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The map label for this gene is epd

Identifier: 119775890

GI number: 119775890

Start: 3297714

End: 3298730

Strand: Reverse

Name: epd

Synonym: Sama_2758

Alternate gene names: 119775890

Gene position: 3298730-3297714 (Counterclockwise)

Preceding gene: 119775891

Following gene: 119775889

Centisome position: 76.61

GC content: 58.41

Gene sequence:

>1017_bases
ATGATCCGTGTTGCTATCAATGGTTATGGCCGCATCGGCCGCTCCGTGCTGAGGGCGCTTTATGAGTCCGGCAAACGGGG
CCAGATGCAGCTGGTCGCCATTAATGAACTGGCCAAGCCCGAGGCCATAGTTCACCTGACCAATTACGACACCACCCACG
GCCGTTTCCATACCCGTGCCAGCCTCGATGAAGGCATGATGCATCTGGGGAATGACGCCATACGTTTACTTGCCATCGAA
GATGCCGCTGCGCTGCCCTGGCAGGCGCTGGATGTAGACTTGGTGTTCGAATGCACAGGCGCCCTCAATGACAGACAAAG
CGCCGAAGCCCATATTACTGCCGGTGCCCGCAAGGTACTGATAAGTCATCCGTCTTCTGCCGATGTCGATGCCACCATCG
TCTATGGTGTCAACGACGCCAGCCTCAAAGCCACAGATACCGTTGTCTCCAACGCCTCCTGCACCACCAATTGTCTGGTG
CCGGTCATCGACGTGCTCGACCGCCACTTTGGCGTGAAGAGCGGTGCCATCACCACCATTCACTCGGCCATGAACGATCA
GCAGGTGATTGATGCCTACCATGATGACCTGCGCCGCACCCGCGCCGCCAGTCAGTCGATTATTCCGGTGGACACCAAGC
TCGCCCGCGGGATTGAGCGCATTTTGCCGCAGATGAAAGACAAGTTTGAGGCCATTTCGGTGCGGGTGCCTACAATAAAC
GTCACCGCCATCGACCTCTCGGTGACCCTGGATACCCGGGTAGATATCGCTACCGTGAATGCGGCGCTCAAGGCCGCCGC
CGATGGCAGTGCCAGCGGCATACTGGGCTATACCGATGAGCCTCTGGTATCATGTGACTTTAACCATGACCCGCGCTCCA
GCGTGGTGGATGGTACCCAGACCCGTGTCAGCGCCGGGCATCTGGTGAAAATGCTGCTTTGGTGCGACAACGAGTGGGGT
TTTGCCAACCGCATGCTCGATACCGCCCTGGCCATGGCGGCCACACAGGCTGAATGA

Upstream 100 bases:

>100_bases
AGCCAGGCTGCCACCGGTCTGACCGGCAAATGCCGGTCAGCCTCTGTCGGCAGGGGAGCCGACAGGGTTTTCACCCTCCC
CAGAGGATTTGCTCACCACT

Downstream 100 bases:

>100_bases
CCCTACAGGATAATGAAGAAGAGCAGGGACAAGCTTTTCTCACAAGAATTTGTTTTTGATTAAAAATAAGGAAGCAATAC
CATGACAATTATCAAAATGT

Product: erythrose 4-phosphate dehydrogenase

Products: NA

Alternate protein names: E4PDH

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MIRVAINGYGRIGRSVLRALYESGKRGQMQLVAINELAKPEAIVHLTNYDTTHGRFHTRASLDEGMMHLGNDAIRLLAIE
DAAALPWQALDVDLVFECTGALNDRQSAEAHITAGARKVLISHPSSADVDATIVYGVNDASLKATDTVVSNASCTTNCLV
PVIDVLDRHFGVKSGAITTIHSAMNDQQVIDAYHDDLRRTRAASQSIIPVDTKLARGIERILPQMKDKFEAISVRVPTIN
VTAIDLSVTLDTRVDIATVNAALKAAADGSASGILGYTDEPLVSCDFNHDPRSSVVDGTQTRVSAGHLVKMLLWCDNEWG
FANRMLDTALAMAATQAE

Sequences:

>Translated_338_residues
MIRVAINGYGRIGRSVLRALYESGKRGQMQLVAINELAKPEAIVHLTNYDTTHGRFHTRASLDEGMMHLGNDAIRLLAIE
DAAALPWQALDVDLVFECTGALNDRQSAEAHITAGARKVLISHPSSADVDATIVYGVNDASLKATDTVVSNASCTTNCLV
PVIDVLDRHFGVKSGAITTIHSAMNDQQVIDAYHDDLRRTRAASQSIIPVDTKLARGIERILPQMKDKFEAISVRVPTIN
VTAIDLSVTLDTRVDIATVNAALKAAADGSASGILGYTDEPLVSCDFNHDPRSSVVDGTQTRVSAGHLVKMLLWCDNEWG
FANRMLDTALAMAATQAE
>Mature_338_residues
MIRVAINGYGRIGRSVLRALYESGKRGQMQLVAINELAKPEAIVHLTNYDTTHGRFHTRASLDEGMMHLGNDAIRLLAIE
DAAALPWQALDVDLVFECTGALNDRQSAEAHITAGARKVLISHPSSADVDATIVYGVNDASLKATDTVVSNASCTTNCLV
PVIDVLDRHFGVKSGAITTIHSAMNDQQVIDAYHDDLRRTRAASQSIIPVDTKLARGIERILPQMKDKFEAISVRVPTIN
VTAIDLSVTLDTRVDIATVNAALKAAADGSASGILGYTDEPLVSCDFNHDPRSSVVDGTQTRVSAGHLVKMLLWCDNEWG
FANRMLDTALAMAATQAE

Specific function: Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily

Homologues:

Organism=Homo sapiens, GI7669492, Length=338, Percent_Identity=36.094674556213, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI7657116, Length=330, Percent_Identity=37.8787878787879, Blast_Score=230, Evalue=1e-60,
Organism=Escherichia coli, GI1789295, Length=332, Percent_Identity=63.855421686747, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1788079, Length=327, Percent_Identity=40.6727828746177, Blast_Score=253, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17534677, Length=332, Percent_Identity=39.1566265060241, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17534679, Length=332, Percent_Identity=38.855421686747, Blast_Score=238, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI32566163, Length=342, Percent_Identity=37.4269005847953, Blast_Score=225, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17568413, Length=342, Percent_Identity=37.4269005847953, Blast_Score=225, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6322409, Length=331, Percent_Identity=38.0664652567976, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6322468, Length=329, Percent_Identity=37.6899696048632, Blast_Score=243, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6321631, Length=329, Percent_Identity=37.6899696048632, Blast_Score=239, Evalue=4e-64,
Organism=Drosophila melanogaster, GI17933600, Length=330, Percent_Identity=37.5757575757576, Blast_Score=224, Evalue=5e-59,
Organism=Drosophila melanogaster, GI18110149, Length=330, Percent_Identity=37.5757575757576, Blast_Score=224, Evalue=5e-59,
Organism=Drosophila melanogaster, GI85725000, Length=330, Percent_Identity=37.2727272727273, Blast_Score=220, Evalue=9e-58,
Organism=Drosophila melanogaster, GI22023983, Length=330, Percent_Identity=37.2727272727273, Blast_Score=220, Evalue=9e-58,
Organism=Drosophila melanogaster, GI19922412, Length=333, Percent_Identity=35.4354354354354, Blast_Score=214, Evalue=5e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): E4PD_SHEAM (A1S9A4)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_928630.1
- ProteinModelPortal:   A1S9A4
- SMR:   A1S9A4
- STRING:   A1S9A4
- GeneID:   4605005
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_2758
- NMPDR:   fig|326297.7.peg.2585
- eggNOG:   COG0057
- HOGENOM:   HBG571736
- OMA:   IQAKAVR
- PhylomeDB:   A1S9A4
- ProtClustDB:   PRK13535
- GO:   GO:0005737
- HAMAP:   MF_01640
- InterPro:   IPR006422
- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10836
- PIRSF:   PIRSF000149
- PRINTS:   PR00078
- SMART:   SM00846
- TIGRFAMs:   TIGR01532

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N

EC number: =1.2.1.72

Molecular weight: Translated: 36430; Mature: 36430

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00071 GAPDH

Important sites: ACT_SITE 154-154 BINDING 199-199 BINDING 235-235 BINDING 317-317

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVAINGYGRIGRSVLRALYESGKRGQMQLVAINELAKPEAIVHLTNYDTTHGRFHTRA
CEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCEEECC
SLDEGMMHLGNDAIRLLAIEDAAALPWQALDVDLVFECTGALNDRQSAEAHITAGARKVL
CHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCEEEE
ISHPSSADVDATIVYGVNDASLKATDTVVSNASCTTNCLVPVIDVLDRHFGVKSGAITTI
EECCCCCCCCEEEEEECCCCCCEEHHHEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHHH
HSAMNDQQVIDAYHDDLRRTRAASQSIIPVDTKLARGIERILPQMKDKFEAISVRVPTIN
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECEEE
VTAIDLSVTLDTRVDIATVNAALKAAADGSASGILGYTDEPLVSCDFNHDPRSSVVDGTQ
EEEEEEEEEECCCEEEEEHHHHHHHCCCCCCCCEECCCCCCEEEECCCCCCCCCCCCCCH
TRVSAGHLVKMLLWCDNEWGFANRMLDTALAMAATQAE
HHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIRVAINGYGRIGRSVLRALYESGKRGQMQLVAINELAKPEAIVHLTNYDTTHGRFHTRA
CEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCEEECC
SLDEGMMHLGNDAIRLLAIEDAAALPWQALDVDLVFECTGALNDRQSAEAHITAGARKVL
CHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCEEEE
ISHPSSADVDATIVYGVNDASLKATDTVVSNASCTTNCLVPVIDVLDRHFGVKSGAITTI
EECCCCCCCCEEEEEECCCCCCEEHHHEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHHH
HSAMNDQQVIDAYHDDLRRTRAASQSIIPVDTKLARGIERILPQMKDKFEAISVRVPTIN
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECEEE
VTAIDLSVTLDTRVDIATVNAALKAAADGSASGILGYTDEPLVSCDFNHDPRSSVVDGTQ
EEEEEEEEEECCCEEEEEHHHHHHHCCCCCCCCEECCCCCCEEEECCCCCCCCCCCCCCH
TRVSAGHLVKMLLWCDNEWGFANRMLDTALAMAATQAE
HHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA