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The map label for this gene is pfpI [H]

Identifier: 120610278

GI number: 120610278

Start: 1761186

End: 1761785

Strand: Reverse

Name: pfpI [H]

Synonym: Aave_1595

Alternate gene names: 120610278

Gene position: 1761785-1761186 (Counterclockwise)

Preceding gene: 120610279

Following gene: 120610277

Centisome position: 32.91

GC content: 69.67

Gene sequence:

>600_bases
ATGGCATCTTCCTCCAACGGAACTTCCGCTTCCTCCTCCATGGCCCGTGGCCGCCGCATCGCCCTGCTCGTCACCGACGG
CTTCGAGCAGGCCGAGCTGACCGGCCCCCGCGACGCCCTGGAAGGCGCCGGGTTCGACGCGCAGATCGTGGCCCCGAAGC
CGGGCCAGGTCCAGGGCTTCAACCACGTGGACAAGGCCGACCGCTTCGACGTGGACCAGACGCTGGACCAGGCGTCGCCC
GACGCATTCGACGCGGTCGTGCTGCCCGGCGGCGTCGTGAATGCCGACGAATTGCGTACCGACGAAAAGGCCCGGGCCTT
CGTGCAGGCGATCGACCGCGCGGGCAAGCCCGTGGCCGTGATCTGCCACGGCGCCTGGCTGCTGATCGATGCGGGCCTGG
TCAAGGGCAAAACCCTGACCAGCTGGCCGAGCCTCGCGACCGACCTGCGCAACGCCGGCGCCCAATGGGTGGACCGGCCC
GTCCAGGTCGAGGGCCGCTGGATCAGCAGCCGCAAGCCCGACGACATCCCGCAGTTCAACGAACAGATCCTGAAGACGCT
CCAGCAGGGCGCCGGCACGGAACGCGAAGCCCGCAGCTGA

Upstream 100 bases:

>100_bases
CCGGCCCGTGCATGCCCACGGGCATCGTCGCCATCGGCCGACAGGCGTGCCCGCGCCCGGTGCCTAGATTGGAAGCTTTC
CCTTTCCAGGAGCTTTCCCC

Downstream 100 bases:

>100_bases
CCCGGAGAGACGCACCATGGTGACCCAGCTCGACTCCCCCGACGGCAAGCCCCGCAAGGACCCGGACCGCCCCAGCCCCA
CCTTCGTGGAAACGGACGAC

Product: PfpI family intracellular peptidase

Products: NA

Alternate protein names: Intracellular protease I [H]

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MASSSNGTSASSSMARGRRIALLVTDGFEQAELTGPRDALEGAGFDAQIVAPKPGQVQGFNHVDKADRFDVDQTLDQASP
DAFDAVVLPGGVVNADELRTDEKARAFVQAIDRAGKPVAVICHGAWLLIDAGLVKGKTLTSWPSLATDLRNAGAQWVDRP
VQVEGRWISSRKPDDIPQFNEQILKTLQQGAGTEREARS

Sequences:

>Translated_199_residues
MASSSNGTSASSSMARGRRIALLVTDGFEQAELTGPRDALEGAGFDAQIVAPKPGQVQGFNHVDKADRFDVDQTLDQASP
DAFDAVVLPGGVVNADELRTDEKARAFVQAIDRAGKPVAVICHGAWLLIDAGLVKGKTLTSWPSLATDLRNAGAQWVDRP
VQVEGRWISSRKPDDIPQFNEQILKTLQQGAGTEREARS
>Mature_198_residues
ASSSNGTSASSSMARGRRIALLVTDGFEQAELTGPRDALEGAGFDAQIVAPKPGQVQGFNHVDKADRFDVDQTLDQASPD
AFDAVVLPGGVVNADELRTDEKARAFVQAIDRAGKPVAVICHGAWLLIDAGLVKGKTLTSWPSLATDLRNAGAQWVDRPV
QVEGRWISSRKPDDIPQFNEQILKTLQQGAGTEREARS

Specific function: Highly stable protease. Although the physiological function is unclear it is the dominant protease in P.furiosus [H]

COG id: COG0693

COG function: function code R; Putative intracellular protease/amidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PfpI endopeptidase domain [H]

Homologues:

Organism=Escherichia coli, GI87082219, Length=173, Percent_Identity=37.5722543352601, Blast_Score=119, Evalue=9e-29,
Organism=Drosophila melanogaster, GI28571932, Length=178, Percent_Identity=29.2134831460674, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006286
- InterPro:   IPR002818 [H]

Pfam domain/function: PF01965 DJ-1_PfpI [H]

EC number: NA

Molecular weight: Translated: 21293; Mature: 21162

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSSNGTSASSSMARGRRIALLVTDGFEQAELTGPRDALEGAGFDAQIVAPKPGQVQGF
CCCCCCCCCCHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHCCCCCCEEECCCCCCCCCC
NHVDKADRFDVDQTLDQASPDAFDAVVLPGGVVNADELRTDEKARAFVQAIDRAGKPVAV
CCCCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCHHHHCCCHHHHHHHHHHHHCCCCEEE
ICHGAWLLIDAGLVKGKTLTSWPSLATDLRNAGAQWVDRPVQVEGRWISSRKPDDIPQFN
EECCCEEEEECCCCCCCCCCCCHHHHHHHHHCCHHHHCCCEEECCEEECCCCCCCCHHHH
EQILKTLQQGAGTEREARS
HHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ASSSNGTSASSSMARGRRIALLVTDGFEQAELTGPRDALEGAGFDAQIVAPKPGQVQGF
CCCCCCCCCHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHCCCCCCEEECCCCCCCCCC
NHVDKADRFDVDQTLDQASPDAFDAVVLPGGVVNADELRTDEKARAFVQAIDRAGKPVAV
CCCCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCHHHHCCCHHHHHHHHHHHHCCCCEEE
ICHGAWLLIDAGLVKGKTLTSWPSLATDLRNAGAQWVDRPVQVEGRWISSRKPDDIPQFN
EECCCEEEEECCCCCCCCCCCCHHHHHHHHHCCHHHHCCCEEECCEEECCCCCCCCHHHH
EQILKTLQQGAGTEREARS
HHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626329 [H]