAAACGCTGTCGCAATACCT
CGTGCGTGGGAGCACGGTGGCCATCGCCGACATCGACACCCGCAAGCTCACCCGTCTGCTGCGTGACAAGGGCGCGCAGA
ACGGCGCGATCCTGGGCCTGGCGGCCGGCGAGGCGGTGACGCAGGCGCGCATCGACGAAGCCCTGGCGGCCGCCAAGGCG
GCGCCCAGCATGAAGGGGCTGGACCTCGCCCAGGTGGTGAGCACGCCGTCTTCCTACGTCTGGGAGCAGACCGAGTGGAA
GCTCGGCGAAGGCTACGGCCGGCAGGAGGCTCCCCGCTTCCACGTGGTGGCGTACGACTACGGCGTGAAGAAGAACATCC
TGCGCATGCTGGCCGAGCGCGGCTGCAAGCTCACCGTGGTGCCGGCGAAGACACCGGCCGCCGACGTGCTCGCGATGCGC
CCGGACGGCGTGTTCCTGTCCAACGGCCCCGGCGACCCGGCGCCCTGCGACTACGCCATCGAAGCCACGCGCCAGATCAT
CGACGCCGGCGTGCCCACCTTCGGCATCTGCCTGGGCCACCAGATCATGGCCCTGGCCAGCGGCGCGAAGACCTTCAAGA
TGGACAACAGCCACCACGGCGCCAACCATCCCGTGAAGGACCTGGACAACGGCCGCGTGAGCATCACCAGCCAGAACCAC
GGCTTCGCCGTCGAGGCCGATTCGCTGCCCGCCAGCCTGCGCGCCACCCACGTGAGCCTGTTCGACGGCACGCTGCAGGG
CCTGGAGCACACCAGCCAGCCCGCATTCTGCTTCCAGGGCCACCCCGAGGCGTCGCCCGGCCCGCACGACATCGCCTATC
TGTTCGACCGCTTCACGGCGCTGATGGAAAAGCACAAGACGGAGAACAAGAATGCCTAA

Upstream 100 bases:

>100_bases
CGCCCGGCCGCAACCAAAGCAATCCTTCCACAAAGCGCAGTCCTCAGGTCCATCCCGAGGGCTCCGGGCGACCCGTAACC
ATCCGGAGAACCCAGTGCTT

Downstream 100 bases:

>100_bases
GCGCAGCGACCTCAAATCGATCCTCATCATCGGCGCCGGCCCGATCATCATCGGCCAGGCCTGCGAGTTCGACTACTCCG
GCGTGCAGGCCTGCAAGGCG

Product: carbamoyl-phosphate synthase small subunit

Products: NA

Alternate protein names: Carbamoyl-phosphate synthetase glutamine chain [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSLKGTFPPAILALADGTVFIGRSIGATGTTVGEVVFNTAITGYQEILTDPSYCQQIVTLTYPHIGNYGVNTEDVEADKI
HAAGLIIKDLPLLASNFRSTETLSQYLVRGSTVAIADIDTRKLTRLLRDKGAQNGAILGLAAGEAVTQARIDEALAAAKA
APSMKGLDLAQVVSTPSSYVWEQTEWKLGEGYGRQEAPRFHVVAYDYGVKKNILRMLAERGCKLTVVPAKTPAADVLAMR
PDGVFLSNGPGDPAPCDYAIEATRQIIDAGVPTFGICLGHQIMALASGAKTFKMDNSHHGANHPVKDLDNGRVSITSQNH
GFAVEADSLPASLRATHVSLFDGTLQGLEHTSQPAFCFQGHPEASPGPHDIAYLFDRFTALMEKHKTENKNA

Sequences:

>Translated_392_residues
MSLKGTFPPAILALADGTVFIGRSIGATGTTVGEVVFNTAITGYQEILTDPSYCQQIVTLTYPHIGNYGVNTEDVEADKI
HAAGLIIKDLPLLASNFRSTETLSQYLVRGSTVAIADIDTRKLTRLLRDKGAQNGAILGLAAGEAVTQARIDEALAAAKA
APSMKGLDLAQVVSTPSSYVWEQTEWKLGEGYGRQEAPRFHVVAYDYGVKKNILRMLAERGCKLTVVPAKTPAADVLAMR
PDGVFLSNGPGDPAPCDYAIEATRQIIDAGVPTFGICLGHQIMALASGAKTFKMDNSHHGANHPVKDLDNGRVSITSQNH
GFAVEADSLPASLRATHVSLFDGTLQGLEHTSQPAFCFQGHPEASPGPHDIAYLFDRFTALMEKHKTENKNA
>Mature_391_residues
SLKGTFPPAILALADGTVFIGRSIGATGTTVGEVVFNTAITGYQEILTDPSYCQQIVTLTYPHIGNYGVNTEDVEADKIH
AAGLIIKDLPLLASNFRSTETLSQYLVRGSTVAIADIDTRKLTRLLRDKGAQNGAILGLAAGEAVTQARIDEALAAAKAA
PSMKGLDLAQVVSTPSSYVWEQTEWKLGEGYGRQEAPRFHVVAYDYGVKKNILRMLAERGCKLTVVPAKTPAADVLAMRP
DGVFLSNGPGDPAPCDYAIEATRQIIDAGVPTFGICLGHQIMALASGAKTFKMDNSHHGANHPVKDLDNGRVSITSQNHG
FAVEADSLPASLRATHVSLFDGTLQGLEHTSQPAFCFQGHPEASPGPHDIAYLFDRFTALMEKHKTENKNA

Specific function: Arginine biosynthesis. Pyrimidine biosynthesis; first step. [C]

COG id: COG0505

COG function: function code EF; Carbamoylphosphate synthase small subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=380, Percent_Identity=38.4210526315789, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI169790915, Length=387, Percent_Identity=36.4341085271318, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI21361331, Length=387, Percent_Identity=36.4341085271318, Blast_Score=222, Evalue=6e-58,
Organism=Escherichia coli, GI1786215, Length=384, Percent_Identity=63.0208333333333, Blast_Score=499, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI193204318, Length=391, Percent_Identity=37.5959079283887, Blast_Score=243, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6324878, Length=396, Percent_Identity=36.8686868686869, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6322331, Length=394, Percent_Identity=36.0406091370558, Blast_Score=231, Evalue=2e-61,
Organism=Drosophila melanogaster, GI45555749, Length=392, Percent_Identity=35.7142857142857, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24642586, Length=392, Percent_Identity=35.7142857142857, Blast_Score=225, Evalue=4e-59,

Paralogues:

None

Copy number: 620 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2599 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001317
- InterPro:   IPR006274
- InterPro:   IPR002474
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF00988 CPSase_sm_chain; PF00117 GATase [H]

EC number: =6.3.5.5 [H]

Molecular weight: Translated: 41884; Mature: 41753

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKGTFPPAILALADGTVFIGRSIGATGTTVGEVVFNTAITGYQEILTDPSYCQQIVTL
CCCCCCCCCEEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TYPHIGNYGVNTEDVEADKIHAAGLIIKDLPLLASNFRSTETLSQYLVRGSTVAIADIDT
CCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCH
RKLTRLLRDKGAQNGAILGLAAGEAVTQARIDEALAAAKAAPSMKGLDLAQVVSTPSSYV
HHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHH
WEQTEWKLGEGYGRQEAPRFHVVAYDYGVKKNILRMLAERGCKLTVVPAKTPAADVLAMR
CCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEC
PDGVFLSNGPGDPAPCDYAIEATRQIIDAGVPTFGICLGHQIMALASGAKTFKMDNSHHG
CCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCC
ANHPVKDLDNGRVSITSQNHGFAVEADSLPASLRATHVSLFDGTLQGLEHTSQPAFCFQG
CCCCCCCCCCCEEEEEECCCCEEEECCCCCCHHHHHEEHHHHHHHHHHHHCCCCCEEECC
HPEASPGPHDIAYLFDRFTALMEKHKTENKNA
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SLKGTFPPAILALADGTVFIGRSIGATGTTVGEVVFNTAITGYQEILTDPSYCQQIVTL
CCCCCCCCEEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TYPHIGNYGVNTEDVEADKIHAAGLIIKDLPLLASNFRSTETLSQYLVRGSTVAIADIDT
CCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCH
RKLTRLLRDKGAQNGAILGLAAGEAVTQARIDEALAAAKAAPSMKGLDLAQVVSTPSSYV
HHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHH
WEQTEWKLGEGYGRQEAPRFHVVAYDYGVKKNILRMLAERGCKLTVVPAKTPAADVLAMR
CCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEC
PDGVFLSNGPGDPAPCDYAIEATRQIIDAGVPTFGICLGHQIMALASGAKTFKMDNSHHG
CCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCC
ANHPVKDLDNGRVSITSQNHGFAVEADSLPASLRATHVSLFDGTLQGLEHTSQPAFCFQG
CCCCCCCCCCCEEEEEECCCCEEEECCCCCCHHHHHEEHHHHHHHHHHHHCCCCCEEECC
HPEASPGPHDIAYLFDRFTALMEKHKTENKNA
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11343129 [H]