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The map label for this gene is cmaA1 [H]

Identifier: 119867022

GI number: 119867022

Start: 1058792

End: 1059661

Strand: Reverse

Name: cmaA1 [H]

Synonym: Mkms_0970

Alternate gene names: 119867022

Gene position: 1059661-1058792 (Counterclockwise)

Preceding gene: 119867023

Following gene: 119867021

Centisome position: 18.47

GC content: 64.02

Gene sequence:

>870_bases
ATGGCCCCATCGGGCAAACTGAAGCCGCATTTCGAAGACGTCCAGGCCCATTACGACCTGTCCGACGACTTCTTCCGGCT
GTTCCTCGACCCCTCGCAGATGTACAGCTGCGCGTACTTCGAGCGTGACGATATGACGCTCGAGGAGGCGCAGCGCGCCA
AGGTCGATCTCGCGCTGGGCAAGCTGGGTCTGGAGCCCGGTATGACGCTGCTCGACGTGGGTTGCGGCTGGGGCTACACG
ATGATGCGCGCGGTCGAGAAGTACGACGTGAACGTCATCGGCCTGACGTTGAGCAAGAACCAGCACGCGCACGTCGAACG
GATCTTCGCCGAATCGGACAGCCCGCGCAGCAAGCAGGTGCTGCTCAAGGGCTGGGAGGACTTCGATCAGCCCGTCGACC
GGATCGTGTCGATCGGCGCGTTCGAGCACTTCGGCCGCGACCGCTGGGACGACTTCTTCACCACCGCCTACCGGGTGCTG
CCCGATAGCGGCGTGATGCTGCTGCACACCATCACGGCGCTGACGATCCCGCAGATGATCGAGCGTGGCATCCCGCTGAC
GTTCTCGGTGGCGCGGTTCATCAAATTCATCCTCACCGAGATCTTCCCCGGTGGCTACCTGCCGACGATCGACCTCGTCG
GTGAGCACGCCGGCAAGGCCGGGTTCACGCTGACCCGTGAGCAGTCGCTGCAGCCGCACTACGCCAAGACGCTGGACCAC
TGGGCGGCGGCGCTGGAGGCGCACAAAGACGAGGCCATCGCGGTGCAGTCCGAAGAGGTCTACGACCGCTACATGCACTA
CCTGACCGGGTGCGCGGACGCGTTCCGCAAGGGCTACACCGATGTCAACCAGTTCACGCTGGTGAAGTAG

Upstream 100 bases:

>100_bases
GCATCCCTTCCGTTACCATCACCAGTCGAGCGCAGGTGTGCCGTTGCGGCCGTCGACGATGACGCGGACAAGGCCCTCAC
CCGCTAGGAAAGGCACCACC

Downstream 100 bases:

>100_bases
CCGGATCACCCAGCAAAGCTTCGAACTATCGCGGGCGTCAAACAGCTGGCGACCGGGTTGACCGACACGTACCGGGGTGG
CCTGAAGGCTGTCCGGGGCC

Product: cyclopropane-fatty-acyl-phospholipid synthase

Products: NA

Alternate protein names: CMAS; Cyclopropane-fatty-acyl-phospholipid synthase; CFA synthase; Cyclopropane fatty acid synthase; Mycolic acid methyltransferase; MA-MT; S-adenosylmethionine-dependent methyltransferase; AdoMet-MT; SAM-MT [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MAPSGKLKPHFEDVQAHYDLSDDFFRLFLDPSQMYSCAYFERDDMTLEEAQRAKVDLALGKLGLEPGMTLLDVGCGWGYT
MMRAVEKYDVNVIGLTLSKNQHAHVERIFAESDSPRSKQVLLKGWEDFDQPVDRIVSIGAFEHFGRDRWDDFFTTAYRVL
PDSGVMLLHTITALTIPQMIERGIPLTFSVARFIKFILTEIFPGGYLPTIDLVGEHAGKAGFTLTREQSLQPHYAKTLDH
WAAALEAHKDEAIAVQSEEVYDRYMHYLTGCADAFRKGYTDVNQFTLVK

Sequences:

>Translated_289_residues
MAPSGKLKPHFEDVQAHYDLSDDFFRLFLDPSQMYSCAYFERDDMTLEEAQRAKVDLALGKLGLEPGMTLLDVGCGWGYT
MMRAVEKYDVNVIGLTLSKNQHAHVERIFAESDSPRSKQVLLKGWEDFDQPVDRIVSIGAFEHFGRDRWDDFFTTAYRVL
PDSGVMLLHTITALTIPQMIERGIPLTFSVARFIKFILTEIFPGGYLPTIDLVGEHAGKAGFTLTREQSLQPHYAKTLDH
WAAALEAHKDEAIAVQSEEVYDRYMHYLTGCADAFRKGYTDVNQFTLVK
>Mature_288_residues
APSGKLKPHFEDVQAHYDLSDDFFRLFLDPSQMYSCAYFERDDMTLEEAQRAKVDLALGKLGLEPGMTLLDVGCGWGYTM
MRAVEKYDVNVIGLTLSKNQHAHVERIFAESDSPRSKQVLLKGWEDFDQPVDRIVSIGAFEHFGRDRWDDFFTTAYRVLP
DSGVMLLHTITALTIPQMIERGIPLTFSVARFIKFILTEIFPGGYLPTIDLVGEHAGKAGFTLTREQSLQPHYAKTLDHW
AAALEAHKDEAIAVQSEEVYDRYMHYLTGCADAFRKGYTDVNQFTLVK

Specific function: Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfers of a methylene group from S-adenosyl-L- methionine. Cyclopropanated mycolic acids are key factors participating in cell enve

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CFA/CMAS family [H]

Homologues:

Organism=Escherichia coli, GI1787951, Length=262, Percent_Identity=33.969465648855, Blast_Score=146, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI133904226, Length=285, Percent_Identity=31.5789473684211, Blast_Score=123, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003333 [H]

Pfam domain/function: PF02353 CMAS [H]

EC number: =2.1.1.79 [H]

Molecular weight: Translated: 32846; Mature: 32715

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPSGKLKPHFEDVQAHYDLSDDFFRLFLDPSQMYSCAYFERDDMTLEEAQRAKVDLALG
CCCCCCCCCCHHHHHHHCCCCHHHHHHHCCHHHHHEEHEECCCCCCHHHHHHHHHHHHHH
KLGLEPGMTLLDVGCGWGYTMMRAVEKYDVNVIGLTLSKNQHAHVERIFAESDSPRSKQV
HHCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCCCHHHH
LLKGWEDFDQPVDRIVSIGAFEHFGRDRWDDFFTTAYRVLPDSGVMLLHTITALTIPQMI
HHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ERGIPLTFSVARFIKFILTEIFPGGYLPTIDLVGEHAGKAGFTLTREQSLQPHYAKTLDH
HCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCEEEHHCCCCCHHHHHHHH
WAAALEAHKDEAIAVQSEEVYDRYMHYLTGCADAFRKGYTDVNQFTLVK
HHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
>Mature Secondary Structure 
APSGKLKPHFEDVQAHYDLSDDFFRLFLDPSQMYSCAYFERDDMTLEEAQRAKVDLALG
CCCCCCCCCHHHHHHHCCCCHHHHHHHCCHHHHHEEHEECCCCCCHHHHHHHHHHHHHH
KLGLEPGMTLLDVGCGWGYTMMRAVEKYDVNVIGLTLSKNQHAHVERIFAESDSPRSKQV
HHCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCCCHHHH
LLKGWEDFDQPVDRIVSIGAFEHFGRDRWDDFFTTAYRVLPDSGVMLLHTITALTIPQMI
HHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ERGIPLTFSVARFIKFILTEIFPGGYLPTIDLVGEHAGKAGFTLTREQSLQPHYAKTLDH
HCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCEEEHHCCCCCHHHHHHHH
WAAALEAHKDEAIAVQSEEVYDRYMHYLTGCADAFRKGYTDVNQFTLVK
HHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7604045 [H]