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The map label for this gene is folK [H]

Identifier: 119944354

GI number: 119944354

Start: 760404

End: 760886

Strand: Reverse

Name: folK [H]

Synonym: Ping_0581

Alternate gene names: 119944354

Gene position: 760886-760404 (Counterclockwise)

Preceding gene: 119944355

Following gene: 119944353

Centisome position: 16.69

GC content: 43.27

Gene sequence:

>483_bases
TTGATTAGTTATATCGGTGTGGGCAGCAATCAAACGGATCCCGTTAAACAGGCAAAATTAGCCATTGAAAGACTGCAACA
CTTACCTGACAGTCTATTTTGTGACTGCTCGTCGTTGTACCGCAGTGCGCCGATGGGGCCACAGGACCAACCTGACTATA
TTAATGCCGTGGTTAAAATTGATACGAAACTAACGGCCATTGAGTTGTTGGATGAATTGCAAAAAATAGAGCTATCGCAG
GGCAGAGTCCGTAAAGAAAACCGTTGGGGACCGCGCACCTTAGATCTTGATATTATTTTATATGGTAATGAAGTTATCAA
TAATGCACGCCTAACCGTTCCACATTATGGAATGAAAGAGCGTGAATTTGTGCTATATCCCTTATTAGAAATCGACAATG
AGCTGCGTTTGCCCGATGGCAAAGCATTATCACAACTCTCCGCGCATTGTCATAAAAACGGCTTGATCCGGATTAGCAGT
TGA

Upstream 100 bases:

>100_bases
AATGCGAGCAAAGCCACTGAAGTTAAACCTGCGGATAAAAAACCCTATAAAAAACGCAGATACCCCAATAAAAAACATAA
AAAAACAGAGACTACTGGCG

Downstream 100 bases:

>100_bases
ATAAAAAAGTCATCCCCGTAAAATAATAAAAATATTGTAAATAATATAAATATTATTTATCAGCAACTTAAAAATGCGAT
TAACTGTTCGGGTGGAGTGG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MISYIGVGSNQTDPVKQAKLAIERLQHLPDSLFCDCSSLYRSAPMGPQDQPDYINAVVKIDTKLTAIELLDELQKIELSQ
GRVRKENRWGPRTLDLDIILYGNEVINNARLTVPHYGMKEREFVLYPLLEIDNELRLPDGKALSQLSAHCHKNGLIRISS

Sequences:

>Translated_160_residues
MISYIGVGSNQTDPVKQAKLAIERLQHLPDSLFCDCSSLYRSAPMGPQDQPDYINAVVKIDTKLTAIELLDELQKIELSQ
GRVRKENRWGPRTLDLDIILYGNEVINNARLTVPHYGMKEREFVLYPLLEIDNELRLPDGKALSQLSAHCHKNGLIRISS
>Mature_160_residues
MISYIGVGSNQTDPVKQAKLAIERLQHLPDSLFCDCSSLYRSAPMGPQDQPDYINAVVKIDTKLTAIELLDELQKIELSQ
GRVRKENRWGPRTLDLDIILYGNEVINNARLTVPHYGMKEREFVLYPLLEIDNELRLPDGKALSQLSAHCHKNGLIRISS

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=145, Percent_Identity=57.2413793103448, Blast_Score=181, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324073, Length=140, Percent_Identity=35, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18113; Mature: 18113

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISYIGVGSNQTDPVKQAKLAIERLQHLPDSLFCDCSSLYRSAPMGPQDQPDYINAVVKI
CEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHCHHHHHHCCCCCCCCCCCCEEEEEEE
DTKLTAIELLDELQKIELSQGRVRKENRWGPRTLDLDIILYGNEVINNARLTVPHYGMKE
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCHHHCCCEEEECCCCCCC
REFVLYPLLEIDNELRLPDGKALSQLSAHCHKNGLIRISS
CCEEEEEHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECC
>Mature Secondary Structure
MISYIGVGSNQTDPVKQAKLAIERLQHLPDSLFCDCSSLYRSAPMGPQDQPDYINAVVKI
CEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHCHHHHHHCCCCCCCCCCCCEEEEEEE
DTKLTAIELLDELQKIELSQGRVRKENRWGPRTLDLDIILYGNEVINNARLTVPHYGMKE
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCHHHCCCEEEECCCCCCC
REFVLYPLLEIDNELRLPDGKALSQLSAHCHKNGLIRISS
CCEEEEEHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1325970; 8202364; 9278503; 1657875; 2537812; 10378268; 10452528 [H]