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The map label for this gene is mraW

Identifier: 120609507

GI number: 120609507

Start: 878785

End: 879720

Strand: Direct

Name: mraW

Synonym: Aave_0813

Alternate gene names: 120609507

Gene position: 878785-879720 (Clockwise)

Preceding gene: 120609506

Following gene: 120609508

Centisome position: 16.42

GC content: 69.98

Gene sequence:

>936_bases
ATGGCGGACACCACGACACTGCTGCACACCACCGTCCTGCTGGACGAGGCGGTCGATGCCCTGCTGGGGGGCGCCGGCCC
TGCGCCCGCCGGCGTCTGGATCGACGCGACCTTCGGCCGCGGCGGGCATTCCCGCCGGATACTGGAGAGGCTCGGGCCGG
ATGGCCGCCTCGTGGCCTTCGACAAGGACCCCGAGGCGATCCACGAAGCAGCGCGCATCACCGATGCGCGCTTTTCCATT
CGGCACGAGGGTTTCCGCCACCTGGCCGACCTGCCCGAGCGCAGCGCGGCTGGCATCCTCATGGATCTGGGCGTGAGTTC
GCCGCAGATCGACAGCCCGGAGCGCGGCTTCAGCTTCCGGTTCGACGGCCCCCTGGACATGCGCATGGACACCACGCGCG
GCGAGAGCGTGGCCGACTGGCTGGCGACGGCCGACGTGGGGCAGATTGCGGAGGTGATTCGTGAATACGGTGAAGAACGG
TTTGCTGGCCCCATTGCAAAGGCGATTGCTGCTCGGCGCGCGGAGCGCGGCCCGCTGCGCACCACTTCCGAGCTGGCCCA
GCTCGTGGCTGGCGCGGTCAAGACCCGCGAAGCCGGCCAGAACCCCGCGACCCGGACCTTTCAGGCTCTTCGGATTTTCA
TCAACGCAGAACTTGAGGAGCTGCAGGCCGCGCTAGAGGCCAGCCTGCGCGTGCTCGCGCCGGGCGGCCGGCTCGCGGTC
ATCAGCTTCCACTCGCTCGAAGACCGCATCGTCAAGCAGTTCATCGCGCAGCACTCCAGGGAGGTCTATGACCGCCGCGC
GCCCTTCGCCGCCCCGCAGCCGATGCGGCTGAAGGCGCTGGACCGCATCAAGCCGGGCGCCTGCGAGGTGGATGCCAACC
CGCGCGCGCGCAGCGCCGTGATGCGCGTGGCCGAGCGCACGGAGGTGCCGGCATGA

Upstream 100 bases:

>100_bases
ACTTCGAGCTCTGGGACAAGGCCACCTACGAGGCCCAGGAAGCCCAGGCCATGCAGGGCGAGATGCCCGAAGCCTTCAAG
GACTTTTCTTTCTGAAGGCC

Downstream 100 bases:

>100_bases
CGCGCCTGAGCCTCGTGCTGCTGCTGGGCGTGCTGGCCAGCGCCCTCTACCTCGTGCACACGCAGTACGAGTCGCGCCTG
CTGTTCACCGAGCTGGACCG

Product: S-adenosyl-methyltransferase MraW

Products: NA

Alternate protein names: 16S rRNA m(4)C1402 methyltransferase; rRNA (cytosine-N(4)-)-methyltransferase RsmH

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MADTTTLLHTTVLLDEAVDALLGGAGPAPAGVWIDATFGRGGHSRRILERLGPDGRLVAFDKDPEAIHEAARITDARFSI
RHEGFRHLADLPERSAAGILMDLGVSSPQIDSPERGFSFRFDGPLDMRMDTTRGESVADWLATADVGQIAEVIREYGEER
FAGPIAKAIAARRAERGPLRTTSELAQLVAGAVKTREAGQNPATRTFQALRIFINAELEELQAALEASLRVLAPGGRLAV
ISFHSLEDRIVKQFIAQHSREVYDRRAPFAAPQPMRLKALDRIKPGACEVDANPRARSAVMRVAERTEVPA

Sequences:

>Translated_311_residues
MADTTTLLHTTVLLDEAVDALLGGAGPAPAGVWIDATFGRGGHSRRILERLGPDGRLVAFDKDPEAIHEAARITDARFSI
RHEGFRHLADLPERSAAGILMDLGVSSPQIDSPERGFSFRFDGPLDMRMDTTRGESVADWLATADVGQIAEVIREYGEER
FAGPIAKAIAARRAERGPLRTTSELAQLVAGAVKTREAGQNPATRTFQALRIFINAELEELQAALEASLRVLAPGGRLAV
ISFHSLEDRIVKQFIAQHSREVYDRRAPFAAPQPMRLKALDRIKPGACEVDANPRARSAVMRVAERTEVPA
>Mature_310_residues
ADTTTLLHTTVLLDEAVDALLGGAGPAPAGVWIDATFGRGGHSRRILERLGPDGRLVAFDKDPEAIHEAARITDARFSIR
HEGFRHLADLPERSAAGILMDLGVSSPQIDSPERGFSFRFDGPLDMRMDTTRGESVADWLATADVGQIAEVIREYGEERF
AGPIAKAIAARRAERGPLRTTSELAQLVAGAVKTREAGQNPATRTFQALRIFINAELEELQAALEASLRVLAPGGRLAVI
SFHSLEDRIVKQFIAQHSREVYDRRAPFAAPQPMRLKALDRIKPGACEVDANPRARSAVMRVAERTEVPA

Specific function: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA

COG id: COG0275

COG function: function code M; Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmH family

Homologues:

Organism=Homo sapiens, GI165377209, Length=350, Percent_Identity=38, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI165377202, Length=206, Percent_Identity=38.3495145631068, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1786270, Length=313, Percent_Identity=54.9520766773163, Blast_Score=308, Evalue=4e-85,
Organism=Drosophila melanogaster, GI62472493, Length=344, Percent_Identity=36.9186046511628, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI28571637, Length=344, Percent_Identity=36.9186046511628, Blast_Score=176, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RSMH_ACIAC (A1TKC3)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969185.1
- ProteinModelPortal:   A1TKC3
- SMR:   A1TKC3
- STRING:   A1TKC3
- GeneID:   4668563
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_0813
- eggNOG:   COG0275
- HOGENOM:   HBG302779
- OMA:   PQLDDPE
- PhylomeDB:   A1TKC3
- ProtClustDB:   PRK00050
- BioCyc:   AAVE397945:AAVE_0813-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01007
- InterPro:   IPR002903
- PANTHER:   PTHR11265
- PIRSF:   PIRSF004486
- TIGRFAMs:   TIGR00006

Pfam domain/function: PF01795 Methyltransf_5

EC number: NA

Molecular weight: Translated: 33855; Mature: 33724

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: BINDING 61-61 BINDING 85-85 BINDING 102-102 BINDING 109-109

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTTTLLHTTVLLDEAVDALLGGAGPAPAGVWIDATFGRGGHSRRILERLGPDGRLVAF
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEE
DKDPEAIHEAARITDARFSIRHEGFRHLADLPERSAAGILMDLGVSSPQIDSPERGFSFR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCEEEECCCCCCCCCCCCCCCEEE
FDGPLDMRMDTTRGESVADWLATADVGQIAEVIREYGEERFAGPIAKAIAARRAERGPLR
ECCCCCCEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TTSELAQLVAGAVKTREAGQNPATRTFQALRIFINAELEELQAALEASLRVLAPGGRLAV
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCCEEE
ISFHSLEDRIVKQFIAQHSREVYDRRAPFAAPQPMRLKALDRIKPGACEVDANPRARSAV
EEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCEECCCCCHHHHHH
MRVAERTEVPA
HHHHHHHCCCC
>Mature Secondary Structure 
ADTTTLLHTTVLLDEAVDALLGGAGPAPAGVWIDATFGRGGHSRRILERLGPDGRLVAF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEE
DKDPEAIHEAARITDARFSIRHEGFRHLADLPERSAAGILMDLGVSSPQIDSPERGFSFR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCEEEECCCCCCCCCCCCCCCEEE
FDGPLDMRMDTTRGESVADWLATADVGQIAEVIREYGEERFAGPIAKAIAARRAERGPLR
ECCCCCCEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TTSELAQLVAGAVKTREAGQNPATRTFQALRIFINAELEELQAALEASLRVLAPGGRLAV
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCCEEE
ISFHSLEDRIVKQFIAQHSREVYDRRAPFAAPQPMRLKALDRIKPGACEVDANPRARSAV
EEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCEECCCCCHHHHHH
MRVAERTEVPA
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA