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The map label for this gene is ubiA

Identifier: 120609296

GI number: 120609296

Start: 653081

End: 653968

Strand: Direct

Name: ubiA

Synonym: Aave_0596

Alternate gene names: 120609296

Gene position: 653081-653968 (Clockwise)

Preceding gene: 120609295

Following gene: 120609304

Centisome position: 12.2

GC content: 71.28

Gene sequence:

>888_bases
ATGCAGAGCACCGCACCGCACCGCCCCCCCCAGCCTTCGCGCCTGGCGCTGTACCTCGACCTGATCCGCTGGAGCCGGCC
CGCCGGCTGGCTGCTGCTGCTCTGGCCCACGCTGTCGGCCCTGTGGATCGCGGCCGGAGGCTTTCCGGGCTGGCACCTGC
TGGCCGTCTTCACGCTGGGCACCATCCTCATGCGCAGCGCGGGATGCTGCGTGAACGATGTCGCCGACCGCGACTTCGAC
CGGCACGTCAAGCGCACCGCGCAGCGCCCCGTCACCAGCGGCGCCGTGTCGGTGCGCGAGGCGCTGGGCGTGGGCGCGGT
GCTCGCCCTGGTGTCGTTCGGCCTCGTGCTCACCACCAATGCGGCCACCATCGCCTGGTCGCTGCCGGCCCTGGCGGTGA
CCATTGCCTACCCGTTCGCCAAGCGCTTCGTGTCCATGCCCCAGGCCGTGCTCGGCGTGGCCTTCAGCATGGGCATCCCG
ATGGCCTTCACCGCGGTGGGCGGCGCCGTGCCGATGCTGGCTGCCTGGCTGGTGCTGGGCAACCTCTGCTGGGTGCTGGC
CTATGACACCGAATACGCCATGGTGGACCGCGACGACGACCTGAAGATCGGCATGAAGACCTCGGCGATCACCCTGGGGC
GCCACGACGTGCCGGCCGTGATGGCCTTCTACCTGGCGTTCGTCGCCCTCTGGGCCTGGGCGCTGGCGCCCTTCGGCCTG
GGCTGGCCCCTGCATGCCGTGCTGGCCGCCATGCTGCTCCAGGTAGCGTGGCACTGGCGCCTCATCCGGCACCGCACCCG
CGAAGGGTGCTTCCGCGCGTTCACCGGCAACCACTGGCTGGGCTTCACGCTGTTCGCGGGCATCGTGGCGGGGTTCGCGC
TGCGCTGA

Upstream 100 bases:

>100_bases
TGCCTCGCAGAACCGCTTCGCTGGACCGTGTCAGCCGCTCCGAGCGCCATCCAGCCCACGCCCGCCCGCCGCGGGCGTTT
TTCATTCCCGCCGCACGCCC

Downstream 100 bases:

>100_bases
TCCGCCGCCGGCGCGCGTCCTTCGCGCCCGCCGGCCCGGCGGGCTGCTACGGCGCGAACGGCCCCTGCTGCACATGCCGG
CCGCTGCGCCGCAGCAGCTC

Product: 4-hydroxybenzoate octaprenyltransferase

Products: @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

Alternate protein names: 4-HB polyprenyltransferase

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MQSTAPHRPPQPSRLALYLDLIRWSRPAGWLLLLWPTLSALWIAAGGFPGWHLLAVFTLGTILMRSAGCCVNDVADRDFD
RHVKRTAQRPVTSGAVSVREALGVGAVLALVSFGLVLTTNAATIAWSLPALAVTIAYPFAKRFVSMPQAVLGVAFSMGIP
MAFTAVGGAVPMLAAWLVLGNLCWVLAYDTEYAMVDRDDDLKIGMKTSAITLGRHDVPAVMAFYLAFVALWAWALAPFGL
GWPLHAVLAAMLLQVAWHWRLIRHRTREGCFRAFTGNHWLGFTLFAGIVAGFALR

Sequences:

>Translated_295_residues
MQSTAPHRPPQPSRLALYLDLIRWSRPAGWLLLLWPTLSALWIAAGGFPGWHLLAVFTLGTILMRSAGCCVNDVADRDFD
RHVKRTAQRPVTSGAVSVREALGVGAVLALVSFGLVLTTNAATIAWSLPALAVTIAYPFAKRFVSMPQAVLGVAFSMGIP
MAFTAVGGAVPMLAAWLVLGNLCWVLAYDTEYAMVDRDDDLKIGMKTSAITLGRHDVPAVMAFYLAFVALWAWALAPFGL
GWPLHAVLAAMLLQVAWHWRLIRHRTREGCFRAFTGNHWLGFTLFAGIVAGFALR
>Mature_295_residues
MQSTAPHRPPQPSRLALYLDLIRWSRPAGWLLLLWPTLSALWIAAGGFPGWHLLAVFTLGTILMRSAGCCVNDVADRDFD
RHVKRTAQRPVTSGAVSVREALGVGAVLALVSFGLVLTTNAATIAWSLPALAVTIAYPFAKRFVSMPQAVLGVAFSMGIP
MAFTAVGGAVPMLAAWLVLGNLCWVLAYDTEYAMVDRDDDLKIGMKTSAITLGRHDVPAVMAFYLAFVALWAWALAPFGL
GWPLHAVLAAMLLQVAWHWRLIRHRTREGCFRAFTGNHWLGFTLFAGIVAGFALR

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family

Homologues:

Organism=Homo sapiens, GI260656052, Length=293, Percent_Identity=34.8122866894198, Blast_Score=156, Evalue=3e-38,
Organism=Escherichia coli, GI1790473, Length=282, Percent_Identity=50, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17553718, Length=292, Percent_Identity=36.3013698630137, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI32565247, Length=297, Percent_Identity=34.006734006734, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17553720, Length=349, Percent_Identity=30.3724928366762, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI32565245, Length=144, Percent_Identity=40.2777777777778, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI32565243, Length=143, Percent_Identity=39.8601398601399, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324370, Length=242, Percent_Identity=35.1239669421488, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21355567, Length=286, Percent_Identity=34.6153846153846, Blast_Score=142, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIA_ACIAC (A1TJR2)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_968974.1
- STRING:   A1TJR2
- GeneID:   4668175
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_0596
- NMPDR:   fig|397945.5.peg.513
- eggNOG:   COG0382
- HOGENOM:   HBG324383
- OMA:   YHYTLIR
- PhylomeDB:   A1TJR2
- BioCyc:   AAVE397945:AAVE_0596-MONOMER
- HAMAP:   MF_01635
- InterPro:   IPR006370
- InterPro:   IPR000537
- TIGRFAMs:   TIGR01474

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 32153; Mature: 32153

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1107d23c)-; HASH(0xff8b970)-; HASH(0x112441f8)-; HASH(0x1156de88)-; HASH(0x1041e9b4)-; HASH(0x10d58ba4)-; HASH(0x1171a940)-; HASH(0x118b7148)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSTAPHRPPQPSRLALYLDLIRWSRPAGWLLLLWPTLSALWIAAGGFPGWHLLAVFTLG
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHH
TILMRSAGCCVNDVADRDFDRHVKRTAQRPVTSGAVSVREALGVGAVLALVSFGLVLTTN
HHHHHHCCCCHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AATIAWSLPALAVTIAYPFAKRFVSMPQAVLGVAFSMGIPMAFTAVGGAVPMLAAWLVLG
CHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
NLCWVLAYDTEYAMVDRDDDLKIGMKTSAITLGRHDVPAVMAFYLAFVALWAWALAPFGL
HHHEEEEECCCEEEECCCCCCEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
GWPLHAVLAAMLLQVAWHWRLIRHRTREGCFRAFTGNHWLGFTLFAGIVAGFALR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MQSTAPHRPPQPSRLALYLDLIRWSRPAGWLLLLWPTLSALWIAAGGFPGWHLLAVFTLG
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHH
TILMRSAGCCVNDVADRDFDRHVKRTAQRPVTSGAVSVREALGVGAVLALVSFGLVLTTN
HHHHHHCCCCHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AATIAWSLPALAVTIAYPFAKRFVSMPQAVLGVAFSMGIPMAFTAVGGAVPMLAAWLVLG
CHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
NLCWVLAYDTEYAMVDRDDDLKIGMKTSAITLGRHDVPAVMAFYLAFVALWAWALAPFGL
HHHEEEEECCCEEEECCCCCCEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
GWPLHAVLAAMLLQVAWHWRLIRHRTREGCFRAFTGNHWLGFTLFAGIVAGFALR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-Hydroxybenzoate; Farnesylfarnesylgeraniol [C]

Specific reaction: 4-Hydroxybenzoate + Farnesylfarnesylgeraniol = @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA