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The map label for this gene is frdB [H]

Identifier: 119946885

GI number: 119946885

Start: 4046503

End: 4047240

Strand: Direct

Name: frdB [H]

Synonym: Ping_3279

Alternate gene names: 119946885

Gene position: 4046503-4047240 (Clockwise)

Preceding gene: 119946884

Following gene: 119946886

Centisome position: 88.75

GC content: 42.41

Gene sequence:

>738_bases
ATGAACGCATCAACTATTACAATAGATGTACTGAGATACCGCCCCGAAATGGATGAAAAACCATTTACTCAATCTTTTGA
AGTCCCCTACAGCCCAGACTTATCTGTTTTGGAATCCCTGCAATATATTAAAGATCATCTGGATAGCACGGTTAGTTTCC
GCTGGTCTTGCCGTATGGCGATTTGTGGCAGCTGCGGAATGATGGTAAATGGCGTTCCTAAATTAGGCTGTAAAGTATTC
CTGCGTGATTATTTTCCAAAGAAAGTCAGTTTAGCACCCTTGGCTAACTTCCCTATTGAACGCGATTTGGTGGTCGTCAT
GGATGACTTTATCGATAAATTAGAGTCCGTTAAACCCTATCTTATACCTGAAAAAGAAAAAGATTTAGCCGAAGGCCCTC
ATCGGCAAACACCTTTACAGATGGAAAAATTTAAACAGTTTTCAATGTGCATAAATTGCGGCTTATGTTACGCCGCCTGC
CCGCAATATGCCTTAGACAAGAAGTTTACCGGCCCTGCGGCTCTTGCATTGCTAGCGCGATACAACCGCGACAGTCGAGA
TAATGGTGAAGCTGAGCGGATGAAAATAGTCAATCAGGAAGAAGGTGTTTGGGGTTGCACTTTTGTTGGATATTGCTCGG
TAGTTTGCCCTAAAGATGTTGATCCGGCTGCAGCCATTCAACTGCTTAAAGTGGACAGCAGTAAAGATTATTTAATTGGT
ATGTTTAAACCAGATTAA

Upstream 100 bases:

>100_bases
CCAAAAGCCAGCCCGCTGAACGTGTTTATGGTGAAGCATCGGACAAAGCAAACGCTGCTGCTGAGAAAGCACAAGCTGCG
TCTGCACAGGAGGAAGTTTA

Downstream 100 bases:

>100_bases
GGGGATAACTATGCCTAAAGGAAAATCTTACCAACTTGAATTTTCAATTAAATTGATGACAGCTTTAAATTACAGAGGTT
AATAAAATGAGTAAACGTAA

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MNASTITIDVLRYRPEMDEKPFTQSFEVPYSPDLSVLESLQYIKDHLDSTVSFRWSCRMAICGSCGMMVNGVPKLGCKVF
LRDYFPKKVSLAPLANFPIERDLVVVMDDFIDKLESVKPYLIPEKEKDLAEGPHRQTPLQMEKFKQFSMCINCGLCYAAC
PQYALDKKFTGPAALALLARYNRDSRDNGEAERMKIVNQEEGVWGCTFVGYCSVVCPKDVDPAAAIQLLKVDSSKDYLIG
MFKPD

Sequences:

>Translated_245_residues
MNASTITIDVLRYRPEMDEKPFTQSFEVPYSPDLSVLESLQYIKDHLDSTVSFRWSCRMAICGSCGMMVNGVPKLGCKVF
LRDYFPKKVSLAPLANFPIERDLVVVMDDFIDKLESVKPYLIPEKEKDLAEGPHRQTPLQMEKFKQFSMCINCGLCYAAC
PQYALDKKFTGPAALALLARYNRDSRDNGEAERMKIVNQEEGVWGCTFVGYCSVVCPKDVDPAAAIQLLKVDSSKDYLIG
MFKPD
>Mature_245_residues
MNASTITIDVLRYRPEMDEKPFTQSFEVPYSPDLSVLESLQYIKDHLDSTVSFRWSCRMAICGSCGMMVNGVPKLGCKVF
LRDYFPKKVSLAPLANFPIERDLVVVMDDFIDKLESVKPYLIPEKEKDLAEGPHRQTPLQMEKFKQFSMCINCGLCYAAC
PQYALDKKFTGPAALALLARYNRDSRDNGEAERMKIVNQEEGVWGCTFVGYCSVVCPKDVDPAAAIQLLKVDSSKDYLIG
MFKPD

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=228, Percent_Identity=32.8947368421053, Blast_Score=124, Evalue=8e-29,
Organism=Escherichia coli, GI1790596, Length=240, Percent_Identity=60.4166666666667, Blast_Score=306, Evalue=9e-85,
Organism=Escherichia coli, GI1786943, Length=230, Percent_Identity=34.3478260869565, Blast_Score=127, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17533915, Length=227, Percent_Identity=31.2775330396476, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6322987, Length=232, Percent_Identity=33.1896551724138, Blast_Score=118, Evalue=7e-28,
Organism=Drosophila melanogaster, GI17137106, Length=231, Percent_Identity=32.9004329004329, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24643156, Length=243, Percent_Identity=32.9218106995885, Blast_Score=121, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 27672; Mature: 27672

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00197 2FE2S_FER_1 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
8.6 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
8.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNASTITIDVLRYRPEMDEKPFTQSFEVPYSPDLSVLESLQYIKDHLDSTVSFRWSCRMA
CCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEE
ICGSCGMMVNGVPKLGCKVFLRDYFPKKVSLAPLANFPIERDLVVVMDDFIDKLESVKPY
ECCCCCHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC
LIPEKEKDLAEGPHRQTPLQMEKFKQFSMCINCGLCYAACPQYALDKKFTGPAALALLAR
CCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCHHHCCCCCCHHHHHHHHH
YNRDSRDNGEAERMKIVNQEEGVWGCTFVGYCSVVCPKDVDPAAAIQLLKVDSSKDYLIG
HCCCCCCCCCHHHHHHHCCCCCCEEEEHHHHHHEECCCCCCHHHHEEEEEECCCCCEEEE
MFKPD
EECCC
>Mature Secondary Structure
MNASTITIDVLRYRPEMDEKPFTQSFEVPYSPDLSVLESLQYIKDHLDSTVSFRWSCRMA
CCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEE
ICGSCGMMVNGVPKLGCKVFLRDYFPKKVSLAPLANFPIERDLVVVMDDFIDKLESVKPY
ECCCCCHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC
LIPEKEKDLAEGPHRQTPLQMEKFKQFSMCINCGLCYAACPQYALDKKFTGPAALALLAR
CCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCHHHCCCCCCHHHHHHHHH
YNRDSRDNGEAERMKIVNQEEGVWGCTFVGYCSVVCPKDVDPAAAIQLLKVDSSKDYLIG
HCCCCCCCCCHHHHHHHCCCCCCEEEEHHHHHHEECCCCCCHHHHEEEEEECCCCCEEEE
MFKPD
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]