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The map label for this gene is gyaR [H]

Identifier: 120609830

GI number: 120609830

Start: 1255623

End: 1256591

Strand: Direct

Name: gyaR [H]

Synonym: Aave_1141

Alternate gene names: 120609830

Gene position: 1255623-1256591 (Clockwise)

Preceding gene: 120609829

Following gene: 120609831

Centisome position: 23.46

GC content: 71.52

Gene sequence:

>969_bases
TTGATTGTTGGATTGGAAGCTTCCACCGTGTCCACCCCGCGCATTCCCCTCCTGGCCCTGAACACCCTGTCGCCGCAGCA
CCAGGCCCAGATCGCCGCCGCCTACGACCTGCACTACGCGCCCACCCCCAACGACCGCACCCAGGCGATCGCCACGCAGG
GCGGCCGCTTCCGCGCGGTGCTCACCATCGGCTCCATCGGCCTCACGGCCCAGGAAATCGAGTCCATGCCCGGGCTCGAG
CTCATCTGCGCCCTGGGGGCCGGCTACGAGAACATCGCGCTCGACGCGGCCCGGGCGCGGGGCATCTCCGTGGCGAACGG
CGCCGGCACCAACGACGATTGCGTGGCCGACCATGCCTTCGGCCTGCTCATCTCCATCGTGCGCGGCCTGCGCCCGCTGG
ACCGGCTCTGCCGCGAGGGCGTCTGGCGCGATGCCATCGGCCTGCCGCCGAACGTGTCCGGCAAGCGGCTGGGCATCTTC
GGGCTGGGCACCATCGGCCAGAAGATCGCGCGCCGCGCGTCCGGCTTCGACATGCAGATCGGCTACCACAACCGCAATCC
GCGGGAAGGCGTGCCGCACCAGTACTTCTCCAGCCTGCGCGACCTCGCCGAATGGTGCGACGTGCTGGTGTGCGCCACGC
CCGGCGGTCCGGCCACGCGGCATGCGGTGAACGCCGACATCCTCGACGCCATCGGCCCGCTGGGCTACCTCGTGAACATC
GCGCGCGGCAGCGTGGTCGATACCGAGGCGCTGGCCGATGCGCTGCGCGGGCGCCGCATCGCCGGCGCGGGCCTGGACGT
GTACGAGAGCGAGCCGCACCCGCCCGAGGCGCTCGTCGGGCTCGACAACATCGTGCTCACGCCCCACGTGGCCGGCTGGT
CGCCCGAAGCCGTGCAGGCCAGCGTGGACCGGTTCCTGGCGAATGCGGAAGGGCATTTCGCCGGGCGCGGCGTCGTGTCG
CCGGTCTGA

Upstream 100 bases:

>100_bases
CGGGCTGGCGCACAATCGCACCATACCCGGCCGGCATGCCGCCGCGGCCCCTGGCGCCGCCGCGGCATGCCCGCGCCCGA
TTCCCGGGCGCGCGCCGACC

Downstream 100 bases:

>100_bases
TCCGAAAGGCCCCTCCGGGCCCGCGGAAGGCGGGCCGCGGATAAAATCCCGCCCCTGTCTTCCGCAGAGGCGGACAAAAG
GCTGCTGTCCCGGCAGCCTT

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MIVGLEASTVSTPRIPLLALNTLSPQHQAQIAAAYDLHYAPTPNDRTQAIATQGGRFRAVLTIGSIGLTAQEIESMPGLE
LICALGAGYENIALDAARARGISVANGAGTNDDCVADHAFGLLISIVRGLRPLDRLCREGVWRDAIGLPPNVSGKRLGIF
GLGTIGQKIARRASGFDMQIGYHNRNPREGVPHQYFSSLRDLAEWCDVLVCATPGGPATRHAVNADILDAIGPLGYLVNI
ARGSVVDTEALADALRGRRIAGAGLDVYESEPHPPEALVGLDNIVLTPHVAGWSPEAVQASVDRFLANAEGHFAGRGVVS
PV

Sequences:

>Translated_322_residues
MIVGLEASTVSTPRIPLLALNTLSPQHQAQIAAAYDLHYAPTPNDRTQAIATQGGRFRAVLTIGSIGLTAQEIESMPGLE
LICALGAGYENIALDAARARGISVANGAGTNDDCVADHAFGLLISIVRGLRPLDRLCREGVWRDAIGLPPNVSGKRLGIF
GLGTIGQKIARRASGFDMQIGYHNRNPREGVPHQYFSSLRDLAEWCDVLVCATPGGPATRHAVNADILDAIGPLGYLVNI
ARGSVVDTEALADALRGRRIAGAGLDVYESEPHPPEALVGLDNIVLTPHVAGWSPEAVQASVDRFLANAEGHFAGRGVVS
PV
>Mature_322_residues
MIVGLEASTVSTPRIPLLALNTLSPQHQAQIAAAYDLHYAPTPNDRTQAIATQGGRFRAVLTIGSIGLTAQEIESMPGLE
LICALGAGYENIALDAARARGISVANGAGTNDDCVADHAFGLLISIVRGLRPLDRLCREGVWRDAIGLPPNVSGKRLGIF
GLGTIGQKIARRASGFDMQIGYHNRNPREGVPHQYFSSLRDLAEWCDVLVCATPGGPATRHAVNADILDAIGPLGYLVNI
ARGSVVDTEALADALRGRRIAGAGLDVYESEPHPPEALVGLDNIVLTPHVAGWSPEAVQASVDRFLANAEGHFAGRGVVS
PV

Specific function: Serine biosynthesis; first step. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI61743967, Length=250, Percent_Identity=31.6, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4557497, Length=250, Percent_Identity=31.6, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI145580578, Length=246, Percent_Identity=30.4878048780488, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4557499, Length=246, Percent_Identity=30.4878048780488, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI23308577, Length=236, Percent_Identity=31.3559322033898, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI6912396, Length=220, Percent_Identity=34.0909090909091, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI145580575, Length=246, Percent_Identity=30.4878048780488, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1789279, Length=238, Percent_Identity=32.3529411764706, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082289, Length=232, Percent_Identity=31.0344827586207, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787645, Length=199, Percent_Identity=27.6381909547739, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081824, Length=140, Percent_Identity=32.1428571428571, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147481, Length=254, Percent_Identity=29.1338582677165, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=243, Percent_Identity=26.7489711934156, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324055, Length=240, Percent_Identity=31.25, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=264, Percent_Identity=29.9242424242424, Blast_Score=108, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=264, Percent_Identity=29.5454545454545, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324964, Length=257, Percent_Identity=25.2918287937743, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=289, Percent_Identity=26.2975778546713, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24646446, Length=243, Percent_Identity=32.0987654320988, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24646448, Length=243, Percent_Identity=32.0987654320988, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24646452, Length=243, Percent_Identity=32.0987654320988, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24646450, Length=243, Percent_Identity=32.0987654320988, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI62472511, Length=243, Percent_Identity=32.0987654320988, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI28574286, Length=223, Percent_Identity=31.390134529148, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI45551003, Length=255, Percent_Identity=30.5882352941176, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24585514, Length=255, Percent_Identity=30.5882352941176, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI28574282, Length=255, Percent_Identity=30.5882352941176, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI28574284, Length=255, Percent_Identity=30.5882352941176, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI45552429, Length=255, Percent_Identity=30.5882352941176, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI19921140, Length=251, Percent_Identity=30.2788844621514, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28571528, Length=255, Percent_Identity=30.9803921568627, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24585516, Length=219, Percent_Identity=30.1369863013699, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 33892; Mature: 33892

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVGLEASTVSTPRIPLLALNTLSPQHQAQIAAAYDLHYAPTPNDRTQAIATQGGRFRAV
CEEECCCCCCCCCCCCEEEECCCCCHHHHHEEEEEEEECCCCCCCHHHHHHCCCCEEEEE
LTIGSIGLTAQEIESMPGLELICALGAGYENIALDAARARGISVANGAGTNDDCVADHAF
EEECCCCCCHHHHHCCCCCEEEHHHCCCCHHHHHHHHHHCCCEEECCCCCCCCHHHHHHH
GLLISIVRGLRPLDRLCREGVWRDAIGLPPNVSGKRLGIFGLGTIGQKIARRASGFDMQI
HHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCEEEE
GYHNRNPREGVPHQYFSSLRDLAEWCDVLVCATPGGPATRHAVNADILDAIGPLGYLVNI
EECCCCCCCCCCHHHHHHHHHHHHHHCEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHH
ARGSVVDTEALADALRGRRIAGAGLDVYESEPHPPEALVGLDNIVLTPHVAGWSPEAVQA
HCCCCCCHHHHHHHHHCCEEECCCCCCCCCCCCCCHHHHCCCCEEECCCCCCCCHHHHHH
SVDRFLANAEGHFAGRGVVSPV
HHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIVGLEASTVSTPRIPLLALNTLSPQHQAQIAAAYDLHYAPTPNDRTQAIATQGGRFRAV
CEEECCCCCCCCCCCCEEEECCCCCHHHHHEEEEEEEECCCCCCCHHHHHHCCCCEEEEE
LTIGSIGLTAQEIESMPGLELICALGAGYENIALDAARARGISVANGAGTNDDCVADHAF
EEECCCCCCHHHHHCCCCCEEEHHHCCCCHHHHHHHHHHCCCEEECCCCCCCCHHHHHHH
GLLISIVRGLRPLDRLCREGVWRDAIGLPPNVSGKRLGIFGLGTIGQKIARRASGFDMQI
HHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCEEEE
GYHNRNPREGVPHQYFSSLRDLAEWCDVLVCATPGGPATRHAVNADILDAIGPLGYLVNI
EECCCCCCCCCCHHHHHHHHHHHHHHCEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHH
ARGSVVDTEALADALRGRRIAGAGLDVYESEPHPPEALVGLDNIVLTPHVAGWSPEAVQA
HCCCCCCHHHHHHHHHCCEEECCCCCCCCCCCCCCHHHHCCCCEEECCCCCCCCHHHHHH
SVDRFLANAEGHFAGRGVVSPV
HHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA