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The map label for this gene is zwf [H]

Identifier: 120609636

GI number: 120609636

Start: 1025980

End: 1027446

Strand: Reverse

Name: zwf [H]

Synonym: Aave_0942

Alternate gene names: 120609636

Gene position: 1027446-1025980 (Counterclockwise)

Preceding gene: 120609639

Following gene: 120609635

Centisome position: 19.19

GC content: 71.03

Gene sequence:

>1467_bases
ATGAGTTTCGATCTGGTCCTGTTCGGCGGCACGGGCGATCTGGCGTGGCGCAAATTGCTGCCCGCCCTCTTCCAGGCGTT
CCGGCACGGCTCGCTGCCGGCGGACGGCCGCATCATCGGCGTGGCGCGCGACGACCTGAGCGACGCGGCCTACCGGGAAC
TCATCGCCAGCCGGTTCGCCGCGGTGGAAGGGGACAAGCGGCCCAGCGCCGAGGAGTTCGAGCGCTTCGCCGCGCTGCTC
CATTTCCAGCGCATGGACCTCTCCAAGCCCGCCGACTATGCCGCGCTGGCCGCGCGCCTCGGCGAGCGGCAGGCCGACAC
CGTGGTGATGTACCTCGCGACCGCGCCGGGCCTCTTCACCACGGCCTGCGAGCAACTGGGTGCCGCGGGCCTCGCCACGC
CGCACACGCGGGTGGTGCTGGAAAAGCCCCTGGGCCACGACCTGGCCTCCAACCGCGCCATCAACGCCGCCGTGCGCCGC
GTGTTCGACGAAGAGCAGATCTTCCGCATCGACCACTACCTGGGCAAGCCGTCGGTGCAGAACCTGCTGGCGCTGCGCTT
CGGCAACGCCCTGTTCGAGCCGCTCTGGCGCCGCGAGACCGTGGCCAGCATCGAGATCACCATGGCCGAGAAGCTCGGCG
TCGAAAAGCGCGGCGCCTTCTACGACGGCACGGGCGCGCTGCGCGACATGGTGCAGAACCACGCACTGCAGCTGCTCTGC
GCCATCGGCATGGAGCCGCCCATCAACGCCCATGCCGACGCCATCCGTGACGAGAAGCTCAAGGTGCTGCGCTCGCTGGT
GCCCTGGACCCCGGCCACGCTGTCGCGGGACGTGGTGCGCGGCCAGTACACCGCCGGCTCGCTGGGCGGCGAGCGCGTGC
GCGGCTATGCCGAGGAAGACGGCGTGCCCGCGGACAGCCGCACGGAGACCTTCGTGGCGCTGCGCACCGAAATCGCCAAC
TGGCGCTGGGCGGGCGTGCCGTTCTACGTCCGCACCGGCAAGCGGCTGGCCTCGCACGAGGCGCACATCGCCATCAACTT
CCGGCCCACGCCGCACGCCATCTACCGCACGCCGCTGGGCAGCGCCAACCGCCTCGTGATCCACCTGCAGCCGCGCGACG
GCGTGGCGCTGCACCTCTTCGCCGCGGGCCAGGAAAAGCGCGGCATGCGCATCTCGGAAGTGCAGGCCCTGGCCCCCGTC
CACCTGGACCTGGACTTCGAGCAGCGCTTCGGCACGGAGCGGGTGGGCGCCTACGAACGCCTGCTGCTCGACGTGATCGC
CGGGCGGCTGAACCTCTTCGTGCGCGCCGACGAGCAGGAAGCGGCGTGGCGCTGGGTCGAGCCCATCATGCAATCCTGGC
GCGACTCGGAAGACGGCCCACGGCCCTACGCCGCCGGCAGCTGGGGGCCCAGTGCCGCGAGCGCCATGGTGGCGCGCGAG
GGGCATAGCTGGATGGAGGAGTCTTGA

Upstream 100 bases:

>100_bases
ACTCGGTAACATGCCGCCACGGCCGCGCGGGTGCCACCCGCGCTGTCACGGTTTTCGTTTTCCATCCATCACACCTTCAG
ACTTCGGGAGCGCGGCGGCA

Downstream 100 bases:

>100_bases
AACACCCCCCTGAGCGGCTGCGCCGCATCCCCCCGCTCTCGCCGTGCTGCGCACGGCGGGCAGGGGGACGACGCCGGTGG
CCCGGCAAAGCCGGTTCCAC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MSFDLVLFGGTGDLAWRKLLPALFQAFRHGSLPADGRIIGVARDDLSDAAYRELIASRFAAVEGDKRPSAEEFERFAALL
HFQRMDLSKPADYAALAARLGERQADTVVMYLATAPGLFTTACEQLGAAGLATPHTRVVLEKPLGHDLASNRAINAAVRR
VFDEEQIFRIDHYLGKPSVQNLLALRFGNALFEPLWRRETVASIEITMAEKLGVEKRGAFYDGTGALRDMVQNHALQLLC
AIGMEPPINAHADAIRDEKLKVLRSLVPWTPATLSRDVVRGQYTAGSLGGERVRGYAEEDGVPADSRTETFVALRTEIAN
WRWAGVPFYVRTGKRLASHEAHIAINFRPTPHAIYRTPLGSANRLVIHLQPRDGVALHLFAAGQEKRGMRISEVQALAPV
HLDLDFEQRFGTERVGAYERLLLDVIAGRLNLFVRADEQEAAWRWVEPIMQSWRDSEDGPRPYAAGSWGPSAASAMVARE
GHSWMEES

Sequences:

>Translated_488_residues
MSFDLVLFGGTGDLAWRKLLPALFQAFRHGSLPADGRIIGVARDDLSDAAYRELIASRFAAVEGDKRPSAEEFERFAALL
HFQRMDLSKPADYAALAARLGERQADTVVMYLATAPGLFTTACEQLGAAGLATPHTRVVLEKPLGHDLASNRAINAAVRR
VFDEEQIFRIDHYLGKPSVQNLLALRFGNALFEPLWRRETVASIEITMAEKLGVEKRGAFYDGTGALRDMVQNHALQLLC
AIGMEPPINAHADAIRDEKLKVLRSLVPWTPATLSRDVVRGQYTAGSLGGERVRGYAEEDGVPADSRTETFVALRTEIAN
WRWAGVPFYVRTGKRLASHEAHIAINFRPTPHAIYRTPLGSANRLVIHLQPRDGVALHLFAAGQEKRGMRISEVQALAPV
HLDLDFEQRFGTERVGAYERLLLDVIAGRLNLFVRADEQEAAWRWVEPIMQSWRDSEDGPRPYAAGSWGPSAASAMVARE
GHSWMEES
>Mature_487_residues
SFDLVLFGGTGDLAWRKLLPALFQAFRHGSLPADGRIIGVARDDLSDAAYRELIASRFAAVEGDKRPSAEEFERFAALLH
FQRMDLSKPADYAALAARLGERQADTVVMYLATAPGLFTTACEQLGAAGLATPHTRVVLEKPLGHDLASNRAINAAVRRV
FDEEQIFRIDHYLGKPSVQNLLALRFGNALFEPLWRRETVASIEITMAEKLGVEKRGAFYDGTGALRDMVQNHALQLLCA
IGMEPPINAHADAIRDEKLKVLRSLVPWTPATLSRDVVRGQYTAGSLGGERVRGYAEEDGVPADSRTETFVALRTEIANW
RWAGVPFYVRTGKRLASHEAHIAINFRPTPHAIYRTPLGSANRLVIHLQPRDGVALHLFAAGQEKRGMRISEVQALAPVH
LDLDFEQRFGTERVGAYERLLLDVIAGRLNLFVRADEQEAAWRWVEPIMQSWRDSEDGPRPYAAGSWGPSAASAMVAREG
HSWMEES

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=487, Percent_Identity=34.4969199178645, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI108773793, Length=487, Percent_Identity=34.4969199178645, Blast_Score=286, Evalue=4e-77,
Organism=Homo sapiens, GI52145310, Length=511, Percent_Identity=28.7671232876712, Blast_Score=152, Evalue=9e-37,
Organism=Escherichia coli, GI1788158, Length=488, Percent_Identity=44.2622950819672, Blast_Score=409, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17538218, Length=492, Percent_Identity=35.5691056910569, Blast_Score=295, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6324088, Length=497, Percent_Identity=33.6016096579477, Blast_Score=259, Evalue=6e-70,
Organism=Drosophila melanogaster, GI24643350, Length=476, Percent_Identity=34.8739495798319, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24643352, Length=476, Percent_Identity=34.8739495798319, Blast_Score=269, Evalue=4e-72,
Organism=Drosophila melanogaster, GI221513548, Length=493, Percent_Identity=30.4259634888438, Blast_Score=210, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54109; Mature: 53978

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDLVLFGGTGDLAWRKLLPALFQAFRHGSLPADGRIIGVARDDLSDAAYRELIASRFA
CCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHH
AVEGDKRPSAEEFERFAALLHFQRMDLSKPADYAALAARLGERQADTVVMYLATAPGLFT
HHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCHHH
TACEQLGAAGLATPHTRVVLEKPLGHDLASNRAINAAVRRVFDEEQIFRIDHYLGKPSVQ
HHHHHHCCCCCCCCCCEEEEECCCCCCHHCCHHHHHHHHHHHCHHHHHHHHHHCCCCHHH
NLLALRFGNALFEPLWRRETVASIEITMAEKLGVEKRGAFYDGTGALRDMVQNHALQLLC
HHHHHHHHHHHHHHHHHHHHHHEEEEEEHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHH
AIGMEPPINAHADAIRDEKLKVLRSLVPWTPATLSRDVVRGQYTAGSLGGERVRGYAEED
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHCCCHHHC
GVPADSRTETFVALRTEIANWRWAGVPFYVRTGKRLASHEAHIAINFRPTPHAIYRTPLG
CCCCCCCCHHHHEEHHHHCCCEECCCCEEEECCCHHHCCCCEEEEEECCCCCCEEECCCC
SANRLVIHLQPRDGVALHLFAAGQEKRGMRISEVQALAPVHLDLDFEQRFGTERVGAYER
CCCEEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHCCEEEECCHHHHCCCHHHHHHHH
LLLDVIAGRLNLFVRADEQEAAWRWVEPIMQSWRDSEDGPRPYAAGSWGPSAASAMVARE
HHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHC
GHSWMEES
CCHHCCCC
>Mature Secondary Structure 
SFDLVLFGGTGDLAWRKLLPALFQAFRHGSLPADGRIIGVARDDLSDAAYRELIASRFA
CEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHH
AVEGDKRPSAEEFERFAALLHFQRMDLSKPADYAALAARLGERQADTVVMYLATAPGLFT
HHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCHHH
TACEQLGAAGLATPHTRVVLEKPLGHDLASNRAINAAVRRVFDEEQIFRIDHYLGKPSVQ
HHHHHHCCCCCCCCCCEEEEECCCCCCHHCCHHHHHHHHHHHCHHHHHHHHHHCCCCHHH
NLLALRFGNALFEPLWRRETVASIEITMAEKLGVEKRGAFYDGTGALRDMVQNHALQLLC
HHHHHHHHHHHHHHHHHHHHHHEEEEEEHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHH
AIGMEPPINAHADAIRDEKLKVLRSLVPWTPATLSRDVVRGQYTAGSLGGERVRGYAEED
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHCCCHHHC
GVPADSRTETFVALRTEIANWRWAGVPFYVRTGKRLASHEAHIAINFRPTPHAIYRTPLG
CCCCCCCCHHHHEEHHHHCCCEECCCCEEEECCCHHHCCCCEEEEEECCCCCCEEECCCC
SANRLVIHLQPRDGVALHLFAAGQEKRGMRISEVQALAPVHLDLDFEQRFGTERVGAYER
CCCEEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHCCEEEECCHHHHCCCHHHHHHHH
LLLDVIAGRLNLFVRADEQEAAWRWVEPIMQSWRDSEDGPRPYAAGSWGPSAASAMVARE
HHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHC
GHSWMEES
CCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]