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The map label for this gene is focA [H]

Identifier: 119774637

GI number: 119774637

Start: 1817720

End: 1819363

Strand: Direct

Name: focA [H]

Synonym: Sama_1500

Alternate gene names: 119774637

Gene position: 1817720-1819363 (Clockwise)

Preceding gene: 119774633

Following gene: 119774639

Centisome position: 42.21

GC content: 59.91

Gene sequence:

>1644_bases
ATGCCAACTCATCTTCACCAGCGTAAAACGCCGTTGGCGCAGTCGCGCTCGACCAAGGGGGCGACGCCGCCCGAGACACG
CGAAGGCGGCCTGATGGCCGACATCTGTTATGCAAGCCGAAAGAAGCTTGCCAAGGGGCAGCGGCAACGGTTTGCCGAGG
CCGTGTATGCAGGGATTTTCATCGGTCTGGGGTTTGTCTTTTACCTGACGGTGACCACCGGCAGCGCCGGTGCTCCATGG
GGCATGGTGCGTCTTGCCGGTGCACTCGCCTTCAGTTTGGGGTTGATGTTGGTGGTGCTGCTGGGGATGGAGCTTTTTAC
GGGCACAGTGCTGACCGCCATCCCCTGGGCTCAGGGTTCCGCCCGGTTATCGACCCTGCTTAAAAGCTGGCTGTGCGTGT
ATTGTGGCAACGCCCTGGGGGCACTGAGTCTGGCCGCCTTGGTGCTGCTTGCGGGTGTGTGGCAACTCGATGGTGGGCTG
TGGGGAGTAAATCTGATATCCACGGCCCTTCACAAGCTGCACCACGGGTGGTGGGAGGCGTTTTTCCTGGGGGTACTCTG
TAACTTTTTGGTGTGCCTTGGGGTGTGGCTCAGTTTTCTCAGTACTAACCCGGGTACCCGGGCGCTGCTCCTGATGCTGC
CGGTGGCGCTTTTTGTCAGCAGCGGCTTTGAGCACAGCATTGCCAACCTGTTTTTGCTGCCTCTTGCCGGCATGCTGGCT
CAGCACATCCCGGATACGTTCCTGCTCACCCATGGCATTGAGCCGGCGCGGCTTGCTGAGTTGACACCCGCCAACATGCT
GCAACTGAATCTGCTGCCCGTCACCCTCGGCAACATCGTTGGCGGTGCTGTGCTGGTGGGGATGGGGCTCCTGGGCGTGC
ACAGGTTGGGAGAGCGCTCGGCGCAAGCTGTCTCTGCTGCCCCTGCAAATTTTGGGGCCGGCCTGAGTTTGGTAACCACT
GAAGCCCACTTACCAGTTGGCGAAGGTGCGCCTACAGACCGCCGCTATTTCACGCAGGCAAGCCGGTTCGCGAACACGCA
TTTTACCCCCACACCCAGTTCACCTTGTCTGACACCACTGCCCGATGCGCTTCATCCTGCGGCAGCGTCACCCTTATCTT
TGGAGCAAACCATGATGAATAAACACCTGACTACCCTTACCGTTGCTGCCTTGCTGGAGCCTGCAGTTACCTTAACGCCG
GATATGAACCTGTGGCAGTCGTTGGCACTGATGGAAAGTGCGGACGGCGTGTCCTGTCCTGTGGTGGCCGACGGTGGCCG
CCTTGTGGGAATGCTCGCCCCCCAGGACGCCATGCGGGGCCTGTGGGCGGAAGAGTTTGCCGCCAATGGCAGCTACCGGG
TGGGGGACATGATGCAAAAAGTACTGCATACAGTCGCTGCCGATGAGCCGCTTTTGACAGTACTGGAATACTGGGTGGTA
GACAGGCAGCGGCTCTTTCCGGTGACAGGTGAAGGGCATTGGCTGGGGACGGGCTATCAGGCCTATGAAGAGCGTCTGCG
GGGCGCCGTGGCAGCAAGTCCCGCAACCTTGCCTGTGGTGGAAGCCGGGGTGCTTAAGGGAATTATTCACCGTGATGCCT
TGCTGCGATTGCTGCAAAGTGTCAGAGAAAAGCTGCCCGCATAA

Upstream 100 bases:

>100_bases
AAGTATTCGATATTTCTCATGGTGTCTGCTTGCTACATTTGGCGCAATGCAGCAGCCAAGCTGTTGGTACAGAAACTTTT
TATCGATATGGGTGCCGGAT

Downstream 100 bases:

>100_bases
TCCCTTTCAGATCTTCTCCTGGCTCGTGTGCCTGTGGCGCGCGAGCCTTTTTGCTTCCGAAATCACACAGTCACGCAGCG
GGTTTTCAGTGGCATCGGCG

Product: formate transporter

Products: formate [Periplasm]; formate [Cytoplasm] [C]

Alternate protein names: Formate channel [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MPTHLHQRKTPLAQSRSTKGATPPETREGGLMADICYASRKKLAKGQRQRFAEAVYAGIFIGLGFVFYLTVTTGSAGAPW
GMVRLAGALAFSLGLMLVVLLGMELFTGTVLTAIPWAQGSARLSTLLKSWLCVYCGNALGALSLAALVLLAGVWQLDGGL
WGVNLISTALHKLHHGWWEAFFLGVLCNFLVCLGVWLSFLSTNPGTRALLLMLPVALFVSSGFEHSIANLFLLPLAGMLA
QHIPDTFLLTHGIEPARLAELTPANMLQLNLLPVTLGNIVGGAVLVGMGLLGVHRLGERSAQAVSAAPANFGAGLSLVTT
EAHLPVGEGAPTDRRYFTQASRFANTHFTPTPSSPCLTPLPDALHPAAASPLSLEQTMMNKHLTTLTVAALLEPAVTLTP
DMNLWQSLALMESADGVSCPVVADGGRLVGMLAPQDAMRGLWAEEFAANGSYRVGDMMQKVLHTVAADEPLLTVLEYWVV
DRQRLFPVTGEGHWLGTGYQAYEERLRGAVAASPATLPVVEAGVLKGIIHRDALLRLLQSVREKLPA

Sequences:

>Translated_547_residues
MPTHLHQRKTPLAQSRSTKGATPPETREGGLMADICYASRKKLAKGQRQRFAEAVYAGIFIGLGFVFYLTVTTGSAGAPW
GMVRLAGALAFSLGLMLVVLLGMELFTGTVLTAIPWAQGSARLSTLLKSWLCVYCGNALGALSLAALVLLAGVWQLDGGL
WGVNLISTALHKLHHGWWEAFFLGVLCNFLVCLGVWLSFLSTNPGTRALLLMLPVALFVSSGFEHSIANLFLLPLAGMLA
QHIPDTFLLTHGIEPARLAELTPANMLQLNLLPVTLGNIVGGAVLVGMGLLGVHRLGERSAQAVSAAPANFGAGLSLVTT
EAHLPVGEGAPTDRRYFTQASRFANTHFTPTPSSPCLTPLPDALHPAAASPLSLEQTMMNKHLTTLTVAALLEPAVTLTP
DMNLWQSLALMESADGVSCPVVADGGRLVGMLAPQDAMRGLWAEEFAANGSYRVGDMMQKVLHTVAADEPLLTVLEYWVV
DRQRLFPVTGEGHWLGTGYQAYEERLRGAVAASPATLPVVEAGVLKGIIHRDALLRLLQSVREKLPA
>Mature_546_residues
PTHLHQRKTPLAQSRSTKGATPPETREGGLMADICYASRKKLAKGQRQRFAEAVYAGIFIGLGFVFYLTVTTGSAGAPWG
MVRLAGALAFSLGLMLVVLLGMELFTGTVLTAIPWAQGSARLSTLLKSWLCVYCGNALGALSLAALVLLAGVWQLDGGLW
GVNLISTALHKLHHGWWEAFFLGVLCNFLVCLGVWLSFLSTNPGTRALLLMLPVALFVSSGFEHSIANLFLLPLAGMLAQ
HIPDTFLLTHGIEPARLAELTPANMLQLNLLPVTLGNIVGGAVLVGMGLLGVHRLGERSAQAVSAAPANFGAGLSLVTTE
AHLPVGEGAPTDRRYFTQASRFANTHFTPTPSSPCLTPLPDALHPAAASPLSLEQTMMNKHLTTLTVAALLEPAVTLTPD
MNLWQSLALMESADGVSCPVVADGGRLVGMLAPQDAMRGLWAEEFAANGSYRVGDMMQKVLHTVAADEPLLTVLEYWVVD
RQRLFPVTGEGHWLGTGYQAYEERLRGAVAASPATLPVVEAGVLKGIIHRDALLRLLQSVREKLPA

Specific function: Involved in the bidirectional transport of formate [H]

COG id: COG2116

COG function: function code P; Formate/nitrite family of transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FNT transporter (TC 2.A.44) family [H]

Homologues:

Organism=Escherichia coli, GI1787132, Length=251, Percent_Identity=44.2231075697211, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1788837, Length=253, Percent_Identity=36.3636363636364, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87082249, Length=269, Percent_Identity=31.5985130111524, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321779, Length=207, Percent_Identity=25.6038647342995, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000292 [H]

Pfam domain/function: PF01226 Form_Nir_trans [H]

EC number: NA

Molecular weight: Translated: 58334; Mature: 58203

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCC
>Mature Secondary Structure 
PTHLHQRKTPLAQSRSTKGATPPETREGGLMADICYASRKKLAKGQRQRFAEAVYAGIF
CCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGLGFVFYLTVTTGSAGAPWGMVRLAGALAFSLGLMLVVLLGMELFTGTVLTAIPWAQGS
HHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
ARLSTLLKSWLCVYCGNALGALSLAALVLLAGVWQLDGGLWGVNLISTALHKLHHGWWEA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
FFLGVLCNFLVCLGVWLSFLSTNPGTRALLLMLPVALFVSSGFEHSIANLFLLPLAGMLA
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QHIPDTFLLTHGIEPARLAELTPANMLQLNLLPVTLGNIVGGAVLVGMGLLGVHRLGERS
HHCCCHHHHHCCCCHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQAVSAAPANFGAGLSLVTTEAHLPVGEGAPTDRRYFTQASRFANTHFTPTPSSPCLTPL
HHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
PDALHPAAASPLSLEQTMMNKHLTTLTVAALLEPAVTLTPDMNLWQSLALMESADGVSCP
CHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHCCCCCCCC
VVADGGRLVGMLAPQDAMRGLWAEEFAANGSYRVGDMMQKVLHTVAADEPLLTVLEYWVV
EEECCCEEEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
DRQRLFPVTGEGHWLGTGYQAYEERLRGAVAASPATLPVVEAGVLKGIIHRDALLRLLQS
CHHHCCEECCCCCEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VREKLPA
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formate [Cytoplasm]; formate [Periplasm] [C]

Specific reaction: formate [Cytoplasm] = formate [Periplasm] formate [Periplasm] = formate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]