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The map label for this gene is acsA1 [H]

Identifier: 120608827

GI number: 120608827

Start: 130284

End: 132467

Strand: Direct

Name: acsA1 [H]

Synonym: Aave_0119

Alternate gene names: 120608827

Gene position: 130284-132467 (Clockwise)

Preceding gene: 120608826

Following gene: 120608830

Centisome position: 2.43

GC content: 72.16

Gene sequence:

>2184_bases
ATGGAGACAACCACCCCCCCGCCGCGCAGCGCGGCCGCTGCCGCCGCAGCGCACGCCCCCTTCGTCCCGCAGATCCGGCT
CTACCAGGAATGGCTGCACGCCAGGCATGGCCTGCGGTTCGGCGATTACGAAGCCCTCTGGCGCTGGTCCGTGACCGATC
TGGACGCCTTCTGGCAGAGCATCTGGGATTACTTCGGCCTCGAATCGCCCACGCCGCACACGGCCGTGCTGGCCCGCAAC
ACCATGCCGGGCGCCGAATGGTTTCCCGGCGCCCAGGTGAATTACGCGCGCCAGGCCCTGCGGCATGCCGACGCCGCGCA
TGCGGCCGGGCAGCCGGCCATCATCAGCCGCAACGAGCGCGGCGAGCACCGCGAACTGTCCTGGCCCGAGCTGCGCAGGC
AGGTGGCGGCGCTGGCCTTGCACCTGCGCGCGCAGGGCGTGGGGCCGGGCGACCGCGTCGCGGCCTATCTGCCCAACATC
CCCGAAGCCATGGTGGCCCTGCTGGCCACGGCCAGCCTGGGCGCCATCTGGAGCGTGTGCGCGCCCGACATGGGCACGGC
CGCGGTGCTGGACCGCTTCCGGCAGATCGAACCCAAGGCGCTGATCGCCGTGGACGGCGTGACCTACGGCGGCCGGGACC
TCGACCGCCGCGGCGTGCTCGCCGAATTGCGCGCCGCCCTGCCCACGCTGGAACACGTGGTCGTCGTGGACCAGCTCGGC
ACGGCGGGCACCATCGCCGGCTGCGTGGAATACACCCAGGCCACCGCGCGGGACGATGCCGGGGTGGCGTCCTTCGAGCC
GCTCTGGCTGCCGTTCGACCATCCGCTCTGGATCGTCTATTCCAGCGGCACCACCGGCCTGCCCAAGCCCATCGTGCACG
GCCACGGTGGCATGGTGCTGGTGGCGCTGCTGCTCAAGGGCCTGCACAACGACATCGGCCCGAGCCACGTGCCCAACTCG
TTCGGCGAGCGCTACCACTGGTACAGCTCCACTGGCTGGGTCATGTGGAACGCGCAGGCGAGCGGCCTGCTCTCGGGCAC
CACCTGCGTGATCTACGACGGCAACCCGGGCGGCAGCCGCGAGCGCCCCGACTGGGGCACGCTCTGGCGCTTCGCCGCCG
AGACCGGCGTGACCTTTTTCGGCGCGGGCGCCGCCTTCTACGCCAACTGCATGAAGGCGGGGATCGATCTCGCGGCCTGC
GGCGACCTTTCCCGCATCCGCGCGCTGGGCACCACGGGCTCGCCGCTCTCGCCGGAGGTGCAGGAGTGGGGCACGGCGCA
ATTCGCGCGCATCCAGGCCCGAGCCGGGAATGCTGCCAGCAGCGAGCCGATCTGGTGGGACAACATCTCCGGCGGCACGG
ATTTCTGCGGCGCCTTCATCGGCGGCCACCGCGAGCTGCCCCAGGTGCCCGGCGAAATGCAGTGCCGCATGCTGGGCGCG
GCGGTGGAGTCCTGGGACGAGGCGGGCCGGCCCGTCACCGGCGCGGTGGGCGAGCTGGTCTGCACGCAGCCCATTCCCTC
CATGCCGCTCTACTTCTGGGGCGATGCCCCCGCGGGGGCGCCGGCACTGCCGGGCGACCCGCAGGGGCCGCGCTATCTCG
CGAGCTATTTCGACATGTACCCGCCCGGCCACGGCCGCCGGCCCGGCGGCGGCGACGGCCCCGCGTCCATGGGCGCGGTC
TGGCGCCACGGCGACTGGCTGCGCGTCGGTCCCGAAGGCCGCTGCGTGATCTACGGCCGCAGCGACGCCACCATCAACCG
CCACGGCCTGCGCATGGGCACCAGCGAGCTGTACCGCGCGGTGGAGGCCTTGCCCGAAGTGCTCGACAGCCTCGTGGTGG
ACCTGGAATACCTGGGGCGCGAAAGCCACATGCCGCTCTTCGTGGCGCTGCGCGAGGGCGCCGCGCTGGACGATGCGCTG
CGCGAACGCATCGCAGCTGCCATCCGCACCGCGCTCTCGCCACGCTTCGTGCCCGACGAGATCGTGCAGGTGGCCGAGGT
GCCGCGCACCCTCACGGGCAAGAAGCAGGAGCTGCCCATCAAGAAGCTGCTGCTCGGCCAGCCGCTGGAGAAGGTGGTGA
ACCGCGACGCCATGGCCAATCCCGGCTGCCTTGGCTGGTACGAGGATTTCGCGCGCCGGCACCTGGCGCGCACCGCTGCC
GTCGCCGGCGCCCCGGGGGCTTGA

Upstream 100 bases:

>100_bases
CGTGAAGGAACTCAAGGAAGACTGATCCGGCGCCTGCCTGTCAAGCCCGGGACGCCCCGGCGGTGACACGCCGGGGCACC
ACGCAGTACGCTGCGTGGCC

Downstream 100 bases:

>100_bases
GTTGCGGGGTTAGCGCCGCCCGGCGGGGGCCGGCGCGCGCACCAGCGTGCTCTTGCCGAACAGGCTCTCCACCAGATCCA
CCACGAGTTCGGCGGTCTGG

Product: acetoacetyl-CoA synthetase

Products: NA

Alternate protein names: Acetoacetate--CoA ligase 1; Acyl-activating enzyme 1 [H]

Number of amino acids: Translated: 727; Mature: 727

Protein sequence:

>727_residues
METTTPPPRSAAAAAAAHAPFVPQIRLYQEWLHARHGLRFGDYEALWRWSVTDLDAFWQSIWDYFGLESPTPHTAVLARN
TMPGAEWFPGAQVNYARQALRHADAAHAAGQPAIISRNERGEHRELSWPELRRQVAALALHLRAQGVGPGDRVAAYLPNI
PEAMVALLATASLGAIWSVCAPDMGTAAVLDRFRQIEPKALIAVDGVTYGGRDLDRRGVLAELRAALPTLEHVVVVDQLG
TAGTIAGCVEYTQATARDDAGVASFEPLWLPFDHPLWIVYSSGTTGLPKPIVHGHGGMVLVALLLKGLHNDIGPSHVPNS
FGERYHWYSSTGWVMWNAQASGLLSGTTCVIYDGNPGGSRERPDWGTLWRFAAETGVTFFGAGAAFYANCMKAGIDLAAC
GDLSRIRALGTTGSPLSPEVQEWGTAQFARIQARAGNAASSEPIWWDNISGGTDFCGAFIGGHRELPQVPGEMQCRMLGA
AVESWDEAGRPVTGAVGELVCTQPIPSMPLYFWGDAPAGAPALPGDPQGPRYLASYFDMYPPGHGRRPGGGDGPASMGAV
WRHGDWLRVGPEGRCVIYGRSDATINRHGLRMGTSELYRAVEALPEVLDSLVVDLEYLGRESHMPLFVALREGAALDDAL
RERIAAAIRTALSPRFVPDEIVQVAEVPRTLTGKKQELPIKKLLLGQPLEKVVNRDAMANPGCLGWYEDFARRHLARTAA
VAGAPGA

Sequences:

>Translated_727_residues
METTTPPPRSAAAAAAAHAPFVPQIRLYQEWLHARHGLRFGDYEALWRWSVTDLDAFWQSIWDYFGLESPTPHTAVLARN
TMPGAEWFPGAQVNYARQALRHADAAHAAGQPAIISRNERGEHRELSWPELRRQVAALALHLRAQGVGPGDRVAAYLPNI
PEAMVALLATASLGAIWSVCAPDMGTAAVLDRFRQIEPKALIAVDGVTYGGRDLDRRGVLAELRAALPTLEHVVVVDQLG
TAGTIAGCVEYTQATARDDAGVASFEPLWLPFDHPLWIVYSSGTTGLPKPIVHGHGGMVLVALLLKGLHNDIGPSHVPNS
FGERYHWYSSTGWVMWNAQASGLLSGTTCVIYDGNPGGSRERPDWGTLWRFAAETGVTFFGAGAAFYANCMKAGIDLAAC
GDLSRIRALGTTGSPLSPEVQEWGTAQFARIQARAGNAASSEPIWWDNISGGTDFCGAFIGGHRELPQVPGEMQCRMLGA
AVESWDEAGRPVTGAVGELVCTQPIPSMPLYFWGDAPAGAPALPGDPQGPRYLASYFDMYPPGHGRRPGGGDGPASMGAV
WRHGDWLRVGPEGRCVIYGRSDATINRHGLRMGTSELYRAVEALPEVLDSLVVDLEYLGRESHMPLFVALREGAALDDAL
RERIAAAIRTALSPRFVPDEIVQVAEVPRTLTGKKQELPIKKLLLGQPLEKVVNRDAMANPGCLGWYEDFARRHLARTAA
VAGAPGA
>Mature_727_residues
METTTPPPRSAAAAAAAHAPFVPQIRLYQEWLHARHGLRFGDYEALWRWSVTDLDAFWQSIWDYFGLESPTPHTAVLARN
TMPGAEWFPGAQVNYARQALRHADAAHAAGQPAIISRNERGEHRELSWPELRRQVAALALHLRAQGVGPGDRVAAYLPNI
PEAMVALLATASLGAIWSVCAPDMGTAAVLDRFRQIEPKALIAVDGVTYGGRDLDRRGVLAELRAALPTLEHVVVVDQLG
TAGTIAGCVEYTQATARDDAGVASFEPLWLPFDHPLWIVYSSGTTGLPKPIVHGHGGMVLVALLLKGLHNDIGPSHVPNS
FGERYHWYSSTGWVMWNAQASGLLSGTTCVIYDGNPGGSRERPDWGTLWRFAAETGVTFFGAGAAFYANCMKAGIDLAAC
GDLSRIRALGTTGSPLSPEVQEWGTAQFARIQARAGNAASSEPIWWDNISGGTDFCGAFIGGHRELPQVPGEMQCRMLGA
AVESWDEAGRPVTGAVGELVCTQPIPSMPLYFWGDAPAGAPALPGDPQGPRYLASYFDMYPPGHGRRPGGGDGPASMGAV
WRHGDWLRVGPEGRCVIYGRSDATINRHGLRMGTSELYRAVEALPEVLDSLVVDLEYLGRESHMPLFVALREGAALDDAL
RERIAAAIRTALSPRFVPDEIVQVAEVPRTLTGKKQELPIKKLLLGQPLEKVVNRDAMANPGCLGWYEDFARRHLARTAA
VAGAPGA

Specific function: Involved in poly-3-hydroxybutyrate degradation. Activates acetoacetate to acetoacetyl-CoA [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI31982927, Length=685, Percent_Identity=34.7445255474453, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI28416953, Length=664, Percent_Identity=25.6024096385542, Blast_Score=171, Evalue=3e-42,
Organism=Homo sapiens, GI8923896, Length=684, Percent_Identity=25.2923976608187, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI253970489, Length=696, Percent_Identity=24.5689655172414, Blast_Score=143, Evalue=6e-34,
Organism=Homo sapiens, GI13375727, Length=692, Percent_Identity=23.5549132947977, Blast_Score=134, Evalue=3e-31,
Organism=Escherichia coli, GI1790505, Length=683, Percent_Identity=24.597364568082, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1786529, Length=659, Percent_Identity=24.4309559939302, Blast_Score=125, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17569507, Length=687, Percent_Identity=31.8777292576419, Blast_Score=347, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI71982997, Length=681, Percent_Identity=24.6696035242291, Blast_Score=138, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71983001, Length=681, Percent_Identity=24.6696035242291, Blast_Score=137, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323182, Length=688, Percent_Identity=25.8720930232558, Blast_Score=178, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6319264, Length=688, Percent_Identity=25.1453488372093, Blast_Score=158, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24667955, Length=678, Percent_Identity=23.8938053097345, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI62472339, Length=584, Percent_Identity=24.3150684931507, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24667959, Length=551, Percent_Identity=23.5934664246824, Blast_Score=117, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21355225, Length=654, Percent_Identity=24.9235474006116, Blast_Score=116, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005914
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.16 [H]

Molecular weight: Translated: 78385; Mature: 78385

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METTTPPPRSAAAAAAAHAPFVPQIRLYQEWLHARHGLRFGDYEALWRWSVTDLDAFWQS
CCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHEEECHHHHHHHHHH
IWDYFGLESPTPHTAVLARNTMPGAEWFPGAQVNYARQALRHADAAHAAGQPAIISRNER
HHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCC
GEHRELSWPELRRQVAALALHLRAQGVGPGDRVAAYLPNIPEAMVALLATASLGAIWSVC
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
APDMGTAAVLDRFRQIEPKALIAVDGVTYGGRDLDRRGVLAELRAALPTLEHVVVVDQLG
CCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHEEEEECCC
TAGTIAGCVEYTQATARDDAGVASFEPLWLPFDHPLWIVYSSGTTGLPKPIVHGHGGMVL
CCHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCCCCEECCCHHHH
VALLLKGLHNDIGPSHVPNSFGERYHWYSSTGWVMWNAQASGLLSGTTCVIYDGNPGGSR
HHHHHHHHHCCCCCCCCCHHHHCCEEEECCCCEEEECCCCCCEECCCEEEEECCCCCCCC
ERPDWGTLWRFAAETGVTFFGAGAAFYANCMKAGIDLAACGDLSRIRALGTTGSPLSPEV
CCCCHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCCEEECCCHHHHHHCCCCCCCCCCCH
QEWGTAQFARIQARAGNAASSEPIWWDNISGGTDFCGAFIGGHRELPQVPGEMQCRMLGA
HHCCCHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AVESWDEAGRPVTGAVGELVCTQPIPSMPLYFWGDAPAGAPALPGDPQGPRYLASYFDMY
HHHHHHHCCCCCCCCHHHEEECCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHCC
PPGHGRRPGGGDGPASMGAVWRHGDWLRVGPEGRCVIYGRSDATINRHGLRMGTSELYRA
CCCCCCCCCCCCCCHHHCHHHCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHH
VEALPEVLDSLVVDLEYLGRESHMPLFVALREGAALDDALRERIAAAIRTALSPRFVPDE
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
IVQVAEVPRTLTGKKQELPIKKLLLGQPLEKVVNRDAMANPGCLGWYEDFARRHLARTAA
HHHHHHCCHHHCCCCCCCCHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
VAGAPGA
CCCCCCC
>Mature Secondary Structure
METTTPPPRSAAAAAAAHAPFVPQIRLYQEWLHARHGLRFGDYEALWRWSVTDLDAFWQS
CCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHEEECHHHHHHHHHH
IWDYFGLESPTPHTAVLARNTMPGAEWFPGAQVNYARQALRHADAAHAAGQPAIISRNER
HHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCC
GEHRELSWPELRRQVAALALHLRAQGVGPGDRVAAYLPNIPEAMVALLATASLGAIWSVC
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
APDMGTAAVLDRFRQIEPKALIAVDGVTYGGRDLDRRGVLAELRAALPTLEHVVVVDQLG
CCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHEEEEECCC
TAGTIAGCVEYTQATARDDAGVASFEPLWLPFDHPLWIVYSSGTTGLPKPIVHGHGGMVL
CCHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCCCCEECCCHHHH
VALLLKGLHNDIGPSHVPNSFGERYHWYSSTGWVMWNAQASGLLSGTTCVIYDGNPGGSR
HHHHHHHHHCCCCCCCCCHHHHCCEEEECCCCEEEECCCCCCEECCCEEEEECCCCCCCC
ERPDWGTLWRFAAETGVTFFGAGAAFYANCMKAGIDLAACGDLSRIRALGTTGSPLSPEV
CCCCHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCCEEECCCHHHHHHCCCCCCCCCCCH
QEWGTAQFARIQARAGNAASSEPIWWDNISGGTDFCGAFIGGHRELPQVPGEMQCRMLGA
HHCCCHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AVESWDEAGRPVTGAVGELVCTQPIPSMPLYFWGDAPAGAPALPGDPQGPRYLASYFDMY
HHHHHHHCCCCCCCCHHHEEECCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHCC
PPGHGRRPGGGDGPASMGAVWRHGDWLRVGPEGRCVIYGRSDATINRHGLRMGTSELYRA
CCCCCCCCCCCCCCHHHCHHHCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHH
VEALPEVLDSLVVDLEYLGRESHMPLFVALREGAALDDALRERIAAAIRTALSPRFVPDE
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
IVQVAEVPRTLTGKKQELPIKKLLLGQPLEKVVNRDAMANPGCLGWYEDFARRHLARTAA
HHHHHHCCHHHCCCCCCCCHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
VAGAPGA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10735852; 11481430 [H]