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The map label for this gene is dxs

Identifier: 120610695

GI number: 120610695

Start: 2190440

End: 2192308

Strand: Direct

Name: dxs

Synonym: Aave_2015

Alternate gene names: 120610695

Gene position: 2190440-2192308 (Clockwise)

Preceding gene: 120610694

Following gene: 120610696

Centisome position: 40.92

GC content: 69.23

Gene sequence:

>1869_bases
ATGTCCACGAATTCCTTCCCTCTCCTGCAGACCGTGAACGACCCGGCCGACCTGCGCCGCATGTCGCGCGCCCAGCTGAA
AGAGCTGGCCGCGGAGTTGCGCGCATTCGTGCTGGACAGCGTGTCCAAGACGGGAGGGCACCTCAGTTCCAACCTGGGAA
CGGTGGAACTCACGGTGGCGCTGCACACCGTGTTCGACACGCCGCGCGACCGCCTCGTGTGGGATGTGGGCCACCAGACC
TATCCGCACAAGATCCTCACCGGCCGGCGCGACCGCATGCCCACGCTGCGCCAGCTGGGCGGCCTCTCGGGCTTTCCCCA
GCGCACGGAAAGCGAGTACGACACCTTCGGCACGGCCCACTCCAGCACCAGCATTTCCGCGGCGCTCGGCATGGCCATGG
CCGCCCGCCAGCGCGGCGAGGACCGCCGCGCCGTGGCCATCATCGGCGACGGCGCGATGACGGCCGGCATGGCCTTCGAG
GCGCTGAACAATGCCGGCGTGGCCGACGCCAACCTGCTCGTCATCCTGAATGACAACGACATGAGCATCAGCCCGCCCGT
GGGGGCGCTCAACCGCTACCTGGCACAGCTCATGAGCGGGCAGTTCTACGCGGCCGCGAAGAACGTCGGCAAGACGGTGC
TCGGGCCCGTGCCGCCACTGCTCGAACTCGCCAAGCGCTTCGAGCAGCAGGCCAAGGGCATGGTGTTGCCGGCCACGCTG
TTCGAGAAGTTCGGTTTCAACTACATCGGCCCTATCGACGGGCACGACCTCGATTCGCTCATTCCCACGCTGGAGAACAT
CAAGGGCCTGAAGGGCCCGCAGTTCCTGCACGTGGTCACGAAGAAGGGGCAGGGCTACAAGCTGGCCGAGGCAGATCCCG
TGGCTTACCACGGCCCTGGCAAGTTCGACCCGAGCGTGGGCCTGACCAAGCCCGCCACGCCGCCGAAGCAGACCTTCACG
CAGGTGTTCGGGCAGTGGCTCTGCGACATGGCCGCGCAGGACGACCGGCTCGTGGGCATCACGCCGGCCATGCGCGAGGG
CTCGGGCATGGTGGAGTTCGAGAAGCGCTTCCCCGGCCGCTACTACGACGTGGGCATCGCCGAGCAGCATGCCGTGACCT
TCGCCGCGGGCATGGCCTGCGAGGGCGTGAAGCCGGTGGTGGCGATCTACTCCACCTTCCTGCAGCGCGCCTACGACCAG
CTCATCCACGACGTGGCGCTGCAGAACCTGCCGGTGGTGTTCGCGCTGGACCGCGCAGGCCTCGTCGGTGCCGACGGCGC
CACGCACGCGGGTGCCTACGACATCCCCTTCGTGCGCTGCATCCCGAACATGAGCATCGCCTGTCCGGCGGATGAGCGCG
AGTGCCGGCAGCTGCTGTCCACCGCCTACGCACAGGACCATCCCGTGGCCGTGCGCTATCCGCGCGGCAGCGGCGCGGGC
GTGGCACCCCTGCCGGGGCTGGAGGGGCTTCCCTTCGGCAAGGGCGAGGTGCGCCGCACCGGGCAACGCATCGCGATCCT
GGCATTCGGCACGCTGCTCTATCCCGCGCTGCAGGCCGGCGAGACGCTGGACGCCACGGTGGCCAACATGCGCTGGGCCA
AGCCGCTGGATACCGCATTGCTGCTGGAGATCGCGGCCGGGCACGACGCCCTGGTGACGGTGGAAGAGGGCGCCGTGCTG
GGCGGTGCGGGCAGCGCCGTGTGCGAAGCGCTGAATGCCGCCGGCATCCAGAAGCCCGTGCTGCAGCTCGGCCTGCCGGA
CGTGTTCATCGAGCATGGCGACCCGGCCCGCCTGCTCGCGCTGCAGGGTCTCGATGCCGAGGGCCTCGTGCGCTCCATCA
CGGCGCGCTTCGGTCCCGCCGCCGGCTGA

Upstream 100 bases:

>100_bases
TGGTGATCGACCGATCCCGCTGAGACTGGGGGCCGGACCGCGCCGCGTCCCGCCCCGTTCCCCGGCGCATGCGTGCCGGC
GCCACCCAACCAAGAGCAAT

Downstream 100 bases:

>100_bases
TGCATGGCGCCCGGCCGCACGGCCGGGCCGAACCCCACCGAACGAACCGCGCGGCAAGCTTGCAGAAGGCTGAAGGGCCG
CCCGCGCGGCTTTTTCTTTC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 622; Mature: 621

Protein sequence:

>622_residues
MSTNSFPLLQTVNDPADLRRMSRAQLKELAAELRAFVLDSVSKTGGHLSSNLGTVELTVALHTVFDTPRDRLVWDVGHQT
YPHKILTGRRDRMPTLRQLGGLSGFPQRTESEYDTFGTAHSSTSISAALGMAMAARQRGEDRRAVAIIGDGAMTAGMAFE
ALNNAGVADANLLVILNDNDMSISPPVGALNRYLAQLMSGQFYAAAKNVGKTVLGPVPPLLELAKRFEQQAKGMVLPATL
FEKFGFNYIGPIDGHDLDSLIPTLENIKGLKGPQFLHVVTKKGQGYKLAEADPVAYHGPGKFDPSVGLTKPATPPKQTFT
QVFGQWLCDMAAQDDRLVGITPAMREGSGMVEFEKRFPGRYYDVGIAEQHAVTFAAGMACEGVKPVVAIYSTFLQRAYDQ
LIHDVALQNLPVVFALDRAGLVGADGATHAGAYDIPFVRCIPNMSIACPADERECRQLLSTAYAQDHPVAVRYPRGSGAG
VAPLPGLEGLPFGKGEVRRTGQRIAILAFGTLLYPALQAGETLDATVANMRWAKPLDTALLLEIAAGHDALVTVEEGAVL
GGAGSAVCEALNAAGIQKPVLQLGLPDVFIEHGDPARLLALQGLDAEGLVRSITARFGPAAG

Sequences:

>Translated_622_residues
MSTNSFPLLQTVNDPADLRRMSRAQLKELAAELRAFVLDSVSKTGGHLSSNLGTVELTVALHTVFDTPRDRLVWDVGHQT
YPHKILTGRRDRMPTLRQLGGLSGFPQRTESEYDTFGTAHSSTSISAALGMAMAARQRGEDRRAVAIIGDGAMTAGMAFE
ALNNAGVADANLLVILNDNDMSISPPVGALNRYLAQLMSGQFYAAAKNVGKTVLGPVPPLLELAKRFEQQAKGMVLPATL
FEKFGFNYIGPIDGHDLDSLIPTLENIKGLKGPQFLHVVTKKGQGYKLAEADPVAYHGPGKFDPSVGLTKPATPPKQTFT
QVFGQWLCDMAAQDDRLVGITPAMREGSGMVEFEKRFPGRYYDVGIAEQHAVTFAAGMACEGVKPVVAIYSTFLQRAYDQ
LIHDVALQNLPVVFALDRAGLVGADGATHAGAYDIPFVRCIPNMSIACPADERECRQLLSTAYAQDHPVAVRYPRGSGAG
VAPLPGLEGLPFGKGEVRRTGQRIAILAFGTLLYPALQAGETLDATVANMRWAKPLDTALLLEIAAGHDALVTVEEGAVL
GGAGSAVCEALNAAGIQKPVLQLGLPDVFIEHGDPARLLALQGLDAEGLVRSITARFGPAAG
>Mature_621_residues
STNSFPLLQTVNDPADLRRMSRAQLKELAAELRAFVLDSVSKTGGHLSSNLGTVELTVALHTVFDTPRDRLVWDVGHQTY
PHKILTGRRDRMPTLRQLGGLSGFPQRTESEYDTFGTAHSSTSISAALGMAMAARQRGEDRRAVAIIGDGAMTAGMAFEA
LNNAGVADANLLVILNDNDMSISPPVGALNRYLAQLMSGQFYAAAKNVGKTVLGPVPPLLELAKRFEQQAKGMVLPATLF
EKFGFNYIGPIDGHDLDSLIPTLENIKGLKGPQFLHVVTKKGQGYKLAEADPVAYHGPGKFDPSVGLTKPATPPKQTFTQ
VFGQWLCDMAAQDDRLVGITPAMREGSGMVEFEKRFPGRYYDVGIAEQHAVTFAAGMACEGVKPVVAIYSTFLQRAYDQL
IHDVALQNLPVVFALDRAGLVGADGATHAGAYDIPFVRCIPNMSIACPADERECRQLLSTAYAQDHPVAVRYPRGSGAGV
APLPGLEGLPFGKGEVRRTGQRIAILAFGTLLYPALQAGETLDATVANMRWAKPLDTALLLEIAAGHDALVTVEEGAVLG
GAGSAVCEALNAAGIQKPVLQLGLPDVFIEHGDPARLLALQGLDAEGLVRSITARFGPAAG

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=662, Percent_Identity=22.809667673716, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4507521, Length=662, Percent_Identity=22.809667673716, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI225637459, Length=424, Percent_Identity=25.2358490566038, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI225637461, Length=424, Percent_Identity=25.2358490566038, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI225637463, Length=424, Percent_Identity=25.2358490566038, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI133778974, Length=424, Percent_Identity=23.5849056603774, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786622, Length=612, Percent_Identity=59.1503267973856, Blast_Score=748, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=422, Percent_Identity=26.303317535545, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17538422, Length=274, Percent_Identity=24.4525547445255, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24666278, Length=655, Percent_Identity=23.8167938931298, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI45551847, Length=636, Percent_Identity=25.6289308176101, Blast_Score=93, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45550715, Length=636, Percent_Identity=25.6289308176101, Blast_Score=93, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24645119, Length=553, Percent_Identity=25.8589511754069, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_ACIAC (A1TNR1)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_970373.1
- ProteinModelPortal:   A1TNR1
- SMR:   A1TNR1
- STRING:   A1TNR1
- GeneID:   4668773
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_2015
- NMPDR:   fig|397945.5.peg.1740
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   A1TNR1
- ProtClustDB:   PRK05444
- BioCyc:   AAVE397945:AAVE_2015-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 66255; Mature: 66124

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNSFPLLQTVNDPADLRRMSRAQLKELAAELRAFVLDSVSKTGGHLSSNLGTVELTVA
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEE
LHTVFDTPRDRLVWDVGHQTYPHKILTGRRDRMPTLRQLGGLSGFPQRTESEYDTFGTAH
EEHHHCCCCCCEEEECCCCCCCHHHHCCCCCCCCHHHHHCCCCCCCCCCCCHHHHCCCCC
SSTSISAALGMAMAARQRGEDRRAVAIIGDGAMTAGMAFEALNNAGVADANLLVILNDND
CCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEEECCCC
MSISPPVGALNRYLAQLMSGQFYAAAKNVGKTVLGPVPPLLELAKRFEQQAKGMVLPATL
CCCCCCHHHHHHHHHHHHCCCCEEHHHHCCCHHCCCCCHHHHHHHHHHHHHCCEEEHHHH
FEKFGFNYIGPIDGHDLDSLIPTLENIKGLKGPQFLHVVTKKGQGYKLAEADPVAYHGPG
HHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCCEEECCCC
KFDPSVGLTKPATPPKQTFTQVFGQWLCDMAAQDDRLVGITPAMREGSGMVEFEKRFPGR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHCCCCCEEHHHHCCCC
YYDVGIAEQHAVTFAAGMACEGVKPVVAIYSTFLQRAYDQLIHDVALQNLPVVFALDRAG
EEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
LVGADGATHAGAYDIPFVRCIPNMSIACPADERECRQLLSTAYAQDHPVAVRYPRGSGAG
EECCCCCCCCCCCCCCHHEECCCCEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCC
VAPLPGLEGLPFGKGEVRRTGQRIAILAFGTLLYPALQAGETLDATVANMRWAKPLDTAL
CCCCCCCCCCCCCCCHHHHCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHH
LLEIAAGHDALVTVEEGAVLGGAGSAVCEALNAAGIQKPVLQLGLPDVFIEHGDPARLLA
HHHHHCCCCEEEEEECCEEECCCHHHHHHHHHHCCCHHHHHHHCCCCEEEECCCCEEEEE
LQGLDAEGLVRSITARFGPAAG
ECCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
STNSFPLLQTVNDPADLRRMSRAQLKELAAELRAFVLDSVSKTGGHLSSNLGTVELTVA
CCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEE
LHTVFDTPRDRLVWDVGHQTYPHKILTGRRDRMPTLRQLGGLSGFPQRTESEYDTFGTAH
EEHHHCCCCCCEEEECCCCCCCHHHHCCCCCCCCHHHHHCCCCCCCCCCCCHHHHCCCCC
SSTSISAALGMAMAARQRGEDRRAVAIIGDGAMTAGMAFEALNNAGVADANLLVILNDND
CCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEEECCCC
MSISPPVGALNRYLAQLMSGQFYAAAKNVGKTVLGPVPPLLELAKRFEQQAKGMVLPATL
CCCCCCHHHHHHHHHHHHCCCCEEHHHHCCCHHCCCCCHHHHHHHHHHHHHCCEEEHHHH
FEKFGFNYIGPIDGHDLDSLIPTLENIKGLKGPQFLHVVTKKGQGYKLAEADPVAYHGPG
HHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCCEEECCCC
KFDPSVGLTKPATPPKQTFTQVFGQWLCDMAAQDDRLVGITPAMREGSGMVEFEKRFPGR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHCCCCCEEHHHHCCCC
YYDVGIAEQHAVTFAAGMACEGVKPVVAIYSTFLQRAYDQLIHDVALQNLPVVFALDRAG
EEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
LVGADGATHAGAYDIPFVRCIPNMSIACPADERECRQLLSTAYAQDHPVAVRYPRGSGAG
EECCCCCCCCCCCCCCHHEECCCCEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCC
VAPLPGLEGLPFGKGEVRRTGQRIAILAFGTLLYPALQAGETLDATVANMRWAKPLDTAL
CCCCCCCCCCCCCCCHHHHCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHH
LLEIAAGHDALVTVEEGAVLGGAGSAVCEALNAAGIQKPVLQLGLPDVFIEHGDPARLLA
HHHHHCCCCEEEEEECCEEECCCHHHHHHHHHHCCCHHHHHHHCCCCEEEECCCCEEEEE
LQGLDAEGLVRSITARFGPAAG
ECCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA