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The map label for this gene is gltT [H]

Identifier: 119775900

GI number: 119775900

Start: 3308509

End: 3309801

Strand: Reverse

Name: gltT [H]

Synonym: Sama_2768

Alternate gene names: 119775900

Gene position: 3309801-3308509 (Counterclockwise)

Preceding gene: 119775901

Following gene: 119775898

Centisome position: 76.86

GC content: 56.69

Gene sequence:

>1293_bases
ATGTCTGCTACTCCACCCGCTAATTTGTGGCGCCGCTGGTGCGCCGTGCCCCTTTGGCTGCAAATCCTCACCGGTATGTT
GCTCGGTATTGGGGTTGGCCTTGTCCTTGGACCCGATGCCAGTGCCCTGAAACCCATAGGCACCCTGTTTGTAAACACCA
TCAAGATGTTGATAGTGCCCTTGGTATTTTGCTCGCTGATTGTGGGTGTTACCTCGATGCAGGATACCGCCCGCATGGGG
CGCATCGGTTTTAAGTCCTTCGCCTTTTATCTGGCCACGACCGCCATAGCCATCTCGGTGGGCCTTATGGTGGGTTGGCT
GCTTGAGCCTGGCGCGGGGCTGAGTCTCGAAGGCCATGACCTCAGTGCCGAAGTGAAAACGGCGCCGTCGGTGATGGACA
CCCTTATCAACATAGTGCCCACCAATCCGGTGGCGGCCCTGGCCAGTGGCCAGATTTTACAGGTGATTGTATTCGCCGTG
GCCCTGGGGGTGGCGCTGGTGCTGATTGGTGACCATGGTAAGCCGGCCATCAAGGTGTTTGAGAGCCTTGCCGAAGCCAT
GTATAAACTCACCGACATGGTGATGAAGCTTGCCCCCTATGGCGTATTTGGTCTGATGGCCTGGGTCGCAGGCGAGTACG
GCATTGATATGTTGCTGCCGCTGATTAAGGTGATTATTGCCGTGTATCTGGGCTGTGCCCTGCATATTCTGGGCTTTTAT
TCGTTGGTGCTTAAACTGGTGGCCGGGCTAAGTCCCATTCAGTTTTTTAAAGGCATCAGCAACGCCATGGCCGTGGCTTT
TACCACCTCCAGCAGCGCAGGCACCCTGCCTGCCAGCATGAAGTGCGCCAGCGAGTATCTTGGCGTAAACAAGAAGATTT
CCAGCTTTGTGCTGCCCCTTGGCACCACCATCAATATGGACGGCACGGCCCTGTATCAGGGGGTGACGGCGCTTTTTGTG
GCGCAGGCCTTTGGGGTGGACTTAACCTGGGTTGATTACCTCACCATAGTACTGACCGCCACCCTGGCATCCATTGGTAC
CGCAGGGGTGCCGGGAGCTGGACTTGTGATGCTGACACTGGTGCTGACCACGGTGGGCTTGCCCCTTGAAGGCGTGGCCA
TTATTGCCGGTATTGACCGGATACTGGACATGGCCCGCACTGTGGTGAATGTGTCCGGTGACCTGGTGGCCACCACTGTG
ATTGCCCGCTCGGAGGGGGAAATTGATATTGCCCATTATAATGCCGACATGGAAACCAGTTCCGAGATGGCGCAGGCACG
GGAAGACAGCTGA

Upstream 100 bases:

>100_bases
TGCCACAGCAAATGTTAATATTCGCGCTCGGCTATCTCATGCCGAGCGCGCCGGGAAGGATACTTAGCGTGCCCCTTTGG
CAAGTCTCATAAGGTTCAGA

Downstream 100 bases:

>100_bases
TTGCCTGAACTGAGTTGATAAATGAAAAAAGCCCCGTTTAATTGGGGCTTTTTTCTGATCTCGGATACGTGAGTTCGGAT
GCGTGAGTTCGGATACGTGA

Product: proton/glutamate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSATPPANLWRRWCAVPLWLQILTGMLLGIGVGLVLGPDASALKPIGTLFVNTIKMLIVPLVFCSLIVGVTSMQDTARMG
RIGFKSFAFYLATTAIAISVGLMVGWLLEPGAGLSLEGHDLSAEVKTAPSVMDTLINIVPTNPVAALASGQILQVIVFAV
ALGVALVLIGDHGKPAIKVFESLAEAMYKLTDMVMKLAPYGVFGLMAWVAGEYGIDMLLPLIKVIIAVYLGCALHILGFY
SLVLKLVAGLSPIQFFKGISNAMAVAFTTSSSAGTLPASMKCASEYLGVNKKISSFVLPLGTTINMDGTALYQGVTALFV
AQAFGVDLTWVDYLTIVLTATLASIGTAGVPGAGLVMLTLVLTTVGLPLEGVAIIAGIDRILDMARTVVNVSGDLVATTV
IARSEGEIDIAHYNADMETSSEMAQAREDS

Sequences:

>Translated_430_residues
MSATPPANLWRRWCAVPLWLQILTGMLLGIGVGLVLGPDASALKPIGTLFVNTIKMLIVPLVFCSLIVGVTSMQDTARMG
RIGFKSFAFYLATTAIAISVGLMVGWLLEPGAGLSLEGHDLSAEVKTAPSVMDTLINIVPTNPVAALASGQILQVIVFAV
ALGVALVLIGDHGKPAIKVFESLAEAMYKLTDMVMKLAPYGVFGLMAWVAGEYGIDMLLPLIKVIIAVYLGCALHILGFY
SLVLKLVAGLSPIQFFKGISNAMAVAFTTSSSAGTLPASMKCASEYLGVNKKISSFVLPLGTTINMDGTALYQGVTALFV
AQAFGVDLTWVDYLTIVLTATLASIGTAGVPGAGLVMLTLVLTTVGLPLEGVAIIAGIDRILDMARTVVNVSGDLVATTV
IARSEGEIDIAHYNADMETSSEMAQAREDS
>Mature_429_residues
SATPPANLWRRWCAVPLWLQILTGMLLGIGVGLVLGPDASALKPIGTLFVNTIKMLIVPLVFCSLIVGVTSMQDTARMGR
IGFKSFAFYLATTAIAISVGLMVGWLLEPGAGLSLEGHDLSAEVKTAPSVMDTLINIVPTNPVAALASGQILQVIVFAVA
LGVALVLIGDHGKPAIKVFESLAEAMYKLTDMVMKLAPYGVFGLMAWVAGEYGIDMLLPLIKVIIAVYLGCALHILGFYS
LVLKLVAGLSPIQFFKGISNAMAVAFTTSSSAGTLPASMKCASEYLGVNKKISSFVLPLGTTINMDGTALYQGVTALFVA
QAFGVDLTWVDYLTIVLTATLASIGTAGVPGAGLVMLTLVLTTVGLPLEGVAIIAGIDRILDMARTVVNVSGDLVATTVI
ARSEGEIDIAHYNADMETSSEMAQAREDS

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=418, Percent_Identity=33.0143540669856, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI40254478, Length=448, Percent_Identity=31.6964285714286, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI5032093, Length=403, Percent_Identity=37.468982630273, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI169790839, Length=470, Percent_Identity=29.7872340425532, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI66773030, Length=413, Percent_Identity=31.7191283292978, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI4827012, Length=321, Percent_Identity=36.4485981308411, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI223468566, Length=255, Percent_Identity=41.5686274509804, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI223468564, Length=246, Percent_Identity=41.869918699187, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI194239697, Length=257, Percent_Identity=38.1322957198444, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI301601644, Length=199, Percent_Identity=37.6884422110553, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI262359914, Length=377, Percent_Identity=27.3209549071618, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1790514, Length=411, Percent_Identity=39.1727493917275, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1789947, Length=410, Percent_Identity=34.8780487804878, Blast_Score=238, Evalue=4e-64,
Organism=Escherichia coli, GI1788024, Length=426, Percent_Identity=29.3427230046948, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789473, Length=378, Percent_Identity=25.6613756613757, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71996953, Length=460, Percent_Identity=34.7826086956522, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71983106, Length=434, Percent_Identity=33.8709677419355, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71983099, Length=434, Percent_Identity=33.8709677419355, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI193206505, Length=416, Percent_Identity=32.2115384615385, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17537407, Length=457, Percent_Identity=30.6345733041575, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI193206654, Length=452, Percent_Identity=29.646017699115, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17541374, Length=394, Percent_Identity=30.9644670050761, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24583025, Length=394, Percent_Identity=30.9644670050761, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI17137668, Length=394, Percent_Identity=30.9644670050761, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24583023, Length=394, Percent_Identity=30.9644670050761, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI281360483, Length=466, Percent_Identity=30.0429184549356, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI17137666, Length=466, Percent_Identity=30.0429184549356, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI281360481, Length=466, Percent_Identity=30.0429184549356, Blast_Score=141, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45001; Mature: 44870

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCC
>Mature Secondary Structure 
SATPPANLWRRWCAVPLWLQILTGMLLGIGVGLVLGPDASALKPIGTLFVNTIKMLIVP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCHHHHHHHHHHHHHHHHHHHHH
LVFCSLIVGVTSMQDTARMGRIGFKSFAFYLATTAIAISVGLMVGWLLEPGAGLSLEGHD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
LSAEVKTAPSVMDTLINIVPTNPVAALASGQILQVIVFAVALGVALVLIGDHGKPAIKVF
CCCHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHH
ESLAEAMYKLTDMVMKLAPYGVFGLMAWVAGEYGIDMLLPLIKVIIAVYLGCALHILGFY
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SLVLKLVAGLSPIQFFKGISNAMAVAFTTSSSAGTLPASMKCASEYLGVNKKISSFVLPL
HHHHHHHHCCCHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHCC
GTTINMDGTALYQGVTALFVAQAFGVDLTWVDYLTIVLTATLASIGTAGVPGAGLVMLTL
CCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VLTTVGLPLEGVAIIAGIDRILDMARTVVNVSGDLVATTVIARSEGEIDIAHYNADMETS
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEECCCCCEEEEEECCCCCHH
SEMAQAREDS
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]