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The map label for this gene is garR [H]

Identifier: 119855230

GI number: 119855230

Start: 52790

End: 53653

Strand: Reverse

Name: garR [H]

Synonym: Mkms_5844

Alternate gene names: 119855230

Gene position: 53653-52790 (Counterclockwise)

Preceding gene: 119855231

Following gene: 119855229

Centisome position: 24.75

GC content: 64.35

Gene sequence:

>864_bases
GTGATCGGTCTGGGCGCCATGGGTTCCGCGCTGGCGGCGTCGCTTCTCGCGACGGACCATTCGGTGGTTTGTTTCGACAT
TCGGCCCGACGTGTTACGCCCAGTTGTGGAGCTAGGCGCCGAGGCTGCTGCGGACGCGCGTGAGTTGGCCGGCGCATGTG
ATGTCGTTTTGACGTTCCTCCCGGGGCCGAGTCAGGTGCTGGAGGTGGCGCTCGGGTCGGAGCGAGGTGTCCTGGCCGGC
CTTGCCGACGGGGCCGCCCTGCTGGATATGTCGACCTGTAATCCCGAGGTTGCAGCGATCATCGGTCAGGCCTACGACGC
GGCTGGGAGGCGTTTTGTCGATTGCCCCGTCAGCCGAAAGGCGCCGAACATGACCGTTCTGATCGGAGGGCCGCCGGGGG
TACTGGGCCCGGATGCTGATGTCCTCGCCGCCGTCTCGCGCACCTTGGTGTACTGCGGCCATCGAGGTGCGGGTTATGCC
ACCAAGCTTCTCAACCAGCACGTCAAGTACAGCTGGTATCTCGCTTCGGCGGAAGCCCTCTTAATCGCTGAGGCGATGGG
ATTGAATGCCGGCGAGGTAGCCGACGCGATCGCGGAGTGCAGCGGGGGGGACTCGGGTCTCACTACGGCGGCGGCGTACT
TCCGCCACGACACCGAGTCAGTTAGGAACCGCGCCCCCGCTAGCACCATTACGAAAGACTCCGCGCTGGCGGAAAGTATG
GCGACGAACGCCGGTATCCGCAGCAGGACGCTTGAGCCCGTCGTGGACTTCTTCCAAAGTGTTGCGGCCTCGGAGTTTCG
CGACCGTGCCTACCCCGAAAGCACAGAACTTCTTCAGCGAATCCGGTCGATGCCTCCGAAGTGA

Upstream 100 bases:

>100_bases
TGATTTCTCAGCACGCACACGGCGCCGTGGTATGCCAAAAGTGTTGACAGCCGGCGCAGAAGGTGGCGTTGGGCCGGCTG
CTGTCATGAGGCGGGTCGGC

Downstream 100 bases:

>100_bases
ACCCCTACGTCTTGAGTGCGACCCCCGTCACGCTGTATAGCTAACTGAATTGTTAACGGGTCGAATATCGGTGAGCGGAA
AGAAAGACCACCGACCATTT

Product: 6-phosphogluconate dehydrogenase, NAD-binding

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MIGLGAMGSALAASLLATDHSVVCFDIRPDVLRPVVELGAEAAADARELAGACDVVLTFLPGPSQVLEVALGSERGVLAG
LADGAALLDMSTCNPEVAAIIGQAYDAAGRRFVDCPVSRKAPNMTVLIGGPPGVLGPDADVLAAVSRTLVYCGHRGAGYA
TKLLNQHVKYSWYLASAEALLIAEAMGLNAGEVADAIAECSGGDSGLTTAAAYFRHDTESVRNRAPASTITKDSALAESM
ATNAGIRSRTLEPVVDFFQSVAASEFRDRAYPESTELLQRIRSMPPK

Sequences:

>Translated_287_residues
MIGLGAMGSALAASLLATDHSVVCFDIRPDVLRPVVELGAEAAADARELAGACDVVLTFLPGPSQVLEVALGSERGVLAG
LADGAALLDMSTCNPEVAAIIGQAYDAAGRRFVDCPVSRKAPNMTVLIGGPPGVLGPDADVLAAVSRTLVYCGHRGAGYA
TKLLNQHVKYSWYLASAEALLIAEAMGLNAGEVADAIAECSGGDSGLTTAAAYFRHDTESVRNRAPASTITKDSALAESM
ATNAGIRSRTLEPVVDFFQSVAASEFRDRAYPESTELLQRIRSMPPK
>Mature_287_residues
MIGLGAMGSALAASLLATDHSVVCFDIRPDVLRPVVELGAEAAADARELAGACDVVLTFLPGPSQVLEVALGSERGVLAG
LADGAALLDMSTCNPEVAAIIGQAYDAAGRRFVDCPVSRKAPNMTVLIGGPPGVLGPDADVLAAVSRTLVYCGHRGAGYA
TKLLNQHVKYSWYLASAEALLIAEAMGLNAGEVADAIAECSGGDSGLTTAAAYFRHDTESVRNRAPASTITKDSALAESM
ATNAGIRSRTLEPVVDFFQSVAASEFRDRAYPESTELLQRIRSMPPK

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=207, Percent_Identity=27.0531400966184, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI40556376, Length=238, Percent_Identity=24.3697478991597, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI145693186, Length=258, Percent_Identity=35.2713178294574, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790315, Length=214, Percent_Identity=30.8411214953271, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1786719, Length=192, Percent_Identity=27.6041666666667, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24655230, Length=207, Percent_Identity=28.0193236714976, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19922568, Length=207, Percent_Identity=28.0193236714976, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28574115, Length=202, Percent_Identity=25.7425742574257, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 29778; Mature: 29778

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGLGAMGSALAASLLATDHSVVCFDIRPDVLRPVVELGAEAAADARELAGACDVVLTFL
CCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
PGPSQVLEVALGSERGVLAGLADGAALLDMSTCNPEVAAIIGQAYDAAGRRFVDCPVSRK
CCHHHHHHHHHCCCCCEEEECCCCHHEEECCCCCHHHHHHHHHHHHHCCCEEEECCCCCC
APNMTVLIGGPPGVLGPDADVLAAVSRTLVYCGHRGAGYATKLLNQHVKYSWYLASAEAL
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCEEEEEECHHHH
LIAEAMGLNAGEVADAIAECSGGDSGLTTAAAYFRHDTESVRNRAPASTITKDSALAESM
HHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHH
ATNAGIRSRTLEPVVDFFQSVAASEFRDRAYPESTELLQRIRSMPPK
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MIGLGAMGSALAASLLATDHSVVCFDIRPDVLRPVVELGAEAAADARELAGACDVVLTFL
CCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
PGPSQVLEVALGSERGVLAGLADGAALLDMSTCNPEVAAIIGQAYDAAGRRFVDCPVSRK
CCHHHHHHHHHCCCCCEEEECCCCHHEEECCCCCHHHHHHHHHHHHHCCCEEEECCCCCC
APNMTVLIGGPPGVLGPDADVLAAVSRTLVYCGHRGAGYATKLLNQHVKYSWYLASAEAL
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCEEEEEECHHHH
LIAEAMGLNAGEVADAIAECSGGDSGLTTAAAYFRHDTESVRNRAPASTITKDSALAESM
HHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHH
ATNAGIRSRTLEPVVDFFQSVAASEFRDRAYPESTELLQRIRSMPPK
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]