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The map label for this gene is lysC [H]

Identifier: 120610996

GI number: 120610996

Start: 2553005

End: 2554276

Strand: Direct

Name: lysC [H]

Synonym: Aave_2324

Alternate gene names: 120610996

Gene position: 2553005-2554276 (Clockwise)

Preceding gene: 120610995

Following gene: 120611008

Centisome position: 47.7

GC content: 65.02

Gene sequence:

>1272_bases
ATGGCATTGATCGTTCACAAATACGGCGGCACATCGATGGGCTCCACGGAGCGCATCCGCAATGTCGCCAAGCGCGTCGC
CAAGTGGGCACGGGCGGGCCACCAGATGGTGGTGGTGCCCAGCGCCATGAGCGGCGAGACCAACCGCCTGCTCGGCCTGG
CCAAGGACCTCGCTCCCTCGCGCGCCTCCTCCGCCTACCACCGCGAACTCGACATGCTCGCCGCCACCGGCGAACAGGCT
TCTTCCGCCCTGCTGGCCATCGCGCTGCAGGCCGAAGGCATGGAGTCGGTGAGCTACGCCGGCTGGCAGGTGCCCATCCG
CACCGACAGCTCCTACACCAAGGCCCGCATCGAATCCATCGACGACCAGCGCGTGCGTGCCGACCTCGCTGCCGGCAAAG
TGGTGATCGTCACCGGCTTTCAGGGCATCGACGAGCACGGCCACATCACCACGCTGGGCCGTGGCGGCTCCGACACCTCG
GCCGTGGCCGTGGCGGCGGCCATGAAGGCTGCCGAATGCCTGATCTACACCGACGTGGACGGCGTGTACACCACCGACCC
GCGCGTGGTCGCCGAAGCACGCCGCCTGCACACCGTGAGCTTCGAGGAAATGCTCGAGATGGCCAGCCTCGGCAGCAAGG
TGCTGCAGATCCGCTCCGTGGAGTTCGCCGGCAAGTACAAGGTGCCGCTGCGCGTGCTCTCCAGCTTCACGCCCTGGGAC
ATCGACATCGAGGAAGAGGCCCGCTCCGGCACGCTCATCACTTTTGAGGAAGACGAAAAAATGGAACAAGCCGTCGTATC
CGGCATCGCTTTCAACCGCGACGAGGCCAAGATCTCCGTGCTGGGCGTGCCCGACAAGCCCGGCATCGCCTACCAGATCC
TGGGCGCCGTGGCCGACGCCAACATCGAGGTGGACGTCATCATCCAGAACCTCAGCAAGGACGGCAAGACCGACTTCAGC
TTCACGGTGAACCGCAACGACTTCGCGCGCACCGTCGATCTGCTCAAGGAAAAGGTCGTGCCCGCCCTGGGCGCGCAGGA
AGTCGTCGGCGACGCCAAGATCTGCAAGGTGAGCATCGTCGGCATCGGCATGCGCAGCCACGTGGGCGTCGCCTCCAAAA
TGTTCCGCGTGCTGAGCGAGGAGGGCATCAACATCCAGATGATCTCCACGTCCGAGATCAAGACCTCCGTGGTCATCGAC
GAGAAGTACGTCGAGCTGGCCGTGCGCACGCTGCATAAGGCTTTCGAACTCGACCAGCCCTCCGCTGCCTGA

Upstream 100 bases:

>100_bases
GGGCCTGTGAGGCGCAGGGGGCCTTCCATCCCGCAGGTCCGCTCCTGTGTCTTTCCCTCCTTTCGCGCCGCGGCCTTCGT
ACCGTCACCCCGGATATCCA

Downstream 100 bases:

>100_bases
ACGCCCAAAAGCGCGCAAATTTTGGGTTAGAATAGTGGGATTGGAAACGTGACCGAGTGGCCGAAGGTGCTCCCCTGCTA
AGGGAGTATGGGGTGTAGAG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MALIVHKYGGTSMGSTERIRNVAKRVAKWARAGHQMVVVPSAMSGETNRLLGLAKDLAPSRASSAYHRELDMLAATGEQA
SSALLAIALQAEGMESVSYAGWQVPIRTDSSYTKARIESIDDQRVRADLAAGKVVIVTGFQGIDEHGHITTLGRGGSDTS
AVAVAAAMKAAECLIYTDVDGVYTTDPRVVAEARRLHTVSFEEMLEMASLGSKVLQIRSVEFAGKYKVPLRVLSSFTPWD
IDIEEEARSGTLITFEEDEKMEQAVVSGIAFNRDEAKISVLGVPDKPGIAYQILGAVADANIEVDVIIQNLSKDGKTDFS
FTVNRNDFARTVDLLKEKVVPALGAQEVVGDAKICKVSIVGIGMRSHVGVASKMFRVLSEEGINIQMISTSEIKTSVVID
EKYVELAVRTLHKAFELDQPSAA

Sequences:

>Translated_423_residues
MALIVHKYGGTSMGSTERIRNVAKRVAKWARAGHQMVVVPSAMSGETNRLLGLAKDLAPSRASSAYHRELDMLAATGEQA
SSALLAIALQAEGMESVSYAGWQVPIRTDSSYTKARIESIDDQRVRADLAAGKVVIVTGFQGIDEHGHITTLGRGGSDTS
AVAVAAAMKAAECLIYTDVDGVYTTDPRVVAEARRLHTVSFEEMLEMASLGSKVLQIRSVEFAGKYKVPLRVLSSFTPWD
IDIEEEARSGTLITFEEDEKMEQAVVSGIAFNRDEAKISVLGVPDKPGIAYQILGAVADANIEVDVIIQNLSKDGKTDFS
FTVNRNDFARTVDLLKEKVVPALGAQEVVGDAKICKVSIVGIGMRSHVGVASKMFRVLSEEGINIQMISTSEIKTSVVID
EKYVELAVRTLHKAFELDQPSAA
>Mature_422_residues
ALIVHKYGGTSMGSTERIRNVAKRVAKWARAGHQMVVVPSAMSGETNRLLGLAKDLAPSRASSAYHRELDMLAATGEQAS
SALLAIALQAEGMESVSYAGWQVPIRTDSSYTKARIESIDDQRVRADLAAGKVVIVTGFQGIDEHGHITTLGRGGSDTSA
VAVAAAMKAAECLIYTDVDGVYTTDPRVVAEARRLHTVSFEEMLEMASLGSKVLQIRSVEFAGKYKVPLRVLSSFTPWDI
DIEEEARSGTLITFEEDEKMEQAVVSGIAFNRDEAKISVLGVPDKPGIAYQILGAVADANIEVDVIIQNLSKDGKTDFSF
TVNRNDFARTVDLLKEKVVPALGAQEVVGDAKICKVSIVGIGMRSHVGVASKMFRVLSEEGINIQMISTSEIKTSVVIDE
KYVELAVRTLHKAFELDQPSAA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=483, Percent_Identity=29.8136645962733, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1790455, Length=383, Percent_Identity=27.6762402088773, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790376, Length=284, Percent_Identity=26.4084507042254, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320893, Length=392, Percent_Identity=26.2755102040816, Blast_Score=103, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 45633; Mature: 45501

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVHKYGGTSMGSTERIRNVAKRVAKWARAGHQMVVVPSAMSGETNRLLGLAKDLAPS
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHCCCC
RASSAYHRELDMLAATGEQASSALLAIALQAEGMESVSYAGWQVPIRTDSSYTKARIESI
CCCHHHHHHHHHHHHCCCHHCCEEEEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHCC
DDQRVRADLAAGKVVIVTGFQGIDEHGHITTLGRGGSDTSAVAVAAAMKAAECLIYTDVD
CHHHHHHHHCCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCEEEEEECCC
GVYTTDPRVVAEARRLHTVSFEEMLEMASLGSKVLQIRSVEFAGKYKVPLRVLSSFTPWD
CEEECCCHHHHHHHHHHCCCHHHHHHHHHHCHHHEEEEEEEECCCCCCHHHHHCCCCCCC
IDIEEEARSGTLITFEEDEKMEQAVVSGIAFNRDEAKISVLGVPDKPGIAYQILGAVADA
CEEHHCCCCCCEEEECCHHHHHHHHHHHHEECCCCCEEEEEECCCCCCHHHHHHHHHHCC
NIEVDVIIQNLSKDGKTDFSFTVNRNDFARTVDLLKEKVVPALGAQEVVGDAKICKVSIV
CCEEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEEEEE
GIGMRSHVGVASKMFRVLSEEGINIQMISTSEIKTSVVIDEKYVELAVRTLHKAFELDQP
EECHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHCCCCC
SAA
CCC
>Mature Secondary Structure 
ALIVHKYGGTSMGSTERIRNVAKRVAKWARAGHQMVVVPSAMSGETNRLLGLAKDLAPS
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHCCCC
RASSAYHRELDMLAATGEQASSALLAIALQAEGMESVSYAGWQVPIRTDSSYTKARIESI
CCCHHHHHHHHHHHHCCCHHCCEEEEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHCC
DDQRVRADLAAGKVVIVTGFQGIDEHGHITTLGRGGSDTSAVAVAAAMKAAECLIYTDVD
CHHHHHHHHCCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCEEEEEECCC
GVYTTDPRVVAEARRLHTVSFEEMLEMASLGSKVLQIRSVEFAGKYKVPLRVLSSFTPWD
CEEECCCHHHHHHHHHHCCCHHHHHHHHHHCHHHEEEEEEEECCCCCCHHHHHCCCCCCC
IDIEEEARSGTLITFEEDEKMEQAVVSGIAFNRDEAKISVLGVPDKPGIAYQILGAVADA
CEEHHCCCCCCEEEECCHHHHHHHHHHHHEECCCCCEEEEEECCCCCCHHHHHHHHHHCC
NIEVDVIIQNLSKDGKTDFSFTVNRNDFARTVDLLKEKVVPALGAQEVVGDAKICKVSIV
CCEEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEEEEE
GIGMRSHVGVASKMFRVLSEEGINIQMISTSEIKTSVVIDEKYVELAVRTLHKAFELDQP
EECHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHCCCCC
SAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]