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The map label for this gene is groEL [H]

Identifier: 120609639

GI number: 120609639

Start: 1030380

End: 1032017

Strand: Reverse

Name: groEL [H]

Synonym: Aave_0945

Alternate gene names: 120609639

Gene position: 1032017-1030380 (Counterclockwise)

Preceding gene: 120609640

Following gene: 120609636

Centisome position: 19.28

GC content: 65.02

Gene sequence:

>1638_bases
ATGGCAGCAAAAGACGTAGTTTTCGGCGGCGAAGCCCGCGCTCGCATGGTCGAAGGCGTGAACATCCTCGCCAACGCCGT
CAAGGTGACGCTGGGCCCGAAGGGCCGCAACGTGGTGCTCGAGCGCTCCTTCGGCGCCCCCACCGTGACCAAGGACGGCG
TGTCCGTGGCCAAGGAAATCGAACTGAAGGACAAGCTGCAGAACATGGGCGCCCAGCTCGTGAAGGAAGTGGCTTCCAAG
ACCAGCGACAACGCCGGTGACGGCACGACCACCGCCACGGTGCTGGCCCAGGCCATCGTGCGCGAAGGCTCCAAGTACGT
GGCCGCCGGCCTGAACCCGATGGACCTCAAGCGCGGCATCGACAAGGCCGTGACGGCCCTGGTCGCCGAGCTGAAGAAGG
CTTCCAAGGCCACGACGACCTCCAAGGAAATCGCCCAGGTGGGTTCGATCTCCGCCAACTCCGACGAATCCATCGGCAAG
ATCATTGCCGACGCCATGGACAAGGTCGGCAAGGAAGGCGTGATCACCGTGGAAGACGGCAAGAGCCTGGACAACGAGCT
GGATGTCGTGGAAGGCATGCAGTTCGACCGCGGCTACCTGTCGCCCTACTTCATCAACAACCCCGAAAAGCAGGCCGCCC
TGCTGGACAACCCCTTCGTGCTGCTGTTCGACAAGAAGATCAGCAACATCCGTGACCTGCTGCCCACGCTGGAGCAGGTC
GCCAAGGCCGGCCGTCCGCTGCTGATCATCGCCGAGGAAGTCGAGGGCGAAGCCCTGGCGACCCTGGTGGTGAACACCAT
CCGCGGCATCCTGAAGGTCGTGGCCGTGAAGGCGCCTGGCTTCGGCGACCGCCGCAAGGCCATGCTGGAAGACATCGCCA
TCCTGACGGGCGGCAAGGTGATCGCCGAGGAAGTGGGCCTGACGCTCGAGAAGGTGACCCTGGCCGACCTGGGCCAGGCC
AAGCGCATCGAAGTGGGCAAGGAAAACACCACCATCATCGACGGCGCAGGCGCTGCCGCTGACATCGAAGCCCGCGTGAA
GCAGATCCGCATCCAGATCGAGGAAGCCACCAGCGACTACGACCGCGAGAAGCTGCAGGAGCGCGTGGCCAAGCTGGCCG
GCGGCGTGGCCGTGATCAAGGTCGGCGCTGCCACCGAAGTCGAGATGAAGGAAAAGAAGGCACGCGTGGAAGACGCGCTG
CACGCCACCCGCGCTGCCGTGGAAGAAGGCATCGTGGCCGGCGGTGGCGTGGCCCTGCTGCGCGCCAAGCAGGCTGCTGG
CGACATCAAGGGTGACAACCCCGATCAAGACGCCGGCATCAAGCTGATCCTGAAGGCGATCGAAGCGCCCCTGCGCGAGA
TCGTGGCCAACGCCGGTGGCGAGCCGTCCGTGGTGGTCAATGCCGTGCTGAACGGCAAGGGCAACTACGGCTTCAACGCC
GCCAACGACACCTACGGCGACATGCTCGAAATGGGCATCCTGGACCCGACGAAGGTGACCCGCACGGCCCTGCAGAACGC
CGCTTCCGTGGCTTCGCTGCTGCTGACGACCGAAGCCATGGTGGCCGAGGCTCCGAAGGACGATGCACCGGCTCCCGCGA
TGCCCGACATGGGCGGCATGGGTGGCATGGGCATGTAA

Upstream 100 bases:

>100_bases
GTGATGAAGGAAGACGACCTGTTCGCAGTCGTCGAGAAGTGACCGCTTCGCGGATCACATCCTCTTCCAACTTCCTGTTG
ACTGAATCCGGAGAAACAAA

Downstream 100 bases:

>100_bases
TTGCGGCCCGGGCGGCGGCGGACGCGGAAGCGATTTCCGCCCCCGACGCCGCCAGCTGCTCCGCCCCAGGGCGGAAAGCA
AAAAAGCCCGCAGGCTTCAC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MAAKDVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKLQNMGAQLVKEVASK
TSDNAGDGTTTATVLAQAIVREGSKYVAAGLNPMDLKRGIDKAVTALVAELKKASKATTTSKEIAQVGSISANSDESIGK
IIADAMDKVGKEGVITVEDGKSLDNELDVVEGMQFDRGYLSPYFINNPEKQAALLDNPFVLLFDKKISNIRDLLPTLEQV
AKAGRPLLIIAEEVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKVIAEEVGLTLEKVTLADLGQA
KRIEVGKENTTIIDGAGAAADIEARVKQIRIQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVAGGGVALLRAKQAAGDIKGDNPDQDAGIKLILKAIEAPLREIVANAGGEPSVVVNAVLNGKGNYGFNA
ANDTYGDMLEMGILDPTKVTRTALQNAASVASLLLTTEAMVAEAPKDDAPAPAMPDMGGMGGMGM

Sequences:

>Translated_545_residues
MAAKDVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKLQNMGAQLVKEVASK
TSDNAGDGTTTATVLAQAIVREGSKYVAAGLNPMDLKRGIDKAVTALVAELKKASKATTTSKEIAQVGSISANSDESIGK
IIADAMDKVGKEGVITVEDGKSLDNELDVVEGMQFDRGYLSPYFINNPEKQAALLDNPFVLLFDKKISNIRDLLPTLEQV
AKAGRPLLIIAEEVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKVIAEEVGLTLEKVTLADLGQA
KRIEVGKENTTIIDGAGAAADIEARVKQIRIQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVAGGGVALLRAKQAAGDIKGDNPDQDAGIKLILKAIEAPLREIVANAGGEPSVVVNAVLNGKGNYGFNA
ANDTYGDMLEMGILDPTKVTRTALQNAASVASLLLTTEAMVAEAPKDDAPAPAMPDMGGMGGMGM
>Mature_544_residues
AAKDVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKLQNMGAQLVKEVASKT
SDNAGDGTTTATVLAQAIVREGSKYVAAGLNPMDLKRGIDKAVTALVAELKKASKATTTSKEIAQVGSISANSDESIGKI
IADAMDKVGKEGVITVEDGKSLDNELDVVEGMQFDRGYLSPYFINNPEKQAALLDNPFVLLFDKKISNIRDLLPTLEQVA
KAGRPLLIIAEEVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKVIAEEVGLTLEKVTLADLGQAK
RIEVGKENTTIIDGAGAAADIEARVKQIRIQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGIVAGGGVALLRAKQAAGDIKGDNPDQDAGIKLILKAIEAPLREIVANAGGEPSVVVNAVLNGKGNYGFNAA
NDTYGDMLEMGILDPTKVTRTALQNAASVASLLLTTEAMVAEAPKDDAPAPAMPDMGGMGGMGM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=53.8899430740038, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=53.8899430740038, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI5453607, Length=548, Percent_Identity=23.7226277372263, Blast_Score=80, Evalue=7e-15,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=75.6143667296786, Blast_Score=793, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=53.875236294896, Blast_Score=553, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI193210679, Length=221, Percent_Identity=51.5837104072398, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI17564182, Length=543, Percent_Identity=21.731123388582, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=53.4220532319392, Blast_Score=542, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6322350, Length=557, Percent_Identity=23.1597845601436, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322524, Length=367, Percent_Identity=24.5231607629428, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322446, Length=571, Percent_Identity=21.3660245183888, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=52.561669829222, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=52.561669829222, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=51.3358778625954, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=51.3358778625954, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=51.3358778625954, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI17864606, Length=530, Percent_Identity=44.9056603773585, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24584129, Length=536, Percent_Identity=37.1268656716418, Blast_Score=339, Evalue=3e-93,
Organism=Drosophila melanogaster, GI19921262, Length=536, Percent_Identity=37.1268656716418, Blast_Score=339, Evalue=3e-93,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57008; Mature: 56877

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEI
CCCCCEEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDKLQNMGAQLVKEVASKTSDNAGDGTTTATVLAQAIVREGSKYVAAGLNPMDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHH
DKAVTALVAELKKASKATTTSKEIAQVGSISANSDESIGKIIADAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCC
KSLDNELDVVEGMQFDRGYLSPYFINNPEKQAALLDNPFVLLFDKKISNIRDLLPTLEQV
CCCCCHHHHHHCCCCCCCCCCCEEECCCHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHH
AKAGRPLLIIAEEVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHH
IAEEVGLTLEKVTLADLGQAKRIEVGKENTTIIDGAGAAADIEARVKQIRIQIEEATSDY
HHHHHCCCHHEEHHHHCCCCCEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCC
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAKQAAGDIKGDNPDQDAGIKLILKAIEAPLREIVANAGGEPSVVVNAVLNGKGNYGFNA
EEHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCC
ANDTYGDMLEMGILDPTKVTRTALQNAASVASLLLTTEAMVAEAPKDDAPAPAMPDMGGM
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GGMGM
CCCCC
>Mature Secondary Structure 
AAKDVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVLERSFGAPTVTKDGVSVAKEI
CCCCEEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDKLQNMGAQLVKEVASKTSDNAGDGTTTATVLAQAIVREGSKYVAAGLNPMDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHH
DKAVTALVAELKKASKATTTSKEIAQVGSISANSDESIGKIIADAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCC
KSLDNELDVVEGMQFDRGYLSPYFINNPEKQAALLDNPFVLLFDKKISNIRDLLPTLEQV
CCCCCHHHHHHCCCCCCCCCCCEEECCCHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHH
AKAGRPLLIIAEEVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHH
IAEEVGLTLEKVTLADLGQAKRIEVGKENTTIIDGAGAAADIEARVKQIRIQIEEATSDY
HHHHHCCCHHEEHHHHCCCCCEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCC
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAKQAAGDIKGDNPDQDAGIKLILKAIEAPLREIVANAGGEPSVVVNAVLNGKGNYGFNA
EEHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCC
ANDTYGDMLEMGILDPTKVTRTALQNAASVASLLLTTEAMVAEAPKDDAPAPAMPDMGGM
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GGMGM
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA