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The map label for this gene is tmk [H]

Identifier: 119944852

GI number: 119944852

Start: 1364334

End: 1365005

Strand: Direct

Name: tmk [H]

Synonym: Ping_1094

Alternate gene names: 119944852

Gene position: 1364334-1365005 (Clockwise)

Preceding gene: 119944851

Following gene: 119944853

Centisome position: 29.92

GC content: 42.71

Gene sequence:

>672_bases
ATGCCCGTTTCGAAAAAGTCAGCTGCAGAAATATTAGTGAGTAAATTTATCGTTATAGAAGGCCTTGAGGGAGCTGGCAA
AAGTACGGCTGTCTCTTATATAACCAAGTGGTTATTCAAGCAGAATATAGCGACCTGCGATACTGTTTATACGCGTGAGC
CGGGTGGCACGGAATTGGCGGAAAAAATGCGCGATATAGTGAAGATCGAAGTCACTGGTGAAAAATTAGATGATAAAGCG
GAATTATTACTGATGTATGCAGCCCGTGTGCAACTCGTTGAGCATATAATTAAACCGGCATTAGTTGCGGGAAAAATTGT
TGTGGGCGATCGCCATAATATGTCCTCTTTAGCTTATCAAGGTGGTGGGCGAGGCATTGATTTAGCGCTGATTGAAGTGA
TCAAAAAGTTGGCATTAGGTGACTTTAAAGCAGACTTAACACTTTATCTGGATATTGATCCCGAACTTGGTTTACAACGC
GCAAGAGGGCGCGGAGAGTTAGATCGTATTGAGCGGCAAGCGATTGATTTTTTTGATCGTACGCGAGCCGTTTTCCTCTC
TTTAGTAGCAAAGGATAAAAATGCAGTCACCATTAATGCTGGTCAGTCCCCAGAGTTAGTTGAAAAAGCTATCTTTGTGG
CCTTAGATAAATGGGTAATGAGTCTTGCTTGA

Upstream 100 bases:

>100_bases
TTGTACTTCGTGAGCAAGGGGGATGGCACCTCTTATTTCTCTAAGAGTCTAAGAGAGCATAATAATGCTGTGCAAAAATA
TATTTTAGGAAAATAACAAC

Downstream 100 bases:

>100_bases
TATGACCTTGGAAAACAGCAAAAAATCCGTCGTTACTCCCTGGTTAACGCCGGTATTTAAGCAATTAATAAACACTTTTC
AGGCGGGTCGATTTGCGCAT

Product: dTMP kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MPVSKKSAAEILVSKFIVIEGLEGAGKSTAVSYITKWLFKQNIATCDTVYTREPGGTELAEKMRDIVKIEVTGEKLDDKA
ELLLMYAARVQLVEHIIKPALVAGKIVVGDRHNMSSLAYQGGGRGIDLALIEVIKKLALGDFKADLTLYLDIDPELGLQR
ARGRGELDRIERQAIDFFDRTRAVFLSLVAKDKNAVTINAGQSPELVEKAIFVALDKWVMSLA

Sequences:

>Translated_223_residues
MPVSKKSAAEILVSKFIVIEGLEGAGKSTAVSYITKWLFKQNIATCDTVYTREPGGTELAEKMRDIVKIEVTGEKLDDKA
ELLLMYAARVQLVEHIIKPALVAGKIVVGDRHNMSSLAYQGGGRGIDLALIEVIKKLALGDFKADLTLYLDIDPELGLQR
ARGRGELDRIERQAIDFFDRTRAVFLSLVAKDKNAVTINAGQSPELVEKAIFVALDKWVMSLA
>Mature_222_residues
PVSKKSAAEILVSKFIVIEGLEGAGKSTAVSYITKWLFKQNIATCDTVYTREPGGTELAEKMRDIVKIEVTGEKLDDKAE
LLLMYAARVQLVEHIIKPALVAGKIVVGDRHNMSSLAYQGGGRGIDLALIEVIKKLALGDFKADLTLYLDIDPELGLQRA
RGRGELDRIERQAIDFFDRTRAVFLSLVAKDKNAVTINAGQSPELVEKAIFVALDKWVMSLA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=211, Percent_Identity=56.3981042654028, Blast_Score=231, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 24503; Mature: 24372

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVSKKSAAEILVSKFIVIEGLEGAGKSTAVSYITKWLFKQNIATCDTVYTREPGGTELA
CCCCHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHCCCHHHHEEECCCCCHHHH
EKMRDIVKIEVTGEKLDDKAELLLMYAARVQLVEHIIKPALVAGKIVVGDRHNMSSLAYQ
HHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHCC
GGGRGIDLALIEVIKKLALGDFKADLTLYLDIDPELGLQRARGRGELDRIERQAIDFFDR
CCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHCHHHHCCCCHHHHHHHHHHHHHHH
TRAVFLSLVAKDKNAVTINAGQSPELVEKAIFVALDKWVMSLA
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVSKKSAAEILVSKFIVIEGLEGAGKSTAVSYITKWLFKQNIATCDTVYTREPGGTELA
CCCHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHCCCHHHHEEECCCCCHHHH
EKMRDIVKIEVTGEKLDDKAELLLMYAARVQLVEHIIKPALVAGKIVVGDRHNMSSLAYQ
HHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHCC
GGGRGIDLALIEVIKKLALGDFKADLTLYLDIDPELGLQRARGRGELDRIERQAIDFFDR
CCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHCHHHHCCCCHHHHHHHHHHHHHHH
TRAVFLSLVAKDKNAVTINAGQSPELVEKAIFVALDKWVMSLA
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA