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The map label for this gene is clpB [H]

Identifier: 120609936

GI number: 120609936

Start: 1370859

End: 1373468

Strand: Direct

Name: clpB [H]

Synonym: Aave_1249

Alternate gene names: 120609936

Gene position: 1370859-1373468 (Clockwise)

Preceding gene: 120609935

Following gene: 120609937

Centisome position: 25.61

GC content: 67.36

Gene sequence:

>2610_bases
ATGCGTCTCGACAAACTCACCACCAAGTTCCAGGAAGCCCTCGCCGATGCGCAATCGCTCGCGCTGGGCAATGACAACGC
CTACATCGAACCCGTGCACCTGCTGGCCGCCATGCTGCGGCAGCAGGAAGGCCCGCGCGCGCTGCTGCAGCGGGCGGGCG
CCAACGTGGCCGCCCTGCAGACGGCGGCCGAGAACGCCATCAAGCGGCTGCCCCAGGTGCAGGGCCAGGACCAGGTACAG
GTCGGGCCCGAACTGGGCCGCCTGCTGCAGGCCACCGAGAAGGAAGCGATCAAGCGCGGCGACCAGTTCATCGCGAGCGA
ACTCTTCCTGCTCGCGCTCGTGGACGGCAAGGGCGATACCGCCCAGCTGGCGCGCGAGCACGGCCTGACGCGCAAGAGCC
TCGAAGCCGCGATCGACGCGGTGCGCGGCGGCGCCCAGGTCAACAGCGCCGAGGCCGAGGGCCAGCGCGAGGCACTGAAG
AAGTACACGCTCGACCTCACCGAGCGCGCCCGGGCCGGCAAGCTCGACCCGGTGATCGGCCGCGACGACGAGATCCGCCG
CGCCATCCAGGTGCTGCAGCGCCGCAGCAAGAACAACCCCGTGCTCATCGGCGAGCCCGGCGTGGGCAAGACCGCCATCG
TGGAAGGCCTGGCGCAGCGCATCGTCGCGGGCGAGGTGCCCGAGAGCCTGAAGGGCAAGCGCGTGCTGTCGCTCGACATG
GCCGCGCTGCTGGCGGGCGCCAAGTACCGCGGCGAGTTCGAGGAGCGGCTCAAGGCCGTGCTGAACGAACTGGCCAAGGA
CGAGGGCCAGACCATCGTCTTCATCGACGAGCTGCACACCATGGTGGGCGCGGGCAAGGCCGAGGGCGCCATGGACGCGG
GCAACATGCTCAAGCCGGCCCTGGCACGCGGCGAACTGCACTGCGTGGGCGCGACCACGCTCGACGAGTACCGCAAGTAC
ATCGAGAAGGACGCCGCGCTGGAGCGGCGCTTCCAGAAGATCCTCGTGGGCGAGCCCAGCGTGGAGGCGACCATCGCCAT
CCTGCGCGGCCTGCAGGAGCGCTACGAGTTGCACCACGGCGTGGAGATCACCGACCCGGCCATCGTGGCCGCGGCCGAGC
TATCGCACCGCTACATCACCGACCGCTTCCTGCCCGACAAGGCGATCGACCTCATCGACGAGGCCGCGGCCAAGATCAAG
ATCGAGATCGACTCCAAGCCCGAGGCCATCGACAAGCTCGACCGCCGGCTGATCCAGCTGCAGATCGAGCGCGAGGCCGT
GAAAAAGGAAAAAGACGAAGCCTCGCAGAAGCGCCTGGCGCTGCTCGAGGAAGAGATCGGCAAGCTGCAGAAGGAAATCG
CCGACCTGGAGGACATCTGGACCTCCGAGAAGGCGCAGGCCCAGGGCAGCCAGCAGGTGCGCGAGCAGGTCGAGAAGGTG
AAGCTGCAGATCGAGGAGCTCAAGCGCAAGGGCGACTTCAACAAGGTCGCGGAACTGCAGTACGGCAGGCTGCCCGACCT
GGAACGCCAGCTCAAGGAAGCCCAGGCCAAGGAAGAGGGCACCGACGGCACCGCCACGCCCAACCGGCTGCTGCGCACCC
AGGTGGGCGCCGAGGAGATCGCCGAGGTCGTGAGCCGCGCCACGGGCATCCCTGTCTCGAAGATGATGCAGGGCGAGAAG
GACAAGCTGCTGCAGATGGAAGACAAGCTGCACGAGCGCGTGGTGGGCCAGGACGAGGCCATCGCGGCCGTGGCCAACGC
CATCCGCCGCTCGCGCTCGGGCCTCGCCGATCCGAACCGGCCGATGGGCTCGTTCCTGTTCCTCGGCCCCACGGGCGTGG
GCAAGACCGAGCTGTGCAAGGCGCTGGCGGGCTTCCTGTTCGACAGCGAGGAGCACCTCGTGCGCATCGACATGAGCGAG
TTCATGGAGAAGCACTCCGTGGCCCGCCTGATCGGCGCGCCGCCCGGCTACGTGGGCTACGAGGAGGGCGGCTACCTGAC
CGAGGCCGTGCGCCGCAAGCCCTACAGCGTGCTGTTGCTCGACGAGGTCGAGAAGGCGCACCCGGACGTGTTCAACGTGC
TGCTGCAGGTGCTCGACGACGGCCGCCTGACGGATGGCCAGGGCCGTACCGTGGACTTCAAGAACACGGTGATCGTGATG
ACGAGCAACATCGGCTCGCACCTGATCCAGGCGATGGTCGGCCAGGATGCGGACGACGTGAAGGAAGCGGTCTGGGGGGA
ACTCAAGAACCATTTCCGGCCCGAATTCCTCAACCGGATCGACGAAACGGTGGTGTTCCATGCGCTCGACGCGAAGAACA
TCGAAGCGATCGCACGCATCCAGTTGCAACTCCTGGAAGCGCGTCTGGCGAAAATGGACCTGCACCTGCAGGTGTCCCCC
GGCGCGTTGTCCGAGCTGGCCAAGGTGGGATTCGATCCGGTGTTCGGCGCCCGCCCGCTCAAGCGCGCGATCCAGCAGCG
CATCGAGAATCCGCTCTCGAAGCTGCTGCTGGAAGGCCGCTATCCGCCCAAGAGCGTGATCCCGGTGAACGTGGATCCCG
TACAGGACCCTGGGGTCTTCCATTTCGGCGAAGCGGCCGCGGTGGGGTAA

Upstream 100 bases:

>100_bases
TAGCGGCGGTGCCGCGTGTGCGATGCGCATGCCGCGCTGGCGGCTTGAAAACTCCGGGCAGGCCCCTCAATTGCCCACCA
GTTCCGGAGGACCACAGACC

Downstream 100 bases:

>100_bases
GTTCGATGTTGTGTGGAAAGGATGTGCCTTGAATGATTTCCTGGCCGGCGTGATCCGGTGGATCGTGCGCCTCGCGGTCG
TGGCCGTGGGAGCGGTGTTT

Product: ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 869; Mature: 869

Protein sequence:

>869_residues
MRLDKLTTKFQEALADAQSLALGNDNAYIEPVHLLAAMLRQQEGPRALLQRAGANVAALQTAAENAIKRLPQVQGQDQVQ
VGPELGRLLQATEKEAIKRGDQFIASELFLLALVDGKGDTAQLAREHGLTRKSLEAAIDAVRGGAQVNSAEAEGQREALK
KYTLDLTERARAGKLDPVIGRDDEIRRAIQVLQRRSKNNPVLIGEPGVGKTAIVEGLAQRIVAGEVPESLKGKRVLSLDM
AALLAGAKYRGEFEERLKAVLNELAKDEGQTIVFIDELHTMVGAGKAEGAMDAGNMLKPALARGELHCVGATTLDEYRKY
IEKDAALERRFQKILVGEPSVEATIAILRGLQERYELHHGVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAAKIK
IEIDSKPEAIDKLDRRLIQLQIEREAVKKEKDEASQKRLALLEEEIGKLQKEIADLEDIWTSEKAQAQGSQQVREQVEKV
KLQIEELKRKGDFNKVAELQYGRLPDLERQLKEAQAKEEGTDGTATPNRLLRTQVGAEEIAEVVSRATGIPVSKMMQGEK
DKLLQMEDKLHERVVGQDEAIAAVANAIRRSRSGLADPNRPMGSFLFLGPTGVGKTELCKALAGFLFDSEEHLVRIDMSE
FMEKHSVARLIGAPPGYVGYEEGGYLTEAVRRKPYSVLLLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVM
TSNIGSHLIQAMVGQDADDVKEAVWGELKNHFRPEFLNRIDETVVFHALDAKNIEAIARIQLQLLEARLAKMDLHLQVSP
GALSELAKVGFDPVFGARPLKRAIQQRIENPLSKLLLEGRYPPKSVIPVNVDPVQDPGVFHFGEAAAVG

Sequences:

>Translated_869_residues
MRLDKLTTKFQEALADAQSLALGNDNAYIEPVHLLAAMLRQQEGPRALLQRAGANVAALQTAAENAIKRLPQVQGQDQVQ
VGPELGRLLQATEKEAIKRGDQFIASELFLLALVDGKGDTAQLAREHGLTRKSLEAAIDAVRGGAQVNSAEAEGQREALK
KYTLDLTERARAGKLDPVIGRDDEIRRAIQVLQRRSKNNPVLIGEPGVGKTAIVEGLAQRIVAGEVPESLKGKRVLSLDM
AALLAGAKYRGEFEERLKAVLNELAKDEGQTIVFIDELHTMVGAGKAEGAMDAGNMLKPALARGELHCVGATTLDEYRKY
IEKDAALERRFQKILVGEPSVEATIAILRGLQERYELHHGVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAAKIK
IEIDSKPEAIDKLDRRLIQLQIEREAVKKEKDEASQKRLALLEEEIGKLQKEIADLEDIWTSEKAQAQGSQQVREQVEKV
KLQIEELKRKGDFNKVAELQYGRLPDLERQLKEAQAKEEGTDGTATPNRLLRTQVGAEEIAEVVSRATGIPVSKMMQGEK
DKLLQMEDKLHERVVGQDEAIAAVANAIRRSRSGLADPNRPMGSFLFLGPTGVGKTELCKALAGFLFDSEEHLVRIDMSE
FMEKHSVARLIGAPPGYVGYEEGGYLTEAVRRKPYSVLLLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVM
TSNIGSHLIQAMVGQDADDVKEAVWGELKNHFRPEFLNRIDETVVFHALDAKNIEAIARIQLQLLEARLAKMDLHLQVSP
GALSELAKVGFDPVFGARPLKRAIQQRIENPLSKLLLEGRYPPKSVIPVNVDPVQDPGVFHFGEAAAVG
>Mature_869_residues
MRLDKLTTKFQEALADAQSLALGNDNAYIEPVHLLAAMLRQQEGPRALLQRAGANVAALQTAAENAIKRLPQVQGQDQVQ
VGPELGRLLQATEKEAIKRGDQFIASELFLLALVDGKGDTAQLAREHGLTRKSLEAAIDAVRGGAQVNSAEAEGQREALK
KYTLDLTERARAGKLDPVIGRDDEIRRAIQVLQRRSKNNPVLIGEPGVGKTAIVEGLAQRIVAGEVPESLKGKRVLSLDM
AALLAGAKYRGEFEERLKAVLNELAKDEGQTIVFIDELHTMVGAGKAEGAMDAGNMLKPALARGELHCVGATTLDEYRKY
IEKDAALERRFQKILVGEPSVEATIAILRGLQERYELHHGVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAAKIK
IEIDSKPEAIDKLDRRLIQLQIEREAVKKEKDEASQKRLALLEEEIGKLQKEIADLEDIWTSEKAQAQGSQQVREQVEKV
KLQIEELKRKGDFNKVAELQYGRLPDLERQLKEAQAKEEGTDGTATPNRLLRTQVGAEEIAEVVSRATGIPVSKMMQGEK
DKLLQMEDKLHERVVGQDEAIAAVANAIRRSRSGLADPNRPMGSFLFLGPTGVGKTELCKALAGFLFDSEEHLVRIDMSE
FMEKHSVARLIGAPPGYVGYEEGGYLTEAVRRKPYSVLLLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVM
TSNIGSHLIQAMVGQDADDVKEAVWGELKNHFRPEFLNRIDETVVFHALDAKNIEAIARIQLQLLEARLAKMDLHLQVSP
GALSELAKVGFDPVFGARPLKRAIQQRIENPLSKLLLEGRYPPKSVIPVNVDPVQDPGVFHFGEAAAVG

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=418, Percent_Identity=32.2966507177034, Blast_Score=206, Evalue=1e-52,
Organism=Escherichia coli, GI1788943, Length=855, Percent_Identity=66.3157894736842, Blast_Score=1138, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=385, Percent_Identity=42.8571428571429, Blast_Score=287, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6320464, Length=691, Percent_Identity=54.2691751085383, Blast_Score=748, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=859, Percent_Identity=43.0733410942957, Blast_Score=682, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 95699; Mature: 95699

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLDKLTTKFQEALADAQSLALGNDNAYIEPVHLLAAMLRQQEGPRALLQRAGANVAALQ
CCCHHHHHHHHHHHHHHHHHEECCCCCEECHHHHHHHHHHHCCCHHHHHHHCCCCHHHHH
TAAENAIKRLPQVQGQDQVQVGPELGRLLQATEKEAIKRGDQFIASELFLLALVDGKGDT
HHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCH
AQLAREHGLTRKSLEAAIDAVRGGAQVNSAEAEGQREALKKYTLDLTERARAGKLDPVIG
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RDDEIRRAIQVLQRRSKNNPVLIGEPGVGKTAIVEGLAQRIVAGEVPESLKGKRVLSLDM
CCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCCEEHHHHH
AALLAGAKYRGEFEERLKAVLNELAKDEGQTIVFIDELHTMVGAGKAEGAMDAGNMLKPA
HHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHHHH
LARGELHCVGATTLDEYRKYIEKDAALERRFQKILVGEPSVEATIAILRGLQERYELHHG
HHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
VEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAAKIKIEIDSKPEAIDKLDRRLIQL
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHH
QIEREAVKKEKDEASQKRLALLEEEIGKLQKEIADLEDIWTSEKAQAQGSQQVREQVEKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHH
KLQIEELKRKGDFNKVAELQYGRLPDLERQLKEAQAKEEGTDGTATPNRLLRTQVGAEEI
HHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHH
AEVVSRATGIPVSKMMQGEKDKLLQMEDKLHERVVGQDEAIAAVANAIRRSRSGLADPNR
HHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC
PMGSFLFLGPTGVGKTELCKALAGFLFDSEEHLVRIDMSEFMEKHSVARLIGAPPGYVGY
CCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCC
EEGGYLTEAVRRKPYSVLLLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVM
CCCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEE
TSNIGSHLIQAMVGQDADDVKEAVWGELKNHFRPEFLNRIDETVVFHALDAKNIEAIARI
ECCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
QLQLLEARLAKMDLHLQVSPGALSELAKVGFDPVFGARPLKRAIQQRIENPLSKLLLEGR
HHHHHHHHHHHHCEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
YPPKSVIPVNVDPVQDPGVFHFGEAAAVG
CCCCCEEECCCCCCCCCCCEECCCHHCCC
>Mature Secondary Structure
MRLDKLTTKFQEALADAQSLALGNDNAYIEPVHLLAAMLRQQEGPRALLQRAGANVAALQ
CCCHHHHHHHHHHHHHHHHHEECCCCCEECHHHHHHHHHHHCCCHHHHHHHCCCCHHHHH
TAAENAIKRLPQVQGQDQVQVGPELGRLLQATEKEAIKRGDQFIASELFLLALVDGKGDT
HHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCH
AQLAREHGLTRKSLEAAIDAVRGGAQVNSAEAEGQREALKKYTLDLTERARAGKLDPVIG
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RDDEIRRAIQVLQRRSKNNPVLIGEPGVGKTAIVEGLAQRIVAGEVPESLKGKRVLSLDM
CCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCCEEHHHHH
AALLAGAKYRGEFEERLKAVLNELAKDEGQTIVFIDELHTMVGAGKAEGAMDAGNMLKPA
HHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHHHH
LARGELHCVGATTLDEYRKYIEKDAALERRFQKILVGEPSVEATIAILRGLQERYELHHG
HHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
VEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAAKIKIEIDSKPEAIDKLDRRLIQL
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHH
QIEREAVKKEKDEASQKRLALLEEEIGKLQKEIADLEDIWTSEKAQAQGSQQVREQVEKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHH
KLQIEELKRKGDFNKVAELQYGRLPDLERQLKEAQAKEEGTDGTATPNRLLRTQVGAEEI
HHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHH
AEVVSRATGIPVSKMMQGEKDKLLQMEDKLHERVVGQDEAIAAVANAIRRSRSGLADPNR
HHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC
PMGSFLFLGPTGVGKTELCKALAGFLFDSEEHLVRIDMSEFMEKHSVARLIGAPPGYVGY
CCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCC
EEGGYLTEAVRRKPYSVLLLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVM
CCCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEE
TSNIGSHLIQAMVGQDADDVKEAVWGELKNHFRPEFLNRIDETVVFHALDAKNIEAIARI
ECCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
QLQLLEARLAKMDLHLQVSPGALSELAKVGFDPVFGARPLKRAIQQRIENPLSKLLLEGR
HHHHHHHHHHHHCEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
YPPKSVIPVNVDPVQDPGVFHFGEAAAVG
CCCCCEEECCCCCCCCCCCEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]