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The map label for this gene is mexA [H]

Identifier: 119944629

GI number: 119944629

Start: 1087331

End: 1088407

Strand: Direct

Name: mexA [H]

Synonym: Ping_0868

Alternate gene names: 119944629

Gene position: 1087331-1088407 (Clockwise)

Preceding gene: 119944628

Following gene: 119944630

Centisome position: 23.85

GC content: 39.93

Gene sequence:

>1077_bases
ATGTTTGCTCGTATTGCTTATTTCTTTTCGTTGCGCCCTTATTGGCTGGCGTTGCTTATCAGCCTCTTATTATTCTTATG
GATGTTTTCCGGCAGTGAAGAAAACAGATCCCCAACAGCGGTAAAAAAACCACAAGAAAACTTTCCCCAAGTGCAAATAA
CCCATTTTATTCCTCGACAAATGACTAAATCATTAACCTTATATGCCCACAGTGAGGCTGAAAGTCACATTATAGTGCGG
GCAGAGGTTGCCGGTGGAATCAGTAAAACCTATGTTGAAAAGGGCAACTATGTGGAAATTAACAATAACTTGGCAGAAAT
AGATAAAAACGAACACCCTTTCAGGTTTGAACAAGCCAAAGCCCTTTTGTATGAAAGGCAGTTAAATTATAACGCAGTCA
AATTGTTAAATGCCAAAGGATTACAAGCCGACATTTATTTAGCTGAAGCAAACAGTTTGTTATTAGCAGCCAAATCCAAC
CTTGCACTGTTAGGCTTAACCTTAAAAAATACGCATATTACTGCGCCTTTTACGGGTGTTCTGCAGGAGAAATTTGTTGA
ACAAGGGGATTATGTAAAGGTGGGTGATCCTCTTTTTAGTCTCGAAAATATTGATCCTATTGTTTTCCGTGGGGACACAA
CTGAGCATTATGTTAACCAATTAAGCTTAAACCAGGAAGTTCGAGCAACACTATTATCGGCTGAGGTATTAACCGGTAAA
TTGACTTACATTGCATCAATGGCTGACCCGCAGAGCAGTACTTTTCGTGTTGAAGCGCAATTTGCAAATCCGAATAGGAA
AATATTTTCCGGCATGAGTGCGCAACTCTCTATCCCGCTTTATTCCGTACAAGCGATTTATCTCTCGCCTTCAGCGTTAG
CATTGGATAAAGAGGGCAATTTAGGGGTTAAATTAGTACAGAATGAGCGGGTTAGTTTTAAAAAAATTAATCTGGTTGAA
GCTGATATTAATGGTGTTTGGTTAACGGGTTTTGCTGGTGAAGTGGATATTATCACCTTAGGGCAAGGTTTTGTGAAATC
GGGTGATCGCGTGCAGGCGATAATAGTGGAGAAATAA

Upstream 100 bases:

>100_bases
AACAAAATATGACTTCATTCAATGCCTTTCTCGGTTATTAACTCGCGCAGTTTTTTTTATCAACTAAATTATAAGTTGTT
AGTAAAATTGAGGCTCTGCT

Downstream 100 bases:

>100_bases
TCATGACAGGGGTTATTGAGGGGACATTATCACGTAAACGTGTGGTCCTAACGTTGTTAGCTTTTTTATTGACCGCGGGT
CTTTCTGCTTATATTAATAT

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MFARIAYFFSLRPYWLALLISLLLFLWMFSGSEENRSPTAVKKPQENFPQVQITHFIPRQMTKSLTLYAHSEAESHIIVR
AEVAGGISKTYVEKGNYVEINNNLAEIDKNEHPFRFEQAKALLYERQLNYNAVKLLNAKGLQADIYLAEANSLLLAAKSN
LALLGLTLKNTHITAPFTGVLQEKFVEQGDYVKVGDPLFSLENIDPIVFRGDTTEHYVNQLSLNQEVRATLLSAEVLTGK
LTYIASMADPQSSTFRVEAQFANPNRKIFSGMSAQLSIPLYSVQAIYLSPSALALDKEGNLGVKLVQNERVSFKKINLVE
ADINGVWLTGFAGEVDIITLGQGFVKSGDRVQAIIVEK

Sequences:

>Translated_358_residues
MFARIAYFFSLRPYWLALLISLLLFLWMFSGSEENRSPTAVKKPQENFPQVQITHFIPRQMTKSLTLYAHSEAESHIIVR
AEVAGGISKTYVEKGNYVEINNNLAEIDKNEHPFRFEQAKALLYERQLNYNAVKLLNAKGLQADIYLAEANSLLLAAKSN
LALLGLTLKNTHITAPFTGVLQEKFVEQGDYVKVGDPLFSLENIDPIVFRGDTTEHYVNQLSLNQEVRATLLSAEVLTGK
LTYIASMADPQSSTFRVEAQFANPNRKIFSGMSAQLSIPLYSVQAIYLSPSALALDKEGNLGVKLVQNERVSFKKINLVE
ADINGVWLTGFAGEVDIITLGQGFVKSGDRVQAIIVEK
>Mature_358_residues
MFARIAYFFSLRPYWLALLISLLLFLWMFSGSEENRSPTAVKKPQENFPQVQITHFIPRQMTKSLTLYAHSEAESHIIVR
AEVAGGISKTYVEKGNYVEINNNLAEIDKNEHPFRFEQAKALLYERQLNYNAVKLLNAKGLQADIYLAEANSLLLAAKSN
LALLGLTLKNTHITAPFTGVLQEKFVEQGDYVKVGDPLFSLENIDPIVFRGDTTEHYVNQLSLNQEVRATLLSAEVLTGK
LTYIASMADPQSSTFRVEAQFANPNRKIFSGMSAQLSIPLYSVQAIYLSPSALALDKEGNLGVKLVQNERVSFKKINLVE
ADINGVWLTGFAGEVDIITLGQGFVKSGDRVQAIIVEK

Specific function: The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor. Note=The membrane anchor is not necessary for antibiotic efflux as the protein is functional when targeted to the periplasm by a foreign signal peptide [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39923; Mature: 39923

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFARIAYFFSLRPYWLALLISLLLFLWMFSGSEENRSPTAVKKPQENFPQVQITHFIPRQ
CCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCHHH
MTKSLTLYAHSEAESHIIVRAEVAGGISKTYVEKGNYVEINNNLAEIDKNEHPFRFEQAK
HHCEEEEEEECCCCCEEEEEEECCCCCHHHEECCCCEEEECCCCEECCCCCCCCHHHHHH
ALLYERQLNYNAVKLLNAKGLQADIYLAEANSLLLAAKSNLALLGLTLKNTHITAPFTGV
HHHHHHCCCCCEEEEEECCCCEEEEEEEECCEEEEEECCCEEEEEEEEECCEEECCHHHH
LQEKFVEQGDYVKVGDPLFSLENIDPIVFRGDTTEHYVNQLSLNQEVRATLLSAEVLTGK
HHHHHHCCCCEEEECCCEEECCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHCE
LTYIASMADPQSSTFRVEAQFANPNRKIFSGMSAQLSIPLYSVQAIYLSPSALALDKEGN
EEEEEECCCCCCCEEEEEEEECCCCHHHHCCCCCEEEEEEEEEEEEEECCCEEEEECCCC
LGVKLVQNERVSFKKINLVEADINGVWLTGFAGEVDIITLGQGFVKSGDRVQAIIVEK
CCEEEEECCCCCEEEEEEEEECCCEEEEEECCCCEEEEEECCHHHCCCCEEEEEEEEC
>Mature Secondary Structure
MFARIAYFFSLRPYWLALLISLLLFLWMFSGSEENRSPTAVKKPQENFPQVQITHFIPRQ
CCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCHHH
MTKSLTLYAHSEAESHIIVRAEVAGGISKTYVEKGNYVEINNNLAEIDKNEHPFRFEQAK
HHCEEEEEEECCCCCEEEEEEECCCCCHHHEECCCCEEEECCCCEECCCCCCCCHHHHHH
ALLYERQLNYNAVKLLNAKGLQADIYLAEANSLLLAAKSNLALLGLTLKNTHITAPFTGV
HHHHHHCCCCCEEEEEECCCCEEEEEEEECCEEEEEECCCEEEEEEEEECCEEECCHHHH
LQEKFVEQGDYVKVGDPLFSLENIDPIVFRGDTTEHYVNQLSLNQEVRATLLSAEVLTGK
HHHHHHCCCCEEEECCCEEECCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHCE
LTYIASMADPQSSTFRVEAQFANPNRKIFSGMSAQLSIPLYSVQAIYLSPSALALDKEGN
EEEEEECCCCCCCEEEEEEEECCCCHHHHCCCCCEEEEEEEEEEEEEECCCEEEEECCCC
LGVKLVQNERVSFKKINLVEADINGVWLTGFAGEVDIITLGQGFVKSGDRVQAIIVEK
CCEEEEECCCCCEEEEEEEEECCCEEEEEECCCCEEEEEECCHHHCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968531; 10984043; 9989496; 8226684; 8540696; 9603892; 10671490 [H]