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The map label for this gene is ndk

Identifier: 119774438

GI number: 119774438

Start: 1586191

End: 1586622

Strand: Direct

Name: ndk

Synonym: Sama_1301

Alternate gene names: 119774438

Gene position: 1586191-1586622 (Clockwise)

Preceding gene: 119774437

Following gene: 119774441

Centisome position: 36.84

GC content: 54.17

Gene sequence:

>432_bases
ATGGCGATCGAACGCACTTTTTCTATCATCAAGCCTGATGCTGTTGCCAAGAACCACATCGGTGCTATCTACAACCGTTT
TGAATCAGCTGGCCTGAAAATCATCGCTGCCAAGATGGTTCACCTGACCAAAGAGCAGGCTGAAGGTTTCTACGCTGAGC
ACAGCGAGCGTCCTTTCTTCGGCGCCCTGGTGTCTTTCATGACTTCTGGCCCTATCATGGTTCAGGTTCTGGAAGGTGAA
AACGCCGTTCTGGCCAACCGCGAAATCATGGGTGCTACCAACCCAGCTCAAGCTGCCCGCGGTACTCTGCGTGCTGACTA
TGCTGCCAGCATCGATGAGAACGCTGTACACGGTTCTGACGCTCTGGCTTCTGCCGAGCGCGAAATCGCTTACTTCTTCG
CTGCTGACGAGCTGTGCCCACGCACTCGCTAA

Upstream 100 bases:

>100_bases
TTTGGTTGTGCCTGTCTATGTGATAAAGATAGGCTTTGTGAAATAAATCCCGTATAATCCGCGCGAATTTTACAAACTTG
CTCATCAAAGGAAGCTAGTT

Downstream 100 bases:

>100_bases
TCAGTCGCAGAAAATAAAAAAGGAGCCGAAAGGCTCCTTTTTTATTCCCCGTCACTCAGGGATTGGCCATACTCACATGC
CGTTTTTGCAAATGATGGCC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MAIERTFSIIKPDAVAKNHIGAIYNRFESAGLKIIAAKMVHLTKEQAEGFYAEHSERPFFGALVSFMTSGPIMVQVLEGE
NAVLANREIMGATNPAQAARGTLRADYAASIDENAVHGSDALASAEREIAYFFAADELCPRTR

Sequences:

>Translated_143_residues
MAIERTFSIIKPDAVAKNHIGAIYNRFESAGLKIIAAKMVHLTKEQAEGFYAEHSERPFFGALVSFMTSGPIMVQVLEGE
NAVLANREIMGATNPAQAARGTLRADYAASIDENAVHGSDALASAEREIAYFFAADELCPRTR
>Mature_142_residues
AIERTFSIIKPDAVAKNHIGAIYNRFESAGLKIIAAKMVHLTKEQAEGFYAEHSERPFFGALVSFMTSGPIMVQVLEGEN
AVLANREIMGATNPAQAARGTLRADYAASIDENAVHGSDALASAEREIAYFFAADELCPRTR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=47.4074074074074, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=41.9117647058824, Blast_Score=131, Evalue=3e-31,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=41.9117647058824, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=41.9117647058824, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=41.9117647058824, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=41.9117647058824, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI38045913, Length=139, Percent_Identity=40.2877697841727, Blast_Score=126, Evalue=7e-30,
Organism=Homo sapiens, GI4557797, Length=139, Percent_Identity=40.2877697841727, Blast_Score=126, Evalue=7e-30,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=37.5, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=35.2517985611511, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=35.2517985611511, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=37.5, Blast_Score=86, Evalue=7e-18,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=34.8148148148148, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=35.7664233576642, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=29.7101449275362, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788866, Length=143, Percent_Identity=69.9300699300699, Blast_Score=209, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=42.2222222222222, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=46.3235294117647, Blast_Score=135, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45549037, Length=139, Percent_Identity=46.7625899280576, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=36.5671641791045, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_SHEAM (A1S552)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927178.1
- ProteinModelPortal:   A1S552
- SMR:   A1S552
- STRING:   A1S552
- GeneID:   4603553
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_1301
- NMPDR:   fig|326297.7.peg.1228
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   A1S552
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15520; Mature: 15389

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTFSIIKPDAVAKNHIGAIYNRFESAGLKIIAAKMVHLTKEQAEGFYAEHSERPFF
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
GALVSFMTSGPIMVQVLEGENAVLANREIMGATNPAQAARGTLRADYAASIDENAVHGSD
HHHHHHHCCCCEEEEEECCCCEEEECCEECCCCCHHHHHHCCCCCCHHCCCCCCCCCCCH
ALASAEREIAYFFAADELCPRTR
HHHHHHHHEEEEEECCCCCCCCC
>Mature Secondary Structure 
AIERTFSIIKPDAVAKNHIGAIYNRFESAGLKIIAAKMVHLTKEQAEGFYAEHSERPFF
CCCCCHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
GALVSFMTSGPIMVQVLEGENAVLANREIMGATNPAQAARGTLRADYAASIDENAVHGSD
HHHHHHHCCCCEEEEEECCCCEEEECCEECCCCCHHHHHHCCCCCCHHCCCCCCCCCCCH
ALASAEREIAYFFAADELCPRTR
HHHHHHHHEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA