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The map label for this gene is frdA [H]

Identifier: 119946884

GI number: 119946884

Start: 4044692

End: 4046503

Strand: Direct

Name: frdA [H]

Synonym: Ping_3278

Alternate gene names: 119946884

Gene position: 4044692-4046503 (Clockwise)

Preceding gene: 119946880

Following gene: 119946885

Centisome position: 88.71

GC content: 46.25

Gene sequence:

>1812_bases
GTGCAGATAATTCAAACAGATGTTGCCATTATTGGTGCCGGCGGCTCAGGCCTTCGAGCCGCTATTGAAATTGCAAAAAA
CCATCCAGAGCTCGATATCGCATTAATATCCAAGGTTTATCCGATGCGCAGCCATACCGTTGCAGCTGAAGGTGGCGCGG
CAGGCGTTGTTCAAGGTCATGATTCATTGGATAACCACTTCAATGATACTGTCTCCGGCGGAGATTGGTTATGCGAACAG
GATGTTGTTGAGTATTTTGTAGAGAATGCCGCCAAACAACTTACCCAACTTGAACATTGGGGCTGTCCGTGGAGCCGTAA
AGAGGATGGCTCGATTAATGTCCGTGCATTCGGGGGGATGAAAATAGAACGTACTTGGTTCGCTGCCGATAAAAGTGGCT
TCCATATTCTGCACACTCTTTTTCAAACCTCACTTCAGCACCCCAAAATCAGACGCTTTGATGAGCATTTCTGCCTGGAT
TTGATTGTTGAAGACAACAAAATCCAAGGTATTGTGATCCTTGATATTGCCGAAGGTGAAGTAAAACTGATCCAGGCTAA
ATCGGTAATTATGGCAACCGGCGGCGCAGGTCGCGTATACAGCTATAATACCAATGGCGGCATTGTCACCGGTGATGGCA
TGTCCCTCGCTTATCGGCACGGTGTTGCGCTCCGTGACATGGAGTTTGTGCAGTATCATCCGACGGGTTTACCGGGCAGT
GGTATTTTAATGACCGAAGGTTGTCGTGGTGAAGGGGGTATCTTAGTCAATAAAAATGGTTACCGTTATCTGCAAGATTA
TGGATTGGGGCCTGAAGTACCCGTCGGACAGACTAAAAACAAACACATGGAACTTGGACCACGTGACAAACTCAGTCAAT
GTTTCTGGCAGGAGCAGCAAAAAGGTAATGTCTTTGAAGGAGAACGCGGAGACTATATTCATATGGATCTTCGCCACTTG
GGTGAAGATAAAATTAATGAACGCCTGCCACTTATCCGTGAACTGGCAAAAGCCTATGCCGGAGTCGATCCTGTTTATGA
CCCCATCCCTGTGCGCCCTACCGTACATTATACAATGGGGGGTATCGAAACGAACGCGAAAACGGCAACCAGTCTGGCTG
GGTTATATGCAATAGGCGAATGTGCTTCTATTGGTTTGCATGGTGCCAACCGTTTGGGCTCGAATTCGTTAACTGAGCTT
GCCGTATTTGGCCAGTTAGGCGGGCAGGAAGCTGCAAATTATGCACTTAATACAGAACACCAGGAAATAGCGCCTTTAAA
AAAACAGGCCGATGCTATTTTGGCCCGCACAGAAGCCTTATTGCACAGTGAAGGCACTGAAAAGATGGCAGACATCCGCT
TAGAAATGGGCGACTGCATGGAAGAGGGGGTTGGCATTTATCGCACCAAAGAACTAATGCAAAAAACCATCGATAAACTT
GCCGAACTTAAAGAGCGCTATAAAAACATTAAGATTGTTGATAAATCCAGTGTGTTTAATACTGAGTTTTTATATGCCAT
TGAATTGGGATATTTACTCGACAGCGCAGAAGCAATGGCACACAGTGCAATAAATCGGGAAGAGTCGCGCGGGTCACATC
AGCGCATTGACGATTTTGATAAACGTGATGACCAAAACTTCTTAAAACATTCACTGGCATATTATCAAGCGGATAAAGCA
CCCAAAATAAAGTATTCCGCCGTGACAATTACCAAAAGCCAGCCCGCTGAACGTGTTTATGGTGAAGCATCGGACAAAGC
AAACGCTGCTGCTGAGAAAGCACAAGCTGCGTCTGCACAGGAGGAAGTTTAA

Upstream 100 bases:

>100_bases
GTTTATTTCGCGGTTTTTTACCAACTCACTGTTAGAATCAAAGAATAATCTTAATAATGTGAATAAGATGAATAACATAA
ACAACTAAGGGAGTAGAAAT

Downstream 100 bases:

>100_bases
TGAACGCATCAACTATTACAATAGATGTACTGAGATACCGCCCCGAAATGGATGAAAAACCATTTACTCAATCTTTTGAA
GTCCCCTACAGCCCAGACTT

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MQIIQTDVAIIGAGGSGLRAAIEIAKNHPELDIALISKVYPMRSHTVAAEGGAAGVVQGHDSLDNHFNDTVSGGDWLCEQ
DVVEYFVENAAKQLTQLEHWGCPWSRKEDGSINVRAFGGMKIERTWFAADKSGFHILHTLFQTSLQHPKIRRFDEHFCLD
LIVEDNKIQGIVILDIAEGEVKLIQAKSVIMATGGAGRVYSYNTNGGIVTGDGMSLAYRHGVALRDMEFVQYHPTGLPGS
GILMTEGCRGEGGILVNKNGYRYLQDYGLGPEVPVGQTKNKHMELGPRDKLSQCFWQEQQKGNVFEGERGDYIHMDLRHL
GEDKINERLPLIRELAKAYAGVDPVYDPIPVRPTVHYTMGGIETNAKTATSLAGLYAIGECASIGLHGANRLGSNSLTEL
AVFGQLGGQEAANYALNTEHQEIAPLKKQADAILARTEALLHSEGTEKMADIRLEMGDCMEEGVGIYRTKELMQKTIDKL
AELKERYKNIKIVDKSSVFNTEFLYAIELGYLLDSAEAMAHSAINREESRGSHQRIDDFDKRDDQNFLKHSLAYYQADKA
PKIKYSAVTITKSQPAERVYGEASDKANAAAEKAQAASAQEEV

Sequences:

>Translated_603_residues
MQIIQTDVAIIGAGGSGLRAAIEIAKNHPELDIALISKVYPMRSHTVAAEGGAAGVVQGHDSLDNHFNDTVSGGDWLCEQ
DVVEYFVENAAKQLTQLEHWGCPWSRKEDGSINVRAFGGMKIERTWFAADKSGFHILHTLFQTSLQHPKIRRFDEHFCLD
LIVEDNKIQGIVILDIAEGEVKLIQAKSVIMATGGAGRVYSYNTNGGIVTGDGMSLAYRHGVALRDMEFVQYHPTGLPGS
GILMTEGCRGEGGILVNKNGYRYLQDYGLGPEVPVGQTKNKHMELGPRDKLSQCFWQEQQKGNVFEGERGDYIHMDLRHL
GEDKINERLPLIRELAKAYAGVDPVYDPIPVRPTVHYTMGGIETNAKTATSLAGLYAIGECASIGLHGANRLGSNSLTEL
AVFGQLGGQEAANYALNTEHQEIAPLKKQADAILARTEALLHSEGTEKMADIRLEMGDCMEEGVGIYRTKELMQKTIDKL
AELKERYKNIKIVDKSSVFNTEFLYAIELGYLLDSAEAMAHSAINREESRGSHQRIDDFDKRDDQNFLKHSLAYYQADKA
PKIKYSAVTITKSQPAERVYGEASDKANAAAEKAQAASAQEEV
>Mature_603_residues
MQIIQTDVAIIGAGGSGLRAAIEIAKNHPELDIALISKVYPMRSHTVAAEGGAAGVVQGHDSLDNHFNDTVSGGDWLCEQ
DVVEYFVENAAKQLTQLEHWGCPWSRKEDGSINVRAFGGMKIERTWFAADKSGFHILHTLFQTSLQHPKIRRFDEHFCLD
LIVEDNKIQGIVILDIAEGEVKLIQAKSVIMATGGAGRVYSYNTNGGIVTGDGMSLAYRHGVALRDMEFVQYHPTGLPGS
GILMTEGCRGEGGILVNKNGYRYLQDYGLGPEVPVGQTKNKHMELGPRDKLSQCFWQEQQKGNVFEGERGDYIHMDLRHL
GEDKINERLPLIRELAKAYAGVDPVYDPIPVRPTVHYTMGGIETNAKTATSLAGLYAIGECASIGLHGANRLGSNSLTEL
AVFGQLGGQEAANYALNTEHQEIAPLKKQADAILARTEALLHSEGTEKMADIRLEMGDCMEEGVGIYRTKELMQKTIDKL
AELKERYKNIKIVDKSSVFNTEFLYAIELGYLLDSAEAMAHSAINREESRGSHQRIDDFDKRDDQNFLKHSLAYYQADKA
PKIKYSAVTITKSQPAERVYGEASDKANAAAEKAQAASAQEEV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=566, Percent_Identity=37.2791519434629, Blast_Score=358, Evalue=7e-99,
Organism=Escherichia coli, GI1790597, Length=582, Percent_Identity=66.6666666666667, Blast_Score=797, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=570, Percent_Identity=40, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1788928, Length=549, Percent_Identity=30.4189435336976, Blast_Score=237, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17505833, Length=540, Percent_Identity=39.2592592592593, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17550100, Length=538, Percent_Identity=39.0334572490706, Blast_Score=357, Evalue=7e-99,
Organism=Caenorhabditis elegans, GI71986328, Length=433, Percent_Identity=25.4041570438799, Blast_Score=109, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6322701, Length=558, Percent_Identity=37.9928315412186, Blast_Score=371, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6322416, Length=567, Percent_Identity=38.0952380952381, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6320788, Length=493, Percent_Identity=25.7606490872211, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17137288, Length=533, Percent_Identity=39.3996247654784, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24655642, Length=533, Percent_Identity=39.3996247654784, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24655647, Length=533, Percent_Identity=39.3996247654784, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24663005, Length=594, Percent_Identity=34.5117845117845, Blast_Score=335, Evalue=4e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005884
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66375; Mature: 66375

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIIQTDVAIIGAGGSGLRAAIEIAKNHPELDIALISKVYPMRSHTVAAEGGAAGVVQGH
CCEEEECEEEEECCCCCHHHHHHHHCCCCCEEHHHHHHHCCCCCCEEEECCCCCEEEECC
DSLDNHFNDTVSGGDWLCEQDVVEYFVENAAKQLTQLEHWGCPWSRKEDGSINVRAFGGM
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCE
KIERTWFAADKSGFHILHTLFQTSLQHPKIRRFDEHFCLDLIVEDNKIQGIVILDIAEGE
EEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHCCCCEEEEEEEECCCCCEEEEEEECCCC
VKLIQAKSVIMATGGAGRVYSYNTNGGIVTGDGMSLAYRHGVALRDMEFVQYHPTGLPGS
EEEEEECEEEEEECCCCEEEEEECCCCEEECCCCEEHHHCCCEEECCCEEEECCCCCCCC
GILMTEGCRGEGGILVNKNGYRYLQDYGLGPEVPVGQTKNKHMELGPRDKLSQCFWQEQQ
CEEEECCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
KGNVFEGERGDYIHMDLRHLGEDKINERLPLIRELAKAYAGVDPVYDPIPVRPTVHYTMG
CCCCCCCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
GIETNAKTATSLAGLYAIGECASIGLHGANRLGSNSLTELAVFGQLGGQEAANYALNTEH
CEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCH
QEIAPLKKQADAILARTEALLHSEGTEKMADIRLEMGDCMEEGVGIYRTKELMQKTIDKL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AELKERYKNIKIVDKSSVFNTEFLYAIELGYLLDSAEAMAHSAINREESRGSHQRIDDFD
HHHHHHHCCEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCHHHCCCHHCCCCHH
KRDDQNFLKHSLAYYQADKAPKIKYSAVTITKSQPAERVYGEASDKANAAAEKAQAASAQ
CCCHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHHH
EEV
CCC
>Mature Secondary Structure
MQIIQTDVAIIGAGGSGLRAAIEIAKNHPELDIALISKVYPMRSHTVAAEGGAAGVVQGH
CCEEEECEEEEECCCCCHHHHHHHHCCCCCEEHHHHHHHCCCCCCEEEECCCCCEEEECC
DSLDNHFNDTVSGGDWLCEQDVVEYFVENAAKQLTQLEHWGCPWSRKEDGSINVRAFGGM
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCE
KIERTWFAADKSGFHILHTLFQTSLQHPKIRRFDEHFCLDLIVEDNKIQGIVILDIAEGE
EEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHCCCCEEEEEEEECCCCCEEEEEEECCCC
VKLIQAKSVIMATGGAGRVYSYNTNGGIVTGDGMSLAYRHGVALRDMEFVQYHPTGLPGS
EEEEEECEEEEEECCCCEEEEEECCCCEEECCCCEEHHHCCCEEECCCEEEECCCCCCCC
GILMTEGCRGEGGILVNKNGYRYLQDYGLGPEVPVGQTKNKHMELGPRDKLSQCFWQEQQ
CEEEECCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
KGNVFEGERGDYIHMDLRHLGEDKINERLPLIRELAKAYAGVDPVYDPIPVRPTVHYTMG
CCCCCCCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
GIETNAKTATSLAGLYAIGECASIGLHGANRLGSNSLTELAVFGQLGGQEAANYALNTEH
CEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCH
QEIAPLKKQADAILARTEALLHSEGTEKMADIRLEMGDCMEEGVGIYRTKELMQKTIDKL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AELKERYKNIKIVDKSSVFNTEFLYAIELGYLLDSAEAMAHSAINREESRGSHQRIDDFD
HHHHHHHCCEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCHHHCCCHHCCCCHH
KRDDQNFLKHSLAYYQADKAPKIKYSAVTITKSQPAERVYGEASDKANAAAEKAQAASAQ
CCCHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHHH
EEV
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3308458 [H]