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The map label for this gene is ilvG [H]

Identifier: 120610937

GI number: 120610937

Start: 2493721

End: 2495439

Strand: Reverse

Name: ilvG [H]

Synonym: Aave_2263

Alternate gene names: 120610937

Gene position: 2495439-2493721 (Counterclockwise)

Preceding gene: 120610941

Following gene: 120610935

Centisome position: 46.62

GC content: 72.37

Gene sequence:

>1719_bases
ATGCCAAATATTAAAGCTCTTAGTTCACTTAAGCGGTCAAGACCAGAATTGGCACGCACCGGCGGCCAGATCCTCGTGGA
CCAGCTCATCCTGCACGGCGTGCGCCAGCTCTTCTGCGTGCCCGGCGAAAGCTACCTGGCGGTGCTGGACGCGCTGCACG
ATGCCGACATCGCCGTCACCGTCTGCCGGCAGGAAGGCGGCGCGGCCATGATGGCCGAGGCGCAGGGCAAGCTCACGGGC
CGGCCGGGCATCTGCTTCGTCACGCGCGGCCCGGGGGCCACGAATGCCTCGGCCGGCATCCATATCGCGCACCAGGATTC
GACGCCGCTGATCGTCTTCGTGGGCCAGGTGGCCCGCGAGGCGCTGGGCCGCGAGGCCTTCCAGGAGCTGGACTATGGCG
CCGTGTTCGGCACCATGGCCAAGTGGGTGGTGCAGGTGGACGATGCGCGGCGCCTGCCGGAGCTGCTGTCGCGGGCGTTC
CACGTGGCCACCTCGGGCCGGCCCGGGCCGGTGGTGGTGGCGCTGCCGGAAGACATGCTGACCGATGCCGTGCAGGCCGC
CGACGCCCTGCCCCACGCGGTGGCCGAGACGCACCCCGGCCCAGTTGCACTGCGCGAGCTGGCCCGGCGGCTGGCCTCGG
CCGAGCGGCCGGTGGCCATCCTGGGCGGCAGCCGCTGGACGGAGGAGGCCGTGCGCGATTTCACGGCCTTCGCCGAGGCG
TGGAGCCTGCCGGTGTGCTGCTCGTTTCGCCGGCAGATGCTGTTTCCGGCCAGCCACCGCTGCTACGGCGGCGACCTGGG
CCTGGGCGCCAATCCGGAGCTGCTGGCGCGCATCCGCGAAAGCGACCTGGTGCTGCTGGTGGGCGGACGGCTGTCGGAAG
TGCCTTCACAGGGCTACACGCTGCTGGACATTCCCGTGCCGGCGCAGCCCCTGGTCCACGTGCATGCGGATGCCGACGAA
CTCGGCCGGCTGTACCGCCCGGCGCAGGCCATCCATGCCACGCCGCAGGCTTTCACGGCCGCCCTGGCCGCGGTGCGGCC
GGAAGGCCCGGTGCGCTGGGCCGCGCATGCCGCCGCGGCGCGCGCCGATTACCTGGCCTGGAGCGATCCCGCGCCGATCC
GCATTCCGGGCCCGCTGCAGATGGGCGAGGTGATGCGCCACCTGCGCGAGGTGCTGCCGCCGGACACCATCTTCTGCAAC
GGCGCGGGCAACTTCGCCACCTGGGTGCACCGGTTCTGGCCCTTCACGGCCTTCGCCAGCCAGCTCGCGCCCACCAGCGG
CTCCATGGGCTACGGCCTGCCGGCCGGCGTGGGCGCCAAGCGGCTGTGGCCGCAGCGCGAGGTGGTGGTGTTCTCGGGCG
ACGGCGACTTCCTCATGCACGGGCAGGAGTTCGCCACCGCCGTGCAGTACGGCCTGCCGGTGATCGTGGTGCTGCTGGAC
AACGGCATGTACGGCACGATCCGCATGCACCAGGAGCGCGAGTACCCGGGGCGCGTGAGCGCCACGCAACTGCGCAACCC
CGACTTCCGCGCCTACGCGCAGGCCTTCGGCGGGCACGGAGAGCGGGTGGAGCGGACGGAGGATTTCGCGCCCGCGCTGG
CCCGCGCCCGCGCGAGCGGCCTGCCCAGCGTGCTGCACTGCCTGCTGGACGCGGAGGCGATCACGCCCACGGGTACGCTG
GCGGGCATCCGCGGCGCGGCGCAGGCGGCCGGCCGCTGA

Upstream 100 bases:

>100_bases
ACCATAGAAGATCAGCAACTTCGAAATGTTCGCTTAATTTTTCCACAGGTTAGTAGTGTCCCACTAAAATTTAAAGCCCT
GCCAAGTCTGCGACGAGGAC

Downstream 100 bases:

>100_bases
CAGAAAGCCTATGCAACAGGCCTATACGGTCTGCGCGAGCGGCGCGTCCGCCAGGGACGAGGCCGCGCCGATGGCCATGT
AGCGCTTGCGCCAGCTCTCG

Product: thiamine pyrophosphate protein

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 572; Mature: 571

Protein sequence:

>572_residues
MPNIKALSSLKRSRPELARTGGQILVDQLILHGVRQLFCVPGESYLAVLDALHDADIAVTVCRQEGGAAMMAEAQGKLTG
RPGICFVTRGPGATNASAGIHIAHQDSTPLIVFVGQVAREALGREAFQELDYGAVFGTMAKWVVQVDDARRLPELLSRAF
HVATSGRPGPVVVALPEDMLTDAVQAADALPHAVAETHPGPVALRELARRLASAERPVAILGGSRWTEEAVRDFTAFAEA
WSLPVCCSFRRQMLFPASHRCYGGDLGLGANPELLARIRESDLVLLVGGRLSEVPSQGYTLLDIPVPAQPLVHVHADADE
LGRLYRPAQAIHATPQAFTAALAAVRPEGPVRWAAHAAAARADYLAWSDPAPIRIPGPLQMGEVMRHLREVLPPDTIFCN
GAGNFATWVHRFWPFTAFASQLAPTSGSMGYGLPAGVGAKRLWPQREVVVFSGDGDFLMHGQEFATAVQYGLPVIVVLLD
NGMYGTIRMHQEREYPGRVSATQLRNPDFRAYAQAFGGHGERVERTEDFAPALARARASGLPSVLHCLLDAEAITPTGTL
AGIRGAAQAAGR

Sequences:

>Translated_572_residues
MPNIKALSSLKRSRPELARTGGQILVDQLILHGVRQLFCVPGESYLAVLDALHDADIAVTVCRQEGGAAMMAEAQGKLTG
RPGICFVTRGPGATNASAGIHIAHQDSTPLIVFVGQVAREALGREAFQELDYGAVFGTMAKWVVQVDDARRLPELLSRAF
HVATSGRPGPVVVALPEDMLTDAVQAADALPHAVAETHPGPVALRELARRLASAERPVAILGGSRWTEEAVRDFTAFAEA
WSLPVCCSFRRQMLFPASHRCYGGDLGLGANPELLARIRESDLVLLVGGRLSEVPSQGYTLLDIPVPAQPLVHVHADADE
LGRLYRPAQAIHATPQAFTAALAAVRPEGPVRWAAHAAAARADYLAWSDPAPIRIPGPLQMGEVMRHLREVLPPDTIFCN
GAGNFATWVHRFWPFTAFASQLAPTSGSMGYGLPAGVGAKRLWPQREVVVFSGDGDFLMHGQEFATAVQYGLPVIVVLLD
NGMYGTIRMHQEREYPGRVSATQLRNPDFRAYAQAFGGHGERVERTEDFAPALARARASGLPSVLHCLLDAEAITPTGTL
AGIRGAAQAAGR
>Mature_571_residues
PNIKALSSLKRSRPELARTGGQILVDQLILHGVRQLFCVPGESYLAVLDALHDADIAVTVCRQEGGAAMMAEAQGKLTGR
PGICFVTRGPGATNASAGIHIAHQDSTPLIVFVGQVAREALGREAFQELDYGAVFGTMAKWVVQVDDARRLPELLSRAFH
VATSGRPGPVVVALPEDMLTDAVQAADALPHAVAETHPGPVALRELARRLASAERPVAILGGSRWTEEAVRDFTAFAEAW
SLPVCCSFRRQMLFPASHRCYGGDLGLGANPELLARIRESDLVLLVGGRLSEVPSQGYTLLDIPVPAQPLVHVHADADEL
GRLYRPAQAIHATPQAFTAALAAVRPEGPVRWAAHAAAARADYLAWSDPAPIRIPGPLQMGEVMRHLREVLPPDTIFCNG
AGNFATWVHRFWPFTAFASQLAPTSGSMGYGLPAGVGAKRLWPQREVVVFSGDGDFLMHGQEFATAVQYGLPVIVVLLDN
GMYGTIRMHQEREYPGRVSATQLRNPDFRAYAQAFGGHGERVERTEDFAPALARARASGLPSVLHCLLDAEAITPTGTLA
GIRGAAQAAGR

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=578, Percent_Identity=24.9134948096886, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI21361361, Length=566, Percent_Identity=23.6749116607774, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI87081685, Length=534, Percent_Identity=30.8988764044944, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI1790104, Length=542, Percent_Identity=29.7047970479705, Blast_Score=205, Evalue=6e-54,
Organism=Escherichia coli, GI1786717, Length=560, Percent_Identity=28.0357142857143, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1787096, Length=555, Percent_Identity=25.045045045045, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788716, Length=526, Percent_Identity=25.0950570342205, Blast_Score=99, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17542570, Length=563, Percent_Identity=23.9786856127886, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17531301, Length=572, Percent_Identity=25.5244755244755, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17531299, Length=572, Percent_Identity=25.5244755244755, Blast_Score=103, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323755, Length=561, Percent_Identity=27.4509803921569, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6323163, Length=487, Percent_Identity=21.7659137577002, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI19922626, Length=484, Percent_Identity=26.6528925619835, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 61298; Mature: 61167

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNIKALSSLKRSRPELARTGGQILVDQLILHGVRQLFCVPGESYLAVLDALHDADIAVT
CCCHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCEEEE
VCRQEGGAAMMAEAQGKLTGRPGICFVTRGPGATNASAGIHIAHQDSTPLIVFVGQVARE
EEECCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCEEEEHHHHHHH
ALGREAFQELDYGAVFGTMAKWVVQVDDARRLPELLSRAFHVATSGRPGPVVVALPEDML
HHHHHHHHHCCCHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHH
TDAVQAADALPHAVAETHPGPVALRELARRLASAERPVAILGGSRWTEEAVRDFTAFAEA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHH
WSLPVCCSFRRQMLFPASHRCYGGDLGLGANPELLARIRESDLVLLVGGRLSEVPSQGYT
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCHHCCCCCCCE
LLDIPVPAQPLVHVHADADELGRLYRPAQAIHATPQAFTAALAAVRPEGPVRWAAHAAAA
EEECCCCCCCEEEEECCHHHHHHHHCCHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHH
RADYLAWSDPAPIRIPGPLQMGEVMRHLREVLPPDTIFCNGAGNFATWVHRFWPFTAFAS
HHCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHCCHHHHHH
QLAPTSGSMGYGLPAGVGAKRLWPQREVVVFSGDGDFLMHGQEFATAVQYGLPVIVVLLD
HHCCCCCCCCCCCCCCCCHHHCCCCCEEEEEECCCCEEECCHHHHHHHHHCCCEEEEEEC
NGMYGTIRMHQEREYPGRVSATQLRNPDFRAYAQAFGGHGERVERTEDFAPALARARASG
CCCEEEEEEECCCCCCCCCCHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
LPSVLHCLLDAEAITPTGTLAGIRGAAQAAGR
CHHHHHHHHHHCCCCCCCHHHHHCHHHHHCCC
>Mature Secondary Structure 
PNIKALSSLKRSRPELARTGGQILVDQLILHGVRQLFCVPGESYLAVLDALHDADIAVT
CCHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCEEEE
VCRQEGGAAMMAEAQGKLTGRPGICFVTRGPGATNASAGIHIAHQDSTPLIVFVGQVARE
EEECCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCEEEEHHHHHHH
ALGREAFQELDYGAVFGTMAKWVVQVDDARRLPELLSRAFHVATSGRPGPVVVALPEDML
HHHHHHHHHCCCHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHH
TDAVQAADALPHAVAETHPGPVALRELARRLASAERPVAILGGSRWTEEAVRDFTAFAEA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHH
WSLPVCCSFRRQMLFPASHRCYGGDLGLGANPELLARIRESDLVLLVGGRLSEVPSQGYT
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCHHCCCCCCCE
LLDIPVPAQPLVHVHADADELGRLYRPAQAIHATPQAFTAALAAVRPEGPVRWAAHAAAA
EEECCCCCCCEEEEECCHHHHHHHHCCHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHH
RADYLAWSDPAPIRIPGPLQMGEVMRHLREVLPPDTIFCNGAGNFATWVHRFWPFTAFAS
HHCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHCCHHHHHH
QLAPTSGSMGYGLPAGVGAKRLWPQREVVVFSGDGDFLMHGQEFATAVQYGLPVIVVLLD
HHCCCCCCCCCCCCCCCCHHHCCCCCEEEEEECCCCEEECCHHHHHHHHHCCCEEEEEEC
NGMYGTIRMHQEREYPGRVSATQLRNPDFRAYAQAFGGHGERVERTEDFAPALARARASG
CCCEEEEEEECCCCCCCCCCHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
LPSVLHCLLDAEAITPTGTLAGIRGAAQAAGR
CHHHHHHHHHHCCCCCCCHHHHHCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]