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The map label for this gene is wecA [H]

Identifier: 119944558

GI number: 119944558

Start: 995661

End: 996794

Strand: Direct

Name: wecA [H]

Synonym: Ping_0795

Alternate gene names: 119944558

Gene position: 995661-996794 (Clockwise)

Preceding gene: 119944556

Following gene: 119944559

Centisome position: 21.84

GC content: 39.68

Gene sequence:

>1134_bases
ATGCTGTTTTATTTTTCTGTTCTTATTTTTGCCTTTGTTGCTTCATTTTCTGCGATTAAGGTATTAAAACCATTGGCAGT
AAAACTTGGGTTGACGGATAAACCTAATGCACGAAAGAATCATCGGGGAGAAATTCCTTTAGTGGGGGGGATTTCAGTTT
ATATTGGTCTGTTTTGTTCTGGGTTTTTACTCCTTATTGTCGAACCAGTAAACATTGATCTGTTGACTTATCTCTTTGCG
TCATTGCTGATGGTGGTTACCGGCGCCTTAGATGACCGTTTTGATTTGAGTGTTCGAATCCGCATTTTAGCCCAAGTGCT
TATAGCTTCAATCATGATGTTTGTTGCAGATCGTGTCCTCTTTAATTTGGGTGATTTATTATCGATCGGTGAAATCTCTC
TTGGCTATTTTGCCTATCCTTTTACTGTTCTTGCAGTGTTAGGGGCAATTAACGCTTATAACATGATCGATGGTATTGAT
GGTTTGATTGGCGGTGTTAGTTTCGCTACTTTTGTGCCGCTGACTATTATCTTTTATATGGCAGGCGATATTGAGGTGGC
CTTTTTCTGCCTGTTATGTGTTGTTGTCTTAGCACCTTATCTGCTTCACAATCTGCAATTAACCCGCTTTAGCAGTAAAA
AAATATTTATGGGTGATGCGGGTAGTATGTTTATCGGCTTTACTGTGATTTGGTTATTGGCAATTGGCAGTCAGGGAGAT
TCATCGGGCAGCGAGCCTTATTTTTCTCCCGTCGTGGCAGTTTGGTTTATTGCCTTACCTTTAATGGATATGACGGCCAT
TATAATACGACGTATTAAAAAGGGAAATTCACCTTTTGCGGCAGATCGAGACCACCTGCATCATCTCTTTATGCGAGCGG
GTTTTACTCCCAGACAAACCTTGATTTTTATTACCTGTCTGGCCCTAATGTTAAGTATGATCGGGGTATTCACTACTCTT
TATTCAATACCCGATTGGATACAGTTAGTGGCTTTTATTACGCTGTTCGGTATTTTCCAAACTTCGCTTGCGTACATCTG
GGTTTTACTAAAAACATTCAGAAAAATAATGGCCTTAAAGCGCCTGGCAAAGTTCAAAAAAATACGTAAAAAGTTAAAAG
CAGATCGATACTGA

Upstream 100 bases:

>100_bases
GCCATATTGATTTTTTTGCTGGAAGAACAGATAATTTGCACTGTTTTGAATTTTCATTAATAGTGTTTGTTGATCATTTT
ATTTTTAGGGGTTTTATTCC

Downstream 100 bases:

>100_bases
CAGACCTCAGCTGTCGGTTGTCGGTTGTTGGTTGTCTGCCGTCAGCTTTCAGCCGTCAGCACACTCTGACACCCGTCCGT
TTTTATACTTTTTTCTTATC

Product: undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MLFYFSVLIFAFVASFSAIKVLKPLAVKLGLTDKPNARKNHRGEIPLVGGISVYIGLFCSGFLLLIVEPVNIDLLTYLFA
SLLMVVTGALDDRFDLSVRIRILAQVLIASIMMFVADRVLFNLGDLLSIGEISLGYFAYPFTVLAVLGAINAYNMIDGID
GLIGGVSFATFVPLTIIFYMAGDIEVAFFCLLCVVVLAPYLLHNLQLTRFSSKKIFMGDAGSMFIGFTVIWLLAIGSQGD
SSGSEPYFSPVVAVWFIALPLMDMTAIIIRRIKKGNSPFAADRDHLHHLFMRAGFTPRQTLIFITCLALMLSMIGVFTTL
YSIPDWIQLVAFITLFGIFQTSLAYIWVLLKTFRKIMALKRLAKFKKIRKKLKADRY

Sequences:

>Translated_377_residues
MLFYFSVLIFAFVASFSAIKVLKPLAVKLGLTDKPNARKNHRGEIPLVGGISVYIGLFCSGFLLLIVEPVNIDLLTYLFA
SLLMVVTGALDDRFDLSVRIRILAQVLIASIMMFVADRVLFNLGDLLSIGEISLGYFAYPFTVLAVLGAINAYNMIDGID
GLIGGVSFATFVPLTIIFYMAGDIEVAFFCLLCVVVLAPYLLHNLQLTRFSSKKIFMGDAGSMFIGFTVIWLLAIGSQGD
SSGSEPYFSPVVAVWFIALPLMDMTAIIIRRIKKGNSPFAADRDHLHHLFMRAGFTPRQTLIFITCLALMLSMIGVFTTL
YSIPDWIQLVAFITLFGIFQTSLAYIWVLLKTFRKIMALKRLAKFKKIRKKLKADRY
>Mature_377_residues
MLFYFSVLIFAFVASFSAIKVLKPLAVKLGLTDKPNARKNHRGEIPLVGGISVYIGLFCSGFLLLIVEPVNIDLLTYLFA
SLLMVVTGALDDRFDLSVRIRILAQVLIASIMMFVADRVLFNLGDLLSIGEISLGYFAYPFTVLAVLGAINAYNMIDGID
GLIGGVSFATFVPLTIIFYMAGDIEVAFFCLLCVVVLAPYLLHNLQLTRFSSKKIFMGDAGSMFIGFTVIWLLAIGSQGD
SSGSEPYFSPVVAVWFIALPLMDMTAIIIRRIKKGNSPFAADRDHLHHLFMRAGFTPRQTLIFITCLALMLSMIGVFTTL
YSIPDWIQLVAFITLFGIFQTSLAYIWVLLKTFRKIMALKRLAKFKKIRKKLKADRY

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55). It is the first lipid-linked intermediate involved in enterobacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=307, Percent_Identity=47.2312703583062, Blast_Score=255, Evalue=4e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012750
- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 42004; Mature: 42004

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFYFSVLIFAFVASFSAIKVLKPLAVKLGLTDKPNARKNHRGEIPLVGGISVYIGLFCS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHH
GFLLLIVEPVNIDLLTYLFASLLMVVTGALDDRFDLSVRIRILAQVLIASIMMFVADRVL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FNLGDLLSIGEISLGYFAYPFTVLAVLGAINAYNMIDGIDGLIGGVSFATFVPLTIIFYM
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGDIEVAFFCLLCVVVLAPYLLHNLQLTRFSSKKIFMGDAGSMFIGFTVIWLLAIGSQGD
CCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEECCCCHHHHHHHHHHHHHHCCCCC
SSGSEPYFSPVVAVWFIALPLMDMTAIIIRRIKKGNSPFAADRDHLHHLFMRAGFTPRQT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHH
LIFITCLALMLSMIGVFTTLYSIPDWIQLVAFITLFGIFQTSLAYIWVLLKTFRKIMALK
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLAKFKKIRKKLKADRY
HHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLFYFSVLIFAFVASFSAIKVLKPLAVKLGLTDKPNARKNHRGEIPLVGGISVYIGLFCS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHH
GFLLLIVEPVNIDLLTYLFASLLMVVTGALDDRFDLSVRIRILAQVLIASIMMFVADRVL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FNLGDLLSIGEISLGYFAYPFTVLAVLGAINAYNMIDGIDGLIGGVSFATFVPLTIIFYM
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGDIEVAFFCLLCVVVLAPYLLHNLQLTRFSSKKIFMGDAGSMFIGFTVIWLLAIGSQGD
CCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEECCCCHHHHHHHHHHHHHHCCCCC
SSGSEPYFSPVVAVWFIALPLMDMTAIIIRRIKKGNSPFAADRDHLHHLFMRAGFTPRQT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHH
LIFITCLALMLSMIGVFTTLYSIPDWIQLVAFITLFGIFQTSLAYIWVLLKTFRKIMALK
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLAKFKKIRKKLKADRY
HHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]