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The map label for this gene is lpxC

Identifier: 120609521

GI number: 120609521

Start: 896685

End: 897608

Strand: Direct

Name: lpxC

Synonym: Aave_0827

Alternate gene names: 120609521

Gene position: 896685-897608 (Clockwise)

Preceding gene: 120609520

Following gene: 120609522

Centisome position: 16.75

GC content: 67.64

Gene sequence:

>924_bases
ATGCTCCAGCAACGCACGATCAAGACCCTCACCCGCGCCGTCGGCGTGGGCCTGCACAGTGGCCAGCGGGTCGAGCTCAC
GTTGCGTCCCGCCGCGCCGGATACGGGCATCGTGTTCCGCCGCGTCGATCTGCCCGAACCCGTGGACATCCCGATCCGGG
CCGAATCCGTCGTGGATACGCGCATGGCCTCCACCATCGGCGTGGGCGGTGCCAAGGTGCATACGGTCGAGCATTTGATG
TCGGCCTGCGCGGGCCTGGGGCTGGACAACCTCTACATCGACATCACGGCCGAGGAGGTGCCCATCCTCGACGGCTCGTC
GGCCTCCTTCGTGTTCCTGCTGCAGAGCGCCGGCGTGGTGCTGCAGAACGCGCCCAAGAAGTTCATCCGCGTCACGCGTC
CCGTCGAGGTGCGCGAGGGCGAGGGCCAGCAGCTCAAGTGGGCGCGGCTGGAGCCCTACCACGGCTACAAGCTGCGCTTC
GAGATCGACTTCGCCCACCCTGCGGTGGATTCCACCGGCCAGAGCGTCGAGTTCGATCTCGGCTCGGGCAACTACACGCG
CGACATCGCGCGTGCCCGCACCTTCGGCTTCACGAAGGACGTGGAGATGATGCGCGCGAGCGGCCTGGCCCTGGGCGGCG
GGTTGGACAACGCCATCGTCATGGACGACTACAAGGTGCTCAATGCCGACGGCCTGCGCTACGACGACGAGTTCGTGAAG
CACAAGATCCTCGACGCCATCGGTGATCTCTACATCGTCGGCCGGCCGCTGCTGGCGGCCTACAGCGCGTTCCGTTCGGG
CCACGCGATGAACAACCGGCTGCTGCGCGAACTGCTGGCCCACGAGGACGCGTGGGAGATCGCCACGTTCGAGAGCGAGC
GGCAGGCACCCAGCGGGTTCGCCGCCCCCGTGCAGGCCTGGTGA

Upstream 100 bases:

>100_bases
AGGAGCCGGGCGGCTTTTTGTTTCCGTTGTGACGCATGCGCTATGAATGGCATAGCCATCTGTGCGGGCAGGGACGGGTG
CCGCCACCTAAAATTGCGGG

Downstream 100 bases:

>100_bases
GGCCCCGCCATGCTGCTGTTCCGCGGTCTCTTCTTCTTCCTGCTGCTGCTGGCGGTGGTGTCGTTCGTGTTCTACGTGGC
CACCGGGCAGCCGCGCTACA

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine; Acetate. [C]

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MLQQRTIKTLTRAVGVGLHSGQRVELTLRPAAPDTGIVFRRVDLPEPVDIPIRAESVVDTRMASTIGVGGAKVHTVEHLM
SACAGLGLDNLYIDITAEEVPILDGSSASFVFLLQSAGVVLQNAPKKFIRVTRPVEVREGEGQQLKWARLEPYHGYKLRF
EIDFAHPAVDSTGQSVEFDLGSGNYTRDIARARTFGFTKDVEMMRASGLALGGGLDNAIVMDDYKVLNADGLRYDDEFVK
HKILDAIGDLYIVGRPLLAAYSAFRSGHAMNNRLLRELLAHEDAWEIATFESERQAPSGFAAPVQAW

Sequences:

>Translated_307_residues
MLQQRTIKTLTRAVGVGLHSGQRVELTLRPAAPDTGIVFRRVDLPEPVDIPIRAESVVDTRMASTIGVGGAKVHTVEHLM
SACAGLGLDNLYIDITAEEVPILDGSSASFVFLLQSAGVVLQNAPKKFIRVTRPVEVREGEGQQLKWARLEPYHGYKLRF
EIDFAHPAVDSTGQSVEFDLGSGNYTRDIARARTFGFTKDVEMMRASGLALGGGLDNAIVMDDYKVLNADGLRYDDEFVK
HKILDAIGDLYIVGRPLLAAYSAFRSGHAMNNRLLRELLAHEDAWEIATFESERQAPSGFAAPVQAW
>Mature_307_residues
MLQQRTIKTLTRAVGVGLHSGQRVELTLRPAAPDTGIVFRRVDLPEPVDIPIRAESVVDTRMASTIGVGGAKVHTVEHLM
SACAGLGLDNLYIDITAEEVPILDGSSASFVFLLQSAGVVLQNAPKKFIRVTRPVEVREGEGQQLKWARLEPYHGYKLRF
EIDFAHPAVDSTGQSVEFDLGSGNYTRDIARARTFGFTKDVEMMRASGLALGGGLDNAIVMDDYKVLNADGLRYDDEFVK
HKILDAIGDLYIVGRPLLAAYSAFRSGHAMNNRLLRELLAHEDAWEIATFESERQAPSGFAAPVQAW

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=304, Percent_Identity=49.671052631579, Blast_Score=335, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_ACIAC (A1TKD7)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969199.1
- ProteinModelPortal:   A1TKD7
- SMR:   A1TKD7
- STRING:   A1TKD7
- GeneID:   4668143
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_0827
- NMPDR:   fig|397945.5.peg.718
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- PhylomeDB:   A1TKD7
- ProtClustDB:   PRK13186
- BioCyc:   AAVE397945:AAVE_0827-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.- [C]

Molecular weight: Translated: 33693; Mature: 33693

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQQRTIKTLTRAVGVGLHSGQRVELTLRPAAPDTGIVFRRVDLPEPVDIPIRAESVVDT
CCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCEEHHHHHHH
RMASTIGVGGAKVHTVEHLMSACAGLGLDNLYIDITAEEVPILDGSSASFVFLLQSAGVV
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCCEEEEEECCCEE
LQNAPKKFIRVTRPVEVREGEGQQLKWARLEPYHGYKLRFEIDFAHPAVDSTGQSVEFDL
ECCCCHHHHEECCCEEEECCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCCCCEEEEEC
GSGNYTRDIARARTFGFTKDVEMMRASGLALGGGLDNAIVMDDYKVLNADGLRYDDEFVK
CCCCCHHHHHHHHHCCCCHHHHHHHHCCEEECCCCCCEEEECCEEEECCCCCCCCHHHHH
HKILDAIGDLYIVGRPLLAAYSAFRSGHAMNNRLLRELLAHEDAWEIATFESERQAPSGF
HHHHHHHCCEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCHHCCCCCCC
AAPVQAW
CCCCCCC
>Mature Secondary Structure
MLQQRTIKTLTRAVGVGLHSGQRVELTLRPAAPDTGIVFRRVDLPEPVDIPIRAESVVDT
CCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCEEHHHHHHH
RMASTIGVGGAKVHTVEHLMSACAGLGLDNLYIDITAEEVPILDGSSASFVFLLQSAGVV
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCCEEEEEECCCEE
LQNAPKKFIRVTRPVEVREGEGQQLKWARLEPYHGYKLRFEIDFAHPAVDSTGQSVEFDL
ECCCCHHHHEECCCEEEECCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCCCCEEEEEC
GSGNYTRDIARARTFGFTKDVEMMRASGLALGGGLDNAIVMDDYKVLNADGLRYDDEFVK
CCCCCHHHHHHHHHCCCCHHHHHHHHCCEEECCCCCCEEEECCEEEECCCCCCCCHHHHH
HKILDAIGDLYIVGRPLLAAYSAFRSGHAMNNRLLRELLAHEDAWEIATFESERQAPSGF
HHHHHHHCCEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCHHCCCCCCC
AAPVQAW
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine; H2O [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine + H2O = UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine + Acetate. [C]

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA