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The map label for this gene is metA

Identifier: 119774511

GI number: 119774511

Start: 1664497

End: 1665447

Strand: Direct

Name: metA

Synonym: Sama_1374

Alternate gene names: 119774511

Gene position: 1664497-1665447 (Clockwise)

Preceding gene: 119774510

Following gene: 119774512

Centisome position: 38.65

GC content: 53.21

Gene sequence:

>951_bases
ATGCCGGTAAAAATCCCCGACAATCTGCCCGCGGCAGAGATACTGTCGGCCGAAAATATCTTTGTGATGTCAGAAACCCG
GGCGGCCCATCAGGACATACGTCCGATGAAGGTGCTTATCCTCAATCTGATGCCCAACAAGATAGAAACAGAAACCCAAC
TGCTGAGGCTCCTTGGCAATACACCCTTGCAGGTGGATGTGGACTTGCTGCGCATCCATGACAAGGAGTCCCGCCACACC
TCGCTTGACCACATGAATACCTTTTACCGGGACTTTGAGGATGTACGGCATAAAAATTATGACGGCCTGATCATCACGGG
AGCGCCGCTGGGGCAGCTCGATTTTGAAGAGGTGACCTATTGGGACCACATCCGCGAAATCATCGACTGGTCCCAAAGCC
ATGTCACCTCGGTATTGTTTTTGTGCTGGGCTGCCCATGCAGGGCTATATCATCTCTATGGTCTCAAGCGTGAATTGCTG
AAAACCAAACGCTCCGGCGTATTTGTGCACAGTCGCAGCTGCGACCACCATCCGCTGCTGCGTGGTTTCGATGAGGAGTT
TTTCGCCCCTCATTCACGTTATGCCGAAATTCCGGTGGCGCAAATTCATGCTCACCCGGCACTGCAGGTACTGGCAGAGT
CTGATGAGGCTGGGGCCTATCTGGTGCTGAGCCGAAACAGCCGTAACCTGTTTGTGATTGGTCACCCCGAATACCAAAAA
TCCACCCTGAGCGATGAATATCACCGGGATTTGGCTGCGGGTATTAACCCCGAAATCCCCCAAAATTACTTTCGAAATGA
CGATCCGGCCCAGCCGCCGGTGGCGCGCTGGCACAGCCATGGCAGCCTCCTGGTGAGTAACTGGCTTAATTATTATGTGT
ACCAGTTGACCCCTTACGATTTGTCCGACATGAGTGCCATCACCCCCTGGGAGGCCAGCTCAAAATCTTGA

Upstream 100 bases:

>100_bases
ACCGGCATGTCGGTGAGGCTGGACAGTGTGGGGCGCTGAACCGGGTTAAGTTTTACACTTACCGGCATCGCCCCGGAGTT
AATCAAGGGAGAGGCGCAGT

Downstream 100 bases:

>100_bases
AAATCAATGTGAAAAGGTCGCGATTCTGCGGCCTTTTTATGTAATGCGCAGGCCCTTGAAATCCGCTTCGGCACCCGTGT
CAATCTCAGTTCCCGCCACT

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MPVKIPDNLPAAEILSAENIFVMSETRAAHQDIRPMKVLILNLMPNKIETETQLLRLLGNTPLQVDVDLLRIHDKESRHT
SLDHMNTFYRDFEDVRHKNYDGLIITGAPLGQLDFEEVTYWDHIREIIDWSQSHVTSVLFLCWAAHAGLYHLYGLKRELL
KTKRSGVFVHSRSCDHHPLLRGFDEEFFAPHSRYAEIPVAQIHAHPALQVLAESDEAGAYLVLSRNSRNLFVIGHPEYQK
STLSDEYHRDLAAGINPEIPQNYFRNDDPAQPPVARWHSHGSLLVSNWLNYYVYQLTPYDLSDMSAITPWEASSKS

Sequences:

>Translated_316_residues
MPVKIPDNLPAAEILSAENIFVMSETRAAHQDIRPMKVLILNLMPNKIETETQLLRLLGNTPLQVDVDLLRIHDKESRHT
SLDHMNTFYRDFEDVRHKNYDGLIITGAPLGQLDFEEVTYWDHIREIIDWSQSHVTSVLFLCWAAHAGLYHLYGLKRELL
KTKRSGVFVHSRSCDHHPLLRGFDEEFFAPHSRYAEIPVAQIHAHPALQVLAESDEAGAYLVLSRNSRNLFVIGHPEYQK
STLSDEYHRDLAAGINPEIPQNYFRNDDPAQPPVARWHSHGSLLVSNWLNYYVYQLTPYDLSDMSAITPWEASSKS
>Mature_315_residues
PVKIPDNLPAAEILSAENIFVMSETRAAHQDIRPMKVLILNLMPNKIETETQLLRLLGNTPLQVDVDLLRIHDKESRHTS
LDHMNTFYRDFEDVRHKNYDGLIITGAPLGQLDFEEVTYWDHIREIIDWSQSHVTSVLFLCWAAHAGLYHLYGLKRELLK
TKRSGVFVHSRSCDHHPLLRGFDEEFFAPHSRYAEIPVAQIHAHPALQVLAESDEAGAYLVLSRNSRNLFVIGHPEYQKS
TLSDEYHRDLAAGINPEIPQNYFRNDDPAQPPVARWHSHGSLLVSNWLNYYVYQLTPYDLSDMSAITPWEASSKS

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=305, Percent_Identity=54.7540983606557, Blast_Score=369, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_SHEAM (A1S5C5)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927251.1
- ProteinModelPortal:   A1S5C5
- SMR:   A1S5C5
- STRING:   A1S5C5
- GeneID:   4603626
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_1374
- NMPDR:   fig|326297.7.peg.1292
- eggNOG:   COG1897
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- PhylomeDB:   A1S5C5
- ProtClustDB:   PRK05368
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 36314; Mature: 36183

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKIPDNLPAAEILSAENIFVMSETRAAHQDIRPMKVLILNLMPNKIETETQLLRLLGN
CCCCCCCCCCHHHHHCCCCEEEEECCHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCC
TPLQVDVDLLRIHDKESRHTSLDHMNTFYRDFEDVRHKNYDGLIITGAPLGQLDFEEVTY
CCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHH
WDHIREIIDWSQSHVTSVLFLCWAAHAGLYHLYGLKRELLKTKRSGVFVHSRSCDHHPLL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHH
RGFDEEFFAPHSRYAEIPVAQIHAHPALQVLAESDEAGAYLVLSRNSRNLFVIGHPEYQK
HCCCHHHCCCCCCCCCCCHHHHHCCHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCHHH
STLSDEYHRDLAAGINPEIPQNYFRNDDPAQPPVARWHSHGSLLVSNWLNYYVYQLTPYD
HHCCHHHHHHHHCCCCCCCCHHHCCCCCCCCCCHHHHHCCCCHHHHHHHCEEEEEECCCC
LSDMSAITPWEASSKS
CCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PVKIPDNLPAAEILSAENIFVMSETRAAHQDIRPMKVLILNLMPNKIETETQLLRLLGN
CCCCCCCCCHHHHHCCCCEEEEECCHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCC
TPLQVDVDLLRIHDKESRHTSLDHMNTFYRDFEDVRHKNYDGLIITGAPLGQLDFEEVTY
CCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHH
WDHIREIIDWSQSHVTSVLFLCWAAHAGLYHLYGLKRELLKTKRSGVFVHSRSCDHHPLL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHH
RGFDEEFFAPHSRYAEIPVAQIHAHPALQVLAESDEAGAYLVLSRNSRNLFVIGHPEYQK
HCCCHHHCCCCCCCCCCCHHHHHCCHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCHHH
STLSDEYHRDLAAGINPEIPQNYFRNDDPAQPPVARWHSHGSLLVSNWLNYYVYQLTPYD
HHCCHHHHHHHHCCCCCCCCHHHCCCCCCCCCCHHHHHCCCCHHHHHHHCEEEEEECCCC
LSDMSAITPWEASSKS
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA