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The map label for this gene is accC [H]

Identifier: 120609552

GI number: 120609552

Start: 928320

End: 929669

Strand: Direct

Name: accC [H]

Synonym: Aave_0858

Alternate gene names: 120609552

Gene position: 928320-929669 (Clockwise)

Preceding gene: 120609551

Following gene: 120609553

Centisome position: 17.34

GC content: 66.59

Gene sequence:

>1350_bases
ATGTTTAAAAAGATCCTTGTCGCCAATCGCGGCGAAATCGCCCTGCGCATCCAGCGCGCCTGCCATGAGCTGGGCGTGAA
GGCCGTCATGGTGTATTCCGAGGCCGATCGCGACGCCAAGTACGTCAAGCTGGCCGAAGAGGCCGTGTGCATCGGCCCCG
CGCCGTCGCCGCTGTCCTATCTCAACATGCCGGCGATCATCTCGGCCGCCGAGGTGACCGACGCCGAGGCCATCCACCCC
GGCTACGGCTTCCTGTCCGAGAACGCCGACTTCGCCGAGCGCGTGGAAAAGAGCGGCTTCCAGTTCATCGGCCCCACGCC
CGAGTCCATCCGCACGATGGGCGACAAGGTGTCGGCCAAGCAGGCCATGATCCGCGCGGGCGTGCCCTGCGTGCCGGGCT
CGGACGGCGAGCTGCCCGACGATCCGGTGCAGATCCGCCGCATCGCGCGCAGCGTCGGCTATCCCGTCATCATCAAGGCG
GCGGGCGGCGGCGGCGGGCGCGGCATGCGCGTGGTGCACACCGAGGCCGCCCTGGTGAACGCCGTGCAGATGACCAAGGC
CGAGGCCCAGGCCGCGTTCGGCAACCCGGCCGTCTACATGGAGAAGTTCCTCCAGAACCCGCGCCACATCGAAATCCAGG
TGCTGGCCGACAAGTTCCGCAATGCGGTCTATCTGGGTGAGCGCGACTGTTCCATGCAGCGCCGCCACCAGAAGGTGATC
GAGGAAGCGCCGGCGCCCGGCATTCCGCGCAAGCTCATCGAGAAGATCGGCGAGCGCTGCGTGGCCGCCTGCAAGAAGAT
CGGCTACCGCGGCGCGGGCACGTTCGAGTTCCTCTACGAGAACGGCGAGTTCTACTTCATCGAGATGAACACGCGCGTGC
AGGTCGAGCACCCGGTGACGGAGTGGATCACGGGCGTGGACATCGTGAAGACGCAGATCATGGTCGCCGCGGGCGAGAAG
CTGCCCTTCACCCAGCGCCAGATCGAGATCCGCGGCCATGCCATCGAATGCCGCGTGAACGCGGAGGACGCCTACAAGTT
CACCCCCTCGCCCGGCCGCATCACCATGTGGCACGCGCCGGGCGGCCCGGGCGTGCGCGTGGATTCGCACGCCTACACCA
ACTACTACGTGCCGCCCAACTACGACTCCATGATCGGCAAGATCATCGTGCACGGCGACACGCGCGAGCAGGCCCTGGCC
CGCATGCGCACGGCCCTGTCCGAGACCGTGATCGAGGGCATCAACACCAACATCCCGCTGCACCGCGAGCTGATGGTGGA
TGCCAAGTTCGTCGCCGGGGGCACGAACATCCATTACCTGGAAGAGTGGCTGGGCGCGCACAAGCGCTGA

Upstream 100 bases:

>100_bases
AAAGATCCTTGTCGCCAATCGCGGCGTACTTGCCGCGGGCAAGGCGAAGCAAAGCGCCCTGGCACGCGCCAGCGTGCGGC
GATGAGCCGCGAGAGAGCCT

Downstream 100 bases:

>100_bases
CCGGCACCGGCCCGACGCCGGTCACTGGCATGCTGGCCGCCCGGAGACGGGGGCCAGCATTGTCGTTTCTGCAGGAGATT
GACATCCATGTTTGAGCTGA

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFKKILVANRGEIALRIQRACHELGVKAVMVYSEADRDAKYVKLAEEAVCIGPAPSPLSYLNMPAIISAAEVTDAEAIHP
GYGFLSENADFAERVEKSGFQFIGPTPESIRTMGDKVSAKQAMIRAGVPCVPGSDGELPDDPVQIRRIARSVGYPVIIKA
AGGGGGRGMRVVHTEAALVNAVQMTKAEAQAAFGNPAVYMEKFLQNPRHIEIQVLADKFRNAVYLGERDCSMQRRHQKVI
EEAPAPGIPRKLIEKIGERCVAACKKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTEWITGVDIVKTQIMVAAGEK
LPFTQRQIEIRGHAIECRVNAEDAYKFTPSPGRITMWHAPGGPGVRVDSHAYTNYYVPPNYDSMIGKIIVHGDTREQALA
RMRTALSETVIEGINTNIPLHRELMVDAKFVAGGTNIHYLEEWLGAHKR

Sequences:

>Translated_449_residues
MFKKILVANRGEIALRIQRACHELGVKAVMVYSEADRDAKYVKLAEEAVCIGPAPSPLSYLNMPAIISAAEVTDAEAIHP
GYGFLSENADFAERVEKSGFQFIGPTPESIRTMGDKVSAKQAMIRAGVPCVPGSDGELPDDPVQIRRIARSVGYPVIIKA
AGGGGGRGMRVVHTEAALVNAVQMTKAEAQAAFGNPAVYMEKFLQNPRHIEIQVLADKFRNAVYLGERDCSMQRRHQKVI
EEAPAPGIPRKLIEKIGERCVAACKKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTEWITGVDIVKTQIMVAAGEK
LPFTQRQIEIRGHAIECRVNAEDAYKFTPSPGRITMWHAPGGPGVRVDSHAYTNYYVPPNYDSMIGKIIVHGDTREQALA
RMRTALSETVIEGINTNIPLHRELMVDAKFVAGGTNIHYLEEWLGAHKR
>Mature_449_residues
MFKKILVANRGEIALRIQRACHELGVKAVMVYSEADRDAKYVKLAEEAVCIGPAPSPLSYLNMPAIISAAEVTDAEAIHP
GYGFLSENADFAERVEKSGFQFIGPTPESIRTMGDKVSAKQAMIRAGVPCVPGSDGELPDDPVQIRRIARSVGYPVIIKA
AGGGGGRGMRVVHTEAALVNAVQMTKAEAQAAFGNPAVYMEKFLQNPRHIEIQVLADKFRNAVYLGERDCSMQRRHQKVI
EEAPAPGIPRKLIEKIGERCVAACKKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTEWITGVDIVKTQIMVAAGEK
LPFTQRQIEIRGHAIECRVNAEDAYKFTPSPGRITMWHAPGGPGVRVDSHAYTNYYVPPNYDSMIGKIIVHGDTREQALA
RMRTALSETVIEGINTNIPLHRELMVDAKFVAGGTNIHYLEEWLGAHKR

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=47.7272727272727, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=48.0898876404494, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=48.0898876404494, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=48.0898876404494, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=46.0850111856823, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=46.0850111856823, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=46.0850111856823, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI38679974, Length=479, Percent_Identity=30.6889352818372, Blast_Score=215, Evalue=8e-56,
Organism=Homo sapiens, GI38679960, Length=479, Percent_Identity=30.6889352818372, Blast_Score=215, Evalue=9e-56,
Organism=Homo sapiens, GI38679971, Length=479, Percent_Identity=30.6889352818372, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI38679977, Length=479, Percent_Identity=30.6889352818372, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI38679967, Length=479, Percent_Identity=30.6889352818372, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI134142062, Length=480, Percent_Identity=30.4166666666667, Blast_Score=210, Evalue=2e-54,
Organism=Escherichia coli, GI1789654, Length=449, Percent_Identity=67.4832962138085, Blast_Score=603, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI17567343, Length=445, Percent_Identity=48.0898876404494, Blast_Score=411, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=47.1655328798186, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=44.2222222222222, Blast_Score=352, Evalue=3e-97,
Organism=Caenorhabditis elegans, GI133931226, Length=487, Percent_Identity=28.952772073922, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI71997168, Length=510, Percent_Identity=27.6470588235294, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71997163, Length=510, Percent_Identity=27.6470588235294, Blast_Score=183, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319695, Length=450, Percent_Identity=46.6666666666667, Blast_Score=348, Evalue=9e-97,
Organism=Saccharomyces cerevisiae, GI6319685, Length=446, Percent_Identity=39.9103139013453, Blast_Score=347, Evalue=3e-96,
Organism=Saccharomyces cerevisiae, GI6321376, Length=450, Percent_Identity=47.1111111111111, Blast_Score=342, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6323863, Length=455, Percent_Identity=31.4285714285714, Blast_Score=209, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6324343, Length=484, Percent_Identity=29.3388429752066, Blast_Score=204, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24652212, Length=451, Percent_Identity=48.1152993348115, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652210, Length=451, Percent_Identity=48.1152993348115, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652214, Length=451, Percent_Identity=48.1152993348115, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI19921944, Length=451, Percent_Identity=48.1152993348115, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652216, Length=451, Percent_Identity=48.1152993348115, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI281363050, Length=451, Percent_Identity=48.1152993348115, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652224, Length=451, Percent_Identity=48.1152993348115, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652222, Length=451, Percent_Identity=48.1152993348115, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652220, Length=451, Percent_Identity=48.1152993348115, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652218, Length=451, Percent_Identity=48.1152993348115, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24651757, Length=443, Percent_Identity=43.7923250564334, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24651759, Length=406, Percent_Identity=43.3497536945813, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=28.6282306163022, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=28.6282306163022, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=28.6282306163022, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=28.6282306163022, Blast_Score=199, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49560; Mature: 49560

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKILVANRGEIALRIQRACHELGVKAVMVYSEADRDAKYVKLAEEAVCIGPAPSPLSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHCCEEEECCCCCCHHH
LNMPAIISAAEVTDAEAIHPGYGFLSENADFAERVEKSGFQFIGPTPESIRTMGDKVSAK
CCCCHHEEHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCHHHHHHHCCHHHHH
QAMIRAGVPCVPGSDGELPDDPVQIRRIARSVGYPVIIKAAGGGGGRGMRVVHTEAALVN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AVQMTKAEAQAAFGNPAVYMEKFLQNPRHIEIQVLADKFRNAVYLGERDCSMQRRHQKVI
HHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEEHHHCCEEEECCCCHHHHHHHHHHH
EEAPAPGIPRKLIEKIGERCVAACKKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EWITGVDIVKTQIMVAAGEKLPFTQRQIEIRGHAIECRVNAEDAYKFTPSPGRITMWHAP
HHHCCHHHHHHEEEEECCCCCCCCCEEEEEECEEEEEEECCCCCEEECCCCCEEEEEECC
GGPGVRVDSHAYTNYYVPPNYDSMIGKIIVHGDTREQALARMRTALSETVIEGINTNIPL
CCCCCEECCCCCEEEECCCCHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCC
HRELMVDAKFVAGGTNIHYLEEWLGAHKR
CHHHEEEEEEEECCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MFKKILVANRGEIALRIQRACHELGVKAVMVYSEADRDAKYVKLAEEAVCIGPAPSPLSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHCCEEEECCCCCCHHH
LNMPAIISAAEVTDAEAIHPGYGFLSENADFAERVEKSGFQFIGPTPESIRTMGDKVSAK
CCCCHHEEHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCHHHHHHHCCHHHHH
QAMIRAGVPCVPGSDGELPDDPVQIRRIARSVGYPVIIKAAGGGGGRGMRVVHTEAALVN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AVQMTKAEAQAAFGNPAVYMEKFLQNPRHIEIQVLADKFRNAVYLGERDCSMQRRHQKVI
HHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEEHHHCCEEEECCCCHHHHHHHHHHH
EEAPAPGIPRKLIEKIGERCVAACKKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EWITGVDIVKTQIMVAAGEKLPFTQRQIEIRGHAIECRVNAEDAYKFTPSPGRITMWHAP
HHHCCHHHHHHEEEEECCCCCCCCCEEEEEECEEEEEEECCCCCEEECCCCCEEEEEECC
GGPGVRVDSHAYTNYYVPPNYDSMIGKIIVHGDTREQALARMRTALSETVIEGINTNIPL
CCCCCEECCCCCEEEECCCCHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCC
HRELMVDAKFVAGGTNIHYLEEWLGAHKR
CHHHEEEEEEEECCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9560425 [H]