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The map label for this gene is kdgR [H]

Identifier: 120608824

GI number: 120608824

Start: 127084

End: 128736

Strand: Direct

Name: kdgR [H]

Synonym: Aave_0116

Alternate gene names: 120608824

Gene position: 127084-128736 (Clockwise)

Preceding gene: 120608822

Following gene: 120608825

Centisome position: 2.37

GC content: 75.02

Gene sequence:

>1653_bases
ATGGCCTCGTCTTCCTCCGAAGGCACCGCGGCCCTCGAAAAAGCCCTCGATCTCCTGGAGGCGGTCGGCGCCTCCCAGGA
CGGGCTGAGCCAGGCCGAACTGGCGCAGCGCTTTGCGTTGCCGCGGACCACTGCCTACCGCCTGCTCGCCACCCTGGTCG
CGCGCGGGTTGTTGCGGCGCGATCCGGTGCGCAGGGTCTATTGCCTGGGCATGCGCTGCTTCGAGATGGCGCGGCAGGCC
TACGCCATGCCCGACCTCGCCGCGGCCGCGGCGCTGGAACTGCGGGCGCTGCGCGACCTGACGGGCGAAACCTCCTACCT
CGCCGCCCTCGATGGCCGGGAAGTGGTATCGCTCGAGCGCTGCGACGGGGCGCACAGCGAACGCTCCTCCAGCGCGCTGG
GCCAGCGCAAGCCGGTGCATTGCACCAGCCAGGGCAAGGCCATTCTGTCGGCGCTGCCCGCAGCCGACCGGGAAACGCTG
CTGCGGGGACTGTCCCTGAAGGCCGTCACGCCCCGCACCATCACCGACCGGCGCCGGCTGCAGGCGGAATTGCGCGTGAC
GGCGGCGCGCGGCTACGCCATCGACGATGAGGAAATCGTGCCCGGCGTGCGCTGCGTCGGCGCGCCCATCGTGGACGCCC
AGGGCGAGGTGCACGGAGCCCTCAGCGTGGCCGGCCCCGCCTGGCGTCTCACGCCGGAGCGGCTGGAGCTGCTCGGCCCC
GAACTGGCCGAAGCCGCCCGCCGGGTGGGTGCCCAGCTCGGGCGCACACGCGCCCCGGTGGCCGACACCATGGCGTGCGC
CCTGGCCGGCCCCTGGGCGTTCCATGGCGCCCATCCCCACTGGTGCGCGGAGGCCAACCTGCTGTACTGGGCGGACAGCC
TCGCCCCGGCGCTGCGCGCCTGGTCGCCGCAGGCCGCCCCGGACGGAGAGCCGCGCGAGGCCGGGGCGGCGCCCCTGCCG
GCCGGCACCGATCAGGCCCTGGCGGAGTGCGACGAGCCCATTGCCGGCGTGCTCGTGCACGGCCCGCAGGACGTGTCGCT
GGCAGGGGCGCGGGGCGCCGTACGCTGGCGCCCGGGCGCCGCGCAGCCCGAGCCGTGGCCCGCCTGGCCGGATGGCGCCG
CCGTGCGGGCCGCGTGCCTGGGCGGGGCCGATGCCGACGGCGAAAGCGTCTGGATCGCGATGGAAACCGCCGGGGGCGGC
AGCGCGGTGGGGCGCCTGCAGGCCGCAGGAAACGTCGAAGTGCTGTGGCGCCTGGCCGAAGCCCTGCAGTGCCTGCGTTG
GCGCGCCGGGGACGGTGCCCTGCTGGCCACCGTGCCCGACACCGGCGCCATCCTGCACATGCACCCCGACAGCCCGGGCG
TGGTGCGGAGGCTGGTCACCGTGCCCAAGGGCTCGGGGCGCGTGAGCGGGCTCGCCTTCGACGCCGAGGGCGGCGTATGG
ACCGCGCTGCGCGATGGCTGGAGCGTGGTGCGCTTTCTGCCGGACGGCGGGCTGGATCGCGTCGCCGCGCTGCCGGTACC
GTGTCCGACCGATGTGGCCATCGGCGGCGCGGAAGGCCGTACGCTCTTCGTGACGACGGCACGCCAGCCGGTGGCGCTGG
ACCTGCTGGCGAATGCGCCGCTGTCTGGCCGTCTCTTCGCGCTTCCGCTCTGA

Upstream 100 bases:

>100_bases
GGTGCGCAAATCCTGCCGGGGAGATCGTAGTCAGCGCCCGTGGCGCCGGCGTCCGGGGGGCCGTTACAGTCGCAGGCAGT
ACCACTATCTGAGACAAACC

Downstream 100 bases:

>100_bases
TCAGGCCCCTTGTCAGGGCCTTTTTTGCAACAAGATGTGCTTTTCTGATGGAAAGAACGTACTTGAAAAACAGCAAAAGT
TCCCGCGTGGTGCAGGTGTT

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MASSSSEGTAALEKALDLLEAVGASQDGLSQAELAQRFALPRTTAYRLLATLVARGLLRRDPVRRVYCLGMRCFEMARQA
YAMPDLAAAAALELRALRDLTGETSYLAALDGREVVSLERCDGAHSERSSSALGQRKPVHCTSQGKAILSALPAADRETL
LRGLSLKAVTPRTITDRRRLQAELRVTAARGYAIDDEEIVPGVRCVGAPIVDAQGEVHGALSVAGPAWRLTPERLELLGP
ELAEAARRVGAQLGRTRAPVADTMACALAGPWAFHGAHPHWCAEANLLYWADSLAPALRAWSPQAAPDGEPREAGAAPLP
AGTDQALAECDEPIAGVLVHGPQDVSLAGARGAVRWRPGAAQPEPWPAWPDGAAVRAACLGGADADGESVWIAMETAGGG
SAVGRLQAAGNVEVLWRLAEALQCLRWRAGDGALLATVPDTGAILHMHPDSPGVVRRLVTVPKGSGRVSGLAFDAEGGVW
TALRDGWSVVRFLPDGGLDRVAALPVPCPTDVAIGGAEGRTLFVTTARQPVALDLLANAPLSGRLFALPL

Sequences:

>Translated_550_residues
MASSSSEGTAALEKALDLLEAVGASQDGLSQAELAQRFALPRTTAYRLLATLVARGLLRRDPVRRVYCLGMRCFEMARQA
YAMPDLAAAAALELRALRDLTGETSYLAALDGREVVSLERCDGAHSERSSSALGQRKPVHCTSQGKAILSALPAADRETL
LRGLSLKAVTPRTITDRRRLQAELRVTAARGYAIDDEEIVPGVRCVGAPIVDAQGEVHGALSVAGPAWRLTPERLELLGP
ELAEAARRVGAQLGRTRAPVADTMACALAGPWAFHGAHPHWCAEANLLYWADSLAPALRAWSPQAAPDGEPREAGAAPLP
AGTDQALAECDEPIAGVLVHGPQDVSLAGARGAVRWRPGAAQPEPWPAWPDGAAVRAACLGGADADGESVWIAMETAGGG
SAVGRLQAAGNVEVLWRLAEALQCLRWRAGDGALLATVPDTGAILHMHPDSPGVVRRLVTVPKGSGRVSGLAFDAEGGVW
TALRDGWSVVRFLPDGGLDRVAALPVPCPTDVAIGGAEGRTLFVTTARQPVALDLLANAPLSGRLFALPL
>Mature_549_residues
ASSSSEGTAALEKALDLLEAVGASQDGLSQAELAQRFALPRTTAYRLLATLVARGLLRRDPVRRVYCLGMRCFEMARQAY
AMPDLAAAAALELRALRDLTGETSYLAALDGREVVSLERCDGAHSERSSSALGQRKPVHCTSQGKAILSALPAADRETLL
RGLSLKAVTPRTITDRRRLQAELRVTAARGYAIDDEEIVPGVRCVGAPIVDAQGEVHGALSVAGPAWRLTPERLELLGPE
LAEAARRVGAQLGRTRAPVADTMACALAGPWAFHGAHPHWCAEANLLYWADSLAPALRAWSPQAAPDGEPREAGAAPLPA
GTDQALAECDEPIAGVLVHGPQDVSLAGARGAVRWRPGAAQPEPWPAWPDGAAVRAACLGGADADGESVWIAMETAGGGS
AVGRLQAAGNVEVLWRLAEALQCLRWRAGDGALLATVPDTGAILHMHPDSPGVVRRLVTVPKGSGRVSGLAFDAEGGVWT
ALRDGWSVVRFLPDGGLDRVAALPVPCPTDVAIGGAEGRTLFVTTARQPVALDLLANAPLSGRLFALPL

Specific function: Transcriptional repressor of genes involved in pectinolysis and in pectinase secretion. Controls all the genes involved in pectin catabolism, including the pel genes encoding pectate lyases, kdgT which encodes the 2-keto-3-deoxygluconate transport system

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=254, Percent_Identity=31.496062992126, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87082359, Length=249, Percent_Identity=32.1285140562249, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786468, Length=244, Percent_Identity=31.5573770491803, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1786715, Length=255, Percent_Identity=29.0196078431373, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788581, Length=249, Percent_Identity=28.9156626506024, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1790752, Length=243, Percent_Identity=26.3374485596708, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789999, Length=255, Percent_Identity=27.4509803921569, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 57553; Mature: 57422

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSSSEGTAALEKALDLLEAVGASQDGLSQAELAQRFALPRTTAYRLLATLVARGLLRR
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
DPVRRVYCLGMRCFEMARQAYAMPDLAAAAALELRALRDLTGETSYLAALDGREVVSLER
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEHH
CDGAHSERSSSALGQRKPVHCTSQGKAILSALPAADRETLLRGLSLKAVTPRTITDRRRL
CCCCCCCHHHHHHCCCCCCEECCCCHHHHHHCCCCCHHHHHHCCCEEECCCCHHHHHHHH
QAELRVTAARGYAIDDEEIVPGVRCVGAPIVDAQGEVHGALSVAGPAWRLTPERLELLGP
HHHHEEEEECCCCCCCHHHCCCHHCCCCCEECCCCCCCEEEEECCCCCCCCHHHHHHCCH
ELAEAARRVGAQLGRTRAPVADTMACALAGPWAFHGAHPHWCAEANLLYWADSLAPALRA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHCCCCCCCCCCCCCEEEEHHHHHHHHHH
WSPQAAPDGEPREAGAAPLPAGTDQALAECDEPIAGVLVHGPQDVSLAGARGAVRWRPGA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCEEECCCCCEEECCCC
AQPEPWPAWPDGAAVRAACLGGADADGESVWIAMETAGGGSAVGRLQAAGNVEVLWRLAE
CCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHHEECCCCHHHHHHHHH
ALQCLRWRAGDGALLATVPDTGAILHMHPDSPGVVRRLVTVPKGSGRVSGLAFDAEGGVW
HHHHHHHCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHCCCCCCCCEEEEEEECCCCEE
TALRDGWSVVRFLPDGGLDRVAALPVPCPTDVAIGGAEGRTLFVTTARQPVALDLLANAP
EEHHCCCEEEEECCCCCCCCEEECCCCCCCCCEECCCCCCEEEEEECCCCEEEEEECCCC
LSGRLFALPL
CCCCEEEECC
>Mature Secondary Structure 
ASSSSEGTAALEKALDLLEAVGASQDGLSQAELAQRFALPRTTAYRLLATLVARGLLRR
CCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
DPVRRVYCLGMRCFEMARQAYAMPDLAAAAALELRALRDLTGETSYLAALDGREVVSLER
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEHH
CDGAHSERSSSALGQRKPVHCTSQGKAILSALPAADRETLLRGLSLKAVTPRTITDRRRL
CCCCCCCHHHHHHCCCCCCEECCCCHHHHHHCCCCCHHHHHHCCCEEECCCCHHHHHHHH
QAELRVTAARGYAIDDEEIVPGVRCVGAPIVDAQGEVHGALSVAGPAWRLTPERLELLGP
HHHHEEEEECCCCCCCHHHCCCHHCCCCCEECCCCCCCEEEEECCCCCCCCHHHHHHCCH
ELAEAARRVGAQLGRTRAPVADTMACALAGPWAFHGAHPHWCAEANLLYWADSLAPALRA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHCCCCCCCCCCCCCEEEEHHHHHHHHHH
WSPQAAPDGEPREAGAAPLPAGTDQALAECDEPIAGVLVHGPQDVSLAGARGAVRWRPGA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCEEECCCCCEEECCCC
AQPEPWPAWPDGAAVRAACLGGADADGESVWIAMETAGGGSAVGRLQAAGNVEVLWRLAE
CCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHHEECCCCHHHHHHHHH
ALQCLRWRAGDGALLATVPDTGAILHMHPDSPGVVRRLVTVPKGSGRVSGLAFDAEGGVW
HHHHHHHCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHCCCCCCCCEEEEEEECCCCEE
TALRDGWSVVRFLPDGGLDRVAALPVPCPTDVAIGGAEGRTLFVTTARQPVALDLLANAP
EEHHCCCEEEEECCCCCCCCEEECCCCCCCCCEECCCCCCEEEEEECCCCEEEEEECCCC
LSGRLFALPL
CCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1840643; 1545709 [H]