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The map label for this gene is adh [H]

Identifier: 119867141

GI number: 119867141

Start: 1173758

End: 1174813

Strand: Reverse

Name: adh [H]

Synonym: Mkms_1089

Alternate gene names: 119867141

Gene position: 1174813-1173758 (Counterclockwise)

Preceding gene: 119867142

Following gene: 119867140

Centisome position: 20.48

GC content: 67.52

Gene sequence:

>1056_bases
ATGCACGCAATGGTCTACCACGGCCCGGGGCGTCGATCGTGGGAGCAGGTGCCCGACCCGGAAGTCCAACGCGCCACCGA
CGCCATCGTGCGCGTCGACGCGGTCACGATCTGCGGCACCGATCTGCACATCCTCAAAGGGGATGTGCCCGAGGTGCAGC
CCGGCCGGATCCTCGGCCACGAAGCGGTGGGCACCGTGATCGAAATCGGTTCCGCGGTCGAGAAACTCGCAGTCGGTGAC
CGGGTGCTGGTGTCGTGCATCAGCGCCTGCGGCAGTTGCCGGTACTGCCGCGACGGGCAGTACGGCCAGTGCCTCGGCGG
CGGCGGATGGATTCTCGGCCATCTCATCGACGGGACGCAGGCCGAATACGTCCGCGTGCCGTTCGCCGACAACTCCACGC
ACAAGGTGCCGGCCGGGGTGAGCGACGAGCAGATGGTCATGCTCGCCGACATCCTGCCCACCTCCTACGAGGTGGGCGTG
CTCAGCGCAGCGGTGCGACCCGGCGACACCGTGGCGATCGTCGGCGCCGGTCCCATCGGCCTCGCGGCAGTCCTCACCGC
GAAGCTCTTCAGCCCCAGCCACATCGTCGTCATCGACATCGCCGAGAGCCGGCTGGAAGCGGCCAAGAACATGGGCGCCG
ACGTCGTCGTCAACTCGACATCGCAGGATGCCCGCTCGGTCCTCGACGAACTCACCGATGGTCTCGGCGCCGACGTGGCG
ATGGAAGCCGTGGGTATGCCCGAGACCTTCGAACAGGCGGTCCGGCTGGTCCGGGCCGGCGGGCACGTCGCGAACATCGG
GGTGCACGGGAAGCCGGCCACGCTGCACCTGGAGGACATCTGGATCAAGAACCTCACGATCACCACCGGTCTGGTGGACA
CGCACTCCACCCCCTCCCTGATCAGCCTGGTGGCCAACCATCAGATCGACACGGCGGCGATGATCACCCACCATTTCGGT
ATGGAGGAGTTCGACCTCGCCTACGACGTGTTCAGCCGCGCCGGCGAGACCGGTGCGCTCAAGGTGCTCCTCACGCGTAC
CGCGCACAGCGGCTGA

Upstream 100 bases:

>100_bases
CGGCCGCCCGTTGGCCGACTCCGTGGCCGAAGCGCAGCAGATCTGTTGTCTGGCCTACTGATCCACCACACCGATCCATG
AAACCGAGGAGAATCCGACA

Downstream 100 bases:

>100_bases
CCCACGGAAAGGCACGCACATGGCGCAACGCACCGCCCCGGTCGTCGTCGGGATCGACGGCTCGCAGACCAGCATCCACG
CCGCACAGTGGGCCGCGGCG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MHAMVYHGPGRRSWEQVPDPEVQRATDAIVRVDAVTICGTDLHILKGDVPEVQPGRILGHEAVGTVIEIGSAVEKLAVGD
RVLVSCISACGSCRYCRDGQYGQCLGGGGWILGHLIDGTQAEYVRVPFADNSTHKVPAGVSDEQMVMLADILPTSYEVGV
LSAAVRPGDTVAIVGAGPIGLAAVLTAKLFSPSHIVVIDIAESRLEAAKNMGADVVVNSTSQDARSVLDELTDGLGADVA
MEAVGMPETFEQAVRLVRAGGHVANIGVHGKPATLHLEDIWIKNLTITTGLVDTHSTPSLISLVANHQIDTAAMITHHFG
MEEFDLAYDVFSRAGETGALKVLLTRTAHSG

Sequences:

>Translated_351_residues
MHAMVYHGPGRRSWEQVPDPEVQRATDAIVRVDAVTICGTDLHILKGDVPEVQPGRILGHEAVGTVIEIGSAVEKLAVGD
RVLVSCISACGSCRYCRDGQYGQCLGGGGWILGHLIDGTQAEYVRVPFADNSTHKVPAGVSDEQMVMLADILPTSYEVGV
LSAAVRPGDTVAIVGAGPIGLAAVLTAKLFSPSHIVVIDIAESRLEAAKNMGADVVVNSTSQDARSVLDELTDGLGADVA
MEAVGMPETFEQAVRLVRAGGHVANIGVHGKPATLHLEDIWIKNLTITTGLVDTHSTPSLISLVANHQIDTAAMITHHFG
MEEFDLAYDVFSRAGETGALKVLLTRTAHSG
>Mature_351_residues
MHAMVYHGPGRRSWEQVPDPEVQRATDAIVRVDAVTICGTDLHILKGDVPEVQPGRILGHEAVGTVIEIGSAVEKLAVGD
RVLVSCISACGSCRYCRDGQYGQCLGGGGWILGHLIDGTQAEYVRVPFADNSTHKVPAGVSDEQMVMLADILPTSYEVGV
LSAAVRPGDTVAIVGAGPIGLAAVLTAKLFSPSHIVVIDIAESRLEAAKNMGADVVVNSTSQDARSVLDELTDGLGADVA
MEAVGMPETFEQAVRLVRAGGHVANIGVHGKPATLHLEDIWIKNLTITTGLVDTHSTPSLISLVANHQIDTAAMITHHFG
MEEFDLAYDVFSRAGETGALKVLLTRTAHSG

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=341, Percent_Identity=27.2727272727273, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4501929, Length=337, Percent_Identity=27.893175074184, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI34577061, Length=354, Percent_Identity=28.5310734463277, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI71565154, Length=337, Percent_Identity=27.0029673590504, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4501933, Length=351, Percent_Identity=27.0655270655271, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI71565152, Length=341, Percent_Identity=26.3929618768328, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4501939, Length=333, Percent_Identity=22.8228228228228, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI156523966, Length=333, Percent_Identity=22.8228228228228, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI71743840, Length=354, Percent_Identity=24.5762711864407, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI262073058, Length=354, Percent_Identity=24.5762711864407, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786825, Length=394, Percent_Identity=32.994923857868, Blast_Score=197, Evalue=7e-52,
Organism=Escherichia coli, GI1788073, Length=315, Percent_Identity=29.8412698412698, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI1790045, Length=335, Percent_Identity=31.9402985074627, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1787863, Length=331, Percent_Identity=29.9093655589124, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1788075, Length=365, Percent_Identity=26.8493150684932, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI226510992, Length=333, Percent_Identity=27.9279279279279, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87081918, Length=271, Percent_Identity=32.8413284132841, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87082125, Length=265, Percent_Identity=32.8301886792453, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1790718, Length=308, Percent_Identity=26.6233766233766, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788407, Length=343, Percent_Identity=27.9883381924198, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786552, Length=337, Percent_Identity=27.5964391691395, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1786518, Length=277, Percent_Identity=27.0758122743682, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=348, Percent_Identity=27.2988505747126, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25146526, Length=351, Percent_Identity=29.3447293447293, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17565904, Length=342, Percent_Identity=30.1169590643275, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71997431, Length=330, Percent_Identity=29.6969696969697, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17562878, Length=324, Percent_Identity=27.4691358024691, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17562584, Length=277, Percent_Identity=27.7978339350181, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=268, Percent_Identity=27.2388059701493, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=340, Percent_Identity=28.8235294117647, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6319955, Length=340, Percent_Identity=28.8235294117647, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6323099, Length=336, Percent_Identity=26.7857142857143, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6319258, Length=321, Percent_Identity=29.2834890965732, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319257, Length=391, Percent_Identity=26.8542199488491, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=342, Percent_Identity=26.3157894736842, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=269, Percent_Identity=27.8810408921933, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=241, Percent_Identity=27.3858921161826, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=277, Percent_Identity=28.158844765343, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=275, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17137530, Length=348, Percent_Identity=30.1724137931034, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17737897, Length=348, Percent_Identity=29.8850574712644, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17737895, Length=359, Percent_Identity=27.2980501392758, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221457811, Length=328, Percent_Identity=23.1707317073171, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45550770, Length=328, Percent_Identity=23.1707317073171, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45551930, Length=328, Percent_Identity=23.1707317073171, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36961; Mature: 36961

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAMVYHGPGRRSWEQVPDPEVQRATDAIVRVDAVTICGTDLHILKGDVPEVQPGRILGH
CCEEEEECCCCCCCCCCCCHHHHHHHHHHEEEEEEEEECCCEEEEECCCCCCCCCCEECH
EAVGTVIEIGSAVEKLAVGDRVLVSCISACGSCRYCRDGQYGQCLGGGGWILGHLIDGTQ
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEECCCCEEEEEEECCCC
AEYVRVPFADNSTHKVPAGVSDEQMVMLADILPTSYEVGVLSAAVRPGDTVAIVGAGPIG
CCEEEEECCCCCCCCCCCCCCCCCEEEEEHHCCCCCCCHHEEEECCCCCEEEEEECCHHH
LAAVLTAKLFSPSHIVVIDIAESRLEAAKNMGADVVVNSTSQDARSVLDELTDGLGADVA
HHHHHHHHHCCCCEEEEEEECHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCHH
MEAVGMPETFEQAVRLVRAGGHVANIGVHGKPATLHLEDIWIKNLTITTGLVDTHSTPSL
HHHCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEHEEEEEEEEEEEEECCCCCHHH
ISLVANHQIDTAAMITHHFGMEEFDLAYDVFSRAGETGALKVLLTRTAHSG
HHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCC
>Mature Secondary Structure
MHAMVYHGPGRRSWEQVPDPEVQRATDAIVRVDAVTICGTDLHILKGDVPEVQPGRILGH
CCEEEEECCCCCCCCCCCCHHHHHHHHHHEEEEEEEEECCCEEEEECCCCCCCCCCEECH
EAVGTVIEIGSAVEKLAVGDRVLVSCISACGSCRYCRDGQYGQCLGGGGWILGHLIDGTQ
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEECCCCEEEEEEECCCC
AEYVRVPFADNSTHKVPAGVSDEQMVMLADILPTSYEVGVLSAAVRPGDTVAIVGAGPIG
CCEEEEECCCCCCCCCCCCCCCCCEEEEEHHCCCCCCCHHEEEECCCCCEEEEEECCHHH
LAAVLTAKLFSPSHIVVIDIAESRLEAAKNMGADVVVNSTSQDARSVLDELTDGLGADVA
HHHHHHHHHCCCCEEEEEEECHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCHH
MEAVGMPETFEQAVRLVRAGGHVANIGVHGKPATLHLEDIWIKNLTITTGLVDTHSTPSL
HHHCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEHEEEEEEEEEEEEECCCCCHHH
ISLVANHQIDTAAMITHHFGMEEFDLAYDVFSRAGETGALKVLLTRTAHSG
HHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]