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The map label for this gene is recQ [H]

Identifier: 120608889

GI number: 120608889

Start: 201563

End: 203680

Strand: Direct

Name: recQ [H]

Synonym: Aave_0181

Alternate gene names: 120608889

Gene position: 201563-203680 (Clockwise)

Preceding gene: 120608875

Following gene: 120608892

Centisome position: 3.77

GC content: 70.68

Gene sequence:

>2118_bases
ATGGTTGCCGCGCTTCCAGCCTGCGGGACGGAGCACAATAGGCACCTTGCCTGCGTGCAGCGCAGCGGCTCCGCCGGGAC
GCCGTCCTGCCCTGCACCCTGCCCTGCGCCACTGCCGCGCGGGCACCCCCGACGCCATCGACCAGAGAGTTCCACCGCCT
TGTCCCCCGCGCATTTCGTCCTGCACGACGTCTTCGGCTACGAGCATTTCCGCGGCCCGCAGCAGGCCATCGTCGAGCAC
GTGATCGCCGGTGGCGACGCGCTGGTGCTCATGCCCACGGGTGGCGGCAAGTCGCTGTGCTACCAGGTGCCGGCCATCGT
GCGGCGTGATGCGGGCAAGGGCGTGGCCATCGTCGTCTCGCCGCTGATCGCGCTCATGCACGACCAGGTGGGCGCGCTGC
ACGAGGCGGGGGTGGATGCGGCCTATCTCAATTCGACGCTCGACTGGCAGCAGACACAGGAACTGGAGCGGCGCGTGGCG
CGCGGCGACATCACCATGCTGTATGCCGCGCCCGAGCGCCTGACCACGCCGCGCTTCCTGGAGCTGCTCGACGGCCTGCA
CCAGCGCGGGCAGCTCTCCATGTTCGCCATCGACGAGGCGCACTGCGTGAGCCAGTGGGGGCACGACTTCCGGCCCGAAT
ACCGCGCGCTCACCGTGCTGCACGAGCGCTACCCGGGCGTGCCGCGCATCGCGCTCACCGCCACGGCCGACGCGCTCACG
CGCGAGGACATCGTGGAGCGGCTGCAGCTCGAGGGCGCGCAGCACTTCGTCTCCAGCTTCGACCGGCCCAACATCCGCTA
CACCATCGTCGAGAAGAGGGAGCCGCTCGCGCAGCTGCTGCGCTTCATCGAGCGCGAGCACCCGGAGGACGCGGGCGTGG
TCTATTGCCAGTCGCGCAAGCGCGTGGAGGAAATGTCCGCCGCGCTGGTCGATGCGGGCCTCAAATCGCTGCCCTACCAC
GCCGGCCTGCCGCCCGAGGTGCGCCAGGAGAACCAGGACCGCTTCCTGCGCGAGGAAGGCATCGTCATGGTGGCGACCAT
CGCCTTCGGCATGGGCATCGACAAGCCGGACGTGCGCTTCGTGGCCCACGTGGACATGCCCAAGAACATCGAGGGCTACT
ACCAGGAAACGGGCCGCGCGGGCCGCGACGGGCTGCCCGCCGATGCCTGGATGGCCTACGGCCTGCAGGACGTGGTGAAC
CAGCGCCGCATGATCGACGAGAGCCCCGCGGGCGAGGAATTCAAGCAGGTCATGCGCGGCAAGCTCGACGCGCTGCTGGG
CCTGGCCGAGGCCACGGACTGCCGGCGCGTGCGGCTGCTGGGCTACTTCGGCGAAGTCTACGGCGAGCCATCGAGCGCCG
CCGGGCCGCCCCAAGGCGCGAGCGGCCCCCTCGGGGGGCAGCGAGGACACGAAGTGCCGAGCGTGGGGGCGACATGCGGC
AACTGCGACAACTGCCTGAACCCGCCGGCGGTCTGGGACGGCACCGACGCCGCGCGCAAGCTGCTGTCCACCATCTACCG
CGTGCACGAGGCGAGCGGCCTCACATTCGGCACCGGGCACATCATGGACATCGTGCGCGGCAAGGACACCGAGAAGGTCA
AGCAGTTCGGCCACGACAGGCTTTCCACCTTCGGCCTCGGCAAGGACTACACCGAGGCGCAGCTGCGCGGGGTGCTGCGG
CAACTGCTGGCCACGGGGGCCGTGGGCCTGCACAAGGTGATGCTGGAAAGCGGCCACAGCTTCGACACGCTGAGCCTCAC
CGAAGGTTCGCGCCCGGTGCTCAAGGGCCAGGTGCCCGTGATGCTGCGCGAATCGGCCGCCGCGCCGCCTGCCCGGCGCA
CGCGGCGTACCGCGGCCCCGCCCGTGGCCGCGGCCAACCTCGATCCGGATGCGCAGGTGCGCTTCATCAACCTCAAGGCC
TGGCGCGCCGAGGTGGCGCGCGAGCACAACCTGCCGGCCTACGTCATCTTCCACGACGCCACGCTGGCCGCCATCGCCGA
GCGGCGCCCCGCGTCGCTGGCCGACCTGCAGGGCATCAGCGGCATGGGCGCCAAGAAGCTGGAAGCCTACGGCGAGGACG
TGCTGCGCGTGTGCCGCCAGGGCGCCGCGGTGTCCTGA

Upstream 100 bases:

>100_bases
CCTGGAATGGCGGCCTCTGTAGCCGGGCCTGGAGGGCATCTTGGGGGGACCATCCATTCGCGTCCAATTCAATCGTTGAA
GCGTGCGATAGCTTTTGCGA

Downstream 100 bases:

>100_bases
CGCCGCACCGCGCGCTGCGCGCCGGCGTCAGCCGCTGGCCTGCGCCGCGCCCGGACCGGTGGCCGGGCGGTCCTTCAGCA
GCGTGCGGGTGATCGCGCGC

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 705; Mature: 705

Protein sequence:

>705_residues
MVAALPACGTEHNRHLACVQRSGSAGTPSCPAPCPAPLPRGHPRRHRPESSTALSPAHFVLHDVFGYEHFRGPQQAIVEH
VIAGGDALVLMPTGGGKSLCYQVPAIVRRDAGKGVAIVVSPLIALMHDQVGALHEAGVDAAYLNSTLDWQQTQELERRVA
RGDITMLYAAPERLTTPRFLELLDGLHQRGQLSMFAIDEAHCVSQWGHDFRPEYRALTVLHERYPGVPRIALTATADALT
REDIVERLQLEGAQHFVSSFDRPNIRYTIVEKREPLAQLLRFIEREHPEDAGVVYCQSRKRVEEMSAALVDAGLKSLPYH
AGLPPEVRQENQDRFLREEGIVMVATIAFGMGIDKPDVRFVAHVDMPKNIEGYYQETGRAGRDGLPADAWMAYGLQDVVN
QRRMIDESPAGEEFKQVMRGKLDALLGLAEATDCRRVRLLGYFGEVYGEPSSAAGPPQGASGPLGGQRGHEVPSVGATCG
NCDNCLNPPAVWDGTDAARKLLSTIYRVHEASGLTFGTGHIMDIVRGKDTEKVKQFGHDRLSTFGLGKDYTEAQLRGVLR
QLLATGAVGLHKVMLESGHSFDTLSLTEGSRPVLKGQVPVMLRESAAAPPARRTRRTAAPPVAAANLDPDAQVRFINLKA
WRAEVAREHNLPAYVIFHDATLAAIAERRPASLADLQGISGMGAKKLEAYGEDVLRVCRQGAAVS

Sequences:

>Translated_705_residues
MVAALPACGTEHNRHLACVQRSGSAGTPSCPAPCPAPLPRGHPRRHRPESSTALSPAHFVLHDVFGYEHFRGPQQAIVEH
VIAGGDALVLMPTGGGKSLCYQVPAIVRRDAGKGVAIVVSPLIALMHDQVGALHEAGVDAAYLNSTLDWQQTQELERRVA
RGDITMLYAAPERLTTPRFLELLDGLHQRGQLSMFAIDEAHCVSQWGHDFRPEYRALTVLHERYPGVPRIALTATADALT
REDIVERLQLEGAQHFVSSFDRPNIRYTIVEKREPLAQLLRFIEREHPEDAGVVYCQSRKRVEEMSAALVDAGLKSLPYH
AGLPPEVRQENQDRFLREEGIVMVATIAFGMGIDKPDVRFVAHVDMPKNIEGYYQETGRAGRDGLPADAWMAYGLQDVVN
QRRMIDESPAGEEFKQVMRGKLDALLGLAEATDCRRVRLLGYFGEVYGEPSSAAGPPQGASGPLGGQRGHEVPSVGATCG
NCDNCLNPPAVWDGTDAARKLLSTIYRVHEASGLTFGTGHIMDIVRGKDTEKVKQFGHDRLSTFGLGKDYTEAQLRGVLR
QLLATGAVGLHKVMLESGHSFDTLSLTEGSRPVLKGQVPVMLRESAAAPPARRTRRTAAPPVAAANLDPDAQVRFINLKA
WRAEVAREHNLPAYVIFHDATLAAIAERRPASLADLQGISGMGAKKLEAYGEDVLRVCRQGAAVS
>Mature_705_residues
MVAALPACGTEHNRHLACVQRSGSAGTPSCPAPCPAPLPRGHPRRHRPESSTALSPAHFVLHDVFGYEHFRGPQQAIVEH
VIAGGDALVLMPTGGGKSLCYQVPAIVRRDAGKGVAIVVSPLIALMHDQVGALHEAGVDAAYLNSTLDWQQTQELERRVA
RGDITMLYAAPERLTTPRFLELLDGLHQRGQLSMFAIDEAHCVSQWGHDFRPEYRALTVLHERYPGVPRIALTATADALT
REDIVERLQLEGAQHFVSSFDRPNIRYTIVEKREPLAQLLRFIEREHPEDAGVVYCQSRKRVEEMSAALVDAGLKSLPYH
AGLPPEVRQENQDRFLREEGIVMVATIAFGMGIDKPDVRFVAHVDMPKNIEGYYQETGRAGRDGLPADAWMAYGLQDVVN
QRRMIDESPAGEEFKQVMRGKLDALLGLAEATDCRRVRLLGYFGEVYGEPSSAAGPPQGASGPLGGQRGHEVPSVGATCG
NCDNCLNPPAVWDGTDAARKLLSTIYRVHEASGLTFGTGHIMDIVRGKDTEKVKQFGHDRLSTFGLGKDYTEAQLRGVLR
QLLATGAVGLHKVMLESGHSFDTLSLTEGSRPVLKGQVPVMLRESAAAPPARRTRRTAAPPVAAANLDPDAQVRFINLKA
WRAEVAREHNLPAYVIFHDATLAAIAERRPASLADLQGISGMGAKKLEAYGEDVLRVCRQGAAVS

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=661, Percent_Identity=31.4674735249622, Blast_Score=345, Evalue=1e-94,
Organism=Homo sapiens, GI14591902, Length=400, Percent_Identity=35.75, Blast_Score=281, Evalue=2e-75,
Organism=Homo sapiens, GI14591904, Length=400, Percent_Identity=35.75, Blast_Score=281, Evalue=2e-75,
Organism=Homo sapiens, GI110735439, Length=700, Percent_Identity=29.1428571428571, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI169218196, Length=700, Percent_Identity=29.1428571428571, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI148612816, Length=454, Percent_Identity=37.0044052863436, Blast_Score=260, Evalue=3e-69,
Organism=Homo sapiens, GI51242947, Length=424, Percent_Identity=37.9716981132075, Blast_Score=250, Evalue=4e-66,
Organism=Homo sapiens, GI51242943, Length=353, Percent_Identity=41.3597733711048, Blast_Score=249, Evalue=6e-66,
Organism=Homo sapiens, GI284005309, Length=362, Percent_Identity=34.8066298342541, Blast_Score=180, Evalue=3e-45,
Organism=Escherichia coli, GI48994977, Length=645, Percent_Identity=43.4108527131783, Blast_Score=515, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI25145561, Length=557, Percent_Identity=36.2657091561939, Blast_Score=328, Evalue=4e-90,
Organism=Caenorhabditis elegans, GI32564293, Length=693, Percent_Identity=31.7460317460317, Blast_Score=309, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI71987997, Length=399, Percent_Identity=38.8471177944862, Blast_Score=295, Evalue=5e-80,
Organism=Caenorhabditis elegans, GI71987993, Length=399, Percent_Identity=38.8471177944862, Blast_Score=295, Evalue=7e-80,
Organism=Caenorhabditis elegans, GI17552866, Length=428, Percent_Identity=35.981308411215, Blast_Score=252, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17555296, Length=336, Percent_Identity=24.1071428571429, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115533224, Length=381, Percent_Identity=24.6719160104987, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=563, Percent_Identity=32.8596802841918, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6324217, Length=358, Percent_Identity=24.3016759776536, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24646066, Length=655, Percent_Identity=32.9770992366412, Blast_Score=357, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24664226, Length=422, Percent_Identity=37.4407582938389, Blast_Score=259, Evalue=5e-69,
Organism=Drosophila melanogaster, GI62472181, Length=447, Percent_Identity=36.0178970917226, Blast_Score=258, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24664230, Length=447, Percent_Identity=36.0178970917226, Blast_Score=257, Evalue=2e-68,
Organism=Drosophila melanogaster, GI21358123, Length=375, Percent_Identity=34.9333333333333, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI28574962, Length=369, Percent_Identity=26.0162601626016, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28575014, Length=349, Percent_Identity=23.4957020057307, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 76827; Mature: 76827

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAALPACGTEHNRHLACVQRSGSAGTPSCPAPCPAPLPRGHPRRHRPESSTALSPAHFV
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
LHDVFGYEHFRGPQQAIVEHVIAGGDALVLMPTGGGKSLCYQVPAIVRRDAGKGVAIVVS
HHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHH
PLIALMHDQVGALHEAGVDAAYLNSTLDWQQTQELERRVARGDITMLYAAPERLTTPRFL
HHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHCCCEEEEEECCHHCCCHHHH
ELLDGLHQRGQLSMFAIDEAHCVSQWGHDFRPEYRALTVLHERYPGVPRIALTATADALT
HHHHHHHHCCCEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECHHHHH
REDIVERLQLEGAQHFVSSFDRPNIRYTIVEKREPLAQLLRFIEREHPEDAGVVYCQSRK
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEECHHH
RVEEMSAALVDAGLKSLPYHAGLPPEVRQENQDRFLREEGIVMVATIAFGMGIDKPDVRF
HHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHCCCEEEEEHHHHCCCCCCCCEE
VAHVDMPKNIEGYYQETGRAGRDGLPADAWMAYGLQDVVNQRRMIDESPAGEEFKQVMRG
EEEECCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
KLDALLGLAEATDCRRVRLLGYFGEVYGEPSSAAGPPQGASGPLGGQRGHEVPSVGATCG
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NCDNCLNPPAVWDGTDAARKLLSTIYRVHEASGLTFGTGHIMDIVRGKDTEKVKQFGHDR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCHHHHHHHCCCCHHHHHHHCHHH
LSTFGLGKDYTEAQLRGVLRQLLATGAVGLHKVMLESGHSFDTLSLTEGSRPVLKGQVPV
HHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCE
MLRESAAAPPARRTRRTAAPPVAAANLDPDAQVRFINLKAWRAEVAREHNLPAYVIFHDA
EEECCCCCCCHHHHHCCCCCCCEECCCCCCCEEEEEEHHHHHHHHHHHCCCCEEEEEECH
TLAAIAERRPASLADLQGISGMGAKKLEAYGEDVLRVCRQGAAVS
HHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVAALPACGTEHNRHLACVQRSGSAGTPSCPAPCPAPLPRGHPRRHRPESSTALSPAHFV
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
LHDVFGYEHFRGPQQAIVEHVIAGGDALVLMPTGGGKSLCYQVPAIVRRDAGKGVAIVVS
HHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHH
PLIALMHDQVGALHEAGVDAAYLNSTLDWQQTQELERRVARGDITMLYAAPERLTTPRFL
HHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHCCCEEEEEECCHHCCCHHHH
ELLDGLHQRGQLSMFAIDEAHCVSQWGHDFRPEYRALTVLHERYPGVPRIALTATADALT
HHHHHHHHCCCEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECHHHHH
REDIVERLQLEGAQHFVSSFDRPNIRYTIVEKREPLAQLLRFIEREHPEDAGVVYCQSRK
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEECHHH
RVEEMSAALVDAGLKSLPYHAGLPPEVRQENQDRFLREEGIVMVATIAFGMGIDKPDVRF
HHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHCCCEEEEEHHHHCCCCCCCCEE
VAHVDMPKNIEGYYQETGRAGRDGLPADAWMAYGLQDVVNQRRMIDESPAGEEFKQVMRG
EEEECCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
KLDALLGLAEATDCRRVRLLGYFGEVYGEPSSAAGPPQGASGPLGGQRGHEVPSVGATCG
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NCDNCLNPPAVWDGTDAARKLLSTIYRVHEASGLTFGTGHIMDIVRGKDTEKVKQFGHDR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCHHHHHHHCCCCHHHHHHHCHHH
LSTFGLGKDYTEAQLRGVLRQLLATGAVGLHKVMLESGHSFDTLSLTEGSRPVLKGQVPV
HHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCE
MLRESAAAPPARRTRRTAAPPVAAANLDPDAQVRFINLKAWRAEVAREHNLPAYVIFHDA
EEECCCCCCCHHHHHCCCCCCCEECCCCCCCEEEEEEHHHHHHHHHHHCCCCEEEEEECH
TLAAIAERRPASLADLQGISGMGAKKLEAYGEDVLRVCRQGAAVS
HHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]