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The map label for this gene is bhbA [H]

Identifier: 120611179

GI number: 120611179

Start: 2749353

End: 2751521

Strand: Direct

Name: bhbA [H]

Synonym: Aave_2510

Alternate gene names: 120611179

Gene position: 2749353-2751521 (Clockwise)

Preceding gene: 120611175

Following gene: 120611180

Centisome position: 51.36

GC content: 67.4

Gene sequence:

>2169_bases
ATGAGCAGCAGACAGACGCCCCCGCCCGAATTCCAGCCCGCCGATCTCGCCGCCTGGGCGAAGGCGGCGGCCAAGTCCGC
GCCGGGCGGCGATGTCTCCGCGCTGAACTGGGTCACGCCGGACGGGATCACCGTCAAGCCGCTCTACACGGCGGAGGACG
TGGCGGGCCTGCCGCACGCCAATACCCTGCCGGGCTTCGAACCCTACGTGCGCGGTCCGCAGGCCACCATGTATGCGGTG
CGGCCCTGGACGATCCGGCAATACGCGGGCTTTTCCACGGCGGAAGAATCGAACGCCTTCTACCGCAAGGCGCTGGCGGC
CGGCGGGCAGGGCGTCTCGGTGGCGTTCGATCTCGCCACCCACCGCGGTTACGACAGCGACCATCCGCGCGTGACCGGCG
ACGTGGGCAAGGCCGGGGTGGCCATCGACAGCGTGGAGGACATGAAGATCCTCTTCGACGGCATTCCGCTCGACAAGGTG
AGCGTCTCCATGACGATGAACGGCGCCGTGCTGCCCGTGCTGGCGGGCTACGTGGTCGCGGCGGAAGAGCAGGGCGTGCG
GCAGGACCAGCTCTCCGGGACCATCCAGAACGACATCCTCAAGGAGTTCATGGTCCGCAACACGTACATCTACCCGCCCA
AGCCTTCGATGCGCATCATCGGCGACATCATCGGCTATACGGCGCGGAACATGCCGAAGTTCAACTCCATCTCCATCAGT
GGCTACCACATGCAGGAGGCGGGCGCCAACCAGGCGCTGGAGCTGGCGTTCACGCTGGCCGACGGCAAGGAGTACGTGAA
GACGGCGATCGCCTCGGGGCTGGACGTGGACGAGTTCGCGGGGCGGCTGTCGTTCTTCTGGGCGATCGGCATGAACTTCT
ACCTGGAAGTGGCCAAGATGCGCGCCGCGCGCCTGCTGTGGTGCCGCATCATGAAGGGCACGGGCGCCAAGAACCCCAAG
AGCCTGATGCTGCGCACGCACTGCCAGACCTCGGGCTGGTCGCTCACCGAGCAGGACCCCTACAACAACGTGGTGCGCAC
CACCATCGAGGCCATGGCGGCCGTGTTCGGCGGCACGCAGAGCCTGCACACCAACAGCTTCGACGAGGCCATCGCGCTGC
CCACTGAATTCTCGGCCCGCATCGCGCGCAACACGCAGCTCATCATCCAGGAAGAGACGCACATCACCAACGTGATCGAC
CCCTGGGCCGGCAGCTACATGATGGAAAAGCTCACCCAGGACATGGCCGACGCCGCCTGGAAGATCATCGAGGAGGTCGA
GGCCATGGGCGGCATGACCGCCGCGGTGGATTCGGGCTGGGCCAAGCTCAAGATCGAGGCGGCCGCTGCGGAGAAGCAGG
CGCGCATCGATTCGGGCAAGGACGTGATCGTGGGCGTGAACAAGTACCGCCTGGCCAAGGAAGACCCGGTGGACATCCTG
CAGATCGACAACGTGAAGGTGCGCGACGGCCAGATCGCGCGGCTCGAACGCATCCGCGCCACGCGCGATGGCGCAGCCGT
GCAGCAGGCGCTGGATGCCCTGACCGCGGCCGCGGAGTCTGGCTCCGGCAATCTGCTGGAGCTGTCCATCCAGGCGATCC
GCCTGCGCGCCACGGTGGGCGAGGTGAGCGACGCGCTGGAGAAGGTGTTCGGCCGCCACCGTGCCGACACGCAGAAGGTG
ACCGGCGTCTATGCCGCCGCCTACGACTCGGCCGAGGGCTGGGAAAAGCTCAAGGGCGAGATCGACGCCTTCGCGGAAAG
CGAGGGCCGCCGCCCGCGCGTGATGATCGCCAAGCTGGGCCAGGATGGCCACGACCGCGGCGCCAAGGTGGTGGCCACGG
CCTTCGCCGACCTGGGGTTCGACGTGGACATGGGGCCGCTCTTCCAGACGCCCGAGGAATGCGCGCGCCAGGCGATCGAG
AACGACGTGCATGCCGTGGGCGTCTCCACGCTCGCTGCCGGCCACAAGACGCTGGTGCCGGCCATCATCCAGGCCCTCAA
GGACCAGGGCGCCGACGACATCATCGTGTTCGTGGGCGGCGTGATCCCGCAGCAGGACTACGACTTCCTCTACGCATCGG
GCGTGAAGGGCATCTACGGGCCGGGCACGCCCATTCCCGCGAGCGCCAAGGACGTGCTGGAGCAGATCCGCAAGGTCGTG
GCCGCCTGA

Upstream 100 bases:

>100_bases
TACGGAATCGGCTAGACTAGCCCTTGCTTCCCGCGCACGCCAGGAGACAAGCCGGCGCGGAACCTCCGATCGACCTGCAA
AACCCCGACGCGAGCCATCC

Downstream 100 bases:

>100_bases
GGATGCGTGCGCCCGCGATGCCTGTTGCCTCGTCGTCCTCACCACCGTCCGGACCCTCCGGCTTGGGCTGGGAGGCCGTC
TCCGAAGGGGACTTTGCCGC

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 722; Mature: 721

Protein sequence:

>722_residues
MSSRQTPPPEFQPADLAAWAKAAAKSAPGGDVSALNWVTPDGITVKPLYTAEDVAGLPHANTLPGFEPYVRGPQATMYAV
RPWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLATHRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDGIPLDKV
SVSMTMNGAVLPVLAGYVVAAEEQGVRQDQLSGTIQNDILKEFMVRNTYIYPPKPSMRIIGDIIGYTARNMPKFNSISIS
GYHMQEAGANQALELAFTLADGKEYVKTAIASGLDVDEFAGRLSFFWAIGMNFYLEVAKMRAARLLWCRIMKGTGAKNPK
SLMLRTHCQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGTQSLHTNSFDEAIALPTEFSARIARNTQLIIQEETHITNVID
PWAGSYMMEKLTQDMADAAWKIIEEVEAMGGMTAAVDSGWAKLKIEAAAAEKQARIDSGKDVIVGVNKYRLAKEDPVDIL
QIDNVKVRDGQIARLERIRATRDGAAVQQALDALTAAAESGSGNLLELSIQAIRLRATVGEVSDALEKVFGRHRADTQKV
TGVYAAAYDSAEGWEKLKGEIDAFAESEGRRPRVMIAKLGQDGHDRGAKVVATAFADLGFDVDMGPLFQTPEECARQAIE
NDVHAVGVSTLAAGHKTLVPAIIQALKDQGADDIIVFVGGVIPQQDYDFLYASGVKGIYGPGTPIPASAKDVLEQIRKVV
AA

Sequences:

>Translated_722_residues
MSSRQTPPPEFQPADLAAWAKAAAKSAPGGDVSALNWVTPDGITVKPLYTAEDVAGLPHANTLPGFEPYVRGPQATMYAV
RPWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLATHRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDGIPLDKV
SVSMTMNGAVLPVLAGYVVAAEEQGVRQDQLSGTIQNDILKEFMVRNTYIYPPKPSMRIIGDIIGYTARNMPKFNSISIS
GYHMQEAGANQALELAFTLADGKEYVKTAIASGLDVDEFAGRLSFFWAIGMNFYLEVAKMRAARLLWCRIMKGTGAKNPK
SLMLRTHCQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGTQSLHTNSFDEAIALPTEFSARIARNTQLIIQEETHITNVID
PWAGSYMMEKLTQDMADAAWKIIEEVEAMGGMTAAVDSGWAKLKIEAAAAEKQARIDSGKDVIVGVNKYRLAKEDPVDIL
QIDNVKVRDGQIARLERIRATRDGAAVQQALDALTAAAESGSGNLLELSIQAIRLRATVGEVSDALEKVFGRHRADTQKV
TGVYAAAYDSAEGWEKLKGEIDAFAESEGRRPRVMIAKLGQDGHDRGAKVVATAFADLGFDVDMGPLFQTPEECARQAIE
NDVHAVGVSTLAAGHKTLVPAIIQALKDQGADDIIVFVGGVIPQQDYDFLYASGVKGIYGPGTPIPASAKDVLEQIRKVV
AA
>Mature_721_residues
SSRQTPPPEFQPADLAAWAKAAAKSAPGGDVSALNWVTPDGITVKPLYTAEDVAGLPHANTLPGFEPYVRGPQATMYAVR
PWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLATHRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDGIPLDKVS
VSMTMNGAVLPVLAGYVVAAEEQGVRQDQLSGTIQNDILKEFMVRNTYIYPPKPSMRIIGDIIGYTARNMPKFNSISISG
YHMQEAGANQALELAFTLADGKEYVKTAIASGLDVDEFAGRLSFFWAIGMNFYLEVAKMRAARLLWCRIMKGTGAKNPKS
LMLRTHCQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGTQSLHTNSFDEAIALPTEFSARIARNTQLIIQEETHITNVIDP
WAGSYMMEKLTQDMADAAWKIIEEVEAMGGMTAAVDSGWAKLKIEAAAAEKQARIDSGKDVIVGVNKYRLAKEDPVDILQ
IDNVKVRDGQIARLERIRATRDGAAVQQALDALTAAAESGSGNLLELSIQAIRLRATVGEVSDALEKVFGRHRADTQKVT
GVYAAAYDSAEGWEKLKGEIDAFAESEGRRPRVMIAKLGQDGHDRGAKVVATAFADLGFDVDMGPLFQTPEECARQAIEN
DVHAVGVSTLAAGHKTLVPAIIQALKDQGADDIIVFVGGVIPQQDYDFLYASGVKGIYGPGTPIPASAKDVLEQIRKVVA
A

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=703, Percent_Identity=64.7226173541963, Blast_Score=954, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=711, Percent_Identity=63.1504922644163, Blast_Score=901, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=700, Percent_Identity=64.5714285714286, Blast_Score=937, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 77823; Mature: 77692

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRQTPPPEFQPADLAAWAKAAAKSAPGGDVSALNWVTPDGITVKPLYTAEDVAGLPHA
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEECCHHHHCCCCCC
NTLPGFEPYVRGPQATMYAVRPWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLAT
CCCCCCCHHCCCCCCEEEEECCEEEHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEHH
HRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDGIPLDKVSVSMTMNGAVLPVLAGYVVA
CCCCCCCCCEEECCCCCCCEEECCHHHHHHEECCCCCCCEEEEEEECCCHHHHHHHHHEE
AEEQGVRQDQLSGTIQNDILKEFMVRNTYIYPPKPSMRIIGDIIGYTARNMPKFNSISIS
ECCCCCCHHHHCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEE
GYHMQEAGANQALELAFTLADGKEYVKTAIASGLDVDEFAGRLSFFWAIGMNFYLEVAKM
CEEHHHCCCCCEEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RAARLLWCRIMKGTGAKNPKSLMLRTHCQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGTQ
HHHHHHHHHHHHCCCCCCCHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
SLHTNSFDEAIALPTEFSARIARNTQLIIQEETHITNVIDPWAGSYMMEKLTQDMADAAW
CCCCCCCHHHEECCCHHHHHHHCCCEEEEEECCCHHHCCCCCCHHHHHHHHHHHHHHHHH
KIIEEVEAMGGMTAAVDSGWAKLKIEAAAAEKQARIDSGKDVIVGVNKYRLAKEDPVDIL
HHHHHHHHHCCCEEECCCCCEEEEEEHHHHHHHHHCCCCCEEEEECCCEECCCCCCCCEE
QIDNVKVRDGQIARLERIRATRDGAAVQQALDALTAAAESGSGNLLELSIQAIRLRATVG
EECCEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHH
EVSDALEKVFGRHRADTQKVTGVYAAAYDSAEGWEKLKGEIDAFAESEGRRPRVMIAKLG
HHHHHHHHHHHHCCCCCHHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
QDGHDRGAKVVATAFADLGFDVDMGPLFQTPEECARQAIENDVHAVGVSTLAAGHKTLVP
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHH
AIIQALKDQGADDIIVFVGGVIPQQDYDFLYASGVKGIYGPGTPIPASAKDVLEQIRKVV
HHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
AA
CC
>Mature Secondary Structure 
SSRQTPPPEFQPADLAAWAKAAAKSAPGGDVSALNWVTPDGITVKPLYTAEDVAGLPHA
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEECCHHHHCCCCCC
NTLPGFEPYVRGPQATMYAVRPWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLAT
CCCCCCCHHCCCCCCEEEEECCEEEHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEHH
HRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDGIPLDKVSVSMTMNGAVLPVLAGYVVA
CCCCCCCCCEEECCCCCCCEEECCHHHHHHEECCCCCCCEEEEEEECCCHHHHHHHHHEE
AEEQGVRQDQLSGTIQNDILKEFMVRNTYIYPPKPSMRIIGDIIGYTARNMPKFNSISIS
ECCCCCCHHHHCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEE
GYHMQEAGANQALELAFTLADGKEYVKTAIASGLDVDEFAGRLSFFWAIGMNFYLEVAKM
CEEHHHCCCCCEEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RAARLLWCRIMKGTGAKNPKSLMLRTHCQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGTQ
HHHHHHHHHHHHCCCCCCCHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
SLHTNSFDEAIALPTEFSARIARNTQLIIQEETHITNVIDPWAGSYMMEKLTQDMADAAW
CCCCCCCHHHEECCCHHHHHHHCCCEEEEEECCCHHHCCCCCCHHHHHHHHHHHHHHHHH
KIIEEVEAMGGMTAAVDSGWAKLKIEAAAAEKQARIDSGKDVIVGVNKYRLAKEDPVDIL
HHHHHHHHHCCCEEECCCCCEEEEEEHHHHHHHHHCCCCCEEEEECCCEECCCCCCCCEE
QIDNVKVRDGQIARLERIRATRDGAAVQQALDALTAAAESGSGNLLELSIQAIRLRATVG
EECCEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHH
EVSDALEKVFGRHRADTQKVTGVYAAAYDSAEGWEKLKGEIDAFAESEGRRPRVMIAKLG
HHHHHHHHHHHHCCCCCHHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
QDGHDRGAKVVATAFADLGFDVDMGPLFQTPEECARQAIENDVHAVGVSTLAAGHKTLVP
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHH
AIIQALKDQGADDIIVFVGGVIPQQDYDFLYASGVKGIYGPGTPIPASAKDVLEQIRKVV
HHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
AA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]