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The map label for this gene is ispA [C]

Identifier: 120610694

GI number: 120610694

Start: 2189442

End: 2190362

Strand: Direct

Name: ispA [C]

Synonym: Aave_2014

Alternate gene names: 120610694

Gene position: 2189442-2190362 (Clockwise)

Preceding gene: 120610693

Following gene: 120610695

Centisome position: 40.9

GC content: 74.7

Gene sequence:

>921_bases
ATGGGCACCGCTGCGCTTTCCCCGCACGCCGGCGACGCCGGCTTCGACCTTTCCGCCTGGAGCGCGCAGGCACTGCGGCG
TGTCGAGCAAGCCCTGGAAACCTGGGTGCCCGCCGATGCACCGGGCGGCCTGGGCGATGCCATGCGCTACGCGGTGCTGG
GCGCCGGAAAGCGGCTGCGTCCGCTGCTGGTGCTCGCCGCGGCCGAGGCAGTGTCGGGCCATGCCGGCGCGGCCCTGCGC
GCGGCCTGCTCGGTGGAGCTGATCCACGCGTATTCGCTGGTGCACGACGACATGCCCTGCATGGACAACGACGTGCTGCG
CCGCGGCAAGCCCACGGTGCACGTGCAGTTCGGGCAGGCCCAGGCGCTGCTCGCGGGCGATGCGCTGCAGGCCCTGGCCT
TCGAACTGCTCACGCCCGAGGACGACGTGCCCGAGGCCATGCAGGCCCGGCTGTGCCGCCTGCTGGCGCGGGCCGCGGGC
GCCGACGGCATGGCCGGCGGGCAGGCGATCGACCTGGCCAGCGTGGGCGTCGCGCTGTCGGAAGACGAGCTGCGCCGCAT
GCACCGCCTCAAGACCGGGGCGCTGCTGCAGTCCAGCGTGCTGATGGGCGCGGCCTGCGGAGCGGTGGCGCCCGCTGCGT
GGGACGCCCTGTCGCGCTACGGCGCGGCCCTCGGGCTGGCCTTCCAGGTGGTGGACGACGTGCTCGACGTGGTGGCCGAT
TCCGCCACGCTGGGCAAGACGGCCGGCAAGGACGCGGCCAGCGACAAGCCCACCTACGTCTCGCTGCTGGGGCTGGACCG
CGCGCGCGCCTATGCGGCCGCGCTGCGCGACGAGGCGCACGCCGCCCTGCAGGACAGCGGCCTGGCGGGCACGCGCGTGC
TGGCGGCGCTGGCCGACATGGTGATCGACCGATCCCGCTGA

Upstream 100 bases:

>100_bases
GCGCGCAGCTGCTGGCGTTCTGCCGCGGCCGCCTGGAGGCCGTGCAGGACCAGATCAAGGTGCTGGAGAACGGCACGCTG
CAACCGTGGACGCAAGACTG

Downstream 100 bases:

>100_bases
GACTGGGGGCCGGACCGCGCCGCGTCCCGCCCCGTTCCCCGGCGCATGCGTGCCGGCGCCACCCAACCAAGAGCAATATG
TCCACGAATTCCTTCCCTCT

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MGTAALSPHAGDAGFDLSAWSAQALRRVEQALETWVPADAPGGLGDAMRYAVLGAGKRLRPLLVLAAAEAVSGHAGAALR
AACSVELIHAYSLVHDDMPCMDNDVLRRGKPTVHVQFGQAQALLAGDALQALAFELLTPEDDVPEAMQARLCRLLARAAG
ADGMAGGQAIDLASVGVALSEDELRRMHRLKTGALLQSSVLMGAACGAVAPAAWDALSRYGAALGLAFQVVDDVLDVVAD
SATLGKTAGKDAASDKPTYVSLLGLDRARAYAAALRDEAHAALQDSGLAGTRVLAALADMVIDRSR

Sequences:

>Translated_306_residues
MGTAALSPHAGDAGFDLSAWSAQALRRVEQALETWVPADAPGGLGDAMRYAVLGAGKRLRPLLVLAAAEAVSGHAGAALR
AACSVELIHAYSLVHDDMPCMDNDVLRRGKPTVHVQFGQAQALLAGDALQALAFELLTPEDDVPEAMQARLCRLLARAAG
ADGMAGGQAIDLASVGVALSEDELRRMHRLKTGALLQSSVLMGAACGAVAPAAWDALSRYGAALGLAFQVVDDVLDVVAD
SATLGKTAGKDAASDKPTYVSLLGLDRARAYAAALRDEAHAALQDSGLAGTRVLAALADMVIDRSR
>Mature_305_residues
GTAALSPHAGDAGFDLSAWSAQALRRVEQALETWVPADAPGGLGDAMRYAVLGAGKRLRPLLVLAAAEAVSGHAGAALRA
ACSVELIHAYSLVHDDMPCMDNDVLRRGKPTVHVQFGQAQALLAGDALQALAFELLTPEDDVPEAMQARLCRLLARAAGA
DGMAGGQAIDLASVGVALSEDELRRMHRLKTGALLQSSVLMGAACGAVAPAAWDALSRYGAALGLAFQVVDDVLDVVADS
ATLGKTAGKDAASDKPTYVSLLGLDRARAYAAALRDEAHAALQDSGLAGTRVLAALADMVIDRSR

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=222, Percent_Identity=31.0810810810811, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786623, Length=267, Percent_Identity=47.1910112359551, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1789578, Length=210, Percent_Identity=32.8571428571429, Blast_Score=111, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24651612, Length=221, Percent_Identity=29.8642533936652, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31510; Mature: 31379

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTAALSPHAGDAGFDLSAWSAQALRRVEQALETWVPADAPGGLGDAMRYAVLGAGKRLR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHH
PLLVLAAAEAVSGHAGAALRAACSVELIHAYSLVHDDMPCMDNDVLRRGKPTVHVQFGQA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEECCH
QALLAGDALQALAFELLTPEDDVPEAMQARLCRLLARAAGADGMAGGQAIDLASVGVALS
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHCCEEC
EDELRRMHRLKTGALLQSSVLMGAACGAVAPAAWDALSRYGAALGLAFQVVDDVLDVVAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SATLGKTAGKDAASDKPTYVSLLGLDRARAYAAALRDEAHAALQDSGLAGTRVLAALADM
CHHHCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VIDRSR
HHCCCC
>Mature Secondary Structure 
GTAALSPHAGDAGFDLSAWSAQALRRVEQALETWVPADAPGGLGDAMRYAVLGAGKRLR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHH
PLLVLAAAEAVSGHAGAALRAACSVELIHAYSLVHDDMPCMDNDVLRRGKPTVHVQFGQA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEECCH
QALLAGDALQALAFELLTPEDDVPEAMQARLCRLLARAAGADGMAGGQAIDLASVGVALS
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHCCEEC
EDELRRMHRLKTGALLQSSVLMGAACGAVAPAAWDALSRYGAALGLAFQVVDDVLDVVAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SATLGKTAGKDAASDKPTYVSLLGLDRARAYAAALRDEAHAALQDSGLAGTRVLAALADM
CHHHCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VIDRSR
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]