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The map label for this gene is fkpA [H]

Identifier: 119946732

GI number: 119946732

Start: 3836705

End: 3837487

Strand: Reverse

Name: fkpA [H]

Synonym: Ping_3116

Alternate gene names: 119946732

Gene position: 3837487-3836705 (Counterclockwise)

Preceding gene: 119946734

Following gene: 119946731

Centisome position: 84.16

GC content: 43.04

Gene sequence:

>783_bases
ATGAAAAATGTATTTAAAGTTTCGTTATTAGCCGCTGCGGTAGCATTTACTGTAGGGTGTGAAGACAAACCAGAGCCCGT
CGCTCAAGAAAAAGTACAAGAAGAAGTTGTAGAAAAAGTAGCTTTCGAAAATGATGCTGAGAAAGCTGCCTATGCAATTG
GTGCCTCATTTTCAACACAGATTAAAGCGGGTGTTGCTAAACAAGCTGAATTCGGATTAGAGACCCTTGATACAGAAGCT
ATTATTGCCGGTGTTACTGATTCGCTACGTGGTAATTCTAAGTTAACCGAGGAAGAGGTGGTTGCAACCGTCAATGCTTA
TGGTAAACAAGTACAAGCTGCCGCAGAAACTAAAATGAAAGAAGAAGGCGAAAAGATGGCTGCACAAGCAGCACTATTTT
TAACTGAAAATGCCAAGGCCGAGGGTGTTACCGTGACTGACTCTGGTTTACAGTACTCAGTAATGACTGCAGCAGAAGGG
CCTAAACCTCAAGCTGAAGATACAGTAACAGTACATTATGTAGGAACCTTGGTTGACGGAACTGAATTTGATAGCTCAAT
CAGTCGTGGTGAACCTGCTAAGTTCCCGCTTAACCGCGTTATTCCTGGTTGGACGGAAGGTGTGCAGTTGATGAGTGTTG
GCGAAAAATACAAGTTTGTTATCCCAGCTGAATTAGCTTACGGAGAGCAAGGTGCAGGTTCAATTCCTCCTGGTGCAACT
CTGATTTTTGAAGTTGAATTATTAGATCTCGAAGCTCCTAAAGCCGCGGTTTCTCCAGAATAA

Upstream 100 bases:

>100_bases
TGTGAAAATCTGAAAATTTTAATCCTCGTTTTTTCTCTTTTTAAGAAAGAGAAAACAAAAAAACAGTTAATTTAATAATA
AGAAACAATTTGGAGTAACA

Downstream 100 bases:

>100_bases
TAACTAGCATCAAGTGTTAATATCAAGGCCGCTTTAGTGGCCTTTTTTTTGGGCTATTTATTTTACAGCTTCCTATTTTA
CGCGATCATCAATTTCCATT

Product: peptidylprolyl isomerase, FKBP-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MKNVFKVSLLAAAVAFTVGCEDKPEPVAQEKVQEEVVEKVAFENDAEKAAYAIGASFSTQIKAGVAKQAEFGLETLDTEA
IIAGVTDSLRGNSKLTEEEVVATVNAYGKQVQAAAETKMKEEGEKMAAQAALFLTENAKAEGVTVTDSGLQYSVMTAAEG
PKPQAEDTVTVHYVGTLVDGTEFDSSISRGEPAKFPLNRVIPGWTEGVQLMSVGEKYKFVIPAELAYGEQGAGSIPPGAT
LIFEVELLDLEAPKAAVSPE

Sequences:

>Translated_260_residues
MKNVFKVSLLAAAVAFTVGCEDKPEPVAQEKVQEEVVEKVAFENDAEKAAYAIGASFSTQIKAGVAKQAEFGLETLDTEA
IIAGVTDSLRGNSKLTEEEVVATVNAYGKQVQAAAETKMKEEGEKMAAQAALFLTENAKAEGVTVTDSGLQYSVMTAAEG
PKPQAEDTVTVHYVGTLVDGTEFDSSISRGEPAKFPLNRVIPGWTEGVQLMSVGEKYKFVIPAELAYGEQGAGSIPPGAT
LIFEVELLDLEAPKAAVSPE
>Mature_260_residues
MKNVFKVSLLAAAVAFTVGCEDKPEPVAQEKVQEEVVEKVAFENDAEKAAYAIGASFSTQIKAGVAKQAEFGLETLDTEA
IIAGVTDSLRGNSKLTEEEVVATVNAYGKQVQAAAETKMKEEGEKMAAQAALFLTENAKAEGVTVTDSGLQYSVMTAAEG
PKPQAEDTVTVHYVGTLVDGTEFDSSISRGEPAKFPLNRVIPGWTEGVQLMSVGEKYKFVIPAELAYGEQGAGSIPPGAT
LIFEVELLDLEAPKAAVSPE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=93, Percent_Identity=53.763440860215, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI17149844, Length=93, Percent_Identity=53.763440860215, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI17149842, Length=93, Percent_Identity=53.763440860215, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=48.5981308411215, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=48.5981308411215, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI33469985, Length=97, Percent_Identity=42.2680412371134, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4758380, Length=92, Percent_Identity=47.8260869565217, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI192448443, Length=100, Percent_Identity=46, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4503729, Length=117, Percent_Identity=40.1709401709402, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI8923659, Length=103, Percent_Identity=40.7766990291262, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI224809329, Length=93, Percent_Identity=45.1612903225806, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI224809327, Length=93, Percent_Identity=45.1612903225806, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4758384, Length=93, Percent_Identity=45.1612903225806, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4503727, Length=100, Percent_Identity=42, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI7706131, Length=122, Percent_Identity=39.344262295082, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI224809331, Length=93, Percent_Identity=45.1612903225806, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI219842220, Length=102, Percent_Identity=40.1960784313725, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1789745, Length=265, Percent_Identity=41.8867924528302, Blast_Score=194, Evalue=6e-51,
Organism=Escherichia coli, GI87082390, Length=210, Percent_Identity=46.1904761904762, Blast_Score=182, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17561782, Length=102, Percent_Identity=50, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71993519, Length=90, Percent_Identity=54.4444444444444, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17540882, Length=107, Percent_Identity=44.8598130841121, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17561778, Length=114, Percent_Identity=40.3508771929825, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=95, Percent_Identity=54.7368421052632, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324194, Length=92, Percent_Identity=47.8260869565217, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323566, Length=109, Percent_Identity=37.6146788990826, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323482, Length=96, Percent_Identity=38.5416666666667, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281363946, Length=93, Percent_Identity=51.6129032258064, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI17352457, Length=93, Percent_Identity=51.6129032258064, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24655568, Length=92, Percent_Identity=51.0869565217391, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24583150, Length=106, Percent_Identity=44.3396226415094, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21356629, Length=94, Percent_Identity=48.936170212766, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 27451; Mature: 27451

Theoretical pI: Translated: 4.17; Mature: 4.17

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVFKVSLLAAAVAFTVGCEDKPEPVAQEKVQEEVVEKVAFENDAEKAAYAIGASFSTQ
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHH
IKAGVAKQAEFGLETLDTEAIIAGVTDSLRGNSKLTEEEVVATVNAYGKQVQAAAETKMK
HHHHHHHHHHCCCHHCCCHHEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EEGEKMAAQAALFLTENAKAEGVTVTDSGLQYSVMTAAEGPKPQAEDTVTVHYVGTLVDG
HHHHHHHHHHHEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCEEEEEEEEEEECC
TEFDSSISRGEPAKFPLNRVIPGWTEGVQLMSVGEKYKFVIPAELAYGEQGAGSIPPGAT
CCCCCCCCCCCCCCCCHHHCCCCHHHCCCEEECCCCEEEEEEHHHCCCCCCCCCCCCCCE
LIFEVELLDLEAPKAAVSPE
EEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKNVFKVSLLAAAVAFTVGCEDKPEPVAQEKVQEEVVEKVAFENDAEKAAYAIGASFSTQ
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHH
IKAGVAKQAEFGLETLDTEAIIAGVTDSLRGNSKLTEEEVVATVNAYGKQVQAAAETKMK
HHHHHHHHHHCCCHHCCCHHEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EEGEKMAAQAALFLTENAKAEGVTVTDSGLQYSVMTAAEGPKPQAEDTVTVHYVGTLVDG
HHHHHHHHHHHEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCEEEEEEEEEEECC
TEFDSSISRGEPAKFPLNRVIPGWTEGVQLMSVGEKYKFVIPAELAYGEQGAGSIPPGAT
CCCCCCCCCCCCCCCCHHHCCCCHHHCCCEEECCCCEEEEEEHHHCCCCCCCCCCCCCCE
LIFEVELLDLEAPKAAVSPE
EEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]