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The map label for this gene is ffh [H]

Identifier: 119946973

GI number: 119946973

Start: 4159641

End: 4161014

Strand: Reverse

Name: ffh [H]

Synonym: Ping_3368

Alternate gene names: 119946973

Gene position: 4161014-4159641 (Counterclockwise)

Preceding gene: 119946976

Following gene: 119946972

Centisome position: 91.26

GC content: 42.21

Gene sequence:

>1374_bases
ATGTTTGAGAATTTAACCGAACGACTGTCGAAAACCCTGAAAAATGTCAGTGGCAAAGGACGCTTAACCGAAGATAATAT
TAAAGATACCCTGCGTGAAGTGCGCATGGCTTTACTCGAAGCCGATGTTGCGTTACCTGTTGTTCGTGATTTTATAGAAG
CGATAAAGACACGTTCTGTTGGTCAAGATGTTGCTAAAAGTTTAAGCCCCGGTCAAGCCTTTATTAAAATTGTTCAAAAT
GAGCTTGAATTGGCAATGGGGGAAGTTAACGAATCATTAGATCTTGCCACTCAACCCCCCGCTATTTTATTGATGGCAGG
CTTGCAGGGAGCGGGTAAAACAACCTCGGTTGCTAAACTTGGCCGATTATTAAAAACCCGCGATAAAAAAAGTGTGTTAG
TGGTCAGTGCCGATATTTATCGTCCTGCTGCGATCAAACAACTTGAAACACTTGCTGCTGAAGTGGGTGTCGAATTCTTT
CCAAGTGATATTACGCAAAAACCCATTGATATTGCTAATGCGGCGATAGCTTACGCTAAAAAGAAATTTATTGATGTTGT
GATTGTCGATACCGCCGGTCGTTTGCATGTCGACGGCGAAATGATGGATGAGATTAAAGATCTTCATCGTGCCATTAAAC
CGATTGAAACACTCTTTGTTGTTGATGCGATGACCGGTCAAGATGCAGCCAATACCGCTAAATCTTTCAATGAAACATTA
CCCTTGACGGGGATTATATTAACTAAAGCCGATGGTGATGCACGCGGTGGTGCAGCACTTTCTATCCGTCATATTACGGG
TAAACCGATTAAATTTATTGGTATGGGCGAAAAAGTAGATGCGTTAGAGGCTTTTCATCCAGACCGAATTGCCTCACGAA
TTTTAGGTATGGGTGATGTTCTTTCATTAATCGAAGAACTTGAAACTAAGGTCGACAAAGAAAAAGCGGAAAAATTAGCG
CGTAAAGTTAAAGCCGGTAAGGGGTTTGATTTAGAAGACTTTCGTGAGCAGTTAATACAGATGAAAAGTATGGGTGGCAT
GACGGGCATGATGGATAAATTGCCGGGCATGGGGAAAGTGCCTAGCGGTGTTAAAAATCAGGTTAATGATAAAAGTACAG
ATCAGATGGAAGTGATCATTAATTCGATGACCAAAAAAGAGCGTGGCAAACCAGAAATAATTAAAGGTGGTCGTAAACGC
CGGATCGCAGCAGGCTCTGGTACACAAATCCAAGATGTGAATAGATTATTAAAACAATTTATGCAAATGCAGAAAATGAT
GAAAAAGATGTCGGGTAAAGGTGGTATGCGTAAAATGATGGGCAGTATGCAGGGTATGATGTCTGGCGCAGGTGCCCCTC
CCGGGCGGAGATGA

Upstream 100 bases:

>100_bases
GTTATTGCCCGCCCCAGTCACGGTGAATCTGCATATTCAGGTAGTATGGGTATTAATAAGTGCGTATAATAAATTTTATT
TTTAGCAACGAGAGCTGAGT

Downstream 100 bases:

>100_bases
TTTTAGAAACAAATCAGCGCATTAATATTTTTTTATAGTCTACTCAATAAGCTCAAGTTGATTGTTTTCACCGTCTTCTT
GGGCTTTTTTGATCCACTGA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MFENLTERLSKTLKNVSGKGRLTEDNIKDTLREVRMALLEADVALPVVRDFIEAIKTRSVGQDVAKSLSPGQAFIKIVQN
ELELAMGEVNESLDLATQPPAILLMAGLQGAGKTTSVAKLGRLLKTRDKKSVLVVSADIYRPAAIKQLETLAAEVGVEFF
PSDITQKPIDIANAAIAYAKKKFIDVVIVDTAGRLHVDGEMMDEIKDLHRAIKPIETLFVVDAMTGQDAANTAKSFNETL
PLTGIILTKADGDARGGAALSIRHITGKPIKFIGMGEKVDALEAFHPDRIASRILGMGDVLSLIEELETKVDKEKAEKLA
RKVKAGKGFDLEDFREQLIQMKSMGGMTGMMDKLPGMGKVPSGVKNQVNDKSTDQMEVIINSMTKKERGKPEIIKGGRKR
RIAAGSGTQIQDVNRLLKQFMQMQKMMKKMSGKGGMRKMMGSMQGMMSGAGAPPGRR

Sequences:

>Translated_457_residues
MFENLTERLSKTLKNVSGKGRLTEDNIKDTLREVRMALLEADVALPVVRDFIEAIKTRSVGQDVAKSLSPGQAFIKIVQN
ELELAMGEVNESLDLATQPPAILLMAGLQGAGKTTSVAKLGRLLKTRDKKSVLVVSADIYRPAAIKQLETLAAEVGVEFF
PSDITQKPIDIANAAIAYAKKKFIDVVIVDTAGRLHVDGEMMDEIKDLHRAIKPIETLFVVDAMTGQDAANTAKSFNETL
PLTGIILTKADGDARGGAALSIRHITGKPIKFIGMGEKVDALEAFHPDRIASRILGMGDVLSLIEELETKVDKEKAEKLA
RKVKAGKGFDLEDFREQLIQMKSMGGMTGMMDKLPGMGKVPSGVKNQVNDKSTDQMEVIINSMTKKERGKPEIIKGGRKR
RIAAGSGTQIQDVNRLLKQFMQMQKMMKKMSGKGGMRKMMGSMQGMMSGAGAPPGRR
>Mature_457_residues
MFENLTERLSKTLKNVSGKGRLTEDNIKDTLREVRMALLEADVALPVVRDFIEAIKTRSVGQDVAKSLSPGQAFIKIVQN
ELELAMGEVNESLDLATQPPAILLMAGLQGAGKTTSVAKLGRLLKTRDKKSVLVVSADIYRPAAIKQLETLAAEVGVEFF
PSDITQKPIDIANAAIAYAKKKFIDVVIVDTAGRLHVDGEMMDEIKDLHRAIKPIETLFVVDAMTGQDAANTAKSFNETL
PLTGIILTKADGDARGGAALSIRHITGKPIKFIGMGEKVDALEAFHPDRIASRILGMGDVLSLIEELETKVDKEKAEKLA
RKVKAGKGFDLEDFREQLIQMKSMGGMTGMMDKLPGMGKVPSGVKNQVNDKSTDQMEVIINSMTKKERGKPEIIKGGRKR
RIAAGSGTQIQDVNRLLKQFMQMQKMMKKMSGKGGMRKMMGSMQGMMSGAGAPPGRR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=442, Percent_Identity=31.447963800905, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI226371618, Length=344, Percent_Identity=34.0116279069767, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI23308697, Length=318, Percent_Identity=26.7295597484277, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI295424842, Length=318, Percent_Identity=26.7295597484277, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=37.5, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1788963, Length=455, Percent_Identity=72.5274725274725, Blast_Score=655, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=240, Percent_Identity=34.5833333333333, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17539958, Length=457, Percent_Identity=28.8840262582057, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI193206261, Length=215, Percent_Identity=33.4883720930233, Blast_Score=102, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6325345, Length=415, Percent_Identity=34.6987951807229, Blast_Score=216, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6320498, Length=314, Percent_Identity=27.7070063694268, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17647949, Length=449, Percent_Identity=29.1759465478842, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=30, Blast_Score=102, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49736; Mature: 49736

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLTERLSKTLKNVSGKGRLTEDNIKDTLREVRMALLEADVALPVVRDFIEAIKTRSV
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
GQDVAKSLSPGQAFIKIVQNELELAMGEVNESLDLATQPPAILLMAGLQGAGKTTSVAKL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCHHEEEECCCCCCCCHHHHHH
GRLLKTRDKKSVLVVSADIYRPAAIKQLETLAAEVGVEFFPSDITQKPIDIANAAIAYAK
HHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHCCCHHCCCCHHHHHHHHHHHH
KKFIDVVIVDTAGRLHVDGEMMDEIKDLHRAIKPIETLFVVDAMTGQDAANTAKSFNETL
HHHEEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCC
PLTGIILTKADGDARGGAALSIRHITGKPIKFIGMGEKVDALEAFHPDRIASRILGMGDV
CCEEEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHCCHHHHHHHHHCHHHH
LSLIEELETKVDKEKAEKLARKVKAGKGFDLEDFREQLIQMKSMGGMTGMMDKLPGMGKV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
PSGVKNQVNDKSTDQMEVIINSMTKKERGKPEIIKGGRKRRIAAGSGTQIQDVNRLLKQF
CCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEECCCCCHHHHHHHHHHHH
MQMQKMMKKMSGKGGMRKMMGSMQGMMSGAGAPPGRR
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFENLTERLSKTLKNVSGKGRLTEDNIKDTLREVRMALLEADVALPVVRDFIEAIKTRSV
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
GQDVAKSLSPGQAFIKIVQNELELAMGEVNESLDLATQPPAILLMAGLQGAGKTTSVAKL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCHHEEEECCCCCCCCHHHHHH
GRLLKTRDKKSVLVVSADIYRPAAIKQLETLAAEVGVEFFPSDITQKPIDIANAAIAYAK
HHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHCCCHHCCCCHHHHHHHHHHHH
KKFIDVVIVDTAGRLHVDGEMMDEIKDLHRAIKPIETLFVVDAMTGQDAANTAKSFNETL
HHHEEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCC
PLTGIILTKADGDARGGAALSIRHITGKPIKFIGMGEKVDALEAFHPDRIASRILGMGDV
CCEEEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHCCHHHHHHHHHCHHHH
LSLIEELETKVDKEKAEKLARKVKAGKGFDLEDFREQLIQMKSMGGMTGMMDKLPGMGKV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
PSGVKNQVNDKSTDQMEVIINSMTKKERGKPEIIKGGRKRRIAAGSGTQIQDVNRLLKQF
CCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEECCCCCHHHHHHHHHHHH
MQMQKMMKKMSGKGGMRKMMGSMQGMMSGAGAPPGRR
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]