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The map label for this gene is moaE [H]

Identifier: 120609935

GI number: 120609935

Start: 1370159

End: 1370677

Strand: Direct

Name: moaE [H]

Synonym: Aave_1248

Alternate gene names: 120609935

Gene position: 1370159-1370677 (Clockwise)

Preceding gene: 120609934

Following gene: 120609936

Centisome position: 25.6

GC content: 68.98

Gene sequence:

>519_bases
ATGGCCGATCCGTTGTCTTCCATTCCTCCGGCCCGCGCGGAAGGCCGCGCCCGGGTTTCCATCCAGCCGCAGGACTTCGA
TGTCTCGGCCGAACTGGCGGCGCTGCGTGCGCGGGACGGACGCGTGGGTGCCGTCTGCTGCTTCGTGGGTACGGTGCGCG
ACCGCAGCGACGGCGACGCCGTGGCGGCGATGGAGCTGGAGCACTATCCCGGCATGACCGAGAAATCCATCGAGGCCATG
GTGGACGAAGCCCTGGGGCGCTTCGACATCTTCGGCGCGCGCGTGGTGCACCGGGTGGGCCTGCTGGCGCCGCAGGACCA
GATCGTGATGGTGGCCGTCACCTCGGCCCACCGTGGCCAGAGCTTCCAGGCCTGCGAGTTCCTCATGGACTACCTCAAGA
CCCAGGCACCTTTCTGGAAGAAGGAAACCACTCCGCTGGGGGCGCGCTGGGTGGACGCGCGCGTCAGCGACGACGCGGCT
CTGGCCCGTTGGGGCATCGTGTCGGGCCACAACGCCTGA

Upstream 100 bases:

>100_bases
TTCCGTCCGATACCGCGGTGCGCCGCCAGCTCGATGCTTTCATCGAGGAAGAGCGCGCGCTGCTCGCCGCGCCCCGCCTG
CACCGGGCGCCGTGACCGCC

Downstream 100 bases:

>100_bases
TCGGCCTGTGCCGGCCCGATGGCCGGCACGAGAAATCCCTGCGCCGTCTCTCCGCCGCGAGTATGGTTGCTCCTCTTTTG
GTAGCGGCGGTGCCGCGTGT

Product: molybdopterin synthase subunit MoaE

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MADPLSSIPPARAEGRARVSIQPQDFDVSAELAALRARDGRVGAVCCFVGTVRDRSDGDAVAAMELEHYPGMTEKSIEAM
VDEALGRFDIFGARVVHRVGLLAPQDQIVMVAVTSAHRGQSFQACEFLMDYLKTQAPFWKKETTPLGARWVDARVSDDAA
LARWGIVSGHNA

Sequences:

>Translated_172_residues
MADPLSSIPPARAEGRARVSIQPQDFDVSAELAALRARDGRVGAVCCFVGTVRDRSDGDAVAAMELEHYPGMTEKSIEAM
VDEALGRFDIFGARVVHRVGLLAPQDQIVMVAVTSAHRGQSFQACEFLMDYLKTQAPFWKKETTPLGARWVDARVSDDAA
LARWGIVSGHNA
>Mature_171_residues
ADPLSSIPPARAEGRARVSIQPQDFDVSAELAALRARDGRVGAVCCFVGTVRDRSDGDAVAAMELEHYPGMTEKSIEAMV
DEALGRFDIFGARVVHRVGLLAPQDQIVMVAVTSAHRGQSFQACEFLMDYLKTQAPFWKKETTPLGARWVDARVSDDAAL
ARWGIVSGHNA

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=108, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1787003, Length=148, Percent_Identity=52.7027027027027, Blast_Score=160, Evalue=4e-41,
Organism=Drosophila melanogaster, GI21356259, Length=114, Percent_Identity=32.4561403508772, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 18671; Mature: 18540

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADPLSSIPPARAEGRARVSIQPQDFDVSAELAALRARDGRVGAVCCFVGTVRDRSDGDA
CCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCE
VAAMELEHYPGMTEKSIEAMVDEALGRFDIFGARVVHRVGLLAPQDQIVMVAVTSAHRGQ
EEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCC
SFQACEFLMDYLKTQAPFWKKETTPLGARWVDARVSDDAALARWGIVSGHNA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure 
ADPLSSIPPARAEGRARVSIQPQDFDVSAELAALRARDGRVGAVCCFVGTVRDRSDGDA
CCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCE
VAAMELEHYPGMTEKSIEAMVDEALGRFDIFGARVVHRVGLLAPQDQIVMVAVTSAHRGQ
EEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCC
SFQACEFLMDYLKTQAPFWKKETTPLGARWVDARVSDDAALARWGIVSGHNA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]