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The map label for this gene is fsr [H]

Identifier: 120608793

GI number: 120608793

Start: 88169

End: 89440

Strand: Direct

Name: fsr [H]

Synonym: Aave_0083

Alternate gene names: 120608793

Gene position: 88169-89440 (Clockwise)

Preceding gene: 120608788

Following gene: 120608794

Centisome position: 1.65

GC content: 72.25

Gene sequence:

>1272_bases
ATGACCTCGATCAACGCACCCACGGCCACGCTGCGGCAGGACGCCCGCACCATCGGCCTCATCGGCCTGGCGCACGGCTC
TTCGCACTTCTTCCACCTGCTGCTGCCGCCGCTGTTCCCCTTCCTCATCGCGGAGTTCGGCTACAGCTACTCCGAGCTGG
GCCTGCTGGTGTCGGTGTTCTTCGTCATCTCCGGCGTGGGCCAGGCTCTGTCGGGCTTCATCGTGGACCGGGTCGGCGCG
CGCCCGGTGATGTTCTTCGCGCTGTCGAGCTTCGTCCTGTCCGGCCTCGTGGCCAGCATCGCCACCGGTTATGCCGGGCT
GATGGCGGCCGCGGCGCTGGCGGGCCTGGGCAACGCCCCCTTCCATCCGGTGGACTTCACCATCCTCAACAAGCGCGTGT
CACCCCAGCGCCTGGGCCACGGCTTCTCGGTGCACGGCATCTCCGGCAACCTGGGCTGGGCCACCGCGCCCGTCTTCATG
GCCGGCATCACCGCGGCCACCGGGTCCTGGCGGGCGGCCTGCCTCTGCGGCGGCCTGCTGGCGCTGGTCATCCTGTCCAT
CATGGTCCTGAACCGCGACGCGCTCGACGACCGCCGGGGCAAGGCCGCACCCGCCGCGGGCAAGCCCGGCGCCGCCACCG
CGCCGGCAGGCGCCCCGGCCGAACACCCCATGGCCTTCCTCCGGCTGCCTTCCGTCTGGCTCTGCTTCTCGTTCTTCTTC
TGGACCACCTGCTCGCTGAGCGTCATCCAGAGCTTCGCCGGCCCCACGCTGCAGAAGATGTACGGCCTGCCGCTGTCCGT
CACCTCCATGGTCGTCACCGGCTACATGCTGTGCGGCGCCGCCGGCATGGTGGTCGGCGGCTTCCTGGCCGGCCGCGTGG
CCCGGCTGGAGCGCACCATCACCGTCTGCCTGCTGGCCACGGCCGTGCTGCTGGTCGCCGCGGGCACGGGCCTGCTGCCG
GGCATGGCCGCCATGGTCTTCGTGGCGCTGGCGGGCGTGGGCACCGGCCTGGCCGGCCCCTCGCGCGACATGCTCATCAA
GCGCGCCGCGCCGCCCGGCGCCACCGGCCGCGTCTATGGCACGGTGTACTCGGGCCTGGACCTCGGCTTCTGCATGGCCG
CCCCGGTGTTCGGCGCCATGCTGGACGCGGGCATGACCTCCGGCATCTTCTACGGCTCGGCCGCCGCCCTGGTGCTGGGC
GTGGCTTCGGCGGGTGTCGTCGGCATCGGCGTCGCGGCCAGGGCGCGCGCGCAGCGCATGGCCGTGGCATGA

Upstream 100 bases:

>100_bases
TCCGTCCCCGGATGCGGAAAGTGCGGTGCTTGGCATGTTCGCGACAATCTTTGGCCGGCTATCGTAATCCGGACGCGGGG
CGGCTTCTTAAGATCGCCGC

Downstream 100 bases:

>100_bases
ACGGCGGCCCCACCGCATCCCCACCCACGGGAGGCGCCGCGCGTTGCCGGGCGTGCTGATCGAACAGCTGCACGGCGGGA
ACTGCCTGCGCGTCTGCGTG

Product: major facilitator superfamily transporter

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MTSINAPTATLRQDARTIGLIGLAHGSSHFFHLLLPPLFPFLIAEFGYSYSELGLLVSVFFVISGVGQALSGFIVDRVGA
RPVMFFALSSFVLSGLVASIATGYAGLMAAAALAGLGNAPFHPVDFTILNKRVSPQRLGHGFSVHGISGNLGWATAPVFM
AGITAATGSWRAACLCGGLLALVILSIMVLNRDALDDRRGKAAPAAGKPGAATAPAGAPAEHPMAFLRLPSVWLCFSFFF
WTTCSLSVIQSFAGPTLQKMYGLPLSVTSMVVTGYMLCGAAGMVVGGFLAGRVARLERTITVCLLATAVLLVAAGTGLLP
GMAAMVFVALAGVGTGLAGPSRDMLIKRAAPPGATGRVYGTVYSGLDLGFCMAAPVFGAMLDAGMTSGIFYGSAAALVLG
VASAGVVGIGVAARARAQRMAVA

Sequences:

>Translated_423_residues
MTSINAPTATLRQDARTIGLIGLAHGSSHFFHLLLPPLFPFLIAEFGYSYSELGLLVSVFFVISGVGQALSGFIVDRVGA
RPVMFFALSSFVLSGLVASIATGYAGLMAAAALAGLGNAPFHPVDFTILNKRVSPQRLGHGFSVHGISGNLGWATAPVFM
AGITAATGSWRAACLCGGLLALVILSIMVLNRDALDDRRGKAAPAAGKPGAATAPAGAPAEHPMAFLRLPSVWLCFSFFF
WTTCSLSVIQSFAGPTLQKMYGLPLSVTSMVVTGYMLCGAAGMVVGGFLAGRVARLERTITVCLLATAVLLVAAGTGLLP
GMAAMVFVALAGVGTGLAGPSRDMLIKRAAPPGATGRVYGTVYSGLDLGFCMAAPVFGAMLDAGMTSGIFYGSAAALVLG
VASAGVVGIGVAARARAQRMAVA
>Mature_422_residues
TSINAPTATLRQDARTIGLIGLAHGSSHFFHLLLPPLFPFLIAEFGYSYSELGLLVSVFFVISGVGQALSGFIVDRVGAR
PVMFFALSSFVLSGLVASIATGYAGLMAAAALAGLGNAPFHPVDFTILNKRVSPQRLGHGFSVHGISGNLGWATAPVFMA
GITAATGSWRAACLCGGLLALVILSIMVLNRDALDDRRGKAAPAAGKPGAATAPAGAPAEHPMAFLRLPSVWLCFSFFFW
TTCSLSVIQSFAGPTLQKMYGLPLSVTSMVVTGYMLCGAAGMVVGGFLAGRVARLERTITVCLLATAVLLVAAGTGLLPG
MAAMVFVALAGVGTGLAGPSRDMLIKRAAPPGATGRVYGTVYSGLDLGFCMAAPVFGAMLDAGMTSGIFYGSAAALVLGV
ASAGVVGIGVAARARAQRMAVA

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=295, Percent_Identity=26.4406779661017, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43068; Mature: 42937

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSINAPTATLRQDARTIGLIGLAHGSSHFFHLLLPPLFPFLIAEFGYSYSELGLLVSVF
CCCCCCCHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
FVISGVGQALSGFIVDRVGARPVMFFALSSFVLSGLVASIATGYAGLMAAAALAGLGNAP
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FHPVDFTILNKRVSPQRLGHGFSVHGISGNLGWATAPVFMAGITAATGSWRAACLCGGLL
CCCCCHHEECCCCCHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
ALVILSIMVLNRDALDDRRGKAAPAAGKPGAATAPAGAPAEHPMAFLRLPSVWLCFSFFF
HHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHH
WTTCSLSVIQSFAGPTLQKMYGLPLSVTSMVVTGYMLCGAAGMVVGGFLAGRVARLERTI
HHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVCLLATAVLLVAAGTGLLPGMAAMVFVALAGVGTGLAGPSRDMLIKRAAPPGATGRVYG
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHEEECCCCCCCCCEEE
TVYSGLDLGFCMAAPVFGAMLDAGMTSGIFYGSAAALVLGVASAGVVGIGVAARARAQRM
HHHCCCHHHHHHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AVA
CCC
>Mature Secondary Structure 
TSINAPTATLRQDARTIGLIGLAHGSSHFFHLLLPPLFPFLIAEFGYSYSELGLLVSVF
CCCCCCHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
FVISGVGQALSGFIVDRVGARPVMFFALSSFVLSGLVASIATGYAGLMAAAALAGLGNAP
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FHPVDFTILNKRVSPQRLGHGFSVHGISGNLGWATAPVFMAGITAATGSWRAACLCGGLL
CCCCCHHEECCCCCHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
ALVILSIMVLNRDALDDRRGKAAPAAGKPGAATAPAGAPAEHPMAFLRLPSVWLCFSFFF
HHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHH
WTTCSLSVIQSFAGPTLQKMYGLPLSVTSMVVTGYMLCGAAGMVVGGFLAGRVARLERTI
HHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVCLLATAVLLVAAGTGLLPGMAAMVFVALAGVGTGLAGPSRDMLIKRAAPPGATGRVYG
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHEEECCCCCCCCCEEE
TVYSGLDLGFCMAAPVFGAMLDAGMTSGIFYGSAAALVLGVASAGVVGIGVAARARAQRM
HHHCCCHHHHHHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AVA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]