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The map label for this gene is ribA

Identifier: 119774414

GI number: 119774414

Start: 1566656

End: 1567273

Strand: Direct

Name: ribA

Synonym: Sama_1277

Alternate gene names: 119774414

Gene position: 1566656-1567273 (Clockwise)

Preceding gene: 119774413

Following gene: 119774415

Centisome position: 36.38

GC content: 52.27

Gene sequence:

>618_bases
ATGTCGATAAAGTATGTCGCCACCTCCAAGTTGCCAACGCCCTGGGGCGTTTTTGCCATGCACGGTTTTGAAGACAGTGA
AACCGGAAAGGAGCATGTGGCACTGACCTTTGGCGATCTCAGTGGTGATGCTCCTGTACTGGGACGGATCCATTCTGAAT
GTTTGACCGGTGACGCCCTGTTCAGCCTGCGCTGTGACTGTGGTTTTCAGCTGCAAACAGCCATGCAGCGCATCGCTGAA
ACCGGCCGTGGCTTTATTTTGTATCTGCGTCAGGAAGGGCGCGGCATTGGTCTGCTAAACAAAATCCGTGCCTATGAGTT
GCAGGATAAAGGAGCCAATACCGTCGAGGCCAACGAGCAGCTCGGATTTGCCGCCGATATGCGCAAGTACGATATGATAG
CCCCCATGTTGGCGCATCTGGGTATTTCCCGGGTCAAGCTGATGACCAATAATCCCCGTAAAGTCAACGCCATGAAAGAT
GTGGGTATGGATGTGGTTGAGCGAGTACCGCTGCAGGTGGGGAAAAATCGCTACAACGAAGCTTACCTCAAAACCAAGTC
TGATAAGCTCGGACACATGATGTCTGAAGAGCACTTCAAGGCTCAGCATCAGGACTGA

Upstream 100 bases:

>100_bases
CATAGAATAGGCCACCCGGTGAGGTTATCTTACCAAGGTTGTTGAGCTGTCAGGGAAAGTGCTGGACTCAGGGATTGAGC
GTAGTCGTTAGGAATATTTC

Downstream 100 bases:

>100_bases
TTGTGCAAACTGGTGTTTAGTGGGGAAACCTTTTATAGTCGGGGCATTCATAGATGGATGCCCCGATTGCTTTGAAGCCT
GCCAGAATTTTCGCCATCCT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MSIKYVATSKLPTPWGVFAMHGFEDSETGKEHVALTFGDLSGDAPVLGRIHSECLTGDALFSLRCDCGFQLQTAMQRIAE
TGRGFILYLRQEGRGIGLLNKIRAYELQDKGANTVEANEQLGFAADMRKYDMIAPMLAHLGISRVKLMTNNPRKVNAMKD
VGMDVVERVPLQVGKNRYNEAYLKTKSDKLGHMMSEEHFKAQHQD

Sequences:

>Translated_205_residues
MSIKYVATSKLPTPWGVFAMHGFEDSETGKEHVALTFGDLSGDAPVLGRIHSECLTGDALFSLRCDCGFQLQTAMQRIAE
TGRGFILYLRQEGRGIGLLNKIRAYELQDKGANTVEANEQLGFAADMRKYDMIAPMLAHLGISRVKLMTNNPRKVNAMKD
VGMDVVERVPLQVGKNRYNEAYLKTKSDKLGHMMSEEHFKAQHQD
>Mature_204_residues
SIKYVATSKLPTPWGVFAMHGFEDSETGKEHVALTFGDLSGDAPVLGRIHSECLTGDALFSLRCDCGFQLQTAMQRIAET
GRGFILYLRQEGRGIGLLNKIRAYELQDKGANTVEANEQLGFAADMRKYDMIAPMLAHLGISRVKLMTNNPRKVNAMKDV
GMDVVERVPLQVGKNRYNEAYLKTKSDKLGHMMSEEHFKAQHQD

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1787533, Length=196, Percent_Identity=62.7551020408163, Blast_Score=269, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6319438, Length=172, Percent_Identity=41.8604651162791, Blast_Score=125, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBA_SHEAM (A1S528)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927154.1
- ProteinModelPortal:   A1S528
- SMR:   A1S528
- STRING:   A1S528
- GeneID:   4603529
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_1277
- NMPDR:   fig|326297.7.peg.1206
- eggNOG:   COG0807
- HOGENOM:   HBG735778
- OMA:   QGFILYL
- PhylomeDB:   A1S528
- ProtClustDB:   PRK00393
- HAMAP:   MF_00179
- InterPro:   IPR000926
- TIGRFAMs:   TIGR00505

Pfam domain/function: PF00925 GTP_cyclohydro2

EC number: =3.5.4.25

Molecular weight: Translated: 22896; Mature: 22764

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: ACT_SITE 126-126 ACT_SITE 128-128 BINDING 70-70 BINDING 114-114 BINDING 149-149 BINDING 154-154

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKYVATSKLPTPWGVFAMHGFEDSETGKEHVALTFGDLSGDAPVLGRIHSECLTGDAL
CCEEEEECCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCE
FSLRCDCGFQLQTAMQRIAETGRGFILYLRQEGRGIGLLNKIRAYELQDKGANTVEANEQ
EEEECCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHEEECCCCCCCCCCCCC
LGFAADMRKYDMIAPMLAHLGISRVKLMTNNPRKVNAMKDVGMDVVERVPLQVGKNRYNE
CCHHHHHHHHHHHHHHHHHCCHHEEEEEECCCCEEHHHHHCCHHHHHHHHHHHCCCCCCH
AYLKTKSDKLGHMMSEEHFKAQHQD
HHEECCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SIKYVATSKLPTPWGVFAMHGFEDSETGKEHVALTFGDLSGDAPVLGRIHSECLTGDAL
CEEEEECCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCE
FSLRCDCGFQLQTAMQRIAETGRGFILYLRQEGRGIGLLNKIRAYELQDKGANTVEANEQ
EEEECCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHEEECCCCCCCCCCCCC
LGFAADMRKYDMIAPMLAHLGISRVKLMTNNPRKVNAMKDVGMDVVERVPLQVGKNRYNE
CCHHHHHHHHHHHHHHHHHCCHHEEEEEECCCCEEHHHHHCCHHHHHHHHHHHCCCCCCH
AYLKTKSDKLGHMMSEEHFKAQHQD
HHEECCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA